RGD Reference Report - TFIIB-related factors in RNA polymerase I transcription. - Rat Genome Database

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TFIIB-related factors in RNA polymerase I transcription.

Authors: Knutson, BA  Hahn, S 
Citation: Knutson BA and Hahn S, Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):265-73. doi: 10.1016/j.bbagrm.2012.08.003. Epub 2012 Aug 30.
RGD ID: 9588243
Pubmed: PMID:22960599   (View Abstract at PubMed)
PMCID: PMC3556359   (View Article at PubMed Central)
DOI: DOI:10.1016/j.bbagrm.2012.08.003   (Journal Full-text)

Eukaryotic RNA polymerases (Pol) I, II, III and archaeal Pol use a related set of general transcription factors to recognize promoter sequences and recruit Pol to promoters and to function at key points in the transcription initiation mechanism. The TFIIB-like general transcription factors (GTFs) function during several important and conserved steps in the initiation pathway for Pols II, III, and archaeal Pol. Until recently, the mechanism of Pol I initiation seemed unique, since it appeared to lack a GTF paralogous to the TFIIB-like proteins. The surprising recent discovery of TFIIB-related Pol I general factors in yeast and humans highlights the evolutionary conservation of transcription initiation mechanisms for all eukaryotic and archaeal Pols. These findings reveal new roles for the function of the Pol I GTFs and insight into the function of TFIIB-related factors. Models for Pol I transcription initiation are reexamined in light of these recent findings. This article is part of a Special Issue entitled: Transcription by Odd Pols.



RGD Manual Annotations

1 to 20 of 57 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
RRN3HumanRNA polymerase I transcription pathway   TAS  RGD 
Rrn3RatRNA polymerase I transcription pathway   ISORRN3 (Homo sapiens) RGD 
Rrn3MouseRNA polymerase I transcription pathway   ISORRN3 (Homo sapiens) RGD 
TAF12HumanRNA polymerase I transcription pathway   TAS  RGD 
TAF1AHumanRNA polymerase I transcription pathway   TAS  RGD 
TAF1BHumanRNA polymerase I transcription pathway   TAS  RGD 
TAF1CHumanRNA polymerase I transcription pathway   TAS  RGD 
TAF1DHumanRNA polymerase I transcription pathway   TAS  RGD 
TBPHumanRNA polymerase I transcription pathway   TAS  RGD 
Taf12RatRNA polymerase I transcription pathway   ISOTAF12 (Homo sapiens) RGD 
Taf12MouseRNA polymerase I transcription pathway   ISOTAF12 (Homo sapiens) RGD 
Taf1aRatRNA polymerase I transcription pathway   ISOTAF1A (Homo sapiens) RGD 
Taf1aMouseRNA polymerase I transcription pathway   ISOTAF1A (Homo sapiens) RGD 
Taf1bMouseRNA polymerase I transcription pathway   ISOTAF1B (Homo sapiens) RGD 
Taf1bRatRNA polymerase I transcription pathway   ISOTAF1B (Homo sapiens) RGD 
Taf1cRatRNA polymerase I transcription pathway   ISOTAF1C (Homo sapiens) RGD 
Taf1cMouseRNA polymerase I transcription pathway   ISOTAF1C (Homo sapiens) RGD 
Taf1dRatRNA polymerase I transcription pathway   ISOTAF1D (Homo sapiens) RGD 
Taf1dMouseRNA polymerase I transcription pathway   ISOTAF1D (Homo sapiens) RGD 
TbpRatRNA polymerase I transcription pathway   ISOTBP (Homo sapiens) RGD 
1 to 20 of 57 rows

Genes (Rattus norvegicus)
Polr2a  (RNA polymerase II subunit A) Polr2b  (RNA polymerase II subunit B) Polr2c  (RNA polymerase II subunit C)
Polr2d  (RNA polymerase II subunit D) Polr2e  (RNA polymerase II, I and III subunit E) Polr2f  (RNA polymerase II, I and III subunit F)
Polr2g  (RNA polymerase II subunit G) Polr2j  (RNA polymerase II subunit J) Polr2k  (RNA polymerase II, I and III subunit K)
Rrn3  (RRN3 homolog, RNA polymerase I transcription factor) Taf12  (TATA-box binding protein associated factor 12) Taf1a  (TATA-box binding protein associated factor, RNA polymerase I subunit A)
Taf1b  (TATA-box binding protein associated factor, RNA polymerase I subunit B) Taf1c  (TATA-box binding protein associated factor, RNA polymerase 1 subunit C) Taf1d  (TATA-box binding protein associated factor, RNA polymerase I subunit D)
Tbp  (TATA box binding protein) Ubtf  (upstream binding transcription factor)

Genes (Mus musculus)
Polr2a  (polymerase (RNA) II (DNA directed) polypeptide A) Polr2b  (polymerase (RNA) II (DNA directed) polypeptide B) Polr2c  (polymerase (RNA) II (DNA directed) polypeptide C)
Polr2d  (polymerase (RNA) II (DNA directed) polypeptide D) Polr2e  (polymerase (RNA) II (DNA directed) polypeptide E) Polr2f  (polymerase (RNA) II (DNA directed) polypeptide F)
Polr2g  (polymerase (RNA) II (DNA directed) polypeptide G) Polr2h  (polymerase (RNA) II (DNA directed) polypeptide H) Polr2i  (polymerase (RNA) II (DNA directed) polypeptide I)
Polr2j  (polymerase (RNA) II (DNA directed) polypeptide J) Polr2k  (polymerase (RNA) II (DNA directed) polypeptide K) Polr2l  (polymerase (RNA) II (DNA directed) polypeptide L)
Rrn3  (RRN3 RNA polymerase I transcription factor homolog (yeast)) Taf12  (TATA-box binding protein associated factor 12) Taf1a  (TATA-box binding protein associated factor, RNA polymerase I, A)
Taf1b  (TATA-box binding protein associated factor, RNA polymerase I, B) Taf1c  (TATA-box binding protein associated factor, RNA polymerase I, C) Taf1d  (TATA-box binding protein associated factor, RNA polymerase I, D)
Tbp  (TATA box binding protein) Ubtf  (upstream binding transcription factor, RNA polymerase I)

Genes (Homo sapiens)
POLR2A  (RNA polymerase II subunit A) POLR2B  (RNA polymerase II subunit B) POLR2C  (RNA polymerase II subunit C)
POLR2D  (RNA polymerase II subunit D) POLR2E  (RNA polymerase II, I and III subunit E) POLR2F  (RNA polymerase II, I and III subunit F)
POLR2G  (RNA polymerase II subunit G) POLR2H  (RNA polymerase II, I and III subunit H) POLR2I  (RNA polymerase II subunit I)
POLR2J  (RNA polymerase II subunit J) POLR2K  (RNA polymerase II, I and III subunit K) POLR2L  (RNA polymerase II, I and III subunit L)
RRN3  (RRN3 homolog, RNA polymerase I transcription factor) TAF12  (TATA-box binding protein associated factor 12) TAF1A  (TATA-box binding protein associated factor, RNA polymerase I subunit A)
TAF1B  (TATA-box binding protein associated factor, RNA polymerase I subunit B) TAF1C  (TATA-box binding protein associated factor, RNA polymerase I subunit C) TAF1D  (TATA-box binding protein associated factor, RNA polymerase I subunit D)
TBP  (TATA-box binding protein) UBTF  (upstream binding transcription factor)