POLR2B (RNA polymerase II subunit B) - Rat Genome Database

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Gene: POLR2B (RNA polymerase II subunit B) Homo sapiens
Analyze
Symbol: POLR2B
Name: RNA polymerase II subunit B
RGD ID: 1319837
HGNC Page HGNC:9188
Description: Enables DNA-directed 5'-3' RNA polymerase activity and RNA-dependent RNA polymerase activity. Involved in transcription by RNA polymerase II. Located in chromosome, telomeric region and nucleoplasm. Part of RNA polymerase II, core complex.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 3'-5' exoribonuclease; DNA directed RNA polymerase II 140 kDa polypeptide, RNA polymerase II subunit 2, RNA polymerase II second largest subunit; DNA-directed RNA polymerase II 140 kDa polypeptide; DNA-directed RNA polymerase II subunit B; DNA-directed RNA polymerase II subunit RPB2; hRPB140; hsRPB2; POL2RB; polymerase (RNA) II (DNA directed) polypeptide B, 140kDa; polymerase (RNA) II subunit B; RNA polymerase II second largest subunit; RNA polymerase II subunit 2; RNA polymerase II subunit B2; RNA-directed RNA polymerase II subunit RPB2; RPB2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38456,978,896 - 57,031,158 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl456,977,722 - 57,031,158 (+)EnsemblGRCh38hg38GRCh38
GRCh37457,845,062 - 57,897,324 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36457,539,866 - 57,592,091 (+)NCBINCBI36Build 36hg18NCBI36
Build 34457,686,036 - 57,738,262NCBI
Celera455,351,060 - 55,402,358 (+)NCBICelera
Cytogenetic Map4q12NCBI
HuRef453,798,541 - 53,850,908 (+)NCBIHuRef
CHM1_1457,880,501 - 57,933,190 (+)NCBICHM1_1
T2T-CHM13v2.0460,470,344 - 60,522,595 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. TFIIB-related factors in RNA polymerase I transcription. Knutson BA and Hahn S, Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):265-73. doi: 10.1016/j.bbagrm.2012.08.003. Epub 2012 Aug 30.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1518060   PMID:1559613   PMID:1939271   PMID:2320128   PMID:2449431   PMID:7638159   PMID:7853496   PMID:8034326   PMID:8619474   PMID:8637904   PMID:8676484   PMID:8876177  
PMID:8910388   PMID:8934526   PMID:8946909   PMID:9054383   PMID:9110174   PMID:9121429   PMID:9184228   PMID:9201987   PMID:9311822   PMID:9315662   PMID:9334327   PMID:9405375  
PMID:9491887   PMID:9570510   PMID:9651670   PMID:9696809   PMID:9852112   PMID:10024883   PMID:10066804   PMID:10069959   PMID:10329125   PMID:10359081   PMID:10364292   PMID:10373521  
PMID:10393184   PMID:10438593   PMID:10536359   PMID:10545121   PMID:10567706   PMID:10617616   PMID:10698937   PMID:10704353   PMID:10725406   PMID:10757782   PMID:10784442   PMID:10866664  
PMID:10931842   PMID:10958691   PMID:11080476   PMID:11112772   PMID:11547919   PMID:11809800   PMID:12049628   PMID:12050112   PMID:12052871   PMID:12089333   PMID:12114499   PMID:12126615  
PMID:12221105   PMID:12226669   PMID:12379213   PMID:12477932   PMID:12634356   PMID:12642036   PMID:12676794   PMID:12775419   PMID:12887902   PMID:14569024   PMID:14702039   PMID:14992727  
PMID:15175163   PMID:15282305   PMID:15489334   PMID:15670829   PMID:15840729   PMID:15886393   PMID:16055720   PMID:16239144   PMID:16289656   PMID:16957778   PMID:17314511   PMID:17353931  
PMID:17494052   PMID:17499043   PMID:17584298   PMID:17643375   PMID:17998332   PMID:18029348   PMID:18562274   PMID:19237606   PMID:19240132   PMID:19270065   PMID:19454010   PMID:20085707  
PMID:20133760   PMID:20211142   PMID:20379614   PMID:20508642   PMID:20516061   PMID:20881960   PMID:21081187   PMID:21145461   PMID:21415862   PMID:21670157   PMID:21729782   PMID:21873635  
PMID:21909106   PMID:22046132   PMID:22268729   PMID:22658674   PMID:22681889   PMID:22863883   PMID:22939629   PMID:22990118   PMID:23087374   PMID:23274668   PMID:23383273   PMID:23395899  
PMID:23416138   PMID:23455922   PMID:23602568   PMID:23748380   PMID:23752268   PMID:24163370   PMID:24217245   PMID:24270157   PMID:24457600   PMID:24550385   PMID:24711643   PMID:24778252  
PMID:24981860   PMID:25281560   PMID:25429064   PMID:25437307   PMID:25544563   PMID:25693804   PMID:25921289   PMID:26030138   PMID:26186194   PMID:26318153   PMID:26344197   PMID:26496610  
PMID:26655721   PMID:26673895   PMID:26777405   PMID:26972000   PMID:27025967   PMID:27049334   PMID:27235625   PMID:27320910   PMID:27375898   PMID:27432908   PMID:27609421   PMID:27684187  
PMID:27880917   PMID:28242625   PMID:28302793   PMID:28514442   PMID:28515276   PMID:28524877   PMID:28561026   PMID:28700933   PMID:28700943   PMID:28718761   PMID:29117863   PMID:29229926  
PMID:29331416   PMID:29395067   PMID:29467282   PMID:29507755   PMID:29509190   PMID:29563501   PMID:29564676   PMID:29568061   PMID:29721183   PMID:29795372   PMID:29844126   PMID:29884807  
PMID:29911972   PMID:29955894   PMID:29991511   PMID:30033366   PMID:30196744   PMID:30258100   PMID:30344098   PMID:30349055   PMID:30404004   PMID:30463901   PMID:30508113   PMID:30804502  
PMID:30833792   PMID:30884312   PMID:30948266   PMID:31048545   PMID:31073040   PMID:31091453   PMID:31180492   PMID:31239290   PMID:31353912   PMID:31527615   PMID:31586073   PMID:31685992  
PMID:31753913   PMID:31980388   PMID:31980649   PMID:32203420   PMID:32235678   PMID:32355176   PMID:32416067   PMID:32457219   PMID:32460013   PMID:32683582   PMID:32694731   PMID:32707033  
PMID:32807901   PMID:32850835   PMID:32877691   PMID:32900933   PMID:32912968   PMID:32971831   PMID:32985767   PMID:33106477   PMID:33144569   PMID:33239621   PMID:33298525   PMID:33306668  
PMID:33545068   PMID:33658012   PMID:33729478   PMID:33957083   PMID:33961781   PMID:34004147   PMID:34004371   PMID:34060620   PMID:34079125   PMID:34108663   PMID:34244482   PMID:34244565  
PMID:34244791   PMID:34373451   PMID:34591877   PMID:34662580   PMID:34672954   PMID:34831298   PMID:34857952   PMID:35012549   PMID:35013218   PMID:35241646   PMID:35256949   PMID:35271311  
PMID:35379950   PMID:35384245   PMID:35439318   PMID:35446349   PMID:35509820   PMID:35530310   PMID:35563538   PMID:35676246   PMID:35831314   PMID:35906200   PMID:35915203   PMID:35944360  
PMID:36114006   PMID:36168627   PMID:36199071   PMID:36215168   PMID:36526897   PMID:36538041   PMID:36574265   PMID:36774506   PMID:37117180   PMID:37167062   PMID:37267103   PMID:37314180  
PMID:37314216   PMID:37317656   PMID:37423037   PMID:37536630   PMID:37682711   PMID:37689310   PMID:37827155   PMID:38113892   PMID:38280479   PMID:38697112   PMID:38943005   PMID:39090090  


Genomics

Comparative Map Data
POLR2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38456,978,896 - 57,031,158 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl456,977,722 - 57,031,158 (+)EnsemblGRCh38hg38GRCh38
GRCh37457,845,062 - 57,897,324 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36457,539,866 - 57,592,091 (+)NCBINCBI36Build 36hg18NCBI36
Build 34457,686,036 - 57,738,262NCBI
Celera455,351,060 - 55,402,358 (+)NCBICelera
Cytogenetic Map4q12NCBI
HuRef453,798,541 - 53,850,908 (+)NCBIHuRef
CHM1_1457,880,501 - 57,933,190 (+)NCBICHM1_1
T2T-CHM13v2.0460,470,344 - 60,522,595 (+)NCBIT2T-CHM13v2.0
Polr2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39577,458,331 - 77,497,175 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl577,457,994 - 77,497,171 (+)EnsemblGRCm39 Ensembl
GRCm38577,310,484 - 77,349,328 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl577,310,147 - 77,349,324 (+)EnsemblGRCm38mm10GRCm38
MGSCv37577,739,509 - 77,778,353 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36578,385,273 - 78,424,099 (+)NCBIMGSCv36mm8
Celera574,577,709 - 74,617,045 (+)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map541.66NCBI
Polr2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81431,151,534 - 31,189,222 (-)NCBIGRCr8
mRatBN7.21430,797,228 - 30,834,916 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1430,797,228 - 30,834,916 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1431,178,151 - 31,215,766 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01432,486,476 - 32,524,093 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01430,971,132 - 31,008,749 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01433,070,104 - 33,107,792 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1433,070,078 - 33,107,776 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01432,863,627 - 32,901,277 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41433,069,966 - 33,107,615 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11433,069,967 - 33,107,600 (-)NCBI
Celera1430,116,602 - 30,154,129 (-)NCBICelera
Cytogenetic Map14p11NCBI
Polr2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544714,110,182 - 14,150,556 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544714,110,182 - 14,150,556 (-)NCBIChiLan1.0ChiLan1.0
POLR2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2372,744,237 - 72,798,118 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1472,949,670 - 73,003,185 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0466,888,215 - 66,940,702 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1473,462,000 - 73,514,985 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl473,462,000 - 73,514,985 (-)Ensemblpanpan1.1panPan2
POLR2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11349,091,458 - 49,138,413 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1349,090,863 - 49,138,487 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1348,982,054 - 49,028,661 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01349,705,912 - 49,752,974 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1349,705,467 - 49,752,975 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11349,378,679 - 49,425,490 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01348,907,935 - 48,954,761 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01349,852,758 - 49,900,240 (+)NCBIUU_Cfam_GSD_1.0
Polr2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528527,179,024 - 27,225,143 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648219,073,124 - 19,119,421 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648219,073,125 - 19,119,424 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLR2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl856,231,789 - 56,285,011 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1856,232,730 - 56,283,367 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2859,014,262 - 59,064,755 (+)NCBISscrofa10.2Sscrofa10.2susScr3
POLR2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1711,694,446 - 11,736,215 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl711,694,619 - 11,736,611 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606612,273,518 - 12,305,507 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Polr2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476112,387,553 - 12,430,871 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476112,387,553 - 12,430,211 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in POLR2B
24 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 4p13-q13.1(chr4:44356201-62245882)x3 copy number gain See cases [RCV000050683] Chr4:44356201..62245882 [GRCh38]
Chr4:44358218..63111600 [GRCh37]
Chr4:44052975..62794195 [NCBI36]
Chr4:4p13-q13.1		 pathogenic
GRCh38/hg38 4q12-13.2(chr4:51831622-66991489)x3 copy number gain See cases [RCV000051771] Chr4:51831622..66991489 [GRCh38]
Chr4:52697788..67857207 [GRCh37]
Chr4:52392545..67539802 [NCBI36]
Chr4:4q12-13.2		 pathogenic
GRCh38/hg38 4q12-22.3(chr4:51831622-97505618)x3 copy number gain See cases [RCV000051772] Chr4:51831622..97505618 [GRCh38]
Chr4:52697788..98426769 [GRCh37]
Chr4:52392545..98645792 [NCBI36]
Chr4:4q12-22.3		 pathogenic
GRCh38/hg38 4q12-13.1(chr4:51899860-59984479)x3 copy number gain See cases [RCV000051773] Chr4:51899860..59984479 [GRCh38]
Chr4:52766026..60850197 [GRCh37]
Chr4:52460783..60532792 [NCBI36]
Chr4:4q12-13.1		 pathogenic
GRCh38/hg38 4q12-13.1(chr4:52639018-59984479)x1 copy number loss See cases [RCV000053265] Chr4:52639018..59984479 [GRCh38]
Chr4:53505185..60850197 [GRCh37]
Chr4:53199942..60532792 [NCBI36]
Chr4:4q12-13.1		 pathogenic
GRCh38/hg38 4q12-13.1(chr4:54198601-62270115)x1 copy number loss See cases [RCV000053266] Chr4:54198601..62270115 [GRCh38]
Chr4:55064768..63135833 [GRCh37]
Chr4:54759525..62818428 [NCBI36]
Chr4:4q12-13.1		 pathogenic
NM_000938.2(POLR2B):c.1757C>T (p.Thr586Ile) single nucleotide variant Malignant melanoma [RCV000066467] Chr4:57011057 [GRCh38]
Chr4:57877223 [GRCh37]
Chr4:57571980 [NCBI36]
Chr4:4q12		 not provided
NM_000938.2(POLR2B):c.3370A>G (p.Ile1124Val) single nucleotide variant Malignant melanoma [RCV000066468] Chr4:57030334 [GRCh38]
Chr4:57896500 [GRCh37]
Chr4:57591257 [NCBI36]
Chr4:4q12		 not provided
GRCh38/hg38 4q12(chr4:56248102-57218522)x4 copy number gain See cases [RCV000137649] Chr4:56248102..57218522 [GRCh38]
Chr4:57114268..58084688 [GRCh37]
Chr4:56809025..57779445 [NCBI36]
Chr4:4q12		 uncertain significance
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q13.1(chr4:68345-66440622)x3 copy number gain See cases [RCV000511193] Chr4:68345..66440622 [GRCh37]
Chr4:4p16.3-q13.1		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4q12(chr4:57859592-58005459)x3 copy number gain not provided [RCV000743598] Chr4:57859592..58005459 [GRCh37]
Chr4:4q12		 benign
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4q12(chr4:57067953-57957651)x3 copy number gain not provided [RCV001005548] Chr4:57067953..57957651 [GRCh37]
Chr4:4q12		 uncertain significance
NM_000938.3(POLR2B):c.2123C>T (p.Ala708Val) single nucleotide variant Tracheoesophageal fistula [RCV001172299] Chr4:57017210 [GRCh38]
Chr4:57883376 [GRCh37]
Chr4:4q12		 likely pathogenic
GRCh37/hg19 4q12(chr4:57588857-57872994)x3 copy number gain not provided [RCV001258646] Chr4:57588857..57872994 [GRCh37]
Chr4:4q12		 uncertain significance
GRCh38/hg38 4q12-21.1(chr4:51891814-76009719)x1 copy number loss Piebaldism [RCV001420508] Chr4:51891814..76009719 [GRCh38]
Chr4:4q12-21.1		 pathogenic
NM_000938.3(POLR2B):c.1312C>T (p.Arg438Trp) single nucleotide variant not specified [RCV004289341] Chr4:57006910 [GRCh38]
Chr4:57873076 [GRCh37]
Chr4:4q12		 uncertain significance
GRCh37/hg19 4q11-12(chr4:52685685-58104722)x1 copy number loss not provided [RCV001829079] Chr4:52685685..58104722 [GRCh37]
Chr4:4q11-12		 pathogenic
GRCh37/hg19 4q12-31.21(chr4:52866944-143582507)x3 copy number gain not provided [RCV001827738] Chr4:52866944..143582507 [GRCh37]
Chr4:4q12-31.21		 pathogenic
NM_000938.3(POLR2B):c.1910A>G (p.Lys637Arg) single nucleotide variant not specified [RCV004325051] Chr4:57015611 [GRCh38]
Chr4:57881777 [GRCh37]
Chr4:4q12		 uncertain significance
GRCh37/hg19 4q11-12(chr4:52685980-59272025)x3 copy number gain not provided [RCV002473779] Chr4:52685980..59272025 [GRCh37]
Chr4:4q11-12		 uncertain significance
NM_000938.3(POLR2B):c.2505A>T (p.Glu835Asp) single nucleotide variant not specified [RCV004083158] Chr4:57022236 [GRCh38]
Chr4:57888402 [GRCh37]
Chr4:4q12		 uncertain significance
NM_000938.3(POLR2B):c.1604G>C (p.Gly535Ala) single nucleotide variant not specified [RCV004150977] Chr4:57010803 [GRCh38]
Chr4:57876969 [GRCh37]
Chr4:4q12		 uncertain significance
NM_000938.3(POLR2B):c.56C>T (p.Pro19Leu) single nucleotide variant not specified [RCV004179143] Chr4:56986390 [GRCh38]
Chr4:57852556 [GRCh37]
Chr4:4q12		 uncertain significance
GRCh38/hg38 4p16.3-q12(chr4:85624-57073230)x3 copy number gain Neurodevelopmental disorder [RCV003327613] Chr4:85624..57073230 [GRCh38]
Chr4:4p16.3-q12		 pathogenic
NM_000938.3(POLR2B):c.2335A>G (p.Ile779Val) single nucleotide variant not specified [RCV004358866] Chr4:57020910 [GRCh38]
Chr4:57887076 [GRCh37]
Chr4:4q12		 uncertain significance
GRCh37/hg19 4q12-13.3(chr4:57584845-72430996)x1 copy number loss not provided [RCV003485417] Chr4:57584845..72430996 [GRCh37]
Chr4:4q12-13.3		 pathogenic
GRCh37/hg19 4q11-13.1(chr4:52685685-61903883)x1 copy number loss not provided [RCV003485416] Chr4:52685685..61903883 [GRCh37]
Chr4:4q11-13.1		 pathogenic
NM_000938.3(POLR2B):c.1677A>C (p.Ala559=) single nucleotide variant not provided [RCV003439325] Chr4:57010876 [GRCh38]
Chr4:57877042 [GRCh37]
Chr4:4q12		 likely benign
NM_000938.3(POLR2B):c.2232G>A (p.Met744Ile) single nucleotide variant not specified [RCV004512404] Chr4:57017637 [GRCh38]
Chr4:57883803 [GRCh37]
Chr4:4q12		 uncertain significance
NM_000938.3(POLR2B):c.2497A>G (p.Thr833Ala) single nucleotide variant not specified [RCV004512405] Chr4:57022228 [GRCh38]
Chr4:57888394 [GRCh37]
Chr4:4q12		 uncertain significance
NM_000938.3(POLR2B):c.2756G>A (p.Cys919Tyr) single nucleotide variant not specified [RCV004512407] Chr4:57023570 [GRCh38]
Chr4:57889736 [GRCh37]
Chr4:4q12		 uncertain significance
NM_000938.3(POLR2B):c.2849G>A (p.Arg950Lys) single nucleotide variant not specified [RCV004512408] Chr4:57023744 [GRCh38]
Chr4:57889910 [GRCh37]
Chr4:4q12		 uncertain significance
NM_000938.3(POLR2B):c.3449G>A (p.Arg1150Gln) single nucleotide variant not specified [RCV004512410] Chr4:57030912 [GRCh38]
Chr4:57897078 [GRCh37]
Chr4:4q12		 uncertain significance
NM_000938.3(POLR2B):c.221C>T (p.Ala74Val) single nucleotide variant not specified [RCV004512403] Chr4:56990876 [GRCh38]
Chr4:57857042 [GRCh37]
Chr4:4q12		 uncertain significance
NM_000938.3(POLR2B):c.2086T>C (p.Cys696Arg) single nucleotide variant not specified [RCV004512402] Chr4:57017173 [GRCh38]
Chr4:57883339 [GRCh37]
Chr4:4q12		 uncertain significance
NM_000938.3(POLR2B):c.1592A>T (p.Tyr531Phe) single nucleotide variant not provided [RCV004555029] Chr4:57010791 [GRCh38]
Chr4:57876957 [GRCh37]
Chr4:4q12		 uncertain significance
NM_000938.3(POLR2B):c.3422G>A (p.Arg1141His) single nucleotide variant not specified [RCV004512409] Chr4:57030386 [GRCh38]
Chr4:57896552 [GRCh37]
Chr4:4q12		 uncertain significance
NM_000938.3(POLR2B):c.1667T>C (p.Ile556Thr) single nucleotide variant not specified [RCV004512400] Chr4:57010866 [GRCh38]
Chr4:57877032 [GRCh37]
Chr4:4q12		 uncertain significance
NM_000938.3(POLR2B):c.1736A>T (p.Asp579Val) single nucleotide variant not specified [RCV004512401] Chr4:57011036 [GRCh38]
Chr4:57877202 [GRCh37]
Chr4:4q12		 uncertain significance
GRCh37/hg19 4p12-q35.2(chr4:45455621-191003541)x3 copy number gain not provided [RCV003885507] Chr4:45455621..191003541 [GRCh37]
Chr4:4p12-q35.2		 pathogenic
NM_000938.3(POLR2B):c.2771G>A (p.Arg924His) single nucleotide variant not specified [RCV004653927] Chr4:57023666 [GRCh38]
Chr4:57889832 [GRCh37]
Chr4:4q12		 uncertain significance
NM_000938.3(POLR2B):c.184G>A (p.Ala62Thr) single nucleotide variant not specified [RCV004653928] Chr4:56990839 [GRCh38]
Chr4:57857005 [GRCh37]
Chr4:4q12		 uncertain significance
NM_000938.3(POLR2B):c.1679C>T (p.Ala560Val) single nucleotide variant not specified [RCV004653929] Chr4:57010878 [GRCh38]
Chr4:57877044 [GRCh37]
Chr4:4q12		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:831
Count of miRNA genes:519
Interacting mature miRNAs:552
Transcripts:ENST00000314595, ENST00000381227, ENST00000431623, ENST00000433463, ENST00000441246, ENST00000450656, ENST00000464918, ENST00000478188, ENST00000484821, ENST00000495311, ENST00000497845, ENST00000510355
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406906656GWAS555632_Hbreast carcinoma QTL GWAS555632 (human)0.000007breast carcinoma45701362657013627Human
406919460GWAS568436_Hbody height QTL GWAS568436 (human)7e-14body height (VT:0001253)body height (CMO:0000106)45698387056983871Human
407258672GWAS907648_Hbody height QTL GWAS907648 (human)0.000003body height (VT:0001253)body height (CMO:0000106)45699102256991023Human
407050207GWAS699183_Hbody height QTL GWAS699183 (human)2e-08body height (VT:0001253)body height (CMO:0000106)45699102256991023Human
406982366GWAS631342_Hbitter alcoholic beverage consumption measurement QTL GWAS631342 (human)0.000002bitter alcoholic beverage consumption measurementdrink intake measurement (CMO:0000771)45699207156992072Human
406907133GWAS556109_Hcongenital heart disease QTL GWAS556109 (human)0.000008congenital heart disease45702760457027605Human
407099741GWAS748717_Hvital capacity QTL GWAS748717 (human)2e-08vital capacity45702032757020328Human
407088572GWAS737548_Hleukocyte count QTL GWAS737548 (human)1e-08leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)45701979757019798Human

Markers in Region
SHGC-12841  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37457,897,272 - 57,897,495UniSTSGRCh37
Build 36457,592,029 - 57,592,252RGDNCBI36
Celera455,402,296 - 55,402,519RGD
Cytogenetic Map4q12UniSTS
HuRef453,850,846 - 53,851,069UniSTS
TNG Radiation Hybrid Map431905.0UniSTS
GeneMap99-G3 RH Map43362.0UniSTS
D4S2603  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37457,890,057 - 57,890,187UniSTSGRCh37
Build 36457,584,814 - 57,584,944RGDNCBI36
Celera455,395,077 - 55,395,207RGD
Cytogenetic Map4q12UniSTS
HuRef453,843,627 - 53,843,757UniSTS
TNG Radiation Hybrid Map431853.0UniSTS
Stanford-G3 RH Map43378.0UniSTS
Whitehead-RH Map4443.3UniSTS
Whitehead-YAC Contig Map4 UniSTS
NCBI RH Map4678.9UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4973 1726 2351 6 624 1951 465 2269 7306 6472 53 3734 1 852 1744 1617 175 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_000938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001303268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001303269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC069307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF055028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK098271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK289823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC046499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU619780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC323029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF536006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X63563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000314595   ⟹   ENSP00000312735
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl456,978,896 - 57,031,158 (+)Ensembl
Ensembl Acc Id: ENST00000381227   ⟹   ENSP00000370625
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl456,977,742 - 57,031,158 (+)Ensembl
Ensembl Acc Id: ENST00000431623   ⟹   ENSP00000391096
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl456,978,864 - 57,031,158 (+)Ensembl
Ensembl Acc Id: ENST00000433463   ⟹   ENSP00000407728
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl456,978,896 - 56,990,906 (+)Ensembl
Ensembl Acc Id: ENST00000441246   ⟹   ENSP00000391452
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl456,978,869 - 57,031,007 (+)Ensembl
Ensembl Acc Id: ENST00000450656   ⟹   ENSP00000408638
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl456,977,722 - 56,990,847 (+)Ensembl
Ensembl Acc Id: ENST00000464918
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl457,023,227 - 57,023,751 (+)Ensembl
Ensembl Acc Id: ENST00000478188
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl457,009,559 - 57,031,158 (+)Ensembl
Ensembl Acc Id: ENST00000484821
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl457,023,491 - 57,024,962 (+)Ensembl
Ensembl Acc Id: ENST00000495311
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl456,977,782 - 56,978,961 (+)Ensembl
Ensembl Acc Id: ENST00000497845
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl456,978,904 - 56,986,803 (+)Ensembl
Ensembl Acc Id: ENST00000510355
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl457,010,173 - 57,015,658 (+)Ensembl
RefSeq Acc Id: NM_000938   ⟹   NP_000929
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38456,978,896 - 57,031,158 (+)NCBI
GRCh37457,844,944 - 57,897,334 (+)NCBI
Build 36457,539,866 - 57,592,091 (+)NCBI Archive
HuRef453,798,541 - 53,850,908 (+)ENTREZGENE
CHM1_1457,880,198 - 57,933,184 (+)NCBI
T2T-CHM13v2.0460,470,344 - 60,522,595 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001303268   ⟹   NP_001290197
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38456,978,896 - 57,031,158 (+)NCBI
CHM1_1457,880,198 - 57,933,184 (+)NCBI
T2T-CHM13v2.0460,470,344 - 60,522,595 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001303269   ⟹   NP_001290198
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38456,978,896 - 57,031,158 (+)NCBI
CHM1_1457,880,198 - 57,933,184 (+)NCBI
T2T-CHM13v2.0460,470,344 - 60,522,595 (+)NCBI
Sequence:
RefSeq Acc Id: NP_000929   ⟸   NM_000938
- Peptide Label: isoform 1
- UniProtKB: A8K1A8 (UniProtKB/Swiss-Prot),   Q8IZ61 (UniProtKB/Swiss-Prot),   P30876 (UniProtKB/Swiss-Prot),   B4DHJ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001290198   ⟸   NM_001303269
- Peptide Label: isoform 3
- UniProtKB: B4DHJ3 (UniProtKB/TrEMBL),   C9J2Y9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001290197   ⟸   NM_001303268
- Peptide Label: isoform 2
- UniProtKB: B4DH29 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000408638   ⟸   ENST00000450656
Ensembl Acc Id: ENSP00000391452   ⟸   ENST00000441246
Ensembl Acc Id: ENSP00000391096   ⟸   ENST00000431623
Ensembl Acc Id: ENSP00000312735   ⟸   ENST00000314595
Ensembl Acc Id: ENSP00000407728   ⟸   ENST00000433463
Ensembl Acc Id: ENSP00000370625   ⟸   ENST00000381227
Protein Domains
DNA-directed RNA polymerase subunit 2 hybrid-   RNA polymerase beta subunit protrusion   RNA polymerase Rpb2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30876-F1-model_v2 AlphaFold P30876 1-1174 view protein structure

Promoters
RGD ID:6867538
Promoter ID:EPDNEW_H6934
Type:initiation region
Name:POLR2B_2
Description:RNA polymerase II subunit B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H6936  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38456,977,739 - 56,977,799EPDNEW
RGD ID:6867542
Promoter ID:EPDNEW_H6936
Type:initiation region
Name:POLR2B_1
Description:RNA polymerase II subunit B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H6934  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38456,978,896 - 56,978,956EPDNEW
RGD ID:6802535
Promoter ID:HG_KWN:48313
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   Jurkat
Transcripts:ENST00000381227,   OTTHUMT00000326506,   OTTHUMT00000326507
Position:
Human AssemblyChrPosition (strand)Source
Build 36457,538,481 - 57,538,981 (+)MPROMDB
RGD ID:6802189
Promoter ID:HG_KWN:48314
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   CD4+TCell_2Hour,   K562,   Lymphoblastoid
Transcripts:ENST00000314595,   OTTHUMT00000326508,   OTTHUMT00000326509,   OTTHUMT00000326510,   OTTHUMT00000326511,   OTTHUMT00000326512
Position:
Human AssemblyChrPosition (strand)Source
Build 36457,539,576 - 57,540,076 (+)MPROMDB
RGD ID:6802537
Promoter ID:HG_KWN:48317
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   Lymphoblastoid
Transcripts:UC003HCM.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36457,569,641 - 57,570,362 (+)MPROMDB
RGD ID:6802538
Promoter ID:HG_KWN:48318
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:OTTHUMT00000326513,   OTTHUMT00000326514
Position:
Human AssemblyChrPosition (strand)Source
Build 36457,584,041 - 57,584,541 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9188 AgrOrtholog
COSMIC POLR2B COSMIC
Ensembl Genes ENSG00000047315 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000314595 ENTREZGENE
  ENST00000314595.6 UniProtKB/Swiss-Prot
  ENST00000381227.5 UniProtKB/Swiss-Prot
  ENST00000431623 ENTREZGENE
  ENST00000431623.6 UniProtKB/TrEMBL
  ENST00000433463.1 UniProtKB/TrEMBL
  ENST00000441246 ENTREZGENE
  ENST00000441246.6 UniProtKB/TrEMBL
  ENST00000450656.5 UniProtKB/TrEMBL
Gene3D-CATH 2.40.270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.50.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.1070.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.1100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.1110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNA polymerase alpha subunit dimerisation domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000047315 GTEx
HGNC ID HGNC:9188 ENTREZGENE
Human Proteome Map POLR2B Human Proteome Map
InterPro DNA-dir_RNA_pol_su2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA-dir_RNAP_su2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA-dir_RNAP_su2_hyb_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNA_pol_bsu_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNA_pol_bsu_protrusion UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNA_pol_Rpb2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNA_pol_Rpb2_2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNA_pol_Rpb2_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNA_pol_Rpb2_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNA_pol_Rpb2_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNA_pol_Rpb2_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNA_pol_RPB2_OB-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5431 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 5431 ENTREZGENE
OMIM 180661 OMIM
PANTHER DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR20856 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RNA_pol_Rpb2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNA_pol_Rpb2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNA_pol_Rpb2_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNA_pol_Rpb2_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNA_pol_Rpb2_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNA_pol_Rpb2_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNA_pol_Rpb2_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33508 PharmGKB
PROSITE RNA_POL_BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP beta and beta-prime subunits of DNA dependent RNA-polymerase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8K1A8 ENTREZGENE
  B4DH29 ENTREZGENE, UniProtKB/TrEMBL
  B4DHJ3 ENTREZGENE, UniProtKB/TrEMBL
  C9J2Y9 ENTREZGENE, UniProtKB/TrEMBL
  C9J4M6_HUMAN UniProtKB/TrEMBL
  C9JMN3_HUMAN UniProtKB/TrEMBL
  C9JZW8_HUMAN UniProtKB/TrEMBL
  P30876 ENTREZGENE
  Q8IZ61 ENTREZGENE
  RPB2_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary A8K1A8 UniProtKB/Swiss-Prot
  Q8IZ61 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-19 POLR2B  RNA polymerase II subunit B    polymerase (RNA) II subunit B  Symbol and/or name change 5135510 APPROVED
2016-03-07 POLR2B  polymerase (RNA) II subunit B    polymerase (RNA) II (DNA directed) polypeptide B, 140kDa  Symbol and/or name change 5135510 APPROVED