POLR2B (RNA polymerase II subunit B) - Rat Genome Database

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Gene: POLR2B (RNA polymerase II subunit B) Pan paniscus
Analyze
Symbol: POLR2B
Name: RNA polymerase II subunit B
RGD ID: 11845343
Description: ENCODES a protein that exhibits 5'-3' RNA polymerase activity (inferred); chromatin binding (inferred); DNA binding (inferred); INVOLVED IN DNA-templated transcription (inferred); RNA-templated transcription (inferred); transcription by RNA polymerase II (inferred); PARTICIPATES IN RNA polymerase II transcription pathway; ASSOCIATED WITH genetic disease (ortholog); Tracheoesophageal Fistula (ortholog); FOUND IN chromosome, telomeric region (inferred); DNA-directed RNA polymerase complex (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA-directed RNA polymerase II subunit RPB2; polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2372,744,237 - 72,798,118 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1472,949,670 - 73,003,185 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0466,888,215 - 66,940,702 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1473,462,000 - 73,514,985 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl473,462,000 - 73,514,985 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
POLR2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2372,744,237 - 72,798,118 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1472,949,670 - 73,003,185 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0466,888,215 - 66,940,702 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1473,462,000 - 73,514,985 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl473,462,000 - 73,514,985 (-)Ensemblpanpan1.1panPan2
POLR2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38456,978,896 - 57,031,158 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl456,977,722 - 57,031,158 (+)EnsemblGRCh38hg38GRCh38
GRCh37457,845,062 - 57,897,324 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36457,539,866 - 57,592,091 (+)NCBINCBI36Build 36hg18NCBI36
Build 34457,686,036 - 57,738,262NCBI
Celera455,351,060 - 55,402,358 (+)NCBICelera
Cytogenetic Map4q12NCBI
HuRef453,798,541 - 53,850,908 (+)NCBIHuRef
CHM1_1457,880,501 - 57,933,190 (+)NCBICHM1_1
T2T-CHM13v2.0460,470,344 - 60,522,595 (+)NCBIT2T-CHM13v2.0
Polr2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39577,458,331 - 77,497,175 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl577,457,994 - 77,497,171 (+)EnsemblGRCm39 Ensembl
GRCm38577,310,484 - 77,349,328 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl577,310,147 - 77,349,324 (+)EnsemblGRCm38mm10GRCm38
MGSCv37577,739,509 - 77,778,353 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36578,385,273 - 78,424,099 (+)NCBIMGSCv36mm8
Celera574,577,709 - 74,617,045 (+)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map541.66NCBI
Polr2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81431,151,534 - 31,189,222 (-)NCBIGRCr8
mRatBN7.21430,797,228 - 30,834,916 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1430,797,228 - 30,834,916 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1431,178,151 - 31,215,766 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01432,486,476 - 32,524,093 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01430,971,132 - 31,008,749 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01433,070,104 - 33,107,792 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1433,070,078 - 33,107,776 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01432,863,627 - 32,901,277 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41433,069,966 - 33,107,615 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11433,069,967 - 33,107,600 (-)NCBI
Celera1430,116,602 - 30,154,129 (-)NCBICelera
Cytogenetic Map14p11NCBI
Polr2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544714,110,182 - 14,150,556 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544714,110,182 - 14,150,556 (-)NCBIChiLan1.0ChiLan1.0
POLR2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11349,091,458 - 49,138,413 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1349,090,863 - 49,138,487 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1348,982,054 - 49,028,661 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01349,705,912 - 49,752,974 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1349,705,467 - 49,752,975 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11349,378,679 - 49,425,490 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01348,907,935 - 48,954,761 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01349,852,758 - 49,900,240 (+)NCBIUU_Cfam_GSD_1.0
Polr2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528527,179,024 - 27,225,143 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648219,073,124 - 19,119,421 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648219,073,125 - 19,119,424 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLR2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl856,231,789 - 56,285,011 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1856,232,730 - 56,283,367 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2859,014,262 - 59,064,755 (+)NCBISscrofa10.2Sscrofa10.2susScr3
POLR2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1711,694,446 - 11,736,215 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl711,694,619 - 11,736,611 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606612,273,518 - 12,305,507 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Polr2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476112,387,553 - 12,430,871 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476112,387,553 - 12,430,211 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000057983   ⟹   ENSPPAP00000035097
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl473,462,000 - 73,514,985 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000057993   ⟹   ENSPPAP00000035107
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl473,462,172 - 73,508,197 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000058000   ⟹   ENSPPAP00000035114
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl473,462,172 - 73,506,386 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000058001   ⟹   ENSPPAP00000035115
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl473,462,172 - 73,502,538 (-)Ensembl
RefSeq Acc Id: XM_034958757   ⟹   XP_034814648
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2372,744,237 - 72,797,696 (-)NCBI
NHGRI_mPanPan1472,949,670 - 73,003,139 (-)NCBI
Mhudiblu_PPA_v0466,888,215 - 66,940,507 (-)NCBI
RefSeq Acc Id: XM_055111518   ⟹   XP_054967493
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2372,744,237 - 72,797,641 (-)NCBI
NHGRI_mPanPan1472,949,670 - 73,003,078 (-)NCBI
RefSeq Acc Id: XM_055111519   ⟹   XP_054967494
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2372,744,237 - 72,797,742 (-)NCBI
NHGRI_mPanPan1472,949,670 - 73,003,185 (-)NCBI
RefSeq Acc Id: XM_063603806   ⟹   XP_063459876
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2372,744,237 - 72,798,118 (-)NCBI
RefSeq Acc Id: XM_063603807   ⟹   XP_063459877
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2372,744,237 - 72,797,583 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_034814648   ⟸   XM_034958757
- UniProtKB: A0A2R9BZK6 (UniProtKB/TrEMBL),   A0A2R9BZL7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000035097   ⟸   ENSPPAT00000057983
RefSeq Acc Id: ENSPPAP00000035107   ⟸   ENSPPAT00000057993
RefSeq Acc Id: ENSPPAP00000035114   ⟸   ENSPPAT00000058000
RefSeq Acc Id: ENSPPAP00000035115   ⟸   ENSPPAT00000058001
RefSeq Acc Id: XP_054967494   ⟸   XM_055111519
- UniProtKB: A0A2R9BZK6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054967493   ⟸   XM_055111518
- UniProtKB: A0A2R9BZK6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063459876   ⟸   XM_063603806
- UniProtKB: A0A2R9BZK6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063459877   ⟸   XM_063603807
- UniProtKB: A0A2R9BZK6 (UniProtKB/TrEMBL)
Protein Domains
DNA-directed RNA polymerase subunit 2 hybrid-   RNA polymerase beta subunit protrusion   RNA polymerase Rpb2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000040253 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000057983.1 UniProtKB/TrEMBL
  ENSPPAT00000057993.1 UniProtKB/TrEMBL
  ENSPPAT00000058000.1 UniProtKB/TrEMBL
  ENSPPAT00000058001.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.270.10 UniProtKB/TrEMBL
  2.40.50.150 UniProtKB/TrEMBL
  3.90.1070.20 UniProtKB/TrEMBL
  3.90.1100.10 UniProtKB/TrEMBL
  3.90.1110.10 UniProtKB/TrEMBL
  RNA polymerase alpha subunit dimerisation domain UniProtKB/TrEMBL
InterPro DNA-dir_RNA_pol_su2 UniProtKB/TrEMBL
  DNA-dir_RNAP_su2_dom UniProtKB/TrEMBL
  DNA-dir_RNAP_su2_hyb_sf UniProtKB/TrEMBL
  RNA_pol_bsu_CS UniProtKB/TrEMBL
  RNA_pol_bsu_protrusion UniProtKB/TrEMBL
  RNA_pol_Rpb2_2 UniProtKB/TrEMBL
  RNA_pol_Rpb2_2_sf UniProtKB/TrEMBL
  RNA_pol_Rpb2_3 UniProtKB/TrEMBL
  RNA_pol_Rpb2_4 UniProtKB/TrEMBL
  RNA_pol_Rpb2_5 UniProtKB/TrEMBL
  RNA_pol_Rpb2_7 UniProtKB/TrEMBL
  RNA_pol_RPB2_OB-fold UniProtKB/TrEMBL
NCBI Gene POLR2B ENTREZGENE
PANTHER DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 UniProtKB/TrEMBL
  PTHR20856 UniProtKB/TrEMBL
Pfam RNA_pol_Rpb2_1 UniProtKB/TrEMBL
  RNA_pol_Rpb2_2 UniProtKB/TrEMBL
  RNA_pol_Rpb2_3 UniProtKB/TrEMBL
  RNA_pol_Rpb2_4 UniProtKB/TrEMBL
  RNA_pol_Rpb2_5 UniProtKB/TrEMBL
  RNA_pol_Rpb2_6 UniProtKB/TrEMBL
  RNA_pol_Rpb2_7 UniProtKB/TrEMBL
PROSITE RNA_POL_BETA UniProtKB/TrEMBL
Superfamily-SCOP beta and beta-prime subunits of DNA dependent RNA-polymerase UniProtKB/TrEMBL
UniProt A0A2R9BZK6 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BZL7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9C2S2_PANPA UniProtKB/TrEMBL
  A0A2R9C9Q8_PANPA UniProtKB/TrEMBL