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Gene: Tbp (TATA box binding protein) Mus musculus
Symbol: Tbp
Name: TATA box binding protein
Description: Exhibits RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and RNA polymerase II repressing transcription factor binding activity. Involved in transcription by RNA polymerase II and transcription by RNA polymerase III. Localizes to cytoplasm; female pronucleus; and male pronucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; limb; and retina. Used to study spinocerebellar ataxia type 17. Human ortholog(s) of this gene implicated in late onset Parkinson's disease; schizophrenia; spinocerebellar ataxia type 17; and type 1 diabetes mellitus. Orthologous to human TBP (TATA-box binding protein); PARTICIPATES IN cisplatin drug pathway; RNA polymerase I transcription pathway; RNA polymerase II transcription initiation pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; Aroclor 1254.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Gtf2d; GTF2D1; SCA17; TATA sequence-binding protein; TATA-binding factor; TATA-binding protein; TATA-box factor; TATA-box-binding protein; TFIID; TFIID core protein; transcription initiation factor TFIID TBP subunit
Homo sapiens (human) : TBP (TATA-box binding protein)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tbp (TATA box binding protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tbp (TATA-box binding protein)
Pan paniscus (bonobo/pygmy chimpanzee) : TBP (TATA-box binding protein)
Canis lupus familiaris (dog) : TBP (TATA-box binding protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tbp (TATA-box binding protein)
Sus scrofa (pig) : TBP (TATA-box binding protein)
Chlorocebus sabaeus (African green monkey) : TBP (TATA-box binding protein)
Heterocephalus glaber (naked mole-rat) : Tbp (TATA-box binding protein)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1715,499,888 - 15,528,379 (+)EnsemblGRCm38mm10GRCm38
GRCm381715,499,888 - 15,517,427 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371715,636,852 - 15,654,391 (+)NCBIGRCm37mm9NCBIm37
MGSCv361715,208,038 - 15,221,746 (+)NCBImm8
Celera1716,285,165 - 16,302,716 (+)NCBICelera
Cytogenetic Map17A2NCBI
cM Map178.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Tbp
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68981
Created: 2001-11-06
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.