RGD Reference Report - Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription.

Authors: Dumay-Odelot, H  Durrieu-Gaillard, S  Da Silva, D  Roeder, RG  Teichmann, M 
Citation: Dumay-Odelot H, etal., Cell Cycle. 2010 Sep 15;9(18):3687-99. Epub 2010 Sep 1.
RGD ID: 9685218
Pubmed: (View Article at PubMed) PMID:20890107
DOI: Full-text: DOI:10.4161/cc.9.18.13203

RNA polymerase III transcribes small untranslated RNAs that fulfill essential cellular functions in regulating transcription, RNA processing, translation and protein translocation. RNA polymerase III transcription activity is tightly regulated during the cell cycle and coupled to growth control mechanisms. Furthermore, there are reports of changes in RNA polymerase III transcription activity during cellular differentiation, including the discovery of a novel isoform of human RNA polymerase III that has been shown to be specifically expressed in undifferentiated human H1 embryonic stem cells. Here, we review major regulatory mechanisms of RNA polymerase III transcription during the cell cycle, cell growth and cell differentiation.

Annotation

Molecular Pathway Annotations    
Objects Annotated

Genes (Rattus norvegicus)
Bdp1  (B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB)
Brf1  (BRF1, RNA polymerase III transcription initiation factor subunit)
Brf2  (BRF2, RNA polymerase III transcription initiation factor subunit)
Polr1c  (RNA polymerase I and III subunit C)
Polr2e  (RNA polymerase II, I and III subunit E)
Polr2f  (RNA polymerase II, I and III subunit F)
Polr2k  (RNA polymerase II, I and III subunit K)
Polr3a  (RNA polymerase III subunit A)
Polr3b  (RNA polymerase III subunit B)
Polr3c  (RNA polymerase III subunit C)
Polr3d  (RNA polymerase III subunit D)
Polr3e  (RNA polymerase III subunit E)
Polr3f  (RNA polymerase III subunit F)
Polr3g  (RNA polymerase III subunit G)
Polr3gl  (RNA polymerase III subunit GL)
Polr3h  (RNA polymerase III subunit H)
Polr3k  (RNA polymerase III subunit K)
Pou2f1  (POU class 2 homeobox 1)
Tbp  (TATA box binding protein)
Zfp143  (zinc finger protein 143)

Genes (Mus musculus)
Bdp1  (B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB)
Brf1  (BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit)
Brf2  (BRF2, RNA polymerase III transcription initiation factor 50kDa subunit)
Polr1c  (polymerase (RNA) I polypeptide C)
Polr1d  (polymerase (RNA) I polypeptide D)
Polr2e  (polymerase (RNA) II (DNA directed) polypeptide E)
Polr2f  (polymerase (RNA) II (DNA directed) polypeptide F)
Polr2h  (polymerase (RNA) II (DNA directed) polypeptide H)
Polr2k  (polymerase (RNA) II (DNA directed) polypeptide K)
Polr2l  (polymerase (RNA) II (DNA directed) polypeptide L)
Polr3a  (polymerase (RNA) III (DNA directed) polypeptide A)
Polr3b  (polymerase (RNA) III (DNA directed) polypeptide B)
Polr3c  (polymerase (RNA) III (DNA directed) polypeptide C)
Polr3d  (polymerase (RNA) III (DNA directed) polypeptide D)
Polr3e  (polymerase (RNA) III (DNA directed) polypeptide E)
Polr3f  (polymerase (RNA) III (DNA directed) polypeptide F)
Polr3g  (polymerase (RNA) III (DNA directed) polypeptide G)
Polr3gl  (polymerase (RNA) III (DNA directed) polypeptide G like)
Polr3h  (polymerase (RNA) III (DNA directed) polypeptide H)
Polr3k  (polymerase (RNA) III (DNA directed) polypeptide K)
Pou2f1  (POU domain, class 2, transcription factor 1)
Tbp  (TATA box binding protein)
Zfp143  (zinc finger protein 143)

Genes (Homo sapiens)
BDP1  (B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB)
BRF1  (BRF1 RNA polymerase III transcription initiation factor subunit)
BRF2  (BRF2 RNA polymerase III transcription initiation factor subunit)
POLR1C  (RNA polymerase I and III subunit C)
POLR1D  (RNA polymerase I and III subunit D)
POLR2E  (RNA polymerase II, I and III subunit E)
POLR2F  (RNA polymerase II, I and III subunit F)
POLR2H  (RNA polymerase II, I and III subunit H)
POLR2K  (RNA polymerase II, I and III subunit K)
POLR2L  (RNA polymerase II, I and III subunit L)
POLR3A  (RNA polymerase III subunit A)
POLR3B  (RNA polymerase III subunit B)
POLR3C  (RNA polymerase III subunit C)
POLR3D  (RNA polymerase III subunit D)
POLR3E  (RNA polymerase III subunit E)
POLR3F  (RNA polymerase III subunit F)
POLR3G  (RNA polymerase III subunit G)
POLR3GL  (RNA polymerase III subunit GL)
POLR3H  (RNA polymerase III subunit H)
POLR3K  (RNA polymerase III subunit K)
POU2F1  (POU class 2 homeobox 1)
TBP  (TATA-box binding protein)
ZNF143  (zinc finger protein 143)


Additional Information