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Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription.

Authors: Dumay-Odelot, H  Durrieu-Gaillard, S  Da Silva, D  Roeder, RG  Teichmann, M 
Citation: Dumay-Odelot H, etal., Cell Cycle. 2010 Sep 15;9(18):3687-99. Epub 2010 Sep 1.
Pubmed: (View Article at PubMed) PMID:20890107
DOI: Full-text: DOI:10.4161/cc.9.18.13203

RNA polymerase III transcribes small untranslated RNAs that fulfill essential cellular functions in regulating transcription, RNA processing, translation and protein translocation. RNA polymerase III transcription activity is tightly regulated during the cell cycle and coupled to growth control mechanisms. Furthermore, there are reports of changes in RNA polymerase III transcription activity during cellular differentiation, including the discovery of a novel isoform of human RNA polymerase III that has been shown to be specifically expressed in undifferentiated human H1 embryonic stem cells. Here, we review major regulatory mechanisms of RNA polymerase III transcription during the cell cycle, cell growth and cell differentiation.


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RGD Object Information
RGD ID: 9685218
Created: 2014-12-30
Species: All species
Last Modified: 2014-12-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.