RGD Reference Report - Structural insights into transcription initiation by RNA polymerase II. - Rat Genome Database

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Structural insights into transcription initiation by RNA polymerase II.

Authors: Grunberg, S  Hahn, S 
Citation: Grunberg S and Hahn S, Trends Biochem Sci. 2013 Dec;38(12):603-11. doi: 10.1016/j.tibs.2013.09.002. Epub 2013 Oct 11.
RGD ID: 9681721
Pubmed: PMID:24120742   (View Abstract at PubMed)
PMCID: PMC3843768   (View Article at PubMed Central)
DOI: DOI:10.1016/j.tibs.2013.09.002   (Journal Full-text)

Transcriptional regulation is one of the most important steps in control of cell identity, growth, differentiation, and development. Many signaling pathways controlling these processes ultimately target the core transcription machinery that, for protein coding genes, consists of RNA polymerase II (Pol II) and the general transcription factors (GTFs). New studies on the structure and mechanism of the core assembly and how it interfaces with promoter DNA and coactivator complexes have given tremendous insight into early steps in the initiation process, genome-wide binding, and mechanisms conserved for all nuclear and archaeal Pols. Here, we review recent developments in dissecting the architecture of the Pol II core machinery with a focus on early and regulated steps in transcription initiation.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GTF2A1HumanRNA polymerase II transcription initiation pathway  TAS  RGD 
GTF2A2HumanRNA polymerase II transcription initiation pathway  TAS  RGD 
GTF2BHumanRNA polymerase II transcription initiation pathway  TAS  RGD 
GTF2E1HumanRNA polymerase II transcription initiation pathway  TAS  RGD 
GTF2E2HumanRNA polymerase II transcription initiation pathway  TAS  RGD 
GTF2F1HumanRNA polymerase II transcription initiation pathway  TAS  RGD 
GTF2F2HumanRNA polymerase II transcription initiation pathway  TAS  RGD 
Gtf2a1RatRNA polymerase II transcription initiation pathway  ISORGD:733620 RGD 
Gtf2a1MouseRNA polymerase II transcription initiation pathway  ISORGD:733620 RGD 
Gtf2a2RatRNA polymerase II transcription initiation pathway  ISORGD:737167 RGD 
Gtf2a2MouseRNA polymerase II transcription initiation pathway  ISORGD:737167 RGD 
Gtf2bRatRNA polymerase II transcription initiation pathway  ISORGD:731364 RGD 
Gtf2bMouseRNA polymerase II transcription initiation pathway  ISORGD:731364 RGD 
Gtf2e1RatRNA polymerase II transcription initiation pathway  ISORGD:1315703 RGD 
Gtf2e1MouseRNA polymerase II transcription initiation pathway  ISORGD:1315703 RGD 
Gtf2e2RatRNA polymerase II transcription initiation pathway  ISORGD:1320859 RGD 
Gtf2e2MouseRNA polymerase II transcription initiation pathway  ISORGD:1320859 RGD 
Gtf2f1RatRNA polymerase II transcription initiation pathway  ISORGD:1343690 RGD 
Gtf2f1MouseRNA polymerase II transcription initiation pathway  ISORGD:1343690 RGD 
Gtf2f2RatRNA polymerase II transcription initiation pathway  ISORGD:733447 RGD 
Gtf2f2MouseRNA polymerase II transcription initiation pathway  ISORGD:733447 RGD 
TBPHumanRNA polymerase II transcription initiation pathway  TAS  RGD 
TbpRatRNA polymerase II transcription initiation pathway  ISORGD:68980 RGD 
TbpMouseRNA polymerase II transcription initiation pathway  ISORGD:68980 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Gtf2a1  (general transcription factor 2A subunit 1)
Gtf2a2  (general transcription factor 2A subunit 2)
Gtf2b  (general transcription factor IIB)
Gtf2e1  (general transcription factor IIE subunit 1)
Gtf2e2  (general transcription factor IIE subunit 2)
Gtf2f1  (general transcription factor IIF subunit 1)
Gtf2f2  (general transcription factor IIF subunit 2)
Tbp  (TATA box binding protein)

Genes (Mus musculus)
Gtf2a1  (general transcription factor II A, 1)
Gtf2a2  (general transcription factor II A, 2)
Gtf2b  (general transcription factor IIB)
Gtf2e1  (general transcription factor II E, polypeptide 1 (alpha subunit))
Gtf2e2  (general transcription factor II E, polypeptide 2 (beta subunit))
Gtf2f1  (general transcription factor IIF, polypeptide 1)
Gtf2f2  (general transcription factor IIF, polypeptide 2)
Tbp  (TATA box binding protein)

Genes (Homo sapiens)
GTF2A1  (general transcription factor IIA subunit 1)
GTF2A2  (general transcription factor IIA subunit 2)
GTF2B  (general transcription factor IIB)
GTF2E1  (general transcription factor IIE subunit 1)
GTF2E2  (general transcription factor IIE subunit 2)
GTF2F1  (general transcription factor IIF subunit 1)
GTF2F2  (general transcription factor IIF subunit 2)
TBP  (TATA-box binding protein)


Additional Information