RGD Reference Report - RNA polymerase I activity is regulated at multiple steps in the transcription cycle: recent insights into factors that influence transcription elongation. - Rat Genome Database
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RNA polymerase I activity is regulated at multiple steps in the transcription cycle: recent insights into factors that influence transcription elongation.

Authors: Schneider, DA 
Citation: Schneider DA Gene. 2012 Feb 10;493(2):176-84. doi: 10.1016/j.gene.2011.08.006. Epub 2011 Aug 26.
RGD ID: 9588244
Pubmed: (View Article at PubMed) PMID:21893173
DOI: Full-text: DOI:10.1016/j.gene.2011.08.006

Synthesis of the translation apparatus is a central activity in growing and/or proliferating cells. Because of its fundamental importance and direct connection to cell proliferation, ribosome synthesis has been a focus of ongoing research for several decades. As a consequence, much is known about the essential factors involved in this process. Many studies have shown that transcription of the ribosomal DNA by RNA polymerase I is a major target for cellular regulation of ribosome synthesis rates. The initiation of transcription by RNA polymerase I has been implicated as a regulatory target, however, recent studies suggest that the elongation step in transcription is also influenced and regulated by trans-acting factors. This review describes the factors required for rRNA synthesis and focuses on recent works that have begun to identify and characterize factors that influence transcription elongation by RNA polymerase I and its regulation.

Annotation

Molecular Pathway Annotations    
Objects Annotated

Genes (Rattus norvegicus)
Ncl  (nucleolin)
Polr1a  (RNA polymerase I subunit A)
Polr1b  (RNA polymerase I subunit B)
Polr1c  (RNA polymerase I and III subunit C)
Polr1e  (RNA polymerase I subunit E)
Polr1f  (RNA polymerase I subunit F)
Polr1g  (RNA polymerase I subunit G)
Polr1h  (RNA polymerase I subunit H)
Polr2e  (RNA polymerase II, I and III subunit E)
Polr2f  (RNA polymerase II, I and III subunit F)
Polr2k  (RNA polymerase II, I and III subunit K)
Rrn3  (RRN3 homolog, RNA polymerase I transcription factor)
Supt4h1  (SPT4 homolog, DSIF elongation factor subunit)
Supt5h  (SPT5 homolog, DSIF elongation factor subunit)
Taf12  (TATA-box binding protein associated factor 12)
Taf1a  (TATA-box binding protein associated factor, RNA polymerase I subunit A)
Taf1b  (TATA-box binding protein associated factor, RNA polymerase I subunit B)
Taf1c  (TATA-box binding protein associated factor, RNA polymerase 1 subunit C)
Taf1d  (TATA-box binding protein associated factor, RNA polymerase I subunit D)
Tbp  (TATA box binding protein)
Ubtf  (upstream binding transcription factor)

Genes (Mus musculus)
Cd3eap  (CD3E antigen, epsilon polypeptide associated protein)
Ncl  (nucleolin)
Polr1a  (polymerase (RNA) I polypeptide A)
Polr1b  (polymerase (RNA) I polypeptide B)
Polr1c  (polymerase (RNA) I polypeptide C)
Polr1d  (polymerase (RNA) I polypeptide D)
Polr1e  (polymerase (RNA) I polypeptide E)
Polr1f  (RNA polymerase I subunit F)
Polr1h  (RNA polymerase I subunit H)
Polr2e  (polymerase (RNA) II (DNA directed) polypeptide E)
Polr2f  (polymerase (RNA) II (DNA directed) polypeptide F)
Polr2h  (polymerase (RNA) II (DNA directed) polypeptide H)
Polr2k  (polymerase (RNA) II (DNA directed) polypeptide K)
Polr2l  (polymerase (RNA) II (DNA directed) polypeptide L)
Rrn3  (RRN3 RNA polymerase I transcription factor homolog (yeast))
Supt4a  (SPT4A, DSIF elongation factor subunit)
Supt5  (suppressor of Ty 5, DSIF elongation factor subunit)
Taf12  (TATA-box binding protein associated factor 12)
Taf1a  (TATA-box binding protein associated factor, RNA polymerase I, A)
Taf1b  (TATA-box binding protein associated factor, RNA polymerase I, B)
Taf1c  (TATA-box binding protein associated factor, RNA polymerase I, C)
Taf1d  (TATA-box binding protein associated factor, RNA polymerase I, D)
Tbp  (TATA box binding protein)
Ubtf  (upstream binding transcription factor, RNA polymerase I)

Genes (Homo sapiens)
NCL  (nucleolin)
POLR1A  (RNA polymerase I subunit A)
POLR1B  (RNA polymerase I subunit B)
POLR1C  (RNA polymerase I and III subunit C)
POLR1D  (RNA polymerase I and III subunit D)
POLR1E  (RNA polymerase I subunit E)
POLR1F  (RNA polymerase I subunit F)
POLR1G  (RNA polymerase I subunit G)
POLR1H  (RNA polymerase I subunit H)
POLR2E  (RNA polymerase II, I and III subunit E)
POLR2F  (RNA polymerase II, I and III subunit F)
POLR2H  (RNA polymerase II, I and III subunit H)
POLR2K  (RNA polymerase II, I and III subunit K)
POLR2L  (RNA polymerase II, I and III subunit L)
RRN3  (RRN3 homolog, RNA polymerase I transcription factor)
SUPT4H1  (SPT4 homolog, DSIF elongation factor subunit)
SUPT5H  (SPT5 homolog, DSIF elongation factor subunit)
TAF12  (TATA-box binding protein associated factor 12)
TAF1A  (TATA-box binding protein associated factor, RNA polymerase I subunit A)
TAF1B  (TATA-box binding protein associated factor, RNA polymerase I subunit B)
TAF1C  (TATA-box binding protein associated factor, RNA polymerase I subunit C)
TAF1D  (TATA-box binding protein associated factor, RNA polymerase I subunit D)
TBP  (TATA-box binding protein)
UBTF  (upstream binding transcription factor)


Additional Information