RGD Reference Report - RNA polymerase I activity is regulated at multiple steps in the transcription cycle: recent insights into factors that influence transcription elongation. - Rat Genome Database

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RNA polymerase I activity is regulated at multiple steps in the transcription cycle: recent insights into factors that influence transcription elongation.

Authors: Schneider, DA 
Citation: Schneider DA Gene. 2012 Feb 10;493(2):176-84. doi: 10.1016/j.gene.2011.08.006. Epub 2011 Aug 26.
RGD ID: 9588244
Pubmed: PMID:21893173   (View Abstract at PubMed)
PMCID: PMC3234310   (View Article at PubMed Central)
DOI: DOI:10.1016/j.gene.2011.08.006   (Journal Full-text)

Synthesis of the translation apparatus is a central activity in growing and/or proliferating cells. Because of its fundamental importance and direct connection to cell proliferation, ribosome synthesis has been a focus of ongoing research for several decades. As a consequence, much is known about the essential factors involved in this process. Many studies have shown that transcription of the ribosomal DNA by RNA polymerase I is a major target for cellular regulation of ribosome synthesis rates. The initiation of transcription by RNA polymerase I has been implicated as a regulatory target, however, recent studies suggest that the elongation step in transcription is also influenced and regulated by trans-acting factors. This review describes the factors required for rRNA synthesis and focuses on recent works that have begun to identify and characterize factors that influence transcription elongation by RNA polymerase I and its regulation.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NCLHumanRNA polymerase I transcription pathway   TAS  RGD 
NclRatRNA polymerase I transcription pathway   ISONCL (Homo sapiens) RGD 
NclMouseRNA polymerase I transcription pathway   ISONCL (Homo sapiens) RGD 
POLR1AHumanRNA polymerase I transcription pathway   TAS  RGD 
POLR1BHumanRNA polymerase I transcription pathway   TAS  RGD 
POLR1CHumanRNA polymerase I transcription pathway   TAS  RGD 
POLR1DHumanRNA polymerase I transcription pathway   TAS  RGD 
POLR1EHumanRNA polymerase I transcription pathway   TAS  RGD 
POLR1FHumanRNA polymerase I transcription pathway   TAS  RGD 
POLR1GHumanRNA polymerase I transcription pathway   TAS  RGD 
POLR1HHumanRNA polymerase I transcription pathway   TAS  RGD 
POLR2EHumanRNA polymerase I transcription pathway   TAS  RGD 
POLR2FHumanRNA polymerase I transcription pathway   TAS  RGD 
POLR2HHumanRNA polymerase I transcription pathway   TAS  RGD 
POLR2KHumanRNA polymerase I transcription pathway   TAS  RGD 
POLR2LHumanRNA polymerase I transcription pathway   TAS  RGD 
Polr1aRatRNA polymerase I transcription pathway   ISOPOLR1A (Homo sapiens) RGD 
Polr1aMouseRNA polymerase I transcription pathway   ISOPOLR1A (Homo sapiens) RGD 
Polr1bRatRNA polymerase I transcription pathway   ISOPOLR1B (Homo sapiens) RGD 
Polr1bMouseRNA polymerase I transcription pathway   ISOPOLR1B (Homo sapiens) RGD 
Polr1cRatRNA polymerase I transcription pathway   ISOPOLR1C (Homo sapiens) RGD 
Polr1cMouseRNA polymerase I transcription pathway   ISOPOLR1C (Homo sapiens) RGD 
Polr1dMouseRNA polymerase I transcription pathway   ISOPOLR1D (Homo sapiens) RGD 
Polr1eMouseRNA polymerase I transcription pathway   ISOPOLR1E (Homo sapiens) RGD 
Polr1eRatRNA polymerase I transcription pathway   ISOPOLR1E (Homo sapiens) RGD 
Polr1fRatRNA polymerase I transcription pathway   ISOPOLR1F (Homo sapiens) RGD 
Polr1fMouseRNA polymerase I transcription pathway   ISOPOLR1F (Homo sapiens) RGD 
Polr1gRatRNA polymerase I transcription pathway   ISOPOLR1G (Homo sapiens) RGD 
Polr1gMouseRNA polymerase I transcription pathway   ISOPOLR1G (Homo sapiens) RGD 
Polr1hRatRNA polymerase I transcription pathway   ISOPOLR1H (Homo sapiens) RGD 
Polr1hMouseRNA polymerase I transcription pathway   ISOPOLR1H (Homo sapiens) RGD 
Polr2eMouseRNA polymerase I transcription pathway   ISOPOLR2E (Homo sapiens) RGD 
Polr2eRatRNA polymerase I transcription pathway   ISOPOLR2E (Homo sapiens) RGD 
Polr2fRatRNA polymerase I transcription pathway   ISOPOLR2F (Homo sapiens) RGD 
Polr2fMouseRNA polymerase I transcription pathway   ISOPOLR2F (Homo sapiens) RGD 
Polr2hMouseRNA polymerase I transcription pathway   ISOPOLR2H (Homo sapiens) RGD 
Polr2kMouseRNA polymerase I transcription pathway   ISOPOLR2K (Homo sapiens) RGD 
Polr2kRatRNA polymerase I transcription pathway   ISOPOLR2K (Homo sapiens) RGD 
Polr2lMouseRNA polymerase I transcription pathway   ISOPOLR2L (Homo sapiens) RGD 
RRN3HumanRNA polymerase I transcription pathway   TAS  RGD 
Rrn3RatRNA polymerase I transcription pathway   ISORRN3 (Homo sapiens) RGD 
Rrn3MouseRNA polymerase I transcription pathway   ISORRN3 (Homo sapiens) RGD 
SUPT4H1HumanRNA polymerase I transcription pathway   TAS  RGD 
SUPT5HHumanRNA polymerase I transcription pathway   TAS  RGD 
Supt4aMouseRNA polymerase I transcription pathway   ISOSUPT4H1 (Homo sapiens) RGD 
Supt4h1RatRNA polymerase I transcription pathway   ISOSUPT4H1 (Homo sapiens) RGD 
Supt5MouseRNA polymerase I transcription pathway   ISOSUPT5H (Homo sapiens) RGD 
Supt5hRatRNA polymerase I transcription pathway   ISOSUPT5H (Homo sapiens) RGD 
TAF12HumanRNA polymerase I transcription pathway   TAS  RGD 
TAF1AHumanRNA polymerase I transcription pathway   TAS  RGD 
TAF1BHumanRNA polymerase I transcription pathway   TAS  RGD 
TAF1CHumanRNA polymerase I transcription pathway   TAS  RGD 
TAF1DHumanRNA polymerase I transcription pathway   TAS  RGD 
TBPHumanRNA polymerase I transcription pathway   TAS  RGD 
Taf12RatRNA polymerase I transcription pathway   ISOTAF12 (Homo sapiens) RGD 
Taf12MouseRNA polymerase I transcription pathway   ISOTAF12 (Homo sapiens) RGD 
Taf1aRatRNA polymerase I transcription pathway   ISOTAF1A (Homo sapiens) RGD 
Taf1aMouseRNA polymerase I transcription pathway   ISOTAF1A (Homo sapiens) RGD 
Taf1bMouseRNA polymerase I transcription pathway   ISOTAF1B (Homo sapiens) RGD 
Taf1bRatRNA polymerase I transcription pathway   ISOTAF1B (Homo sapiens) RGD 
Taf1cRatRNA polymerase I transcription pathway   ISOTAF1C (Homo sapiens) RGD 
Taf1cMouseRNA polymerase I transcription pathway   ISOTAF1C (Homo sapiens) RGD 
Taf1dRatRNA polymerase I transcription pathway   ISOTAF1D (Homo sapiens) RGD 
Taf1dMouseRNA polymerase I transcription pathway   ISOTAF1D (Homo sapiens) RGD 
TbpRatRNA polymerase I transcription pathway   ISOTBP (Homo sapiens) RGD 
TbpMouseRNA polymerase I transcription pathway   ISOTBP (Homo sapiens) RGD 
UBTFHumanRNA polymerase I transcription pathway   TAS  RGD 
UbtfRatRNA polymerase I transcription pathway   ISOUBTF (Homo sapiens) RGD 
UbtfMouseRNA polymerase I transcription pathway   ISOUBTF (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Ncl  (nucleolin)
Polr1a  (RNA polymerase I subunit A)
Polr1b  (RNA polymerase I subunit B)
Polr1c  (RNA polymerase I and III subunit C)
Polr1e  (RNA polymerase I subunit E)
Polr1f  (RNA polymerase I subunit F)
Polr1g  (RNA polymerase I subunit G)
Polr1h  (RNA polymerase I subunit H)
Polr2e  (RNA polymerase II, I and III subunit E)
Polr2f  (RNA polymerase II, I and III subunit F)
Polr2k  (RNA polymerase II, I and III subunit K)
Rrn3  (RRN3 homolog, RNA polymerase I transcription factor)
Supt4h1  (SPT4 homolog, DSIF elongation factor subunit)
Supt5h  (SPT5 homolog, DSIF elongation factor subunit)
Taf12  (TATA-box binding protein associated factor 12)
Taf1a  (TATA-box binding protein associated factor, RNA polymerase I subunit A)
Taf1b  (TATA-box binding protein associated factor, RNA polymerase I subunit B)
Taf1c  (TATA-box binding protein associated factor, RNA polymerase 1 subunit C)
Taf1d  (TATA-box binding protein associated factor, RNA polymerase I subunit D)
Tbp  (TATA box binding protein)
Ubtf  (upstream binding transcription factor)

Genes (Mus musculus)
Ncl  (nucleolin)
Polr1a  (polymerase (RNA) I polypeptide A)
Polr1b  (polymerase (RNA) I polypeptide B)
Polr1c  (polymerase (RNA) I polypeptide C)
Polr1d  (polymerase (RNA) I polypeptide D)
Polr1e  (polymerase (RNA) I polypeptide E)
Polr1f  (RNA polymerase I subunit F)
Polr1g  (RNA polymerase I subunit G)
Polr1h  (RNA polymerase I subunit H)
Polr2e  (polymerase (RNA) II (DNA directed) polypeptide E)
Polr2f  (polymerase (RNA) II (DNA directed) polypeptide F)
Polr2h  (polymerase (RNA) II (DNA directed) polypeptide H)
Polr2k  (polymerase (RNA) II (DNA directed) polypeptide K)
Polr2l  (polymerase (RNA) II (DNA directed) polypeptide L)
Rrn3  (RRN3 RNA polymerase I transcription factor homolog (yeast))
Supt4a  (SPT4A, DSIF elongation factor subunit)
Supt5  (suppressor of Ty 5, DSIF elongation factor subunit)
Taf12  (TATA-box binding protein associated factor 12)
Taf1a  (TATA-box binding protein associated factor, RNA polymerase I, A)
Taf1b  (TATA-box binding protein associated factor, RNA polymerase I, B)
Taf1c  (TATA-box binding protein associated factor, RNA polymerase I, C)
Taf1d  (TATA-box binding protein associated factor, RNA polymerase I, D)
Tbp  (TATA box binding protein)
Ubtf  (upstream binding transcription factor, RNA polymerase I)

Genes (Homo sapiens)
NCL  (nucleolin)
POLR1A  (RNA polymerase I subunit A)
POLR1B  (RNA polymerase I subunit B)
POLR1C  (RNA polymerase I and III subunit C)
POLR1D  (RNA polymerase I and III subunit D)
POLR1E  (RNA polymerase I subunit E)
POLR1F  (RNA polymerase I subunit F)
POLR1G  (RNA polymerase I subunit G)
POLR1H  (RNA polymerase I subunit H)
POLR2E  (RNA polymerase II, I and III subunit E)
POLR2F  (RNA polymerase II, I and III subunit F)
POLR2H  (RNA polymerase II, I and III subunit H)
POLR2K  (RNA polymerase II, I and III subunit K)
POLR2L  (RNA polymerase II, I and III subunit L)
RRN3  (RRN3 homolog, RNA polymerase I transcription factor)
SUPT4H1  (SPT4 homolog, DSIF elongation factor subunit)
SUPT5H  (SPT5 homolog, DSIF elongation factor subunit)
TAF12  (TATA-box binding protein associated factor 12)
TAF1A  (TATA-box binding protein associated factor, RNA polymerase I subunit A)
TAF1B  (TATA-box binding protein associated factor, RNA polymerase I subunit B)
TAF1C  (TATA-box binding protein associated factor, RNA polymerase I subunit C)
TAF1D  (TATA-box binding protein associated factor, RNA polymerase I subunit D)
TBP  (TATA-box binding protein)
UBTF  (upstream binding transcription factor)


Additional Information