View Ontology Report


The three eukaryotic RNA polymerases (RNAPs)- Pol I, II and III, transcribe different sets of genes and require distinct sets of factors to assemble a specific initiation complex which recruits them on gene promoters. The multi-subunit enzymes are composed of 14 (RNAPI), 12 (RNAPII) and 17 (RNAPIII) subunits of which some are shared and others are unique, yet converging on an overall similar structural topology. Complexes specific to each of the three systems share the universal transcription f

Pathway Diagram:

Elsevier Inc. pre-tRNA transcript tRNA maturation pathway Sub1 Rb1 TFIIIB Pou2f1 Rb1 ---- SNAPc Sub1 ---- TFIIIC TFIIIB ---- TFIIIC Sub1 ---- TFIIIB Zfp143 --+> SNAPc chromatin modification/remodeling pathway Pou2f1 --+> SNAPc Zfp143 Maf1 ---- RNA polymerase III Maf1 ---| RNA polymerase III Maf1 ---- TFIIIB Maf1 ---| TFIIIB SNAPc ---- TFIIIB RNA polymerase III ---- TFIIIB TFIIIA ---- TFIIIC Rb1 ---| TFIIIB Rb1 ---- TFIIIB Rb1 ---| SNAPc stress stress --+> Maf1 Maf1 mTOR signaling pathway ---| Maf1 SNAPc TFIIIC TFIIIA RNA polymerase III RNA polymerase III ---> pre-tRNA transcript mTOR signaling pathway

Genes in Pathway:

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RNA polymerase III transcription pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bdp1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB JBrowse link 2 30,248,458 30,340,211 RGD:9685218
G Brf1 BRF1, RNA polymerase III transcription initiation factor subunit JBrowse link 6 137,762,230 137,808,573 RGD:9685218
G Brf2 BRF2, RNA polymerase III transcription initiation factor subunit JBrowse link 16 69,089,955 69,094,678 RGD:9685218
G Crcp CGRP receptor component JBrowse link 12 30,125,237 30,160,857 RGD:9685217
G Gtf3a general transcription factor III A JBrowse link 12 9,856,841 9,864,791 RGD:9588284
G Gtf3c1 general transcription factor IIIC subunit 1 JBrowse link 1 197,032,473 197,098,676 RGD:9588284
G Gtf3c2 general transcription factor IIIC subunit 2 JBrowse link 6 26,560,601 26,584,533 RGD:9588284
G Gtf3c3 general transcription factor IIIC subunit 3 JBrowse link 9 60,999,159 61,033,612 RGD:9588284
G Gtf3c4 general transcription factor IIIC subunit 4 JBrowse link 3 7,404,857 7,422,779 RGD:9588284
G Gtf3c5 general transcription factor IIIC subunit 5 JBrowse link 3 7,144,354 7,164,678 RGD:9588284
G Gtf3c6 general transcription factor 3C subunit 6 JBrowse link 20 45,347,788 45,356,868 RGD:9588284
G Maf1 MAF1 homolog, negative regulator of RNA polymerase III JBrowse link 7 117,417,643 117,420,722 RGD:9588284
G Polr1c RNA polymerase I and III subunit C JBrowse link 9 17,120,759 17,124,871 RGD:9685217
G Polr2e RNA polymerase II subunit E JBrowse link 7 12,532,785 12,536,797 RGD:9685217
G Polr2f RNA polymerase II subunit F JBrowse link 7 120,380,543 120,392,214 RGD:9685217
G Polr2k RNA polymerase II subunit K JBrowse link 7 74,939,010 74,992,594 RGD:9685217
G Polr3a RNA polymerase III subunit A JBrowse link 16 717,821 756,002 RGD:9685217
G Polr3b RNA polymerase III subunit B JBrowse link 7 24,745,051 24,851,227 RGD:9685217
G Polr3c RNA polymerase III subunit C JBrowse link 2 198,836,282 198,852,368 RGD:9685217
G Polr3d RNA polymerase III subunit D JBrowse link 15 52,129,471 52,134,140 RGD:9685217
G Polr3e RNA polymerase III subunit E JBrowse link 1 190,852,954 190,881,539 RGD:9685217
G Polr3f RNA polymerase III subunit F JBrowse link 3 138,684,685 138,701,055 RGD:9685217
G Polr3g RNA polymerase III subunit G JBrowse link 2 9,537,642 9,578,551 RGD:9685217
G Polr3gl RNA polymerase III subunit G like JBrowse link 2 198,698,044 198,719,609 RGD:9685218
G Polr3h RNA polymerase III subunit H JBrowse link 7 123,146,248 123,156,558 RGD:9685217
G Polr3k RNA polymerase III subunit K JBrowse link 3 177,374,812 177,379,009 RGD:9685217
G Pou2f1 POU class 2 homeobox 1 JBrowse link 13 84,075,316 84,217,368 RGD:9685218
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:9685222
G Snapc1 small nuclear RNA activating complex, polypeptide 1 JBrowse link 6 96,871,675 96,893,422 RGD:9588284
G Snapc2 small nuclear RNA activating complex, polypeptide 2 JBrowse link 12 2,537,291 2,540,774 RGD:9588284
G Snapc3 small nuclear RNA activating complex, polypeptide 3 JBrowse link 5 101,526,591 101,554,015 RGD:9588284
G Snapc4 small nuclear RNA activating complex, polypeptide 4 JBrowse link 3 3,808,596 3,827,425 RGD:9588284
G Snapc5 small nuclear RNA activating complex, polypeptide 5 JBrowse link 8 69,127,708 69,131,539 RGD:9588284
G Sub1 SUB1 homolog, transcriptional regulator JBrowse link 2 62,019,902 62,034,704 RGD:9685221
G Tbp TATA box binding protein JBrowse link 1 57,491,381 57,509,335 RGD:9685218
G Zfp143 zinc finger protein 143 JBrowse link 1 174,702,310 174,738,133 RGD:9685218
tRNA maturation pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clp1 cleavage and polyadenylation factor I subunit 1 JBrowse link 3 72,125,269 72,137,122 RGD:9685342
G Elac1 elaC ribonuclease Z 1 JBrowse link 18 69,706,522 69,723,869 RGD:9685334
G Elac2 elaC ribonuclease Z 2 JBrowse link 10 51,478,378 51,501,167 RGD:9685334
G Pop1 POP1 homolog, ribonuclease P/MRP subunit JBrowse link 7 73,270,403 73,298,209 RGD:9685326
G Pop4 POP4 homolog, ribonuclease P/MRP subunit JBrowse link 1 94,661,127 94,669,461 RGD:9685326
G Pop7 POP7 homolog, ribonuclease P/MRP subunit JBrowse link 12 22,259,713 22,260,754 RGD:9685326
G Rpp14 ribonuclease P/MRP subunit p14 JBrowse link 15 18,625,963 18,636,157 RGD:9685326
G Rpp21 ribonuclease P/MRP subunit p21 JBrowse link 20 2,515,541 2,517,471 RGD:9685326
G Rpp25 ribonuclease P and MRP subunit p25 JBrowse link 8 62,283,336 62,284,716 RGD:9685326
G Rpp30 ribonuclease P/MRP subunit p30 JBrowse link 1 254,697,247 254,720,093 RGD:9685326
G Rpp38 ribonuclease P/MRP subunit p38 JBrowse link 17 78,915,450 78,919,144 RGD:9685326
G Rpp40 ribonuclease P/MRP subunit p40 JBrowse link 17 29,638,647 29,647,709 RGD:9685326
G Rtcb RNA 2',3'-cyclic phosphate and 5'-OH ligase JBrowse link 7 23,913,830 23,933,191 RGD:9685342
G Ssb Sjogren syndrome antigen B JBrowse link 3 56,092,425 56,102,008 RGD:9685334
G Tsen15 tRNA splicing endonuclease subunit 15 JBrowse link 13 69,765,093 69,781,019 RGD:9685342
G Tsen2 tRNA splicing endonuclease subunit 2 JBrowse link 4 147,455,506 147,490,869 RGD:9685342
G Tsen34 tRNA splicing endonuclease subunit 34 JBrowse link 1 64,023,924 64,031,756 RGD:9685342
G Tsen54 tRNA splicing endonuclease subunit 54 JBrowse link 10 104,358,401 104,366,926 RGD:9685342

Pathway Gene Annotations

Disease Annotations Associated with Genes in the RNA polymerase III transcription pathway
Disease TermsGene Symbols
acute kidney failureRb1
Adrenal Gland NeoplasmsRb1
adrenocortical carcinomaRb1
Alstrom syndromePolr3b
Alzheimer's diseaseTbp
Animal Mammary NeoplasmsRb1
autistic disorderPolr3e
Autosomal Recessive Nonsyndromic Deafness 112Bdp1
basal cell carcinomaRb1
brain ischemiaRb1
Breast NeoplasmsRb1
cardiofaciocutaneous syndromeSnapc5
CardiomegalyBrf1 , Rb1
Cerebellar Hypoplasia with Endosteal SclerosisPolr3b
Cerebellofaciodental SyndromeBrf1
cervix uteri carcinoma in situRb1
Chromosome 13q Deletion SyndromeRb1
chromosome 13q14 deletion syndromeRb1
common variable immunodeficiencyPolr3h
Diamond-Blackfan anemiaPolr3a
disease of cellular proliferationRb1
Disease ProgressionPolr3k
ductal carcinoma in situRb1
embryonal carcinomaRb1
Endometrial NeoplasmsRb1
Experimental Liver NeoplasmsRb1
Experimental NeoplasmsRb1
gastrointestinal stromal tumorRb1
genetic diseasePolr2f , Polr3h
glioblastoma multiformeRb1
glioblastoma proneural subtypeRb1
hemochromatosis type 2APolr3gl
hepatocellular carcinomaRb1
Hereditary Neoplastic SyndromesPolr3g , Rb1
Hirschsprung Disease 1Polr2f
Hirschsprung's diseasePolr2f
human immunodeficiency virus infectious diseaseGtf3a
Huntington's diseaseTbp
hypogonadotropic hypogonadism 7 with or without anosmiaPolr3b
hypomyelinating leukodystrophy 11Polr1c
hypomyelinating leukodystrophy 4Polr3a
hypomyelinating leukodystrophy 7 with or without oligodontia and-or hypogonadotropic hypogonadismPolr3a , Polr3b
hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadismPolr3b
hypotrichosis 8Rb1
in situ carcinomaRb1
infantile cerebellar-retinal degenerationPolr3h
Insulin ResistanceRb1
intellectual disabilityBrf1 , Polr3b , Rb1
intestinal pseudo-obstructionRb1
Kartagener syndromePolr2k
late onset Parkinson's diseaseTbp
long QT syndromeSnapc4 , Snapc5
lung small cell carcinomaRb1
Mammary Neoplasms, ExperimentalRb1
Mandibulofacial DysostosisPolr1c
Mandibulofacial Dysostosis, Treacher Collins Type, Autosomal RecessivePolr1c
Neoplasm MetastasisRb1
non-small cell lung carcinomaRb1
Noonan syndromeSnapc5
Optic Atrophy 8Polr3h
Optic Atrophy 9Polr3h
Ovarian NeoplasmsRb1
pancreatic cancerRb1
Parkinson's diseaseTbp
PCWH syndromePolr2f
Peutz-Jeghers syndromePolr2e
Phyllodes TumorRb1
Pituitary NeoplasmsRb1
pleomorphic xanthoastrocytomaCrcp
precursor lymphoblastic lymphoma/leukemiaRb1
primary ciliary dyskinesia 28Polr2k
prostate cancerBrf2 , Rb1
Prostatic NeoplasmsRb1
renal cell carcinomaRb1
schizophreniaPolr3c , Polr3e , Polr3gl , Tbp
sciatic neuropathyCrcp
Sezary's diseaseRb1
skin melanomaSnapc5
sleep apneaTbp
small cell carcinomaRb1
Spinal Cord InjuriesTbp
spinocerebellar ataxia type 17Tbp
Spinocerebellar AtaxiasTbp
Stevens-Johnson syndromeRb1
Stomach NeoplasmsPolr3k
thrombocytopenia-absent radius syndromePolr3c , Polr3gl
Treacher Collins syndromePolr1c
trilateral retinoblastomaRb1
type 1 diabetes mellitusTbp
urinary bladder cancerRb1
Urinary Bladder NeoplasmRb1
Waardenburg syndrome type 2APolr2f
Waardenburg syndrome type 2EPolr2f
Waardenburg syndrome type 4APolr2f
Waardenburg syndrome type 4CPolr2f
Waardenburg's syndromePolr2f
Woolly Hair, Autosomal RecessiveRb1
Pathway Annotations Associated with Genes in the RNA polymerase III transcription pathway

References Associated with the RNA polymerase III transcription pathway:

Ontology Path Diagram:

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