Polr2l (polymerase (RNA) II (DNA directed) polypeptide L) - Rat Genome Database
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Gene: Polr2l (polymerase (RNA) II (DNA directed) polypeptide L) Mus musculus
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Symbol: Polr2l
Name: polymerase (RNA) II (DNA directed) polypeptide L
RGD ID: 1623217
Description: Predicted to contribute to DNA-directed 5'-3' RNA polymerase activity. Predicted to be involved in tRNA transcription by RNA polymerase III; transcription by RNA polymerase I; and transcription by RNA polymerase II. Predicted to localize to RNA polymerase I complex; RNA polymerase II, core complex; and RNA polymerase III complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and respiratory system. Orthologous to human POLR2L (RNA polymerase II, I and III subunit L); PARTICIPATES IN RNA polymerase I transcription pathway; RNA polymerase II transcription pathway; RNA polymerase III transcription pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2510029B14Rik; DNA-directed RNA polymerase III subunit L; DNA-directed RNA polymerases I, II, and III subunit RPABC5; RNA polymerases I, II, and III subunit ABC5; RPB10 homolog
Orthologs:
Homo sapiens (human) : POLR2L (RNA polymerase II, I and III subunit L)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Polr2l (RNA polymerase II, I and III subunit L)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Polr2l (RNA polymerase II, I and III subunit L)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC112440089 (RNA polymerase II, I and III subunit L)
Canis lupus familiaris (dog) : POLR2L (RNA polymerase II, I and III subunit L)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Polr2l (RNA polymerase II, I and III subunit L)
Sus scrofa (pig) : LOC102164011 (DNA-directed RNA polymerases I, II, and III subunit RPABC5-like)
Chlorocebus sabaeus (African green monkey) : POLR2L (RNA polymerase II, I and III subunit L)
Heterocephalus glaber (naked mole-rat) : Polr2l (RNA polymerase II, I and III subunit L)
more info ...
Related Pseudogenes: Gm10774   Gm13015  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397141,051,773 - 141,055,066 (-)NCBI
GRCm387141,471,860 - 141,475,153 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,471,860 - 141,475,132 (-)EnsemblGRCm38mm10GRCm38
MGSCv377148,657,759 - 148,661,052 (-)NCBIGRCm37mm9NCBIm37
MGSCv367141,323,179 - 141,326,505 (-)NCBImm8
Celera7141,265,651 - 141,268,944 (-)NCBICelera
Cytogenetic Map7F5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:14681479   PMID:16141072   PMID:16141073   PMID:18799693  
PMID:21267068   PMID:21677750   PMID:21873635  


Genomics

Comparative Map Data
Polr2l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397141,051,773 - 141,055,066 (-)NCBI
GRCm387141,471,860 - 141,475,153 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,471,860 - 141,475,132 (-)EnsemblGRCm38mm10GRCm38
MGSCv377148,657,759 - 148,661,052 (-)NCBIGRCm37mm9NCBIm37
MGSCv367141,323,179 - 141,326,505 (-)NCBImm8
Celera7141,265,651 - 141,268,944 (-)NCBICelera
Cytogenetic Map7F5NCBI
POLR2L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11837,356 - 842,529 (-)EnsemblGRCh38hg38GRCh38
GRCh3811839,721 - 842,529 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711839,721 - 842,529 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611829,721 - 832,529 (-)NCBINCBI36hg18NCBI36
Build 3411829,721 - 832,529NCBI
Celera11906,402 - 909,212 (-)NCBI
Cytogenetic Map11p15.5NCBI
HuRef11655,066 - 657,876 (-)NCBIHuRef
CHM1_111838,762 - 841,571 (-)NCBICHM1_1
Polr2l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01214,451,966 - 214,453,974 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01220,932,289 - 220,934,297 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,659,267 - 201,661,275 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1194,203,547 - 194,205,555 (-)NCBICelera
Cytogenetic Map1q41NCBI
Polr2l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,291,215 - 11,293,536 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547611,291,215 - 11,293,536 (+)NCBIChiLan1.0ChiLan1.0
LOC112440089
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1631,751,398 - 31,752,309 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0630,886,703 - 30,887,284 (+)NCBIMhudiblu_PPA_v0panPan3
POLR2L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11845,201,194 - 45,203,825 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Polr2l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936544652,968 - 653,683 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC102164011
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11109,821,516 - 109,823,848 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21121,251,546 - 121,253,428 (+)NCBISscrofa10.2Sscrofa10.2susScr3
POLR2L
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1646,748 - 649,029 (-)Ensembl
ChlSab1.11646,747 - 649,196 (-)NCBI
Polr2l
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476621,678,994 - 21,680,977 (+)NCBI

Position Markers
35.MMHAP17FRD11.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387141,476,085 - 141,476,235UniSTSGRCm38
MGSCv377148,661,984 - 148,662,134UniSTSGRCm37
Celera7141,269,876 - 141,270,026UniSTS
Cytogenetic Map7F5UniSTS
Whitehead_YAC2 UniSTS
D19252  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
Whitehead_YAC2 UniSTS
D9Mit34.1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F1UniSTS
Cytogenetic Map13D1UniSTS
Cytogenetic Map1C3UniSTS
Cytogenetic Map2C1.3UniSTS
Cytogenetic Map19D1UniSTS
Cytogenetic Map9F1UniSTS
Cytogenetic Map1FUniSTS
Cytogenetic Map7D3UniSTS
Cytogenetic Map11E2UniSTS
Cytogenetic Map3F2UniSTS
Cytogenetic Map14C3UniSTS
Cytogenetic Map9A3UniSTS
Cytogenetic Map2H2UniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map2H4UniSTS
Cytogenetic Map8B3.3UniSTS
Cytogenetic Map4D1UniSTS
Cytogenetic Map4E2UniSTS
Cytogenetic Map2E5UniSTS
Cytogenetic Map11B4UniSTS
Cytogenetic Map5G3UniSTS
Cytogenetic MapXA5UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map6F2UniSTS
Cytogenetic Map1C1.3UniSTS
Cytogenetic Map16B1UniSTS
Cytogenetic Map12C1UniSTS
Cytogenetic Map7E2UniSTS
Cytogenetic Map9F2UniSTS
Cytogenetic Map5FUniSTS
Cytogenetic Map2H1UniSTS
Cytogenetic Map2E2UniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map15E1UniSTS
Cytogenetic Map3G2UniSTS
Cytogenetic Map6F3UniSTS
Cytogenetic Map13B3UniSTS
Cytogenetic Map12F1UniSTS
Cytogenetic Map1E4UniSTS
Cytogenetic Map1E3UniSTS
Cytogenetic Map5E1UniSTS
Cytogenetic Map7F3UniSTS
Cytogenetic Map16B3UniSTS
Cytogenetic Map14D2UniSTS
Cytogenetic Map19C2UniSTS
Cytogenetic Map19D3UniSTS
Cytogenetic Map1H5UniSTS
Cytogenetic Map1DUniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map11CUniSTS
Cytogenetic Map10B4UniSTS
Cytogenetic Map6G3UniSTS
Cytogenetic Map7A1UniSTS
Cytogenetic Map7A3UniSTS
Cytogenetic Map8E1UniSTS
Cytogenetic Map8A2UniSTS
Cytogenetic Map4D3UniSTS
Cytogenetic Map2BUniSTS
Cytogenetic Map5A3UniSTS
Cytogenetic Map9DUniSTS
Cytogenetic Map5C1UniSTS
Cytogenetic Map19C3UniSTS
Cytogenetic Map13A2-A3UniSTS
Cytogenetic Map4C6UniSTS
Cytogenetic Map17DUniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map13A1UniSTS
Cytogenetic Map3F2.1UniSTS
Cytogenetic Map15D3UniSTS
Cytogenetic Map8D2UniSTS
Cytogenetic Map12A3UniSTS
Cytogenetic Map1H2.1UniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map7CUniSTS
Cytogenetic Map2E1UniSTS
Cytogenetic Map11B2UniSTS
Cytogenetic Map16A3UniSTS
Cytogenetic Map5C3.3UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic Map5G1UniSTS
Cytogenetic Map6A2UniSTS
Cytogenetic Map7B1UniSTS
Cytogenetic Map3F2.2UniSTS
Cytogenetic Map5C3.1UniSTS
Cytogenetic Map2C3UniSTS
Cytogenetic Map17A3.2-A3.3UniSTS
Cytogenetic Map6E3UniSTS
Cytogenetic Map11B1.1UniSTS
Cytogenetic Map1H6UniSTS
Cytogenetic Map2C2UniSTS
Cytogenetic Map19CUniSTS
Cytogenetic Map17E1.3UniSTS
Cytogenetic Map5A1UniSTS
Cytogenetic Map11B5UniSTS
Cytogenetic Map9A5.2UniSTS
Cytogenetic Map1A1UniSTS
Cytogenetic Map13A5UniSTS
Cytogenetic MapXA1.1UniSTS
Cytogenetic Map4D2.3UniSTS
Cytogenetic Map4B3UniSTS
Cytogenetic Map3A3UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map8CUniSTS
Cytogenetic Map12EUniSTS
Cytogenetic Map10C2UniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map5B1UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map2H3UniSTS
Cytogenetic Map2A1UniSTS
Cytogenetic Map1H1UniSTS
Cytogenetic Map15F3UniSTS
Cytogenetic Map9E1UniSTS
Cytogenetic Map9CUniSTS
Cytogenetic Map1A2UniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map19AUniSTS
Cytogenetic Map5B2UniSTS
Cytogenetic Map3DUniSTS
Cytogenetic Map11B1.3UniSTS
Cytogenetic Map6B1UniSTS
Cytogenetic MapXC-DUniSTS
Cytogenetic Map5G1.3UniSTS
Cytogenetic Map7D1-E2UniSTS
Cytogenetic Map11A1UniSTS
Cytogenetic Map13B1UniSTS
Cytogenetic Map1H2.2UniSTS
Cytogenetic Map8C3UniSTS
Cytogenetic Map11DUniSTS
Cytogenetic MapXA7.3UniSTS
Cytogenetic Map16C1.1UniSTS
Cytogenetic Map15F2UniSTS
Cytogenetic Map9A2UniSTS
Cytogenetic Map1H4-H6UniSTS
Cytogenetic Map12D2UniSTS
Cytogenetic Map1G3UniSTS
Cytogenetic Map5E5UniSTS
Cytogenetic Map1H3UniSTS
Cytogenetic Map19BUniSTS
cM Map950.0UniSTS
Whitehead Genetic943.7UniSTS
Polr2l  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
cM Map786.83UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753600000143600000Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773500000143600000Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7110108163144108163Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7110108163144108163Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7110108163144108163Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7111365511145365612Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7111365511145365612Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111564398145441459Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111564398145441459Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111564398145441459Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112950524145441459Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7113321003145441459Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7117032360145441459Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7119094158144844577Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119530844145441459Mouse
13207594Nigsq1_mneuroglucopenia-induced glucagon secretion QTL 1 (mouse)7127436844145441459Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127757504145441459Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127844414145441459Mouse
14746988Manh63_mmandible shape 63 (mouse)7128181700145441459Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:524
Count of miRNA genes:378
Interacting mature miRNAs:429
Transcripts:ENSMUST00000043870
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000043870   ⟹   ENSMUSP00000043204
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7141,471,860 - 141,475,132 (-)Ensembl
RefSeq Acc Id: NM_025593   ⟹   NP_079869
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397141,051,773 - 141,055,066 (-)NCBI
GRCm387141,471,860 - 141,475,153 (-)ENTREZGENE
MGSCv377148,657,759 - 148,661,052 (-)RGD
Celera7141,265,651 - 141,268,944 (-)RGD
cM Map7 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_079869 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAB27338 (Get FASTA)   NCBI Sequence Viewer  
  BAE28747 (Get FASTA)   NCBI Sequence Viewer  
  BAE40122 (Get FASTA)   NCBI Sequence Viewer  
  EDL18107 (Get FASTA)   NCBI Sequence Viewer  
  P62876 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_079869   ⟸   NM_025593
- UniProtKB: P62876 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000043204   ⟸   ENSMUST00000043870

Promoters
RGD ID:8666145
Promoter ID:EPDNEW_M11103
Type:initiation region
Name:Polr2l_1
Description:Mus musculus polymerase II polypeptide L , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387141,475,132 - 141,475,192EPDNEW
RGD ID:6841799
Promoter ID:MM_KWN:53276
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_025593,   OTTMUST00000071730,   OTTMUST00000071732,   OTTMUST00000071733,   OTTMUST00000071734,   UC009KLO.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367148,660,131 - 148,662,867 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913741 AgrOrtholog
Ensembl Genes ENSMUSG00000038489 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000043204 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000043870 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro RNA_pol_su_RPB10 UniProtKB/Swiss-Prot
  RNA_pol_suN_Zn-BS UniProtKB/Swiss-Prot
  RNAP_N/Rpb10 UniProtKB/Swiss-Prot
KEGG Report mmu:66491 UniProtKB/Swiss-Prot
MGD MGI:1913741 ENTREZGENE
NCBI Gene 66491 ENTREZGENE
PANTHER PTHR23431 UniProtKB/Swiss-Prot
Pfam RNA_pol_N UniProtKB/Swiss-Prot
PhenoGen Polr2l PhenoGen
PIRSF RNA_pol_N/8_sub UniProtKB/Swiss-Prot
PROSITE RNA_POL_N_8KD UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46924 UniProtKB/Swiss-Prot
UniGene Mm.380115 ENTREZGENE
UniProt P62876 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P52436 UniProtKB/Swiss-Prot
  Q3UF14 UniProtKB/Swiss-Prot