POLR2J (RNA polymerase II subunit J) - Rat Genome Database

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Gene: POLR2J (RNA polymerase II subunit J) Homo sapiens
Analyze
Symbol: POLR2J
Name: RNA polymerase II subunit J
RGD ID: 1320957
HGNC Page HGNC:9197
Description: Enables LRR domain binding activity. Involved in transcription by RNA polymerase II. Located in nucleus. Part of RNA polymerase II, core complex.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: DNA-directed RNA polymerase II subunit J-1; DNA-directed RNA polymerase II subunit RPB11-a; hRPB14; MGC71910; POLR2J1; polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa; polymerase (RNA) II subunit J; RNA polymerase II 13.3 kDa subunit; RNA polymerase II subunit B11-a; RPB11; RPB11A; RPB11m
RGD Orthologs
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: POLR2J4  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387102,473,128 - 102,478,922 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7102,473,128 - 102,478,922 (-)EnsemblGRCh38hg38GRCh38
GRCh377102,113,575 - 102,119,369 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367101,900,552 - 101,906,386 (-)NCBINCBI36Build 36hg18NCBI36
Build 347101,707,623 - 101,713,077NCBI
Celera797,125,817 - 97,127,251 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef796,703,776 - 96,705,210 (-)NCBIHuRef
CHM1_17102,043,567 - 102,049,407 (-)NCBICHM1_1
T2T-CHM13v2.07103,790,727 - 103,796,555 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27101,473,848 - 101,479,682 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. TFIIB-related factors in RNA polymerase I transcription. Knutson BA and Hahn S, Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):265-73. doi: 10.1016/j.bbagrm.2012.08.003. Epub 2012 Aug 30.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1559613   PMID:1939271   PMID:2190099   PMID:2449431   PMID:7638159   PMID:7853496   PMID:8637904   PMID:8676484   PMID:8797801   PMID:8800208   PMID:8849451   PMID:8876177  
PMID:8910388   PMID:8934526   PMID:8946909   PMID:9054383   PMID:9121429   PMID:9184228   PMID:9201987   PMID:9311822   PMID:9315662   PMID:9334327   PMID:9405375   PMID:9409616  
PMID:9491887   PMID:9512541   PMID:9570510   PMID:9607318   PMID:9651670   PMID:9696809   PMID:9765201   PMID:9790902   PMID:9852112   PMID:9874563   PMID:10066804   PMID:10069959  
PMID:10329125   PMID:10359081   PMID:10364292   PMID:10373521   PMID:10393184   PMID:10438593   PMID:10536359   PMID:10545121   PMID:10617616   PMID:10698937   PMID:10704353   PMID:10725406  
PMID:10757782   PMID:10783144   PMID:10784442   PMID:10866664   PMID:10931842   PMID:10958691   PMID:11080476   PMID:11112772   PMID:11547919   PMID:11809800   PMID:12036295   PMID:12049628  
PMID:12052871   PMID:12089333   PMID:12114499   PMID:12126615   PMID:12207009   PMID:12221105   PMID:12226669   PMID:12379213   PMID:12477932   PMID:12634356   PMID:12642036   PMID:12676794  
PMID:12775419   PMID:12853948   PMID:12887902   PMID:14569024   PMID:15175163   PMID:15282305   PMID:15489334   PMID:15586814   PMID:16289656   PMID:16341674   PMID:16838299   PMID:16957778  
PMID:17168834   PMID:17643375   PMID:17661632   PMID:18218627   PMID:18562274   PMID:18854154   PMID:18991615   PMID:19237606   PMID:19240132   PMID:19526283   PMID:20133760   PMID:20227660  
PMID:20471948   PMID:21360054   PMID:21729782   PMID:21873635   PMID:21972559   PMID:21988832   PMID:22022972   PMID:22211660   PMID:22229121   PMID:22422068   PMID:22567366   PMID:22990118  
PMID:23028129   PMID:23087374   PMID:23274668   PMID:23827503   PMID:24217245   PMID:24330569   PMID:24359561   PMID:24981860   PMID:25416956   PMID:25544563   PMID:25648896   PMID:26186194  
PMID:26344197   PMID:26496610   PMID:27609421   PMID:28514442   PMID:28515276   PMID:31048545   PMID:31091453   PMID:32296183   PMID:32460013   PMID:33961781   PMID:34108663   PMID:34244565  
PMID:34373451   PMID:35013218   PMID:35271311   PMID:35563538   PMID:35944360   PMID:37682711  


Genomics

Comparative Map Data
POLR2J
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387102,473,128 - 102,478,922 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7102,473,128 - 102,478,922 (-)EnsemblGRCh38hg38GRCh38
GRCh377102,113,575 - 102,119,369 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367101,900,552 - 101,906,386 (-)NCBINCBI36Build 36hg18NCBI36
Build 347101,707,623 - 101,713,077NCBI
Celera797,125,817 - 97,127,251 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef796,703,776 - 96,705,210 (-)NCBIHuRef
CHM1_17102,043,567 - 102,049,407 (-)NCBICHM1_1
T2T-CHM13v2.07103,790,727 - 103,796,555 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27101,473,848 - 101,479,682 (-)NCBI
Polr2j
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395136,145,545 - 136,151,801 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5136,145,485 - 136,151,801 (+)EnsemblGRCm39 Ensembl
GRCm385136,116,691 - 136,122,947 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5136,116,631 - 136,122,947 (+)EnsemblGRCm38mm10GRCm38
MGSCv375136,592,561 - 136,598,817 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365136,401,364 - 136,407,566 (+)NCBIMGSCv36mm8
Celera5133,137,045 - 133,143,301 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map575.8NCBI
Polr2j
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81226,179,649 - 26,185,201 (-)NCBIGRCr8
mRatBN7.21220,543,038 - 20,548,590 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1220,543,038 - 20,548,594 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1221,683,016 - 21,688,571 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,295,721 - 22,301,276 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01221,361,193 - 21,366,748 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01223,587,222 - 23,592,774 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1223,587,222 - 23,592,774 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,587,572 - 25,593,124 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41221,658,406 - 21,663,958 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11221,649,381 - 21,654,560 (-)NCBI
Celera1222,311,433 - 22,316,972 (-)NCBICelera
Cytogenetic Map12q12NCBI
Polr2j
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545615,146,713 - 15,151,311 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545615,146,713 - 15,151,320 (+)NCBIChiLan1.0ChiLan1.0
POLR2J
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.167,707,426 - 7,710,882 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha69,402,443 - 9,405,898 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.067,527,599 - 7,531,054 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl67,527,645 - 7,531,266 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.167,496,109 - 7,499,564 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.067,459,175 - 7,462,631 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.067,622,887 - 7,626,343 (+)NCBIUU_Cfam_GSD_1.0
Polr2j
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344132,136,578 - 132,140,703 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365431,895,828 - 1,899,904 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365431,895,827 - 1,899,918 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLR2J
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl39,812,441 - 9,816,656 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.139,812,746 - 9,816,657 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.239,695,498 - 9,699,407 (+)NCBISscrofa10.2Sscrofa10.2susScr3
POLR2J
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12810,742,636 - 10,748,084 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2810,742,570 - 10,749,382 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660705,660,475 - 5,666,066 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Polr2j
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474015,169,459 - 15,173,805 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474015,169,414 - 15,174,212 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in POLR2J
7 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7q22.1-31.1(chr7:101807149-112414850)x1 copy number loss See cases [RCV000050924] Chr7:101807149..112414850 [GRCh38]
Chr7:101450429..112054905 [GRCh37]
Chr7:101237149..111842141 [NCBI36]
Chr7:7q22.1-31.1		 pathogenic
GRCh38/hg38 7q22.1-22.3(chr7:101525795-105432462)x3 copy number gain See cases [RCV000050705] Chr7:101525795..105432462 [GRCh38]
Chr7:101169076..105072909 [GRCh37]
Chr7:100955796..104860145 [NCBI36]
Chr7:7q22.1-22.3		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q22.1(chr7:100419914-102482826)x1 copy number loss See cases [RCV000054155] Chr7:100419914..102482826 [GRCh38]
Chr7:100017537..102123273 [GRCh37]
Chr7:99855473..101910278 [NCBI36]
Chr7:7q22.1		 pathogenic
GRCh38/hg38 7q22.1-22.3(chr7:101700341-105162893)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054156]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054156]|See cases [RCV000054156] Chr7:101700341..105162893 [GRCh38]
Chr7:101343621..104803340 [GRCh37]
Chr7:101130341..104590576 [NCBI36]
Chr7:7q22.1-22.3		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3		 pathogenic
GRCh38/hg38 7q22.1-31.31(chr7:102196924-121278641)x1 copy number loss See cases [RCV000137522] Chr7:102196924..121278641 [GRCh38]
Chr7:101912320..120918695 [GRCh37]
Chr7:101626924..120705931 [NCBI36]
Chr7:7q22.1-31.31		 pathogenic
GRCh38/hg38 7q22.1(chr7:99932610-102473188)x3 copy number gain See cases [RCV000138109] Chr7:99932610..102473188 [GRCh38]
Chr7:99530233..102113635 [GRCh37]
Chr7:99368169..101900640 [NCBI36]
Chr7:7q22.1		 uncertain significance
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34		 pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98969247-159119707)x3 copy number gain See cases [RCV000447709] Chr7:98969247..159119707 [GRCh37]
Chr7:7q22.1-36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98693388-159119707)x3 copy number gain not provided [RCV000682911] Chr7:98693388..159119707 [GRCh37]
Chr7:7q22.1-36.3		 pathogenic
GRCh37/hg19 7q22.1(chr7:98847725-102472176)x1 copy number loss not provided [RCV000682904] Chr7:98847725..102472176 [GRCh37]
Chr7:7q22.1		 pathogenic
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Childhood apraxia of speech [RCV000234948] Chr7:21001537..114528369 [GRCh37]
Chr7:7p15.3-q31.1		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q22.1(chr7:99593346-102470275)x1 copy number loss See cases [RCV001195072] Chr7:99593346..102470275 [GRCh37]
Chr7:7q22.1		 likely pathogenic
Single allele complex Ring chromosome 7 [RCV002280646] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q22.1-31.31(chr7:100676872-119156160) copy number loss not specified [RCV002053712] Chr7:100676872..119156160 [GRCh37]
Chr7:7q22.1-31.31		 pathogenic
GRCh37/hg19 7q22.1(chr7:101729998-102114340)x3 copy number gain not provided [RCV001827739] Chr7:101729998..102114340 [GRCh37]
Chr7:7q22.1		 uncertain significance
GRCh37/hg19 7q22.1-31.1(chr7:99417471-111586308) copy number loss not specified [RCV002053711] Chr7:99417471..111586308 [GRCh37]
Chr7:7q22.1-31.1		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:56604613-96692931)x1 copy number loss See cases [RCV002287832] Chr7:56604613..96692931 [GRCh37]
Chr7:7p22.3-q36.3		 uncertain significance
GRCh37/hg19 7q22.1(chr7:102101275-102406667)x1 copy number loss not provided [RCV002474667] Chr7:102101275..102406667 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_006234.6(POLR2J):c.50A>G (p.Lys17Arg) single nucleotide variant not specified [RCV004180701] Chr7:102478811 [GRCh38]
Chr7:102119258 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_006234.6(POLR2J):c.335A>G (p.Lys112Arg) single nucleotide variant not specified [RCV004273079] Chr7:102473668 [GRCh38]
Chr7:102114115 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_006234.6(POLR2J):c.93T>C (p.Cys31=) single nucleotide variant not provided [RCV003434066] Chr7:102476231 [GRCh38]
Chr7:102116678 [GRCh37]
Chr7:7q22.1		 likely benign
NM_006234.6(POLR2J):c.269C>T (p.Ala90Val) single nucleotide variant not specified [RCV004514403] Chr7:102474410 [GRCh38]
Chr7:102114857 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_006234.6(POLR2J):c.87T>G (p.Asn29Lys) single nucleotide variant not specified [RCV004514404] Chr7:102476237 [GRCh38]
Chr7:102116684 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_006234.6(POLR2J):c.347T>C (p.Ile116Thr) single nucleotide variant not specified [RCV004664667] Chr7:102473656 [GRCh38]
Chr7:102114103 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_006234.6(POLR2J):c.236C>T (p.Pro79Leu) single nucleotide variant not specified [RCV004653933] Chr7:102474443 [GRCh38]
Chr7:102114890 [GRCh37]
Chr7:7q22.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:763
Count of miRNA genes:441
Interacting mature miRNAs:485
Transcripts:ENST00000292614, ENST00000393794
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407018962GWAS667938_Hchronotype measurement QTL GWAS667938 (human)3e-13chronotype measurement7102473643102473644Human
407189884GWAS838860_Hmean corpuscular volume QTL GWAS838860 (human)1e-08mean corpuscular volumemean corpuscular volume (CMO:0000038)7102474972102474973Human

Markers in Region
STS-H73947  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377102,113,650 - 102,113,840UniSTSGRCh37
Build 367101,900,655 - 101,900,845RGDNCBI36
Celera797,125,919 - 97,126,109RGD
Cytogenetic Map7q22.1UniSTS
HuRef796,703,878 - 96,704,068UniSTS
CRA_TCAGchr7v27101,473,951 - 101,474,141UniSTS
GeneMap99-GB4 RH Map7521.67UniSTS
STS-L37127  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377102,113,940 - 102,114,105UniSTSGRCh37
Build 367101,900,945 - 101,901,110RGDNCBI36
Celera797,126,209 - 97,126,374RGD
Cytogenetic Map7q22.1UniSTS
HuRef796,704,168 - 96,704,333UniSTS
CRA_TCAGchr7v27101,474,241 - 101,474,406UniSTS
GeneMap99-GB4 RH Map7523.19UniSTS
GDB:4585697  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map7p13UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4974 1726 2351 6 624 1951 465 2270 7306 6472 53 3734 1 852 1744 1617 175 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001371100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001393919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_163857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005250452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017012353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054358467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC093668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC244503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ277928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ277929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ277930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ277932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC040116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC065711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC139902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC141830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM545237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM791979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L37127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X82385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X98433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000292614   ⟹   ENSP00000292614
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7102,473,128 - 102,478,922 (-)Ensembl
Ensembl Acc Id: ENST00000393794   ⟹   ENSP00000377383
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7102,473,938 - 102,478,906 (-)Ensembl
RefSeq Acc Id: NM_001371100   ⟹   NP_001358029
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387102,473,128 - 102,478,922 (-)NCBI
T2T-CHM13v2.07103,790,727 - 103,796,531 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001393919   ⟹   NP_001380848
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387102,473,128 - 102,478,922 (-)NCBI
T2T-CHM13v2.07103,790,727 - 103,796,531 (-)NCBI
Sequence:
RefSeq Acc Id: NM_006234   ⟹   NP_006225
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387102,473,128 - 102,478,922 (-)NCBI
GRCh377102,113,547 - 102,119,446 (-)NCBI
Build 367101,900,552 - 101,906,386 (-)NCBI Archive
HuRef796,703,776 - 96,705,210 (-)ENTREZGENE
CHM1_17102,043,567 - 102,049,407 (-)NCBI
T2T-CHM13v2.07103,790,727 - 103,796,531 (-)NCBI
CRA_TCAGchr7v27101,473,848 - 101,479,682 (-)ENTREZGENE
Sequence:
RefSeq Acc Id: NR_163857
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387102,473,128 - 102,478,922 (-)NCBI
T2T-CHM13v2.07103,790,727 - 103,796,531 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017012353   ⟹   XP_016867842
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387102,473,128 - 102,478,922 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054358467   ⟹   XP_054214442
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.07103,790,727 - 103,796,555 (-)NCBI
RefSeq Acc Id: NP_006225   ⟸   NM_006234
- Peptide Label: isoform 1
- UniProtKB: A5D6V8 (UniProtKB/Swiss-Prot),   O43375 (UniProtKB/Swiss-Prot),   P52435 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016867842   ⟸   XM_017012353
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001358029   ⟸   NM_001371100
- Peptide Label: isoform 2
Ensembl Acc Id: ENSP00000292614   ⟸   ENST00000292614
Ensembl Acc Id: ENSP00000377383   ⟸   ENST00000393794
RefSeq Acc Id: NP_001380848   ⟸   NM_001393919
- Peptide Label: isoform 3
- UniProtKB: E2QRJ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054214442   ⟸   XM_054358467
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P52435-F1-model_v2 AlphaFold P52435 1-117 view protein structure

Promoters
RGD ID:7211493
Promoter ID:EPDNEW_H11492
Type:initiation region
Name:POLR2J_1
Description:RNA polymerase II subunit J
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh387102,478,922 - 102,478,982EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9197 AgrOrtholog
COSMIC POLR2J COSMIC
Ensembl Genes ENSG00000005075 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000292614 ENTREZGENE
  ENST00000292614.10 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1360.10 UniProtKB/Swiss-Prot
GTEx ENSG00000005075 GTEx
HGNC ID HGNC:9197 ENTREZGENE
Human Proteome Map POLR2J Human Proteome Map
InterPro RBP11 UniProtKB/Swiss-Prot
  RBP11-like UniProtKB/Swiss-Prot
  RBP11-like_dimer UniProtKB/Swiss-Prot
  RNA_pol_Rpb11_13-16kDa_CS UniProtKB/Swiss-Prot
  Rpo11-like UniProtKB/Swiss-Prot
KEGG Report hsa:5439 UniProtKB/Swiss-Prot
NCBI Gene 5439 ENTREZGENE
OMIM 604150 OMIM
PANTHER DNA-DIRECTED RNA POLYMERASE I,II,III UniProtKB/Swiss-Prot
  DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11 UniProtKB/Swiss-Prot
Pfam RNA_pol_L_2 UniProtKB/Swiss-Prot
PharmGKB PA33517 PharmGKB
PROSITE RNA_POL_L_13KD UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55257 UniProtKB/Swiss-Prot
UniProt A5D6V8 ENTREZGENE
  E2QRJ6 ENTREZGENE
  O43375 ENTREZGENE
  P52435 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A5D6V8 UniProtKB/Swiss-Prot
  O43375 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-19 POLR2J  RNA polymerase II subunit J  POLR2J  polymerase (RNA) II subunit J  Symbol and/or name change 5135510 APPROVED
2016-03-07 POLR2J  polymerase (RNA) II subunit J  POLR2J  polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa  Symbol and/or name change 5135510 APPROVED