TAF12 (TATA-box binding protein associated factor 12) - Rat Genome Database

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Gene: TAF12 (TATA-box binding protein associated factor 12) Homo sapiens
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Symbol: TAF12
Name: TATA-box binding protein associated factor 12
RGD ID: 1348553
HGNC Page HGNC:11545
Description: Enables DNA binding activity; DNA-binding transcription factor binding activity; and transcription coactivator activity. Contributes to RNA polymerase II general transcription initiation factor activity. Involved in RNA polymerase II preinitiation complex assembly; mRNA transcription by RNA polymerase II; and positive regulation of transcription initiation by RNA polymerase II. Part of SAGA complex; transcription factor TFIID complex; and transcription factor TFTC complex.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa; TAF2J; TAFII-20/TAFII-15; TAFII20; TAFII20/TAFII15; TATA box binding protein (TBP)-associated factor, RNA polymerase II, J, 20kD; TATA box binding protein associated factor 12; transcription initiation factor TFIID 20/15 kDa subunits; transcription initiation factor TFIID subunit 12
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38128,602,850 - 28,648,269 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl128,587,829 - 28,648,291 (-)EnsemblGRCh38hg38GRCh38
GRCh37128,929,362 - 28,969,579 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36128,802,200 - 28,842,172 (-)NCBINCBI36Build 36hg18NCBI36
Build 34128,750,228 - 28,790,201NCBI
Celera127,325,365 - 27,365,501 (-)NCBICelera
Cytogenetic Map1p35.3NCBI
HuRef127,182,618 - 27,222,688 (-)NCBIHuRef
CHM1_1129,045,214 - 29,085,178 (-)NCBICHM1_1
T2T-CHM13v2.0128,444,812 - 28,490,693 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (TAS)
nucleus  (EXP,IDA,IEA,ISO,ISS)
SAGA complex  (IDA,IEA,NAS)
transcription factor TFIID complex  (IBA,IDA,IEA,IPI,ISS,TAS)
transcription factor TFTC complex  (IDA,NAS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. TFIIB-related factors in RNA polymerase I transcription. Knutson BA and Hahn S, Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):265-73. doi: 10.1016/j.bbagrm.2012.08.003. Epub 2012 Aug 30.
3. Structural bioinformatics of the general transcription factor TFIID. Malkowska M, etal., Biochimie. 2013 Apr;95(4):680-91. doi: 10.1016/j.biochi.2012.10.024. Epub 2012 Nov 9.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. RNA polymerase I activity is regulated at multiple steps in the transcription cycle: recent insights into factors that influence transcription elongation. Schneider DA Gene. 2012 Feb 10;493(2):176-84. doi: 10.1016/j.gene.2011.08.006. Epub 2011 Aug 26.
6. ATAC-king the complexity of SAGA during evolution. Spedale G, etal., Genes Dev. 2012 Mar 15;26(6):527-41. doi: 10.1101/gad.184705.111.
Additional References at PubMed
PMID:1939271   PMID:2449431   PMID:7667268   PMID:7729427   PMID:7835343   PMID:7836461   PMID:7933101   PMID:8121496   PMID:8598932   PMID:8647459   PMID:8663456   PMID:8680883  
PMID:8764009   PMID:8764062   PMID:8849451   PMID:8889548   PMID:8946909   PMID:9045704   PMID:9054383   PMID:9133630   PMID:9311784   PMID:9405375   PMID:9603525   PMID:9674425  
PMID:9880483   PMID:9885574   PMID:10373431   PMID:10594036   PMID:11406595   PMID:11438666   PMID:11564863   PMID:11564872   PMID:11689552   PMID:12237304   PMID:12477932   PMID:12601814  
PMID:12660246   PMID:14580349   PMID:15053879   PMID:15489334   PMID:15601843   PMID:15637059   PMID:15735663   PMID:15932940   PMID:16494529   PMID:16710414   PMID:17158164   PMID:17264123  
PMID:17268553   PMID:17694077   PMID:17884155   PMID:17967894   PMID:18029348   PMID:18206972   PMID:18838386   PMID:19114550   PMID:19240132   PMID:19322201   PMID:19635797   PMID:20850016  
PMID:21873635   PMID:22323595   PMID:23292512   PMID:23332750   PMID:23426901   PMID:24981860   PMID:25416956   PMID:25452129   PMID:25965574   PMID:26186194   PMID:26496610   PMID:26638075  
PMID:26673895   PMID:27007846   PMID:27551064   PMID:27601583   PMID:27703004   PMID:28514442   PMID:29111974   PMID:29316427   PMID:29509190   PMID:30415952   PMID:30804502   PMID:31753913  
PMID:32296183   PMID:32416067   PMID:33961781   PMID:35140242   PMID:35271311   PMID:35896951   PMID:35906200   PMID:35914814   PMID:35941108   PMID:35944360   PMID:36244648   PMID:36537216  
PMID:36912080   PMID:37682711   PMID:38113892   PMID:38297188  


Genomics

Comparative Map Data
TAF12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38128,602,850 - 28,648,269 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl128,587,829 - 28,648,291 (-)EnsemblGRCh38hg38GRCh38
GRCh37128,929,362 - 28,969,579 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36128,802,200 - 28,842,172 (-)NCBINCBI36Build 36hg18NCBI36
Build 34128,750,228 - 28,790,201NCBI
Celera127,325,365 - 27,365,501 (-)NCBICelera
Cytogenetic Map1p35.3NCBI
HuRef127,182,618 - 27,222,688 (-)NCBIHuRef
CHM1_1129,045,214 - 29,085,178 (-)NCBICHM1_1
T2T-CHM13v2.0128,444,812 - 28,490,693 (-)NCBIT2T-CHM13v2.0
Taf12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394132,001,667 - 132,020,640 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4132,001,686 - 132,023,077 (+)EnsemblGRCm39 Ensembl
GRCm384132,274,355 - 132,293,329 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4132,274,375 - 132,295,766 (+)EnsemblGRCm38mm10GRCm38
MGSCv374131,830,290 - 131,849,244 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364131,546,489 - 131,565,403 (+)NCBIMGSCv36mm8
Celera4130,435,455 - 130,454,533 (+)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map465.09NCBI
Taf12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85149,756,826 - 149,772,886 (+)NCBIGRCr8
mRatBN7.25144,472,816 - 144,490,299 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5144,472,841 - 144,488,849 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5147,172,810 - 147,188,198 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05148,942,655 - 148,958,096 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05148,931,015 - 148,945,727 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05150,459,701 - 150,476,521 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5150,459,713 - 150,475,186 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05154,126,851 - 154,143,964 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera5142,905,400 - 142,920,328 (+)NCBICelera
Cytogenetic Map5q36NCBI
TAF12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21198,199,107 - 198,239,106 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11197,318,260 - 197,358,257 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,874,675 - 27,914,672 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1128,907,540 - 28,948,322 (-)NCBIpanpan1.1PanPan1.1panPan2
TAF12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1271,865,274 - 71,898,236 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl271,865,289 - 71,898,236 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha268,442,106 - 68,475,051 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,424,252 - 72,457,215 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,424,264 - 72,457,215 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,252,893 - 69,285,838 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0270,260,614 - 70,293,571 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0271,258,668 - 71,291,609 (+)NCBIUU_Cfam_GSD_1.0
Taf12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505846,870,722 - 46,894,620 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647412,693,018 - 12,720,136 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647412,695,508 - 12,719,384 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAF12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl685,618,691 - 85,643,075 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1685,618,679 - 85,643,087 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2679,432,412 - 79,441,136 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TAF12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120104,164,912 - 104,199,925 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20104,164,907 - 104,200,272 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603312,313,419 - 12,350,679 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Taf12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476412,396,938 - 12,445,681 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476412,401,152 - 12,444,978 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TAF12
13 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p36.11-35.2(chr1:26963045-32279045)x3 copy number gain See cases [RCV000051801] Chr1:26963045..32279045 [GRCh38]
Chr1:27289536..32744646 [GRCh37]
Chr1:27162123..32517233 [NCBI36]
Chr1:1p36.11-35.2		 pathogenic
GRCh38/hg38 1p35.3-35.1(chr1:28424867-33122854)x1 copy number loss See cases [RCV000135447] Chr1:28424867..33122854 [GRCh38]
Chr1:28751378..33588455 [GRCh37]
Chr1:28623965..33361042 [NCBI36]
Chr1:1p35.3-35.1		 pathogenic
GRCh38/hg38 1p35.3(chr1:28298657-28634562)x1 copy number loss See cases [RCV000137656] Chr1:28298657..28634562 [GRCh38]
Chr1:28625168..28961074 [GRCh37]
Chr1:28497755..28833661 [NCBI36]
Chr1:1p35.3		 uncertain significance
GRCh38/hg38 1p35.3(chr1:27919199-28607226)x3 copy number gain See cases [RCV000137584] Chr1:27919199..28607226 [GRCh38]
Chr1:28245710..28933738 [GRCh37]
Chr1:28118297..28806325 [NCBI36]
Chr1:1p35.3		 uncertain significance
GRCh38/hg38 1p36.11-34.2(chr1:24381206-41401517)x3 copy number gain See cases [RCV000138891] Chr1:24381206..41401517 [GRCh38]
Chr1:24707696..41886350 [GRCh37]
Chr1:24580283..41658937 [NCBI36]
Chr1:1p36.11-34.2		 pathogenic
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12		 likely benign
GRCh37/hg19 1p35.3(chr1:28292253-28969539)x3 copy number gain See cases [RCV000240431] Chr1:28292253..28969539 [GRCh37]
Chr1:1p35.3		 uncertain significance
GRCh37/hg19 1p35.3(chr1:28891341-28969495)x3 copy number gain See cases [RCV000447346] Chr1:28891341..28969495 [GRCh37]
Chr1:1p35.3		 likely benign
GRCh37/hg19 1p35.3(chr1:28891341-28939710)x3 copy number gain See cases [RCV000446159] Chr1:28891341..28939710 [GRCh37]
Chr1:1p35.3		 likely benign
GRCh37/hg19 1p35.3(chr1:28666901-28929761)x3 copy number gain See cases [RCV000448758] Chr1:28666901..28929761 [GRCh37]
Chr1:1p35.3		 uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1		 uncertain significance
GRCh37/hg19 1p36.11-35.1(chr1:27543877-32819121) copy number gain not specified [RCV002052559] Chr1:27543877..32819121 [GRCh37]
Chr1:1p36.11-35.1		 uncertain significance
GRCh37/hg19 1p35.3(chr1:28493687-29242679)x1 copy number loss not provided [RCV001836514] Chr1:28493687..29242679 [GRCh37]
Chr1:1p35.3		 uncertain significance
NM_005644.4(TAF12):c.113T>C (p.Val38Ala) single nucleotide variant not specified [RCV004104354] Chr1:28621969 [GRCh38]
Chr1:28948481 [GRCh37]
Chr1:1p35.3		 uncertain significance
NM_005644.4(TAF12):c.101G>A (p.Ser34Asn) single nucleotide variant not specified [RCV004174428] Chr1:28621981 [GRCh38]
Chr1:28948493 [GRCh37]
Chr1:1p35.3		 uncertain significance
NM_005644.4(TAF12):c.467G>A (p.Arg156Gln) single nucleotide variant not specified [RCV004123454] Chr1:28603558 [GRCh38]
Chr1:28930070 [GRCh37]
Chr1:1p35.3		 uncertain significance
NM_005644.4(TAF12):c.433A>G (p.Thr145Ala) single nucleotide variant not specified [RCV004086392] Chr1:28605389 [GRCh38]
Chr1:28931901 [GRCh37]
Chr1:1p35.3		 uncertain significance
GRCh38/hg38 1p36.33-35.1(chr1:99125-34026935)x3 copy number gain Trisomy 12p [RCV003447845] Chr1:99125..34026935 [GRCh38]
Chr1:1p36.33-35.1		 pathogenic
NM_005644.4(TAF12):c.119T>C (p.Ile40Thr) single nucleotide variant not specified [RCV004466304] Chr1:28621963 [GRCh38]
Chr1:28948475 [GRCh37]
Chr1:1p35.3		 uncertain significance
NM_005644.4(TAF12):c.146G>A (p.Arg49His) single nucleotide variant not specified [RCV004466305] Chr1:28621936 [GRCh38]
Chr1:28948448 [GRCh37]
Chr1:1p35.3		 uncertain significance
NM_005644.4(TAF12):c.68C>G (p.Ala23Gly) single nucleotide variant not specified [RCV004466307] Chr1:28622014 [GRCh38]
Chr1:28948526 [GRCh37]
Chr1:1p35.3		 uncertain significance
NM_005644.4(TAF12):c.410G>A (p.Arg137Gln) single nucleotide variant not specified [RCV004466306] Chr1:28605412 [GRCh38]
Chr1:28931924 [GRCh37]
Chr1:1p35.3		 uncertain significance
NM_005644.4(TAF12):c.406A>G (p.Ile136Val) single nucleotide variant not specified [RCV004681901] Chr1:28605416 [GRCh38]
Chr1:28931928 [GRCh37]
Chr1:1p35.3		 uncertain significance
NM_005644.4(TAF12):c.398C>G (p.Ser133Cys) single nucleotide variant not specified [RCV004671087] Chr1:28605424 [GRCh38]
Chr1:28931936 [GRCh37]
Chr1:1p35.3		 uncertain significance
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR26Bhsa-miR-26b-5pMirecordsexternal_info{changed}NA20831567

Predicted Target Of
Summary Value
Count of predictions:835
Count of miRNA genes:514
Interacting mature miRNAs:554
Transcripts:ENST00000263974, ENST00000373824, ENST00000471683, ENST00000495422
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576329MYI9_HMyocardial infarction susceptibility QTL 9 (human)12Myocardial infarction susceptibilityearly-onset1758550333585503Human
597319515GWAS1415589_Hsmoking initiation QTL GWAS1415589 (human)3e-10smoking initiation12863055928630560Human
597355534GWAS1451608_Hbody height QTL GWAS1451608 (human)2e-13body height (VT:0001253)body height (CMO:0000106)12863612128636122Human
597456984GWAS1553058_Hbody height QTL GWAS1553058 (human)2e-08body height (VT:0001253)body height (CMO:0000106)12864520228645203Human
597110754GWAS1206828_Htype 2 diabetes mellitus QTL GWAS1206828 (human)0.000004type 2 diabetes mellitus12863295028632951Human
1576325MYI1_HMyocardial infarction susceptibility QTL 1 (human)11.681e-12Myocardial infarction susceptibilityearly-onset1758550333585503Human
1643380BW316_HBody weight QTL 316 (human)2.620.0002Body weightBMI1758550333585503Human

Markers in Region
SHGC-30964  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37128,929,663 - 28,929,787UniSTSGRCh37
Build 36128,802,250 - 28,802,374RGDNCBI36
Celera127,325,420 - 27,325,544RGD
Cytogenetic Map1p35.3UniSTS
HuRef127,182,673 - 27,182,797UniSTS
TNG Radiation Hybrid Map113365.0UniSTS
GeneMap99-GB4 RH Map190.53UniSTS
Whitehead-RH Map192.3UniSTS
NCBI RH Map1142.5UniSTS
RH67949  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37128,929,760 - 28,929,994UniSTSGRCh37
GRCh37114,992,510 - 14,992,744UniSTSGRCh37
Build 36114,865,097 - 14,865,331RGDNCBI36
Celera113,475,466 - 13,475,700RGD
Celera127,325,517 - 27,325,751UniSTS
Cytogenetic Map1p35.3UniSTS
Cytogenetic Map1p36.21UniSTS
HuRef127,182,770 - 27,183,004UniSTS
HuRef113,512,315 - 13,512,549UniSTS
GeneMap99-GB4 RH Map171.55UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4974 1726 2351 6 624 1951 465 2270 7306 6472 53 3734 1 852 1744 1617 175 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001135218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001410769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017002186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024449368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054338493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK310097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL360012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL513497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY206865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE787487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM676557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX095156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX865268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D50544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U57693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X84002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000263974   ⟹   ENSP00000263974
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl128,603,101 - 28,643,005 (-)Ensembl
Ensembl Acc Id: ENST00000373824   ⟹   ENSP00000362930
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl128,602,850 - 28,643,067 (-)Ensembl
Ensembl Acc Id: ENST00000471683
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl128,589,323 - 28,643,115 (-)Ensembl
Ensembl Acc Id: ENST00000495422
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl128,602,850 - 28,643,085 (-)Ensembl
Ensembl Acc Id: ENST00000685312   ⟹   ENSP00000509153
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl128,603,096 - 28,648,291 (-)Ensembl
Ensembl Acc Id: ENST00000685589   ⟹   ENSP00000509854
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl128,587,829 - 28,643,104 (-)Ensembl
Ensembl Acc Id: ENST00000688108   ⟹   ENSP00000510282
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl128,587,861 - 28,643,104 (-)Ensembl
Ensembl Acc Id: ENST00000688425
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl128,603,227 - 28,615,605 (-)Ensembl
Ensembl Acc Id: ENST00000688548
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl128,617,987 - 28,622,233 (-)Ensembl
Ensembl Acc Id: ENST00000689843   ⟹   ENSP00000509370
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl128,603,096 - 28,643,007 (-)Ensembl
Ensembl Acc Id: ENST00000690492   ⟹   ENSP00000510456
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl128,604,027 - 28,643,081 (-)Ensembl
Ensembl Acc Id: ENST00000690860   ⟹   ENSP00000509244
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl128,603,096 - 28,643,085 (-)Ensembl
Ensembl Acc Id: ENST00000691050   ⟹   ENSP00000508898
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl128,603,096 - 28,643,015 (-)Ensembl
Ensembl Acc Id: ENST00000691563   ⟹   ENSP00000508797
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl128,588,495 - 28,643,019 (-)Ensembl
Ensembl Acc Id: ENST00000692098   ⟹   ENSP00000509051
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl128,588,120 - 28,643,085 (-)Ensembl
Ensembl Acc Id: ENST00000693642   ⟹   ENSP00000509910
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl128,587,837 - 28,643,085 (-)Ensembl
Ensembl Acc Id: ENST00000693729   ⟹   ENSP00000509875
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl128,603,366 - 28,643,063 (-)Ensembl
RefSeq Acc Id: NM_001135218   ⟹   NP_001128690
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38128,602,850 - 28,643,067 (-)NCBI
GRCh37128,929,608 - 28,975,416 (-)NCBI
HuRef127,182,618 - 27,222,688 (-)ENTREZGENE
CHM1_1129,045,214 - 29,085,178 (-)NCBI
T2T-CHM13v2.0128,444,812 - 28,485,032 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001410769   ⟹   NP_001397698
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38128,603,096 - 28,643,067 (-)NCBI
T2T-CHM13v2.0128,445,058 - 28,485,032 (-)NCBI
RefSeq Acc Id: NM_005644   ⟹   NP_005635
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38128,602,850 - 28,643,067 (-)NCBI
GRCh37128,929,608 - 28,975,416 (-)NCBI
Build 36128,802,200 - 28,842,172 (-)NCBI Archive
HuRef127,182,618 - 27,222,688 (-)ENTREZGENE
CHM1_1129,045,214 - 29,085,178 (-)NCBI
T2T-CHM13v2.0128,444,812 - 28,485,032 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017002186   ⟹   XP_016857675
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38128,602,850 - 28,648,269 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024449368   ⟹   XP_024305136
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38128,602,850 - 28,643,067 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054338493   ⟹   XP_054194468
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0128,444,812 - 28,490,693 (-)NCBI
RefSeq Acc Id: NP_005635   ⟸   NM_005644
- Peptide Label: isoform 1
- UniProtKB: Q15775 (UniProtKB/Swiss-Prot),   D3DPM5 (UniProtKB/Swiss-Prot),   Q5T077 (UniProtKB/Swiss-Prot),   Q16514 (UniProtKB/Swiss-Prot),   A0A8I5KYW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001128690   ⟸   NM_001135218
- Peptide Label: isoform 1
- UniProtKB: Q15775 (UniProtKB/Swiss-Prot),   D3DPM5 (UniProtKB/Swiss-Prot),   Q5T077 (UniProtKB/Swiss-Prot),   Q16514 (UniProtKB/Swiss-Prot),   A0A8I5KYW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016857675   ⟸   XM_017002186
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_024305136   ⟸   XM_024449368
- Peptide Label: isoform X2
- UniProtKB: Q16514 (UniProtKB/Swiss-Prot),   Q15775 (UniProtKB/Swiss-Prot),   D3DPM5 (UniProtKB/Swiss-Prot),   Q5T077 (UniProtKB/Swiss-Prot),   A0A8I5KYW6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000362930   ⟸   ENST00000373824
Ensembl Acc Id: ENSP00000263974   ⟸   ENST00000263974
Ensembl Acc Id: ENSP00000509875   ⟸   ENST00000693729
Ensembl Acc Id: ENSP00000509244   ⟸   ENST00000690860
Ensembl Acc Id: ENSP00000509370   ⟸   ENST00000689843
Ensembl Acc Id: ENSP00000509153   ⟸   ENST00000685312
Ensembl Acc Id: ENSP00000510456   ⟸   ENST00000690492
Ensembl Acc Id: ENSP00000509910   ⟸   ENST00000693642
Ensembl Acc Id: ENSP00000510282   ⟸   ENST00000688108
Ensembl Acc Id: ENSP00000508797   ⟸   ENST00000691563
Ensembl Acc Id: ENSP00000508898   ⟸   ENST00000691050
Ensembl Acc Id: ENSP00000509854   ⟸   ENST00000685589
Ensembl Acc Id: ENSP00000509051   ⟸   ENST00000692098
RefSeq Acc Id: NP_001397698   ⟸   NM_001410769
- Peptide Label: isoform 2
- UniProtKB: A0A804HLG9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054194468   ⟸   XM_054338493
- Peptide Label: isoform X3
Protein Domains
Histone-fold   Transcription initiation factor TFIID subunit

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q16514-F1-model_v2 AlphaFold Q16514 1-161 view protein structure

Promoters
RGD ID:6854742
Promoter ID:EPDNEW_H536
Type:initiation region
Name:TAF12_1
Description:TATA-box binding protein associated factor 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H545  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38128,643,026 - 28,643,086EPDNEW
RGD ID:6786564
Promoter ID:HG_KWN:1652
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001135218,   OTTHUMT00000010341,   OTTHUMT00000010368,   OTTHUMT00000010370,   UC009VTI.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36128,842,086 - 28,842,927 (+)MPROMDB
RGD ID:6809738
Promoter ID:HG_ACW:1273
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:TAF12.CAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 36128,847,616 - 28,848,116 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11545 AgrOrtholog
COSMIC TAF12 COSMIC
Ensembl Genes ENSG00000120656 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000263974 ENTREZGENE
  ENST00000263974.4 UniProtKB/Swiss-Prot
  ENST00000373824 ENTREZGENE
  ENST00000373824.9 UniProtKB/Swiss-Prot
  ENST00000471683.6 UniProtKB/TrEMBL
  ENST00000495422 ENTREZGENE
  ENST00000495422.2 UniProtKB/TrEMBL
  ENST00000685312.1 UniProtKB/Swiss-Prot
  ENST00000685589.1 UniProtKB/TrEMBL
  ENST00000688108.1 UniProtKB/TrEMBL
  ENST00000689843 ENTREZGENE
  ENST00000689843.1 UniProtKB/Swiss-Prot
  ENST00000690492.1 UniProtKB/TrEMBL
  ENST00000690860.1 UniProtKB/TrEMBL
  ENST00000691050.1 UniProtKB/TrEMBL
  ENST00000691563.1 UniProtKB/TrEMBL
  ENST00000692098.1 UniProtKB/Swiss-Prot
  ENST00000693642.1 UniProtKB/TrEMBL
  ENST00000693729.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000120656 GTEx
HGNC ID HGNC:11545 ENTREZGENE
Human Proteome Map TAF12 Human Proteome Map
InterPro Histone-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAF12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TFIID_TAF12_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:6883 UniProtKB/Swiss-Prot
NCBI Gene 6883 ENTREZGENE
OMIM 600773 OMIM
PANTHER PTHR12264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TFIID_20kDa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA36320 PharmGKB
Superfamily-SCOP SSF47113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A804HLG9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5KP17_HUMAN UniProtKB/TrEMBL
  A0A8I5KPH6_HUMAN UniProtKB/TrEMBL
  A0A8I5KTB6_HUMAN UniProtKB/TrEMBL
  A0A8I5KU09_HUMAN UniProtKB/TrEMBL
  A0A8I5KWX5_HUMAN UniProtKB/TrEMBL
  A0A8I5KXE7_HUMAN UniProtKB/TrEMBL
  A0A8I5KYJ9_HUMAN UniProtKB/TrEMBL
  A0A8I5KYW6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5QKX2_HUMAN UniProtKB/TrEMBL
  D3DPM5 ENTREZGENE
  Q15775 ENTREZGENE
  Q16514 ENTREZGENE
  Q5T077 ENTREZGENE
  TAF12_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary D3DPM5 UniProtKB/Swiss-Prot
  Q15775 UniProtKB/Swiss-Prot
  Q5T077 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 TAF12  TATA-box binding protein associated factor 12  TAF12  TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa  Symbol and/or name change 5135510 APPROVED