Taf12 (TATA-box binding protein associated factor 12) - Rat Genome Database
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Gene: Taf12 (TATA-box binding protein associated factor 12) Mus musculus
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Symbol: Taf12
Name: TATA-box binding protein associated factor 12
RGD ID: 1623219
Description: Exhibits DNA binding activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity and histone acetyltransferase activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly; histone H3 acetylation; and positive regulation of DNA-binding transcription factor activity. Localizes to STAGA complex. Is expressed in early conceptus; limb; oocyte; and tail. Orthologous to human TAF12 (TATA-box binding protein associated factor 12); PARTICIPATES IN RNA polymerase I transcription pathway; RNA polymerase II transcription initiation pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 20kD; 20kDa; 2810422D08Rik; AW557038; TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor; TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20 kDa; Taf2; Taf2J; TAFII-20; TAFII20; transcription initiation factor TFIID 20 kDa subunits; transcription initiation factor TFIID subunit 12
Orthologs:
Homo sapiens (human) : TAF12 (TATA-box binding protein associated factor 12)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Taf12 (TATA-box binding protein associated factor 12)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : TAF12 (TATA-box binding protein associated factor 12)
Canis lupus familiaris (dog) : TAF12 (TATA-box binding protein associated factor 12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Taf12 (TATA-box binding protein associated factor 12)
Sus scrofa (pig) : TAF12 (TATA-box binding protein associated factor 12)
Chlorocebus sabaeus (African green monkey) : TAF12 (TATA-box binding protein associated factor 12)
Heterocephalus glaber (naked mole-rat) : Taf12 (TATA-box binding protein associated factor 12)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394132,001,667 - 132,020,640 (+)NCBI
GRCm384132,274,355 - 132,293,329 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4132,274,375 - 132,295,766 (+)EnsemblGRCm38mm10GRCm38
MGSCv374131,830,290 - 131,849,244 (+)NCBIGRCm37mm9NCBIm37
MGSCv364131,546,489 - 131,565,403 (+)NCBImm8
Celera4130,435,455 - 130,454,533 (+)NCBICelera
Cytogenetic Map4D2.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12237304   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14580349  
PMID:14610273   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16481476   PMID:17967808   PMID:18287559   PMID:18722179   PMID:18799693   PMID:19103755   PMID:20059953   PMID:20412781  
PMID:21873635   PMID:22323595   PMID:23426901   PMID:25209997   PMID:27026076   PMID:28893950  


Genomics

Comparative Map Data
Taf12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394132,001,667 - 132,020,640 (+)NCBI
GRCm384132,274,355 - 132,293,329 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4132,274,375 - 132,295,766 (+)EnsemblGRCm38mm10GRCm38
MGSCv374131,830,290 - 131,849,244 (+)NCBIGRCm37mm9NCBIm37
MGSCv364131,546,489 - 131,565,403 (+)NCBImm8
Celera4130,435,455 - 130,454,533 (+)NCBICelera
Cytogenetic Map4D2.3NCBI
TAF12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl128,589,323 - 28,643,085 (-)EnsemblGRCh38hg38GRCh38
GRCh38128,602,850 - 28,648,707 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37128,929,608 - 28,975,416 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36128,802,200 - 28,842,172 (-)NCBINCBI36hg18NCBI36
Build 34128,750,228 - 28,790,201NCBI
Celera127,325,365 - 27,365,501 (-)NCBI
Cytogenetic Map1p35.3NCBI
HuRef127,182,618 - 27,222,688 (-)NCBIHuRef
CHM1_1129,045,214 - 29,085,178 (-)NCBICHM1_1
Taf12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05150,459,701 - 150,476,521 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5150,459,713 - 150,475,186 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05154,126,851 - 154,143,964 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera5142,905,400 - 142,920,328 (+)NCBICelera
Cytogenetic Map5q36NCBI
TAF12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1128,907,540 - 28,948,322 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0127,874,675 - 27,914,672 (-)NCBIMhudiblu_PPA_v0panPan3
TAF12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl271,865,289 - 71,898,236 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1271,865,274 - 71,898,236 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Taf12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647412,695,508 - 12,719,384 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAF12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl685,618,688 - 85,643,076 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1685,618,679 - 85,643,087 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2679,432,412 - 79,441,136 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TAF12
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl20104,164,907 - 104,200,272 (+)Ensembl
ChlSab1.120104,164,912 - 104,199,925 (+)NCBI
Taf12
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476412,401,152 - 12,444,978 (-)NCBI

Position Markers
AW557038  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384132,293,204 - 132,293,315UniSTSGRCm38
MGSCv374131,849,119 - 131,849,230UniSTSGRCm37
Celera4130,454,408 - 130,454,519UniSTS
Cytogenetic Map4D2.3UniSTS
Whitehead/MRC_RH41702.82UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156183778Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138615442Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155600000Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465800000146500000Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468100000150800000Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined89063832140740892Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined89063832140740892Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined89063832140740892Mouse
1357529Lvrq8_mliver weight QTL 8 (mouse)Not determined489063832140740892Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)489063832140740892Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined489063832151570093Mouse
13208562Wght7_mweight 7 (mouse)491000000148000000Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined495069342150592401Mouse
1301106Skts7_mskin tumor susceptibility 7 (mouse)Not determined4100214774134215009Mouse
1301847Fecq2_mfecundity QTL 2 (mouse)Not determined4100214774134215009Mouse
12880433Fgf23lq1_mFGF23 serum level QTL 1 (mouse)4101300000135300000Mouse
15039377Bw45_mbody weight QTL 45 (mouse)4105812001139812001Mouse
15039378Adip30_madiposity 30 (mouse)4105812001139812001Mouse
15039382Ltgq7_mliver triglyceride QTL 7 (mouse)4105812001139812001Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105978113141706527Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105978113141706527Mouse
12910808Pwbwq9_mpost-weaning body weight QTL 9 (mouse)4105978113141706527Mouse
12910813Pwbwq4_mpre-weaning body weight QTL 4 (mouse)4105978113141706527Mouse
1357800Tgq3_mtriglyceride QTL 3 (mouse)Not determined4107161300141161387Mouse
1300663Start2_mstartle response 2 (mouse)Not determined4107371164141371360Mouse
1300809Ccrs2_mcorpus callosum hemisphere surface size 2 (mouse)Not determined4107371164141371360Mouse
1300781Lith8_mlithogenic gene 8 (mouse)Not determined4107371164141371360Mouse
1301382Arvm2_mautoimmune renal vasculitis 2 (mouse)Not determined4107897771141897963Mouse
10755520Rbc1_mred blood cell count 1 (mouse)4108583899142583899Mouse
10755522Hgb1_mhemoglobin 1 (mouse)4108583899142583899Mouse
10755521Hct1_mhematocrit 1 (mouse)4108583899142583899Mouse
10412072Ssen1_msuseptibility to Sendai virus 1 (mouse)Not determined4109800935133427471Mouse
1300839Dyscalc2_mdystrophic cardiac calcinosis 2 (mouse)Not determined4111115258145115487Mouse
1300743Skull6_mskull morphology 6 (mouse)Not determined4111115258145115487Mouse
15039385Mvlq3_mmacrovesicular liver lesion QTL 3 (mouse)4112288593146288593Mouse
4141001Tgq17_mtriglyceride QTL 17 (mouse)Not determined112629696146629696Mouse
10047132Albq19_malbuminuria QTL 19 (mouse)Not determined4112930596146930596Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116427367150427471Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117673830151673964Mouse
14746982Manh56_mmandible shape 56 (mouse)4118088606152088606Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4120137122154137225Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4120137122154137225Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120890537154890684Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120890537154890684Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120946694154946840Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120946694154946840Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121615338155615442Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121615338155615442Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121615338155615442Mouse
27226757Femd1_mfemur midshaft diameter 1, 5 week (mouse)4124100000144600000Mouse
4141065Shali2_msurvival time to hyperoxic acute lung injury 2 (mouse)Not determined124161300141845481Mouse
1300917Gasa1_mgastritis type A susceptibility locus 1 (mouse)Not determined4124161300142711450Mouse
1302149Tlsr2_mthymic lymphoma suppressor region 2 (mouse)Not determined4124371164142504390Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124371164150592401Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124826172156508116Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124893970156508116Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124893970156508116Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124893970156508116Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125504302156508116Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125504302156508116Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125504302156508116Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125562755156508116Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4128057656156508116Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4128057656156508116Mouse
1301793Tlsr3_mthymic lymphoma suppressor region 3 (mouse)Not determined4129572018137137225Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129572018151570093Mouse
25394568Skmw56_mskeletal muscle weight 56, EDL (mouse)4129965551133983265Mouse
12904009Cfq9_mconditioned fear QTL 9 (mouse)4130142494134045411Mouse
25394567Skmw55_mskeletal muscle weight 55, gastroc (mouse)4131710493133983265Mouse
4141154Nba1_mNew Zealand Black autoimmunity 1 (mouse)Not determined131923413141151964Mouse
14696808Rbcn1_mrod bipolar cell number 1 (mouse)4132220000134320000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1319
Count of miRNA genes:666
Interacting mature miRNAs:809
Transcripts:ENSMUST00000030731, ENSMUST00000105963, ENSMUST00000124365
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000030731   ⟹   ENSMUSP00000030731
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4132,274,375 - 132,295,766 (+)Ensembl
RefSeq Acc Id: ENSMUST00000105963   ⟹   ENSMUSP00000101583
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4132,274,416 - 132,292,712 (+)Ensembl
RefSeq Acc Id: ENSMUST00000124365
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4132,274,413 - 132,276,788 (+)Ensembl
RefSeq Acc Id: NM_025579   ⟹   NP_079855
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394132,001,686 - 132,020,640 (+)NCBI
GRCm384132,274,375 - 132,293,329 (+)NCBI
MGSCv374131,830,290 - 131,849,244 (+)RGD
Celera4130,435,455 - 130,454,533 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006539109   ⟹   XP_006539172
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394132,001,667 - 132,020,640 (+)NCBI
GRCm384132,274,355 - 132,293,329 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006539110   ⟹   XP_006539173
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394132,001,667 - 132,020,640 (+)NCBI
GRCm384132,274,355 - 132,293,329 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017320350   ⟹   XP_017175839
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394132,009,926 - 132,020,640 (+)NCBI
GRCm384132,282,615 - 132,293,329 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036164314   ⟹   XP_036020207
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394132,001,667 - 132,020,640 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_079855   ⟸   NM_025579
- UniProtKB: Q8VE65 (UniProtKB/Swiss-Prot),   Q3UT56 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006539172   ⟸   XM_006539109
- Peptide Label: isoform X3
- UniProtKB: Q8VE65 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006539173   ⟸   XM_006539110
- Peptide Label: isoform X3
- UniProtKB: Q8VE65 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017175839   ⟸   XM_017320350
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000101583   ⟸   ENSMUST00000105963
RefSeq Acc Id: ENSMUSP00000030731   ⟸   ENSMUST00000030731
RefSeq Acc Id: XP_036020207   ⟸   XM_036164314
- Peptide Label: isoform X2
Protein Domains
Histone-fold   TFIID_20kDa

Promoters
RGD ID:6836477
Promoter ID:MM_KWN:39942
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000105963,   OTTMUST00000026003,   OTTMUST00000026004
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364131,829,401 - 131,830,422 (+)MPROMDB
RGD ID:6884872
Promoter ID:EPDNEW_M5887
Type:initiation region
Name:Taf12_1
Description:Mus musculus TATA-box binding protein associated factor 12 ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384132,274,412 - 132,274,472EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913714 AgrOrtholog
Ensembl Genes ENSMUSG00000028899 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000030731 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000101583 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000030731 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000105963 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Histone-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAF12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TFIID_TAF12_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:66464 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1913714 ENTREZGENE
NCBI Gene 66464 ENTREZGENE
PANTHER PTHR12264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TFIID_20kDa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Taf12 PhenoGen
Superfamily-SCOP SSF47113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.331926 ENTREZGENE
UniProt E9QNT5_MOUSE UniProtKB/TrEMBL
  Q3UT56 ENTREZGENE, UniProtKB/TrEMBL
  Q8VE65 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q3V0S7 UniProtKB/Swiss-Prot
  Q9CZ11 UniProtKB/Swiss-Prot
  Q9D8Q0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Taf12  TATA-box binding protein associated factor 12    TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor  Symbol and/or name change 5135510 APPROVED