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ONTOLOGY REPORT - ANNOTATIONS

Term:brown fat cell differentiation
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Accession:GO:0050873 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.
Synonyms:exact_synonym: brown adipocyte cell differentiation;   brown adipocyte differentiation
 never_in_taxon: NCBITaxon:8782 ! Aves


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brown fat cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adig adipogenin involved_in IBA
IEP		 (PMID:15567149) GO_Central
HGNC-UCL		 PMID:15567149 GO_REF:0000033 NCBI chr 2:158,344,532...158,350,118
Ensembl chr 2:158,344,532...158,350,118 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing acts_upstream_of_or_within IDA (PMID:18492766) MGI PMID:18492766 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Adrb1 adrenergic receptor, beta 1 acts_upstream_of_or_within IGI (PMID:12387862) MGI PMID:12387862 NCBI chr19:56,710,549...56,713,582
Ensembl chr19:56,710,631...56,721,545 		JBrowse link
G Adrb2 adrenergic receptor, beta 2 acts_upstream_of_or_within IGI (PMID:12387862) MGI PMID:12387862 NCBI chr18:62,310,784...62,313,052
Ensembl chr18:62,310,887...62,313,030 		JBrowse link
G Adrb3 adrenergic receptor, beta 3 acts_upstream_of_or_within IGI (PMID:12387862) MGI PMID:12387862 NCBI chr 8:27,715,804...27,720,833
Ensembl chr 8:27,715,804...27,740,644 		JBrowse link
G Aldh6a1 aldehyde dehydrogenase family 6, subfamily A1 acts_upstream_of_or_within IDA (PMID:18492766) MGI PMID:18492766 NCBI chr12:84,477,491...84,497,798
Ensembl chr12:84,477,491...84,497,778 		JBrowse link
G Arl4a ADP-ribosylation factor-like 4A acts_upstream_of_or_within IDA (PMID:18492766) MGI PMID:18492766 NCBI chr12:40,083,290...40,087,986
Ensembl chr12:40,055,446...40,088,024 		JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 acts_upstream_of_or_within IDA (PMID:18492766) MGI PMID:18492766 NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha acts_upstream_of_or_within IDA (PMID:18492766) MGI PMID:18492766 NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta involved_in IMP (PMID:19641492) UniProt PMID:19641492 NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338 		JBrowse link
G Dhrs7b dehydrogenase/reductase 7B acts_upstream_of_or_within IDA (PMID:28930673) MGI PMID:28930673 NCBI chr11:60,721,457...60,749,249
Ensembl chr11:60,721,457...60,751,021 		JBrowse link
G Dio2 deiodinase, iodothyronine, type II acts_upstream_of_or_within IDA (PMID:28763438) MGI PMID:28763438 NCBI chr12:90,691,326...90,705,812
Ensembl chr12:90,691,326...90,705,812 		JBrowse link
G Ebf2 early B cell factor 2 acts_upstream_of_or_within IDA (PMID:23499423) MGI PMID:23499423 NCBI chr14:67,470,741...67,668,401
Ensembl chr14:67,470,741...67,668,367 		JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha acts_upstream_of_or_within IDA (PMID:18492766) MGI PMID:18492766 NCBI chr14:45,520,544...45,556,029
Ensembl chr14:45,520,544...45,556,228 		JBrowse link
G Fabp3 fatty acid binding protein 3, muscle and heart acts_upstream_of_or_within IDA (PMID:28763438) MGI PMID:28763438 NCBI chr 4:130,202,531...130,209,256
Ensembl chr 4:130,202,388...130,209,256 		JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte acts_upstream_of_or_within IDA (PMID:18492766) MGI PMID:18492766 NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636 		JBrowse link
G Ffar4 free fatty acid receptor 4 involved_in IMP (PMID:27853148) UniProt PMID:27853148 NCBI chr19:38,085,527...38,102,711
Ensembl chr19:38,085,519...38,102,711 		JBrowse link
G Gata2 GATA binding protein 2 acts_upstream_of IMP (PMID:16082385) MGI PMID:16082385 NCBI chr 6:88,170,873...88,184,014
Ensembl chr 6:88,170,873...88,184,014 		JBrowse link
G Itga6 integrin alpha 6 acts_upstream_of_or_within IDA (PMID:18492766) MGI PMID:18492766 NCBI chr 2:71,617,236...71,688,761
Ensembl chr 2:71,575,960...71,688,760 		JBrowse link
G Lama4 laminin, alpha 4 acts_upstream_of_or_within IDA (PMID:18492766) MGI PMID:18492766 NCBI chr10:38,841,511...38,986,184
Ensembl chr10:38,841,511...38,986,184 		JBrowse link
G Lamb3 laminin, beta 3 acts_upstream_of_or_within IDA (PMID:18492766) MGI PMID:18492766 NCBI chr 1:192,976,661...193,026,186
Ensembl chr 1:192,890,007...193,026,186 		JBrowse link
G Lncbate1 brown adipose tissue enriched long non-coding RNA 1 involved_in IMP (PMID:32513690) MGI PMID:32513690 NCBI chr 8:109,279,884...109,311,309
Ensembl chr 8:109,279,883...109,311,847 		JBrowse link
G Lncbate10 brown adipose tissue enriched long noncoding RNA 10 acts_upstream_of_or_within IDA (PMID:28763438) MGI PMID:28763438 NCBI chr18:61,603,296...61,617,678
Ensembl chr18:61,603,296...61,617,887 		JBrowse link
G Lrg1 leucine-rich alpha-2-glycoprotein 1 acts_upstream_of_or_within IDA (PMID:18492766) MGI PMID:18492766 NCBI chr17:56,426,678...56,428,946
Ensembl chr17:56,426,678...56,429,001 		JBrowse link
G Mb myoglobin acts_upstream_of_or_within IDA (PMID:18492766) MGI PMID:18492766 NCBI chr15:76,899,687...76,934,868
Ensembl chr15:76,899,687...76,934,870 		JBrowse link
G Metrnl meteorin, glial cell differentiation regulator-like involved_in IDA (PMID:24906147) UniProt PMID:24906147 NCBI chr11:121,593,253...121,608,215
Ensembl chr11:121,592,370...121,607,132 		JBrowse link
G Mrap melanocortin 2 receptor accessory protein acts_upstream_of_or_within IDA (PMID:18492766) MGI PMID:18492766 NCBI chr16:90,535,095...90,546,673
Ensembl chr16:90,535,095...90,546,673 		JBrowse link
G Nudt7 nudix hydrolase 7 acts_upstream_of_or_within IDA (PMID:18492766) MGI PMID:18492766 NCBI chr 8:114,860,314...114,881,471
Ensembl chr 8:114,860,297...114,881,479 		JBrowse link
G Pex11a peroxisomal biogenesis factor 11 alpha acts_upstream_of_or_within IDA (PMID:18492766) MGI PMID:18492766 NCBI chr 7:79,385,705...79,392,879
Ensembl chr 7:79,385,705...79,392,879 		JBrowse link
G Plac8 placenta-specific 8 acts_upstream_of_or_within IMP (PMID:21982742) MGI PMID:21982742 NCBI chr 5:100,699,455...100,720,119
Ensembl chr 5:100,701,591...100,720,111 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma acts_upstream_of_or_within IDA (PMID:18492766) MGI PMID:18492766 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Prdm16 PR domain containing 16 acts_upstream_of
involved_in		 IMP
IDA		 (PMID:24703692)
(PMID:18483224), (PMID:18719582), (PMID:19641492)
(PMID:17618855)		 MGI
UniProt		 PMID:17618855 PMID:18483224 PMID:18719582 PMID:19641492 PMID:24703692 NCBI chr 4:154,400,579...154,721,851
Ensembl chr 4:154,400,582...154,721,330 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 involved_in IMP (PMID:20448152) BHF-UCL PMID:20448152 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rarres2 retinoic acid receptor responder (tazarotene induced) 2 acts_upstream_of_or_within IDA (PMID:18492766) MGI PMID:18492766 NCBI chr 6:48,546,630...48,549,778
Ensembl chr 6:48,546,630...48,549,723 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 acts_upstream_of_or_within IDA (PMID:18492766) MGI PMID:18492766 NCBI chr 1:143,875,076...143,879,887
Ensembl chr 1:143,875,076...143,879,899 		JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 acts_upstream_of_or_within IDA (PMID:18492766) MGI PMID:18492766 NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318 		JBrowse link
G Selenbp1 selenium binding protein 1 acts_upstream_of_or_within IDA (PMID:18492766) MGI PMID:18492766 NCBI chr 3:94,840,394...94,852,069
Ensembl chr 3:94,840,367...94,852,069 		JBrowse link
G Sh2b2 SH2B adaptor protein 2 acts_upstream_of_or_within IDA (PMID:18492766) MGI PMID:18492766 NCBI chr 5:136,247,003...136,275,446
Ensembl chr 5:136,247,001...136,275,410 		JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 acts_upstream_of_or_within IDA (PMID:18492766) MGI PMID:18492766 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014 		JBrowse link
G Slc39a13 solute carrier family 39 (metal ion transporter), member 13 involved_in IMP (PMID:28854265) UniProt PMID:28854265 NCBI chr 2:90,892,136...90,900,754
Ensembl chr 2:90,892,136...90,900,762 		JBrowse link
G Ucp1 uncoupling protein 1 (mitochondrial, proton carrier) acts_upstream_of_or_within
involved_in		 IDA
IEP		 (PMID:28763438)
(PMID:15567149)		 MGI
HGNC-UCL		 PMID:15567149 PMID:28763438 NCBI chr 8:84,016,977...84,025,085
Ensembl chr 8:84,016,981...84,025,081 		JBrowse link
G Zfp423 zinc finger protein 423 involved_in IMP (PMID:20200519) BHF-UCL PMID:20200519 NCBI chr 8:88,388,438...88,688,665
Ensembl chr 8:88,388,438...88,686,223 		JBrowse link
G Zfp516 zinc finger protein 516 involved_in IMP (PMID:25578880) UniProt PMID:25578880 NCBI chr18:82,925,324...83,023,439
Ensembl chr18:82,928,788...83,023,439 		JBrowse link
negative regulation of brown fat cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbn1 fibrillin 1 involved_in IMP (PMID:33705351) UniProt PMID:33705351 NCBI chr 2:125,142,514...125,348,417
Ensembl chr 2:125,142,514...125,349,913 		JBrowse link
G Flcn folliculin involved_in IMP (PMID:27913603) UniProt PMID:27913603 NCBI chr11:59,682,234...59,706,138
Ensembl chr11:59,682,234...59,700,842 		JBrowse link
G Gata2 GATA binding protein 2 acts_upstream_of_or_within IMP (PMID:16082385) MGI PMID:16082385 NCBI chr 6:88,170,873...88,184,014
Ensembl chr 6:88,170,873...88,184,014 		JBrowse link
G Mir128-1 microRNA 128-1 involved_in ISO (PMID:33058756) BHF-UCL PMID:33058756 NCBI chr 1:128,130,098...128,130,167
Ensembl chr 1:128,130,098...128,130,167 		JBrowse link
G Mir128-2 microRNA 128-2 involved_in ISO (PMID:33058756) BHF-UCL PMID:33058756 NCBI chr 9:111,947,704...111,947,779
Ensembl chr 9:111,947,704...111,947,779 		JBrowse link
G Slc7a10 solute carrier family 7 (cationic amino acid transporter, y+ system), member 10 involved_in IMP (PMID:33707431) UniProt PMID:33707431 NCBI chr 7:34,885,520...34,900,539
Ensembl chr 7:34,885,810...34,900,539 		JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 involved_in IMP (PMID:23021218) UniProt PMID:23021218 NCBI chr 5:114,760,213...114,796,497
Ensembl chr 5:114,760,213...114,796,482 		JBrowse link
positive regulation of brown fat cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp7 bone morphogenetic protein 7 involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr 2:172,709,805...172,782,114
Ensembl chr 2:172,709,805...172,782,114 		JBrowse link
G Ffar4 free fatty acid receptor 4 involved_in IMP (PMID:29343498) UniProt PMID:29343498 NCBI chr19:38,085,527...38,102,711
Ensembl chr19:38,085,519...38,102,711 		JBrowse link
G Fndc5 fibronectin type III domain containing 5 involved_in IBA
IDA		 (PMID:22237023) GO_Central
UniProt		 PMID:22237023 GO_REF:0000033 NCBI chr 4:129,030,672...129,038,386
Ensembl chr 4:129,030,477...129,038,386 		JBrowse link
G Hnrnpu heterogeneous nuclear ribonucleoprotein U involved_in IMP (PMID:28784777) UniProt PMID:28784777 NCBI chr 1:178,148,673...178,170,063
Ensembl chr 1:178,148,673...178,165,362 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 acts_upstream_of_or_within IMP (PMID:23977283) MGI PMID:23977283 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mecom MDS1 and EVI1 complex locus acts_upstream_of_or_within IMP (PMID:24703692) MGI PMID:24703692 NCBI chr 3:30,005,445...30,563,937
Ensembl chr 3:30,005,445...30,602,157 		JBrowse link
G Metrnl meteorin, glial cell differentiation regulator-like involved_in IBA
IDA		 (PMID:24906147) GO_Central
UniProt		 PMID:24906147 GO_REF:0000033 NCBI chr11:121,593,253...121,608,215
Ensembl chr11:121,592,370...121,607,132 		JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D involved_in IMP (PMID:25757720) UniProt PMID:25757720 NCBI chr 5:21,867,899...21,906,620
Ensembl chr 5:21,867,899...21,906,394 		JBrowse link
G Pim1 proviral integration site 1 involved_in IMP (PMID:27923061) UniProt PMID:27923061 NCBI chr17:29,709,759...29,715,085
Ensembl chr17:29,709,727...29,715,086 		JBrowse link
G Prdm16 PR domain containing 16 acts_upstream_of_or_within IMP (PMID:24703692) MGI PMID:24703692 NCBI chr 4:154,400,579...154,721,851
Ensembl chr 4:154,400,582...154,721,330 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 involved_in IMP (PMID:20448152) BHF-UCL PMID:20448152 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rreb1 ras responsive element binding protein 1 involved_in IMP (PMID:27923061) UniProt PMID:27923061 NCBI chr13:37,962,362...38,135,981
Ensembl chr13:37,962,376...38,135,981 		JBrowse link
G Six1 sine oculis-related homeobox 1 involved_in IMP (PMID:27923061) UniProt PMID:27923061 NCBI chr12:73,088,601...73,093,486
Ensembl chr12:73,086,789...73,100,661 		JBrowse link
G Sox13 SRY (sex determining region Y)-box 13 involved_in IMP (PMID:27923061) UniProt PMID:27923061 NCBI chr 1:133,310,038...133,352,159
Ensembl chr 1:133,310,041...133,352,115 		JBrowse link
G Tfe3 transcription factor E3 involved_in IMP (PMID:27913603) UniProt PMID:27913603 NCBI chr  X:7,628,769...7,641,441
Ensembl chr  X:7,628,799...7,641,441 		JBrowse link
G Vstm2a V-set and transmembrane domain containing 2A involved_in IMP
ISO		 (PMID:28052263) UniProt
GO_Central		 PMID:28052263 GO_REF:0000119 NCBI chr11:16,207,742...16,234,551
Ensembl chr11:16,207,724...16,377,310 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B involved_in IMP (PMID:28784777) UniProt PMID:28784777 NCBI chr 3:89,284,953...89,300,976
Ensembl chr 3:89,284,951...89,302,083 		JBrowse link
regulation of brown fat cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dusp10 dual specificity phosphatase 10 acts_upstream_of_or_within IDA (PMID:23874687) MGI PMID:23874687 NCBI chr 1:183,766,575...183,807,833
Ensembl chr 1:183,745,499...183,807,833 		JBrowse link
G Fto FTO alpha-ketoglutarate dependent dioxygenase involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 8:92,039,995...92,395,061
Ensembl chr 8:92,040,153...92,395,067 		JBrowse link
G Lep leptin involved_in IDA (PMID:20620997) UniProt PMID:20620997 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in ISO RGD
GO_Central		 PMID:20133456 GO_REF:0000096 RGD:10041010 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Sirt1 sirtuin 1 involved_in IMP (PMID:20620997) UniProt PMID:20620997 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28631
    developmental process 7533
      cellular developmental process 5177
        cell differentiation 5176
          fat cell differentiation 304
            brown fat cell differentiation 67
              negative regulation of brown fat cell differentiation 7
              positive regulation of brown fat cell differentiation 17
              regulation of brown fat cell differentiation + 29
paths to the root