Metrnl (meteorin, glial cell differentiation regulator-like) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Metrnl (meteorin, glial cell differentiation regulator-like) Mus musculus
Analyze
Symbol: Metrnl
Name: meteorin, glial cell differentiation regulator-like
RGD ID: 1618193
MGI Page MGI
Description: Enables hormone activity. Involved in several processes, including brown fat cell differentiation; positive regulation of brown fat cell differentiation; and response to muscle activity. Located in extracellular space. Is expressed in central nervous system; sensory organ; skeleton; and vibrissa. Orthologous to human METRNL (meteorin like, glial cell differentiation regulator).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 9430048M07Rik; BC019776; cometin; meteorin-like protein; MGC25696; subfatin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm19056  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911121,593,253 - 121,608,215 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11121,592,370 - 121,607,132 (+)EnsemblGRCm39 Ensembl
GRCm3811121,702,427 - 121,717,389 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11121,701,544 - 121,716,306 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711121,563,741 - 121,578,703 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611121,518,517 - 121,533,479 (+)NCBIMGSCv36mm8
Celera11133,438,018 - 133,453,017 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1186.89NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-deoxy-D-glucose  (EXP)
2-hydroxypropanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
8-Br-cAMP  (ISO)
acetyl-CoA  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
ATP  (EXP)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gentamycin  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
Licochalcone B  (ISO)
methamphetamine  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (ISO)
niclosamide  (ISO)
obeticholic acid  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
propanal  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sodium arsenate  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
hormone activity  (IBA,IDA)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11125038   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:16602821   PMID:20460368  
PMID:21267068   PMID:21677750   PMID:21873635   PMID:21985865   PMID:24006456   PMID:24393292   PMID:24906147   PMID:25486603   PMID:26307585   PMID:29703203   PMID:29854769   PMID:30213948  
PMID:30464051   PMID:30973865   PMID:31949292   PMID:32196931   PMID:32694780   PMID:33635944   PMID:34127677   PMID:34321664   PMID:34943988   PMID:35076116   PMID:35709278   PMID:36130501  
PMID:36229598   PMID:36334887   PMID:36812572   PMID:37423488   PMID:37880599  


Genomics

Comparative Map Data
Metrnl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911121,593,253 - 121,608,215 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11121,592,370 - 121,607,132 (+)EnsemblGRCm39 Ensembl
GRCm3811121,702,427 - 121,717,389 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11121,701,544 - 121,716,306 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711121,563,741 - 121,578,703 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611121,518,517 - 121,533,479 (+)NCBIMGSCv36mm8
Celera11133,438,018 - 133,453,017 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1186.89NCBI
METRNL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381783,079,609 - 83,095,122 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1783,079,609 - 83,095,122 (+)EnsemblGRCh38hg38GRCh38
GRCh371781,037,485 - 81,052,867 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361778,630,856 - 78,646,012 (+)NCBINCBI36Build 36hg18NCBI36
Build 341778,630,855 - 78,646,009NCBI
Celera1777,634,605 - 77,649,087 (+)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1776,439,076 - 76,453,106 (+)NCBIHuRef
CHM1_11781,123,787 - 81,138,795 (+)NCBICHM1_1
T2T-CHM13v2.01784,099,994 - 84,115,581 (+)NCBIT2T-CHM13v2.0
Metrnl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810107,462,148 - 107,476,143 (+)NCBIGRCr8
mRatBN7.210106,963,880 - 106,977,875 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10106,963,880 - 106,977,869 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10112,069,032 - 112,083,137 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010111,532,091 - 111,546,196 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010106,884,278 - 106,898,259 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010110,893,261 - 110,907,256 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10110,893,232 - 110,907,243 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010110,473,811 - 110,487,806 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10105,499,025 - 105,513,020 (+)NCBICelera
Cytogenetic Map10q32.3NCBI
Metrnl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955506133,337 - 165,317 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955506133,337 - 146,472 (-)NCBIChiLan1.0ChiLan1.0
METRNL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21999,737,530 - 99,753,520 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117104,544,585 - 104,560,617 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01777,511,681 - 77,527,677 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11783,287,608 - 83,301,637 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1783,287,606 - 83,301,637 (+)Ensemblpanpan1.1panPan2
METRNL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha9113,044 - 124,150 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.09105,723 - 116,830 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1998,971 - 110,076 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.09260,305 - 271,398 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.09335,510 - 346,630 (-)NCBIUU_Cfam_GSD_1.0
Metrnl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602127,802 - 146,465 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936923423,615 - 442,327 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936923423,618 - 442,261 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
METRNL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl12228,503 - 241,496 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.112228,228 - 241,491 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.212554,564 - 562,456 (+)NCBISscrofa10.2Sscrofa10.2susScr3
METRNL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11674,985,771 - 75,000,970 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1674,985,796 - 75,001,626 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607746,679,076 - 46,696,123 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Metrnl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480111,701,778 - 11,715,383 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480111,701,821 - 11,715,693 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Metrnl
334 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:512
Count of miRNA genes:285
Interacting mature miRNAs:318
Transcripts:ENSMUST00000036742, ENSMUST00000106089, ENSMUST00000125580
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse


Expression


Sequence


RefSeq Acc Id: ENSMUST00000036742   ⟹   ENSMUSP00000038126
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11121,593,237 - 121,607,132 (+)Ensembl
GRCm38.p6 Ensembl11121,702,411 - 121,716,306 (+)Ensembl
RefSeq Acc Id: ENSMUST00000106089   ⟹   ENSMUSP00000101695
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11121,592,370 - 121,607,112 (+)Ensembl
GRCm38.p6 Ensembl11121,701,544 - 121,716,286 (+)Ensembl
RefSeq Acc Id: ENSMUST00000125580   ⟹   ENSMUSP00000122949
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11121,593,589 - 121,606,655 (+)Ensembl
GRCm38.p6 Ensembl11121,702,763 - 121,715,829 (+)Ensembl
RefSeq Acc Id: NM_144797   ⟹   NP_659046
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911121,593,253 - 121,608,215 (+)NCBI
GRCm3811121,702,427 - 121,717,389 (+)ENTREZGENE
MGSCv3711121,563,741 - 121,578,703 (+)RGD
Celera11133,438,018 - 133,453,017 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_659046   ⟸   NM_144797
- Peptide Label: precursor
- UniProtKB: Q8R1J2 (UniProtKB/Swiss-Prot),   Q8VE43 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000122949   ⟸   ENSMUST00000125580
RefSeq Acc Id: ENSMUSP00000101695   ⟸   ENSMUST00000106089
RefSeq Acc Id: ENSMUSP00000038126   ⟸   ENSMUST00000036742

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VE43-F1-model_v2 AlphaFold Q8VE43 1-311 view protein structure

Promoters
RGD ID:6821256
Promoter ID:MM_KWN:11036
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:ENSMUST00000106089
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611121,562,281 - 121,562,781 (+)MPROMDB
RGD ID:6821257
Promoter ID:MM_KWN:11037
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000100117,   OTTMUST00000017436,   OTTMUST00000017438
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611121,563,456 - 121,563,956 (+)MPROMDB
RGD ID:8677794
Promoter ID:EPDNEW_M16927
Type:initiation region
Name:Metrnl_1
Description:Mus musculus meteorin, glial cell differentiation regulator-like, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811121,702,427 - 121,702,487EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2384806 AgrOrtholog
Ensembl Genes ENSMUSG00000039208 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000036742 ENTREZGENE
  ENSMUST00000036742.14 UniProtKB/Swiss-Prot
  ENSMUST00000106089.8 UniProtKB/Swiss-Prot
  ENSMUST00000125580.2 UniProtKB/TrEMBL
KEGG Report mmu:210029 UniProtKB/Swiss-Prot
MGD MGI:2384806 ENTREZGENE
NCBI Gene 210029 ENTREZGENE
PANTHER METEORIN-LIKE PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR28593:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Metrnl PhenoGen
UniProt A2AAV6_MOUSE UniProtKB/TrEMBL
  METRL_MOUSE UniProtKB/Swiss-Prot
  Q3TCT1_MOUSE UniProtKB/TrEMBL
  Q8R1J2 ENTREZGENE
  Q8VE43 ENTREZGENE
UniProt Secondary Q8R1J2 UniProtKB/Swiss-Prot