Flcn (folliculin) - Rat Genome Database

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Gene: Flcn (folliculin) Mus musculus
Analyze
Symbol: Flcn
Name: folliculin
RGD ID: 1615711
MGI Page MGI
Description: Predicted to enable GTPase activator activity. Involved in several processes, including energy homeostasis; negative regulation of brown fat cell differentiation; and negative regulation of nitrogen compound metabolic process. Acts upstream of or within with a positive effect on negative regulation of cell population proliferation. Acts upstream of or within several processes, including negative regulation of cell population proliferation; positive regulation of transforming growth factor beta receptor signaling pathway; and regulation of intracellular signal transduction. Predicted to be located in several cellular components, including cilium; lysosomal membrane; and microtubule cytoskeleton. Predicted to be active in cytosol. Predicted to colocalize with cell-cell contact zone and midbody. Is expressed in several structures, including embryo ectoderm; exocrine gland; extraembryonic component; limb bud; and optic cup. Used to study Birt-Hogg-Dube syndrome and nonpapillary renal cell carcinoma. Human ortholog(s) of this gene implicated in Birt-Hogg-Dube syndrome; colorectal cancer; primary spontaneous pneumothorax; and renal cell carcinoma. Orthologous to human FLCN (folliculin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AU014660; B430214A04Rik; Bhd; birt-Hogg-Dube syndrome protein homolog; FLCL; MGC37841
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,682,234 - 59,706,138 (-)NCBIGRCm39mm39
GRCm39 Ensembl1159,682,234 - 59,700,842 (-)Ensembl
GRCm381159,791,408 - 59,810,039 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,791,408 - 59,810,016 (-)EnsemblGRCm38mm10GRCm38
MGSCv371159,605,252 - 59,623,275 (-)NCBIGRCm37mm9NCBIm37
MGSCv361159,607,945 - 59,625,968 (-)NCBImm8
MGSCv361160,328,330 - 60,346,353 (-)NCBImm8
Cytogenetic Map11B1.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-benzylpiperazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4,4'-sulfonyldiphenol  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
amiodarone  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[b]fluoranthene  (EXP)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
boron nitride  (ISO)
bortezomib  (ISO)
buspirone  (ISO)
butanal  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
clofibrate  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cyclosporin A  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
hydrogen peroxide  (ISO)
leflunomide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nefazodone  (ISO)
Octicizer  (EXP)
paracetamol  (EXP,ISO)
pentanal  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phorone  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propanal  (ISO)
quercetin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sunitinib  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
thimerosal  (ISO)
titanium dioxide  (EXP)
tributyl phosphate  (EXP)
trichloroethene  (ISO)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (EXP)
tris(2-chloroethyl) phosphate  (EXP)
troglitazone  (EXP)
valdecoxib  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell proliferation involved in kidney development  (IMP)
cell-cell junction assembly  (IMP)
cellular response to amino acid starvation  (ISO)
cellular response to starvation  (ISO)
energy homeostasis  (IMP)
epithelial cell proliferation  (IMP)
ERK1 and ERK2 cascade  (IMP)
hemopoiesis  (IMP)
in utero embryonic development  (IMP)
intrinsic apoptotic signaling pathway  (IMP)
lysosome localization  (ISO)
negative regulation of angiogenesis  (NAS)
negative regulation of ATP biosynthetic process  (IMP)
negative regulation of brown fat cell differentiation  (IMP)
negative regulation of cell growth  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (IGI)
negative regulation of cell proliferation involved in kidney development  (IMP)
negative regulation of cellular respiration  (IMP)
negative regulation of cold-induced thermogenesis  (IMP)
negative regulation of DNA-templated transcription  (IMP)
negative regulation of epithelial cell proliferation  (IMP)
negative regulation of ERK1 and ERK2 cascade  (IMP)
negative regulation of gene expression  (IMP)
negative regulation of glycolytic process  (ISO)
negative regulation of mitochondrial DNA metabolic process  (IMP)
negative regulation of mitochondrion organization  (IMP)
negative regulation of muscle tissue development  (IMP)
negative regulation of post-translational protein modification  (IMP)
negative regulation of protein kinase B signaling  (IMP)
negative regulation of protein localization to nucleus  (ISO)
negative regulation of Rho protein signal transduction  (ISO)
negative regulation of TOR signaling  (IMP)
negative regulation of transcription by RNA polymerase II  (IBA,IMP,ISO)
positive regulation of autophagy  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of GTPase activity  (IBA)
positive regulation of intrinsic apoptotic signaling pathway  (IMP)
positive regulation of protein phosphorylation  (IMP)
positive regulation of TOR signaling  (IMP,ISO)
positive regulation of TORC1 signaling  (IBA)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (IBA,IMP,ISO)
protein kinase B signaling  (IMP)
regulation of cytokinesis  (ISO)
regulation of histone acetylation  (IMP)
regulation of pro-B cell differentiation  (IMP)
regulation of protein phosphorylation  (ISO)
regulation of Ras protein signal transduction  (ISO)
regulation of TOR signaling  (IMP)
TOR signaling  (IMP,ISO)
transforming growth factor beta receptor signaling pathway  (IMP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot. Goberdhan DC, etal., Cell Metab. 2016 Apr 12;23(4):580-9. doi: 10.1016/j.cmet.2016.03.013.
2. Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dube syndrome. Nickerson ML, etal., Cancer Cell. 2002 Aug;2(2):157-64.
3. A germ-line insertion in the Birt-Hogg-Dube (BHD) gene gives rise to the Nihon rat model of inherited renal cancer. Okimoto K, etal., Proc Natl Acad Sci U S A 2004 Feb 17;101(7):2023-7. Epub 2004 Feb 09.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene. Togashi Y, etal., Oncogene. 2006 May 11;25(20):2885-9. doi: 10.1038/sj.onc.1209317.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11125038   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12904583  
PMID:14610273   PMID:15489334   PMID:15741177   PMID:15782199   PMID:16141072   PMID:16141073   PMID:18182616   PMID:18799693   PMID:18974783   PMID:19234517   PMID:19843504   PMID:19850877  
PMID:21209915   PMID:21258407   PMID:21873635   PMID:22209521   PMID:22709692   PMID:22965878   PMID:23139756   PMID:23150719   PMID:23582324   PMID:24081491   PMID:24726356   PMID:24762438  
PMID:24908670   PMID:25126726   PMID:25775561   PMID:26083655   PMID:26418749   PMID:26439621   PMID:27095138   PMID:27151976   PMID:27913603   PMID:28007907   PMID:28363698   PMID:28656962  
PMID:29688375   PMID:29893999   PMID:30843872   PMID:30917316   PMID:31272105   PMID:31404503   PMID:31806376   PMID:32049013   PMID:32612235   PMID:33298956   PMID:34711912   PMID:35420934  


Genomics

Comparative Map Data
Flcn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,682,234 - 59,706,138 (-)NCBIGRCm39mm39
GRCm39 Ensembl1159,682,234 - 59,700,842 (-)Ensembl
GRCm381159,791,408 - 59,810,039 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,791,408 - 59,810,016 (-)EnsemblGRCm38mm10GRCm38
MGSCv371159,605,252 - 59,623,275 (-)NCBIGRCm37mm9NCBIm37
MGSCv361159,607,945 - 59,625,968 (-)NCBImm8
MGSCv361160,328,330 - 60,346,353 (-)NCBImm8
Cytogenetic Map11B1.3NCBI
FLCN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381717,212,212 - 17,237,330 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1717,212,212 - 17,237,188 (-)EnsemblGRCh38hg38GRCh38
GRCh371717,115,526 - 17,140,482 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361717,056,251 - 17,081,221 (-)NCBINCBI36hg18NCBI36
Celera1718,055,113 - 18,080,089 (-)NCBI
Cytogenetic Map17p11.2NCBI
HuRef1716,868,444 - 16,893,256 (-)NCBIHuRef
CHM1_11717,125,252 - 17,150,222 (-)NCBICHM1_1
T2T-CHM13v2.01717,158,255 - 17,183,208 (-)NCBI
Flcn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21044,588,621 - 44,607,808 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1044,588,624 - 44,607,769 (-)Ensembl
Rnor_6.01046,153,185 - 46,172,331 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1046,153,188 - 46,172,309 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,909,609 - 45,928,715 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41046,110,527 - 46,129,613 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11046,124,152 - 46,143,236 (-)NCBI
Celera1043,850,423 - 43,869,275 (-)NCBICelera
Cytogenetic Map10q22NCBI
Flcn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955577672,410 - 694,140 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955577672,774 - 694,140 (+)NCBIChiLan1.0ChiLan1.0
FLCN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11738,988,520 - 39,013,189 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1738,988,518 - 39,013,160 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01734,057,127 - 34,081,637 (+)NCBIMhudiblu_PPA_v0panPan3
FLCN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1542,176,093 - 42,195,718 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl542,176,291 - 42,195,711 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha542,316,328 - 42,335,442 (+)NCBI
ROS_Cfam_1.0542,284,487 - 42,304,049 (+)NCBI
ROS_Cfam_1.0 Ensembl542,284,690 - 42,304,044 (+)Ensembl
UMICH_Zoey_3.1542,251,943 - 42,271,053 (+)NCBI
UNSW_CanFamBas_1.0542,199,268 - 42,218,373 (+)NCBI
UU_Cfam_GSD_1.0542,391,398 - 42,410,513 (+)NCBI
Flcn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560261,965,873 - 61,986,098 (+)NCBI
SpeTri2.0NW_004936741881,150 - 901,296 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLCN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1261,031,157 - 61,045,392 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11261,029,186 - 61,045,400 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FLCN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11616,245,840 - 16,271,465 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1616,245,715 - 16,267,698 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660594,642,225 - 4,670,076 (+)NCBIVero_WHO_p1.0
Flcn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248494,157,683 - 4,179,724 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
AU014660  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381159,791,810 - 59,792,009UniSTSGRCm38
MGSCv371159,605,312 - 59,605,511UniSTSGRCm37
Cytogenetic Map11B1.3UniSTS
Whitehead/MRC_RH11793.04UniSTS
PMC357045P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381159,794,136 - 59,794,311UniSTSGRCm38
MGSCv371159,607,638 - 59,607,813UniSTSGRCm37
Cytogenetic Map11B1.3UniSTS
Flcn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B1.3UniSTS
cM Map1137.79UniSTS
Flcn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B1.3UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4141084Spqq1_msperm quality QTL 1 (mouse)Not determined5406567063319522Mouse
1302186Blmpf2_mbleomycin-induced pulmonary fibrosis 2 (mouse)Not determined115406567067078411Mouse
4142148Ckdbp2_mchronic kidney disease blood pressure locus 2 (mouse)Not determined115408094165103841Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5528498572209927Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
13513917Heal54_mwound healing/ regeneration 54 (mouse)115787291759879610Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115849055574754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
11532697Sluc36_msusceptibility to lung cancer 36 (mouse)115925661769482699Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1312
Count of miRNA genes:570
Interacting mature miRNAs:702
Transcripts:ENSMUST00000047706, ENSMUST00000091246, ENSMUST00000102697, ENSMUST00000133647, ENSMUST00000148151, ENSMUST00000151453
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001271356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_146018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_073164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_156702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011248905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003949382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC068808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK039106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL596204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ052419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ059253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000047706   ⟹   ENSMUSP00000037675
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1159,695,348 - 59,700,820 (-)Ensembl
GRCm38.p6 Ensembl1159,804,522 - 59,809,994 (-)Ensembl
RefSeq Acc Id: ENSMUST00000091246   ⟹   ENSMUSP00000091696
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1159,682,616 - 59,700,414 (-)Ensembl
GRCm38.p6 Ensembl1159,791,790 - 59,809,588 (-)Ensembl
RefSeq Acc Id: ENSMUST00000102697   ⟹   ENSMUSP00000099758
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1159,682,234 - 59,700,842 (-)Ensembl
GRCm38.p6 Ensembl1159,791,408 - 59,810,016 (-)Ensembl
RefSeq Acc Id: ENSMUST00000133647
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1159,694,585 - 59,700,427 (-)Ensembl
GRCm38.p6 Ensembl1159,803,759 - 59,809,601 (-)Ensembl
RefSeq Acc Id: ENSMUST00000148151
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1159,682,283 - 59,700,750 (-)Ensembl
GRCm38.p6 Ensembl1159,791,457 - 59,809,924 (-)Ensembl
RefSeq Acc Id: ENSMUST00000151453
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1159,699,854 - 59,700,537 (-)Ensembl
GRCm38.p6 Ensembl1159,809,028 - 59,809,711 (-)Ensembl
RefSeq Acc Id: NM_001271356   ⟹   NP_001258285
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,682,234 - 59,700,865 (-)NCBI
GRCm381159,791,408 - 59,810,039 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001271357   ⟹   NP_001258286
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,682,234 - 59,700,427 (-)NCBI
GRCm381159,791,408 - 59,809,601 (-)NCBI
Sequence:
RefSeq Acc Id: NM_146018   ⟹   NP_666130
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,682,234 - 59,700,865 (-)NCBI
GRCm381159,791,408 - 59,810,039 (-)NCBI
MGSCv371159,605,252 - 59,623,275 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_073164
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,682,234 - 59,700,865 (-)NCBI
GRCm381159,791,408 - 59,810,039 (-)NCBI
Sequence:
RefSeq Acc Id: NR_156702
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,682,234 - 59,700,865 (-)NCBI
GRCm381159,791,408 - 59,810,039 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011248905   ⟹   XP_011247207
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,682,576 - 59,706,138 (-)NCBI
GRCm381159,791,750 - 59,809,823 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036156550   ⟹   XP_036012443
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,682,576 - 59,700,617 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003949382
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,682,576 - 59,700,634 (-)NCBI
GRCm381159,791,750 - 59,809,808 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_666130   ⟸   NM_146018
- UniProtKB: Q8QZS3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001258285   ⟸   NM_001271356
- UniProtKB: Q8QZS3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001258286   ⟸   NM_001271357
- UniProtKB: Q8QZS3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011247207   ⟸   XM_011248905
- Peptide Label: isoform X1
- UniProtKB: Q8QZS3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000091696   ⟸   ENSMUST00000091246
RefSeq Acc Id: ENSMUSP00000037675   ⟸   ENSMUST00000047706
RefSeq Acc Id: ENSMUSP00000099758   ⟸   ENSMUST00000102697
RefSeq Acc Id: XP_036012443   ⟸   XM_036156550
- Peptide Label: isoform X1
Protein Domains
cDENN FLCN/SMCR8-type   dDENN FLCN/SMCR8-type   uDENN FLCN/SMCR8-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8QZS3-F1-model_v2 AlphaFold Q8QZS3 1-579 view protein structure

Promoters
RGD ID:6846835
Promoter ID:MM_ACW:7591
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung
Transcripts:FLCN.GSEP07,   FLCN.ISEP07-UNSPLICED,   FLCN.JSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361159,608,529 - 59,609,029 (-)MPROMDB
RGD ID:6821948
Promoter ID:MM_KWN:7666
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000047706,   ENSMUST00000091246,   OTTMUST00000018397,   OTTMUST00000018399,   OTTMUST00000018400,   OTTMUST00000062093,   OTTMUST00000073507,   UC007JEX.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361159,623,216 - 59,623,917 (+)MPROMDB
RGD ID:8674836
Promoter ID:EPDNEW_M15449
Type:initiation region
Name:Flcn_1
Description:Mus musculus folliculin , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15450  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381159,809,795 - 59,809,855EPDNEW
RGD ID:8674838
Promoter ID:EPDNEW_M15450
Type:multiple initiation site
Name:Flcn_2
Description:Mus musculus folliculin , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15449  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381159,810,039 - 59,810,099EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2442184 AgrOrtholog
Ensembl Genes ENSMUSG00000032633 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000037675.3 UniProtKB/TrEMBL
  ENSMUSP00000091696 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000099758 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000047706.3 UniProtKB/TrEMBL
  ENSMUST00000091246 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000102697 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000148151 ENTREZGENE
Gene3D-CATH 1.10.10.1730 UniProtKB/Swiss-Prot
InterPro FLCN/SMCR8_DENN UniProtKB/Swiss-Prot
  FLCN_DENN_C_sf UniProtKB/Swiss-Prot
  Folliculin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Folliculin/SMCR8_N UniProtKB/Swiss-Prot
  Folliculin_C UniProtKB/Swiss-Prot
KEGG Report mmu:216805 UniProtKB/Swiss-Prot
MGD MGI:2442184 ENTREZGENE
NCBI Gene 216805 ENTREZGENE
PANTHER PTHR31441 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Folliculin UniProtKB/Swiss-Prot
  Folliculin_C UniProtKB/Swiss-Prot
PhenoGen Flcn PhenoGen
PROSITE DENN_FLCN_SMCR8 UniProtKB/Swiss-Prot
UniProt FLCN_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8R2T1_MOUSE UniProtKB/TrEMBL
  Z4YJH7_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3U4U8 UniProtKB/Swiss-Prot
  Q3UFZ1 UniProtKB/Swiss-Prot
  Q5SWZ2 UniProtKB/Swiss-Prot
  Q5SX01 UniProtKB/Swiss-Prot
  Q5SX02 UniProtKB/Swiss-Prot
  Q8CAC0 UniProtKB/Swiss-Prot