ONTOLOGY REPORT - ANNOTATIONS
Term: regulation of CD4-positive, alpha-beta T cell differentiation
Accession: GO:0043370
browse the term
Definition: Any process that modulates the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation.
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms: exact_synonym: regulation of CD4-positive T lymphocyte differentiation; regulation of CD4-positive T-cell differentiation; regulation of CD4-positive, alpha beta T lymphocyte differentiation
related_synonym: regulation of CD4-positive, alpha beta T cell development
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SH3RF1
SH3 domain containing ring finger 1
involved_in
ISS
UniProt
GO_REF:0000024
NCBI chr 4:169,094,259...169,270,956
Ensembl chr 4:169,094,259...169,270,956
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CBFB
core-binding factor subunit beta
involved_in
IEA ISS
Ensembl UniProt
GO_REF:0000024 GO_REF:0000107
NCBI chr16:67,029,149...67,101,058
Ensembl chr16:67,028,984...67,101,058
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HMGB1
high mobility group box 1
involved_in
IDA
(PMID:22473704)
UniProt
PMID:22473704
NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597
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RUNX1
RUNX family transcription factor 1
involved_in
ISS
UniProt
GO_REF:0000024
NCBI chr21:34,787,801...35,049,302
Ensembl chr21:34,787,801...36,004,667
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RUNX3
RUNX family transcription factor 3
involved_in
ISS
UniProt
GO_REF:0000024
NCBI chr 1:24,899,511...24,965,138
Ensembl chr 1:24,899,511...24,965,121
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ASCL2
achaete-scute family bHLH transcription factor 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr11:2,268,498...2,270,588
Ensembl chr11:2,268,498...2,270,588
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IL4R
interleukin 4 receptor
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:16424184)
Ensembl MGI
PMID:16424184
GO_REF:0000107
NCBI chr16:27,313,756...27,364,778
Ensembl chr16:27,313,668...27,364,778
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JAK3
Janus kinase 3
involved_in
ISS
BHF-UCL
GO_REF:0000024
NCBI chr19:17,824,782...17,847,982
Ensembl chr19:17,824,780...17,848,071
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TNFSF4
TNF superfamily member 4
involved_in
ISS
BHF-UCL
GO_REF:0000024
NCBI chr 1:173,172,870...173,450,733
Ensembl chr 1:173,162,645...173,477,583
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ASCL2
achaete-scute family bHLH transcription factor 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr11:2,268,498...2,270,588
Ensembl chr11:2,268,498...2,270,588
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FOXP3
forkhead box P3
involved_in
IMP
(PMID:23169781)
UniProt
PMID:23169781
NCBI chr X:49,250,438...49,264,710
Ensembl chr X:49,250,438...49,264,800
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IL2
interleukin 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
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IL4
interleukin 4
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:18792410)
TreeGrafter MGI
PMID:18792410
GO_REF:0000118
NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
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PF4
platelet factor 4
ISO
RGD
PMID:24986443
RGD:329901907
NCBI chr 4:73,980,811...73,982,124
Ensembl chr 4:73,980,811...73,982,027
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RC3H1
ring finger and CCCH-type domains 1
involved_in
IEA ISS
Ensembl UniProt
GO_REF:0000024 GO_REF:0000107
NCBI chr 1:173,931,084...174,022,357
Ensembl chr 1:173,931,084...174,022,357
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RC3H2
ring finger and CCCH-type domains 2
involved_in
IEA ISS
Ensembl UniProt
GO_REF:0000024 GO_REF:0000107
NCBI chr 9:122,844,556...122,905,359
Ensembl chr 9:122,844,556...122,905,359
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SMAD7
SMAD family member 7
involved_in
IEA ISS
Ensembl BHF-UCL
GO_REF:0000024 GO_REF:0000107
NCBI chr18:48,919,853...48,950,965
Ensembl chr18:48,919,853...48,950,965
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TBX21
T-box transcription factor 21
involved_in
ISS IEA
UniProt Ensembl
GO_REF:0000024 GO_REF:0000107
NCBI chr17:47,733,236...47,746,122
Ensembl chr17:47,733,236...47,746,122
G
ZBTB7B
zinc finger and BTB domain containing 7B
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:23034280)
Ensembl MGI
PMID:23034280
GO_REF:0000107
NCBI chr 1:155,001,750...155,018,523
Ensembl chr 1:155,002,630...155,018,523
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ZC3H12A
zinc finger CCCH-type containing 12A
involved_in
IEA ISS
Ensembl UniProt
GO_REF:0000024 GO_REF:0000107
NCBI chr 1:37,474,580...37,484,377
Ensembl chr 1:37,474,580...37,484,377
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LOXL3
lysyl oxidase like 3
involved_in
IEA IDA ISS
(PMID:28065600)
Ensembl UniProt
PMID:28065600
GO_REF:0000024 GO_REF:0000107
NCBI chr 2:74,532,258...74,555,702
Ensembl chr 2:74,532,258...74,555,690
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TBX21
T-box transcription factor 21
involved_in
IEA ISS
Ensembl UniProt
GO_REF:0000024 GO_REF:0000107
NCBI chr17:47,733,236...47,746,122
Ensembl chr17:47,733,236...47,746,122
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TNFSF18
TNF superfamily member 18
involved_in
ISO
(MGI:5551556|PMID:24107315)
UniProt
PMID:24107315
MGI:5551556
NCBI chr 1:173,039,202...173,050,941
Ensembl chr 1:173,039,202...173,050,941
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ANXA1
annexin A1
involved_in
IDA IEA
(PMID:17008549)
UniProt TreeGrafter
PMID:17008549
GO_REF:0000118
NCBI chr 9:73,151,865...73,170,393
Ensembl chr 9:73,151,865...73,170,393
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ASCL2
achaete-scute family bHLH transcription factor 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr11:2,268,498...2,270,588
Ensembl chr11:2,268,498...2,270,588
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BCL6
BCL6 transcription repressor
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:12594267)
Ensembl MGI
PMID:12594267
GO_REF:0000107
NCBI chr 3:187,721,377...187,745,468
Ensembl chr 3:187,721,377...187,745,725
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HLX
H2.0 like homeobox
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:16424184)
Ensembl MGI
PMID:16424184
GO_REF:0000107
NCBI chr 1:220,879,443...220,885,059
Ensembl chr 1:220,879,431...220,885,059
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SOCS5
suppressor of cytokine signaling 5
involved_in
IEA ISS
Ensembl UniProt
GO_REF:0000024 GO_REF:0000107
NCBI chr 2:46,698,937...46,763,129
Ensembl chr 2:46,698,952...46,780,245
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ZNF271P
zinc finger protein 271, pseudogene
acts_upstream_of_or_within
ISO
(PMID:19783676)
MGI
PMID:19783676
NCBI chr18:35,290,272...35,310,766
Ensembl chr18:35,290,276...35,328,390 Ensembl chr18:35,290,276...35,328,390
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RC3H1
ring finger and CCCH-type domains 1
involved_in acts_upstream_of_or_within
ISS ISO IEA
(PMID:15917799)
BHF-UCL MGI Ensembl
PMID:15917799
GO_REF:0000024 GO_REF:0000107
NCBI chr 1:173,931,084...174,022,357
Ensembl chr 1:173,931,084...174,022,357
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CD83
CD83 molecule
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:15322158)
Ensembl MGI
PMID:15322158
GO_REF:0000107
NCBI chr 6:14,117,256...14,136,918
Ensembl chr 6:14,117,256...14,136,918
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FOXP3
forkhead box P3
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:17028180)
Ensembl MGI
PMID:17028180
GO_REF:0000107
NCBI chr X:49,250,438...49,264,710
Ensembl chr X:49,250,438...49,264,800
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NCKAP1L
NCK associated protein 1 like
involved_in
IEA ISS
Ensembl UniProt
GO_REF:0000024 GO_REF:0000107
NCBI chr12:54,497,752...54,548,243
Ensembl chr12:54,497,752...54,548,243
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SASH3
SAM and SH3 domain containing 3
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:16227612)
Ensembl MGI
PMID:16227612
GO_REF:0000107
NCBI chr X:129,779,949...129,795,201
Ensembl chr X:129,779,949...129,795,201
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SOCS1
suppressor of cytokine signaling 1
involved_in
ISS IEA
UniProt Ensembl
GO_REF:0000024 GO_REF:0000107
NCBI chr16:11,254,417...11,256,204
Ensembl chr16:11,254,417...11,256,204
G
TNFSF4
TNF superfamily member 4
involved_in
ISS
BHF-UCL
GO_REF:0000024
NCBI chr 1:173,172,870...173,450,733
Ensembl chr 1:173,162,645...173,477,583
G
ZBTB7B
zinc finger and BTB domain containing 7B
involved_in
ISS IEA
UniProt Ensembl
GO_REF:0000024 GO_REF:0000107
NCBI chr 1:155,001,750...155,018,523
Ensembl chr 1:155,002,630...155,018,523
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FOXP3
forkhead box P3
involved_in acts_upstream_of_or_within
TAS ISO IEA
(PMID:18368049) (PMID:16275384) (PMID:16301745), (PMID:18573908) (PMID:12612578)
UniProt MGI Ensembl
PMID:12612578 PMID:16275384 PMID:16301745 PMID:18368049 PMID:18573908
GO_REF:0000107
NCBI chr X:49,250,438...49,264,710
Ensembl chr X:49,250,438...49,264,800
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GIMAP5
GTPase, IMAP family member 5
ISO
RGD
PMID:15778366
RGD:2303772
NCBI chr 7:150,737,418...150,743,646
Ensembl chr 7:150,722,253...150,750,033
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HLA-DRA
major histocompatibility complex, class II, DR alpha
involved_in
IDA
(PMID:28467828)
UniProt
PMID:28467828
NCBI chr 6:32,439,887...32,445,046
Ensembl chr 6:32,439,878...32,445,046
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HLA-DRB1
major histocompatibility complex, class II, DR beta 1
involved_in
IDA
(PMID:28467828)
UniProt
PMID:28467828
NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,577,902...32,589,848
G
IL2RG
interleukin 2 receptor subunit gamma
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:16227984)
Ensembl MGI
PMID:16227984
GO_REF:0000107
NCBI chr X:71,107,404...71,111,577
Ensembl chr X:71,107,404...71,112,108
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KLHL25
kelch like family member 25
involved_in
IEA IDA
(PMID:34491895)
Ensembl UniProt
PMID:34491895
GO_REF:0000107
NCBI chr15:85,759,326...85,794,925
Ensembl chr15:85,759,326...85,794,925
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IFNG
interferon gamma
involved_in
IDA
(PMID:20209097)
UniProt
PMID:20209097
NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
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LGALS9
galectin 9
involved_in
IDA
(PMID:20209097)
UniProt
PMID:20209097
NCBI chr17:27,631,188...27,649,560
Ensembl chr17:27,629,798...27,649,560
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ANXA1
annexin A1
involved_in
IDA IEA
(PMID:17008549)
UniProt TreeGrafter
PMID:17008549
GO_REF:0000118
NCBI chr 9:73,151,865...73,170,393
Ensembl chr 9:73,151,865...73,170,393
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CCL19
C-C motif chemokine ligand 19
involved_in
ISS
BHF-UCL
GO_REF:0000024
NCBI chr 9:34,689,570...34,691,276
Ensembl chr 9:34,689,570...34,691,276
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CD80
CD80 molecule
involved_in
NAS
(PMID:9915850)
UniProt
PMID:9915850
NCBI chr 3:119,524,293...119,559,614
Ensembl chr 3:119,524,293...119,559,614
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HLX
H2.0 like homeobox
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:16424184)
Ensembl MGI
PMID:16424184
GO_REF:0000107
NCBI chr 1:220,879,443...220,885,059
Ensembl chr 1:220,879,431...220,885,059
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RIPK2
receptor interacting serine/threonine kinase 2
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:11894097)
Ensembl MGI
PMID:11894097
GO_REF:0000107
NCBI chr 8:89,757,816...89,791,064
Ensembl chr 8:89,757,806...89,791,064
G
SOCS5
suppressor of cytokine signaling 5
involved_in
IEA ISS
Ensembl UniProt
GO_REF:0000024 GO_REF:0000107
NCBI chr 2:46,698,937...46,763,129
Ensembl chr 2:46,698,952...46,780,245
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MALT1
MALT1 paracaspase
involved_in
ISS IEA
UniProt Ensembl
GO_REF:0000024 GO_REF:0000107
NCBI chr18:58,671,465...58,754,477
Ensembl chr18:58,671,465...58,754,477
G
MIR21
microRNA 21
involved_in
ISS
BHF-UCL
GO_REF:0000024
NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337
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MIR326
microRNA 326
acts_upstream_of_or_within
ISO
(PMID:19838199)
MGI
PMID:19838199
NCBI chr11:75,335,092...75,335,186
Ensembl chr11:75,335,092...75,335,186
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NFKBID
NFKB inhibitor delta
involved_in
ISS
UniProt
GO_REF:0000024
NCBI chr19:35,887,952...35,902,303
Ensembl chr19:35,887,630...35,902,303
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NFKBIZ
NFKB inhibitor zeta
involved_in
IEA ISS
Ensembl UniProt
GO_REF:0000024 GO_REF:0000107
NCBI chr 3:101,827,990...101,861,022
Ensembl chr 3:101,827,991...101,861,022
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NLRP3
NLR family pyrin domain containing 3
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,332,331...247,449,108
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BRD2
bromodomain containing 2
involved_in
IEA IDA
(PMID:28262505)
Ensembl UniProt
PMID:28262505
GO_REF:0000107
NCBI chr 6:32,968,594...32,981,505
Ensembl chr 6:32,968,594...32,981,505
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BRD4
bromodomain containing 4
involved_in
ISS
UniProt
GO_REF:0000024
NCBI chr19:15,235,519...15,332,539
Ensembl chr19:15,235,519...15,332,545
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EP300
E1A binding protein p300
involved_in
IDA
(PMID:28262505)
UniProt
PMID:28262505
NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,510...41,180,077
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IL12B
interleukin 12B
involved_in
ISS
BHF-UCL
GO_REF:0000024
NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863
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IL12RB1
interleukin 12 receptor subunit beta 1
involved_in
ISS
BHF-UCL
GO_REF:0000024
NCBI chr19:18,058,995...18,098,816
Ensembl chr19:18,058,995...18,098,944
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IL23A
interleukin 23 subunit alpha
involved_in
IEA IBA ISS
Ensembl GO_Central BHF-UCL
GO_REF:0000024 GO_REF:0000033 GO_REF:0000107
NCBI chr12:56,338,884...56,340,410
Ensembl chr12:56,334,174...56,340,410
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IL23R
interleukin 23 receptor
involved_in
ISS
BHF-UCL
GO_REF:0000024
NCBI chr 1:67,138,637...67,265,903
Ensembl chr 1:67,138,907...67,259,979
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OPA1
OPA1 mitochondrial dynamin like GTPase
involved_in
ISS
UniProt
GO_REF:0000024
NCBI chr 3:193,593,208...193,697,811
Ensembl chr 3:193,593,144...193,697,811
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CD86
CD86 molecule
involved_in
NAS
(PMID:9915850)
UniProt
PMID:9915850
NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139
G
IL18
interleukin 18
involved_in
ISS IEA
BHF-UCL Ensembl
GO_REF:0000024 GO_REF:0000107
NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096
G
IL4R
interleukin 4 receptor
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:16424184)
Ensembl MGI
PMID:16424184
GO_REF:0000107
NCBI chr16:27,313,756...27,364,778
Ensembl chr16:27,313,668...27,364,778
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IL6
interleukin 6
acts_upstream_of_or_within
ISO
(PMID:12594267)
MGI
PMID:12594267
NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
G
NLRP3
NLR family pyrin domain containing 3
involved_in
IEA ISS
Ensembl UniProt
GO_REF:0000024 GO_REF:0000107
NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,332,331...247,449,108
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PRKCZ
protein kinase C zeta
involved_in
ISS IEA
UniProt Ensembl
GO_REF:0000024 GO_REF:0000107
NCBI chr 1:2,048,504...2,185,395
Ensembl chr 1:2,050,411...2,185,395
G
RARA
retinoic acid receptor alpha
involved_in
IDA
(PMID:18416830)
BHF-UCL
PMID:18416830
NCBI chr17:40,309,180...40,357,643
Ensembl chr17:40,309,180...40,357,643
G
TNFSF4
TNF superfamily member 4
involved_in
ISS
BHF-UCL
GO_REF:0000024
NCBI chr 1:173,172,870...173,450,733
Ensembl chr 1:173,162,645...173,477,583
G
SHB
SH2 domain containing adaptor protein B
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:24645804)
Ensembl MGI
PMID:24645804
GO_REF:0000107
NCBI chr 9:37,915,898...38,069,227
Ensembl chr 9:37,915,898...38,069,227
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IL27
interleukin 27
involved_in
IDA IBA
(PMID:12734330)
UniProt GO_Central
PMID:12734330
GO_REF:0000033
NCBI chr16:28,499,362...28,506,834
Ensembl chr16:28,499,362...28,512,051
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BATF
basic leucine zipper ATF-like transcription factor
involved_in
NAS
(PMID:29234109)
ComplexPortal
PMID:29234109
NCBI chr14:75,522,469...75,546,992
Ensembl chr14:75,522,455...75,546,993
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CCL20
C-C motif chemokine ligand 20
NOT|involved_in
ISO
(MGI:3820359|PMID:19050256)
UniProt
PMID:19050256
MGI:3820359
NCBI chr 2:227,813,842...227,817,556
Ensembl chr 2:227,805,739...227,817,564
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CCR6
C-C motif chemokine receptor 6
NOT|involved_in
ISO
(MGI:3820359|PMID:19050256)
UniProt
PMID:19050256
MGI:3820359
NCBI chr 6:167,111,795...167,139,141
Ensembl chr 6:167,111,807...167,139,141
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JUNB
JunB proto-oncogene, AP-1 transcription factor subunit
involved_in
NAS
(PMID:29234109)
ComplexPortal
PMID:29234109
NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315
G
MIR301A
microRNA 301a
acts_upstream_of_or_within
ISO
(PMID:22517757)
MGI
PMID:22517757
NCBI chr17:59,151,136...59,151,221
Ensembl chr17:59,151,136...59,151,221
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GATA3
GATA binding protein 3
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:18776904)
Ensembl MGI
PMID:18776904
GO_REF:0000107
NCBI chr10:8,045,333...8,075,198
Ensembl chr10:8,045,378...8,075,198
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HLA-DRA
major histocompatibility complex, class II, DR alpha
involved_in
IDA
(PMID:15322540)
UniProt
PMID:15322540
NCBI chr 6:32,439,887...32,445,046
Ensembl chr 6:32,439,878...32,445,046
G
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
involved_in
IDA
(PMID:15322540)
UniProt
PMID:15322540
NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,577,902...32,589,848
G
IRF4
interferon regulatory factor 4
involved_in
NAS
(PMID:12374808)
UniProt
PMID:12374808
NCBI chr 6:391,752...411,443
Ensembl chr 6:391,739...411,443
G
ZBTB7B
zinc finger and BTB domain containing 7B
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:18776904)
Ensembl MGI
PMID:18776904
GO_REF:0000107
NCBI chr 1:155,001,750...155,018,523
Ensembl chr 1:155,002,630...155,018,523
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
biological_process
19613
immune system process
3224
leukocyte activation
1137
lymphocyte activation
931
T cell activation
666
alpha-beta T cell activation
221
CD4-positive, alpha-beta T cell activation
145
CD4-positive, alpha-beta T cell differentiation
112
regulation of CD4-positive, alpha-beta T cell differentiation
68
negative regulation of CD4-positive, alpha-beta T cell differentiation +
25
positive regulation of CD4-positive, alpha-beta T cell differentiation +
41
regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation +
8
regulation of T-helper cell differentiation +
54
Path 2
biological_process
19613
developmental process
7605
cellular developmental process
5172
cell differentiation
5171
cell development
3453
hemopoiesis
1167
leukocyte differentiation
749
mononuclear cell differentiation
620
lymphocyte differentiation
513
T cell differentiation
365
alpha-beta T cell differentiation
151
CD4-positive, alpha-beta T cell differentiation
112
regulation of CD4-positive, alpha-beta T cell differentiation
68
negative regulation of CD4-positive, alpha-beta T cell differentiation +
25
positive regulation of CD4-positive, alpha-beta T cell differentiation +
41
regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation +
8
regulation of T-helper cell differentiation +
54