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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of T-helper cell differentiation
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Accession:GO:0045622 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of T-helper cell differentiation.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:related_synonym: regulation of T-helper cell development



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regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il12rb2 interleukin 12 receptor subunit beta 2 NAS RGD PMID:10651948 RGD:1331512 NCBI chr 4:96,424,615...96,515,327
Ensembl chr 4:96,426,842...96,515,289
JBrowse link
G RT1-Da RT1 class II, locus Da involved_in ISO (PMID:15322540) RGD PMID:15322540 NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 involved_in ISO (PMID:15322540) RGD PMID:15322540 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO MGI:96109 (MGI:3761239|PMID:16424184) RGD PMID:16424184 MGI:3761239 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
JBrowse link
G Jak3 Janus kinase 3 involved_in ISS
ISO
GO_REF:0000024
(MGI:3719947|PMID:16020505)
BHF-UCL
RGD
PMID:16020505 GO_REF:0000024 MGI:3719947 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536
JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:4942267|PMID:9670042) RGD PMID:9670042 MGI:4942267 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788
JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 involved_in ISO (PMID:23169781) RGD PMID:23169781 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Il2 interleukin 2 involved_in ISO RNAcentral:URS000039ED8D_10090 (MGI:5634593|PMID:25642768) RGD PMID:25642768 MGI:5634593 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:3817792|PMID:18792410)
RGD PMID:18792410 PMID:21873635 MGI:3817792, RGD:13792537 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in ISO (MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:6142401 NCBI chr13:73,174,075...73,245,762
Ensembl chr13:73,173,946...73,238,839
JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 involved_in ISO (MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:6142401 NCBI chr 3:21,121,531...21,186,711
Ensembl chr 3:21,110,679...21,179,933
JBrowse link
G Smad7 SMAD family member 7 involved_in IEA
ISO
GO_REF:0000107
(MGI:5634593|PMID:25642768)
Ensembl
RGD
PMID:25642768 GO_REF:0000107 MGI:5634593 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (MGI:4868293|PMID:21151104) RGD PMID:21151104 MGI:4868293 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831
JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B acts_upstream_of_or_within ISO MGI:3530739 (MGI:5450776|PMID:23034280) RGD PMID:23034280 MGI:5450776 NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236
JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A involved_in ISS
ISO
GO_REF:0000024
(MGI:6142401|PMID:25282160)
UniProt
RGD
PMID:25282160 GO_REF:0000024 MGI:6142401 NCBI chr 5:137,376,562...137,385,351
Ensembl chr 5:137,376,564...137,385,351
JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Loxl3 lysyl oxidase-like 3 involved_in ISO (MGI:5825383|PMID:28065600) RGD PMID:28065600 MGI:5825383 NCBI chr 4:115,540,640...115,556,958
Ensembl chr 4:115,540,685...115,557,466
JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (MGI:4868293|PMID:21151104) RGD PMID:21151104 MGI:4868293 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831
JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in ISO (MGI:5551556|PMID:24107315) RGD PMID:24107315 MGI:5551556 NCBI chr13:73,833,478...73,907,249
Ensembl chr13:73,831,252...73,843,169
JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:17008549)
UniProt
RGD
PMID:17008549 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:96559 (MGI:2450484|PMID:12594267) RGD PMID:12594267 MGI:2450484 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Hlx H2.0-like homeobox acts_upstream_of_or_within ISO MGI:105367|MGI:2182089 (MGI:3761239|PMID:16424184) RGD PMID:16424184 MGI:3761239 NCBI chr13:96,280,335...96,285,750
Ensembl chr13:96,280,339...96,285,750
JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (MGI:3687909|PMID:12242343) RGD PMID:12242343 MGI:3687909 NCBI chr 6:7,481,039...7,512,644
Ensembl chr 6:7,481,095...7,514,834
JBrowse link
G Zfp35 zinc finger protein 35 acts_upstream_of_or_within ISO MGI:4398896 (MGI:4366385|PMID:19783676) RGD PMID:19783676 MGI:4366385 NCBI chr18:15,268,852...15,284,334
Ensembl chr18:15,268,814...15,285,088
JBrowse link
negative regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rc3h1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within ISO MGI:3581675 (MGI:3580753|PMID:15917799) RGD PMID:15917799 MGI:3580753 NCBI chr13:73,174,075...73,245,762
Ensembl chr13:73,173,946...73,238,839
JBrowse link
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:17008549)
UniProt
RGD
PMID:17008549 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (MGI:3576832|PMID:15845453) RGD PMID:15845453 MGI:3576832 NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308
JBrowse link
G Hlx H2.0-like homeobox acts_upstream_of_or_within ISO MGI:105367|MGI:2182089 (MGI:3761239|PMID:16424184) RGD PMID:16424184 MGI:3761239 NCBI chr13:96,280,335...96,285,750
Ensembl chr13:96,280,339...96,285,750
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of_or_within ISO MGI:2446070 (MGI:2176424|PMID:11894097) RGD PMID:11894097 MGI:2176424 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (MGI:3687909|PMID:12242343) RGD PMID:12242343 MGI:3687909 NCBI chr 6:7,481,039...7,512,644
Ensembl chr 6:7,481,095...7,514,834
JBrowse link
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Malt1 MALT1 paracaspase involved_in ISO (MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:6142401 NCBI chr18:58,942,282...58,996,318
Ensembl chr18:58,942,299...58,994,260
JBrowse link
G Mir326 microRNA 326 acts_upstream_of_or_within ISO (MGI:4436838|PMID:19838199) RGD PMID:19838199 MGI:4436838 NCBI chr 1:153,854,029...153,854,123
Ensembl chr 1:153,854,029...153,854,123
JBrowse link
G Nfkbid NFKB inhibitor delta involved_in ISO (MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:6142401 NCBI chr 1:85,679,353...85,690,415
Ensembl chr 1:85,680,861...85,690,447
JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO (MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:6142401 NCBI chr11:44,782,676...44,810,723
Ensembl chr11:44,782,676...44,810,723
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in ISO (MGI:5689221|PMID:26098997) RGD PMID:26098997 MGI:5689221 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il23a interleukin 23 subunit alpha involved_in IBA
ISO
PMID:21873635
(MGI:3851279|PMID:19501566)
RGD PMID:19501566 PMID:21873635 MGI:3851279, RGD:13792537 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il18 interleukin 18 involved_in IEA
ISO
GO_REF:0000107
(MGI:3608083|PMID:12829194)
Ensembl
RGD
PMID:12829194 GO_REF:0000107 MGI:3608083 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO MGI:96109 (MGI:3761239|PMID:16424184) RGD PMID:16424184 MGI:3761239 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
JBrowse link
G Il6 interleukin 6 acts_upstream_of_or_within ISO (MGI:2450484|PMID:12594267) RGD PMID:12594267 MGI:2450484 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in ISO (MGI:5689221|PMID:26098997) RGD PMID:26098997 MGI:5689221 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Prkcz protein kinase C, zeta involved_in ISS
ISO
GO_REF:0000024
(MGI:3584076|PMID:15987782)
UniProt
RGD
PMID:15987782 GO_REF:0000024 MGI:3584076 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Rara retinoic acid receptor, alpha involved_in ISO (PMID:18416830) RGD PMID:18416830 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:4943387|PMID:18354165) RGD PMID:18354165 MGI:4943387 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788
JBrowse link
positive regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myb MYB proto-oncogene, transcription factor involved_in ISO (PMID:20484083) RGD PMID:20484083 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057
JBrowse link
G Shb SH2 domain containing adaptor protein B acts_upstream_of_or_within ISO MGI:3721903 (MGI:5617929|PMID:24645804) RGD PMID:24645804 MGI:5617929 NCBI chr 5:59,678,066...59,785,443
Ensembl chr 5:59,678,216...59,785,538
JBrowse link
regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il27 interleukin 27 involved_in IBA
ISO
PMID:21873635
(PMID:12734330)
RGD PMID:12734330 PMID:21873635 RGD:13792537 NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582
JBrowse link
regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl20 C-C motif chemokine ligand 20 NOT|involved_in ISO (MGI:3820359|PMID:19050256) RGD PMID:19050256 MGI:3820359 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 NOT|involved_in ISO (MGI:3820359|PMID:19050256) RGD PMID:19050256 MGI:3820359 NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603
JBrowse link
G Mir301a microRNA 301a acts_upstream_of_or_within ISO (MGI:5426073|PMID:22517757) RGD PMID:22517757 MGI:5426073 NCBI chr10:71,925,336...71,925,435
Ensembl chr10:71,925,336...71,925,435
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    immune system process 2829
      regulation of immune system process 1530
        regulation of immune response 930
          regulation of T-helper cell differentiation 40
            negative regulation of T-helper cell differentiation + 19
            positive regulation of T-helper cell differentiation + 19
            regulation of T-helper 1 cell differentiation + 9
            regulation of T-helper 17 cell differentiation + 20
            regulation of T-helper 2 cell differentiation + 12
Path 2
Term Annotations click to browse term
  biological_process 19497
    developmental process 6889
      anatomical structure development 6306
        multicellular organism development 5727
          system development 5373
            immune system development 1105
              hematopoietic or lymphoid organ development 1038
                hemopoiesis 986
                  leukocyte differentiation 617
                    mononuclear cell differentiation 479
                      lymphocyte differentiation 427
                        T cell differentiation 300
                          T cell differentiation involved in immune response 79
                            alpha-beta T cell differentiation involved in immune response 71
                              CD4-positive, alpha-beta T cell differentiation involved in immune response 70
                                T-helper cell differentiation 68
                                  regulation of T-helper cell differentiation 40
                                    negative regulation of T-helper cell differentiation + 19
                                    positive regulation of T-helper cell differentiation + 19
                                    regulation of T-helper 1 cell differentiation + 9
                                    regulation of T-helper 17 cell differentiation + 20
                                    regulation of T-helper 2 cell differentiation + 12
paths to the root