Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of HLX mRNA | CTD | PMID:30165855 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Hlx (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of HLX mRNA | CTD | PMID:24058054 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Hlx (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of HLX mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Hlx (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of HLX mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Hlx (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of HLX mRNA | CTD | PMID:32109520 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HLX mRNA more ... | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of HLX mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | affects methylation | ISO | Hlx (Mus musculus) | 6480464 | bisphenol S affects the methylation of HLX gene | CTD | PMID:31683443 | 4,4'-sulfonyldiphenol | increases expression | ISO | Hlx (Mus musculus) | 6480464 | bisphenol S results in increased expression of HLX mRNA | CTD | PMID:30951980 | 4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid | decreases expression | EXP | | 6480464 | Am 580 results in decreased expression of HLX mRNA | CTD | PMID:16982809 | 4-hydroxynon-2-enal | decreases expression | ISO | Hlx (Mus musculus) | 6480464 | 4-hydroxy-2-nonenal results in decreased expression of HLX mRNA | CTD | PMID:19191707 | acetamide | increases expression | ISO | Hlx (Rattus norvegicus) | 6480464 | acetamide results in increased expression of HLX mRNA | CTD | PMID:31881176 | acrylamide | decreases expression | ISO | Hlx (Rattus norvegicus) | 6480464 | Acrylamide results in decreased expression of HLX mRNA | CTD | PMID:28959563 | acrylamide | increases expression | ISO | Hlx (Mus musculus) | 6480464 | Acrylamide results in increased expression of HLX mRNA | CTD | PMID:30807115 | aflatoxin B1 | decreases expression | EXP | | 6480464 | Aflatoxin B1 results in decreased expression of HLX mRNA | CTD | PMID:21641981 | aflatoxin B1 | increases expression | ISO | Hlx (Rattus norvegicus) | 6480464 | Aflatoxin B1 results in increased expression of HLX mRNA | CTD | PMID:33354967 | all-trans-retinoic acid | affects expression | EXP | | 6480464 | Tretinoin affects the expression of HLX mRNA | CTD | PMID:15498508 | amitrole | increases expression | ISO | Hlx (Rattus norvegicus) | 6480464 | Amitrole results in increased expression of HLX mRNA | CTD | PMID:30047161 | amosite asbestos | decreases methylation | EXP | | 6480464 | Asbestos and Amosite results in decreased methylation of HLX promoter | CTD | PMID:29626692 | benzo[a]pyrene | multiple interactions | ISO | Hlx (Mus musculus) | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of HLX mRNA] | CTD | PMID:22228805 | benzo[a]pyrene | increases methylation | EXP | | 6480464 | Benzo(a)pyrene results in increased methylation of HLX exon and Benzo(a)pyrene results in increased methylation of HLX promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | Hlx (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of HLX mRNA | CTD | PMID:32417428 | benzo[b]fluoranthene | increases expression | ISO | Hlx (Mus musculus) | 6480464 | benzo(b)fluoranthene results in increased expression of HLX mRNA | CTD | PMID:26377693 | bis(2-ethylhexyl) phthalate | increases expression | ISO | Hlx (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in increased expression of HLX mRNA | CTD | PMID:28085963 | bisphenol A | affects expression | ISO | Hlx (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of HLX mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | ISO | Hlx (Mus musculus) | 6480464 | bisphenol A results in increased expression of HLX mRNA | CTD | PMID:32156529 | bisphenol A | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HLX mRNA | CTD | PMID:28628672 | bisphenol A | affects methylation | ISO | Hlx (Mus musculus) | 6480464 | bisphenol A affects the methylation of HLX promoter | CTD | PMID:27334623 | bisphenol F | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of HLX mRNA | CTD | PMID:28628672 | buta-1,3-diene | decreases expression | ISO | Hlx (Mus musculus) | 6480464 | 1 and 3-butadiene results in decreased expression of HLX mRNA | CTD | PMID:29038090 | cefaloridine | decreases expression | ISO | Hlx (Rattus norvegicus) | 6480464 | Cephaloridine results in decreased expression of HLX mRNA | CTD | PMID:18500788 | chloroprene | decreases expression | ISO | Hlx (Mus musculus) | 6480464 | Chloroprene results in decreased expression of HLX mRNA | CTD | PMID:23125180 | chlorpyrifos | increases expression | ISO | Hlx (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of HLX mRNA | CTD | PMID:37019170 | choline | multiple interactions | ISO | Hlx (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HLX gene | CTD | PMID:20938992 | cisplatin | decreases expression | EXP | | 6480464 | Cisplatin results in decreased expression of HLX mRNA | CTD | PMID:27392435 | cisplatin | multiple interactions | EXP | | 6480464 | Cisplatin promotes the reaction [jinfukang results in decreased expression of HLX mRNA] and jinfukang promotes the reaction [Cisplatin results in decreased expression of HLX mRNA] | CTD | PMID:27392435 | copper atom | multiple interactions | EXP | | 6480464 | [Chelating Agents binds to Copper] which results in decreased expression of HLX mRNA | CTD | PMID:31162603 | copper(0) | multiple interactions | EXP | | 6480464 | [Chelating Agents binds to Copper] which results in decreased expression of HLX mRNA | CTD | PMID:31162603 | crocidolite asbestos | decreases methylation | EXP | | 6480464 | Asbestos and Crocidolite results in decreased methylation of HLX promoter | CTD | PMID:29626692 | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of HLX mRNA | CTD | PMID:27989131 | deoxynivalenol | increases expression | EXP | | 6480464 | deoxynivalenol results in increased expression of HLX mRNA | CTD | PMID:31863870 | dexamethasone | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HLX mRNA more ... | CTD | PMID:28628672 | diallyl trisulfide | increases expression | EXP | | 6480464 | diallyl trisulfide results in increased expression of HLX mRNA | CTD | PMID:34995734 | doxorubicin | decreases expression | EXP | | 6480464 | Doxorubicin results in decreased expression of HLX mRNA | CTD | PMID:29803840 | endosulfan | increases expression | ISO | Hlx (Rattus norvegicus) | 6480464 | Endosulfan results in increased expression of HLX mRNA | CTD | PMID:29391264 | entinostat | decreases expression | EXP | | 6480464 | entinostat results in decreased expression of HLX mRNA | CTD | PMID:27188386 | fenthion | increases expression | ISO | Hlx (Mus musculus) | 6480464 | Fenthion results in increased expression of HLX mRNA | CTD | PMID:34813904 | folic acid | multiple interactions | ISO | Hlx (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HLX gene | CTD | PMID:20938992 | fonofos | increases methylation | EXP | | 6480464 | Fonofos results in increased methylation of HLX promoter | CTD | PMID:22847954 | FR900359 | decreases phosphorylation | EXP | | 6480464 | FR900359 results in decreased phosphorylation of HLX protein | CTD | PMID:37730182 | indometacin | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HLX mRNA more ... | CTD | PMID:28628672 | iron dichloride | decreases expression | EXP | | 6480464 | ferrous chloride results in decreased expression of HLX mRNA | CTD | PMID:35984750 | L-methionine | multiple interactions | ISO | Hlx (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HLX gene | CTD | PMID:20938992 | methylisothiazolinone | increases expression | EXP | | 6480464 | 2-methyl-4-isothiazolin-3-one results in increased expression of HLX mRNA | CTD | PMID:31629900 | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine | decreases expression | EXP | | 6480464 | N more ... | CTD | PMID:12756304 | paracetamol | decreases expression | ISO | Hlx (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of HLX mRNA | CTD | PMID:33387578 | parathion | increases methylation | EXP | | 6480464 | Parathion results in increased methylation of HLX promoter | CTD | PMID:22847954 | pirinixic acid | multiple interactions | EXP | | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of HLX mRNA | CTD | PMID:19710929 | protein kinase inhibitor | multiple interactions | EXP | | 6480464 | Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of HLX mRNA] | CTD | PMID:28003376 | S-(1,2-dichlorovinyl)-L-cysteine | decreases expression | EXP | | 6480464 | S-(1 and 2-dichlorovinyl)cysteine results in decreased expression of HLX mRNA | CTD | PMID:33725128 | sulfadimethoxine | increases expression | ISO | Hlx (Rattus norvegicus) | 6480464 | Sulfadimethoxine results in increased expression of HLX mRNA | CTD | PMID:30047161 | tamibarotene | affects expression | EXP | | 6480464 | tamibarotene affects the expression of HLX mRNA | CTD | PMID:15498508 | terbufos | increases methylation | EXP | | 6480464 | terbufos results in increased methylation of HLX promoter | CTD | PMID:22847954 | thioacetamide | increases expression | ISO | Hlx (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of HLX mRNA | CTD | PMID:34492290 | titanium dioxide | decreases expression | ISO | Hlx (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of HLX mRNA | CTD | PMID:23409001 | trichloroethene | increases expression | ISO | Hlx (Rattus norvegicus) | 6480464 | Trichloroethylene results in increased expression of HLX mRNA | CTD | PMID:33387578 | triclosan | increases expression | EXP | | 6480464 | Triclosan results in increased expression of HLX mRNA | CTD | PMID:30510588 | valproic acid | increases methylation | EXP | | 6480464 | Valproic Acid results in increased methylation of HLX gene | CTD | PMID:29154799 | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of HLX mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | Hlx (Rattus norvegicus) | 6480464 | Valproic Acid results in decreased expression of HLX mRNA | CTD | PMID:34779009 | |