IL27 (interleukin 27) - Rat Genome Database

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Gene: IL27 (interleukin 27) Homo sapiens
Analyze
Symbol: IL27
Name: interleukin 27
RGD ID: 1343577
HGNC Page HGNC:19157
Description: Predicted to enable interleukin-27 receptor binding activity. Involved in positive regulation of type II interferon production and regulation of T-helper 1 cell differentiation. Predicted to be located in cytosol; endoplasmic reticulum lumen; and extracellular region. Predicted to be active in extracellular space. Implicated in asthma; chronic obstructive pulmonary disease; and pulmonary tuberculosis. Biomarker of several diseases, including Henoch-Schoenlein purpura; hepatitis B; infectious mononucleosis; peptic ulcer disease (multiple); and tuberculosis (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: IL-27; IL-27 p28 subunit; IL-27 subunit alpha; IL-27-A; IL-27A; IL27-A; IL27A; IL27p28; IL30; interleukin 30; interleukin-27 subunit alpha; interleukin-30; MGC71873; p28
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381628,499,362 - 28,506,834 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1628,499,362 - 28,512,051 (-)EnsemblGRCh38hg38GRCh38
GRCh371628,510,683 - 28,518,155 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361628,418,184 - 28,425,656 (-)NCBINCBI36Build 36hg18NCBI36
Build 341628,418,472 - 28,425,633NCBI
Celera1627,685,614 - 27,693,084 (+)NCBICelera
Cytogenetic Map16p12.1-p11.2NCBI
HuRef1626,536,601 - 26,544,073 (-)NCBIHuRef
CHM1_11629,522,293 - 29,529,765 (-)NCBICHM1_1
T2T-CHM13v2.01628,869,090 - 28,896,415 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Schizophrenia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. IL-27 enhances Leishmania amazonensis infection via ds-RNA dependent kinase (PKR) and IL-10 signaling. Barreto-de-Souza V, etal., Immunobiology. 2015 Apr;220(4):437-44. doi: 10.1016/j.imbio.2014.11.006. Epub 2014 Nov 15.
2. Activation of IL-27 signalling promotes development of postinfluenza pneumococcal pneumonia. Cao J, etal., EMBO Mol Med. 2014 Jan;6(1):120-40. doi: 10.1002/emmm.201302890.
3. IL-27 controls sepsis-induced impairment of lung antibacterial host defence. Cao J, etal., Thorax. 2014 Oct;69(10):926-37. doi: 10.1136/thoraxjnl-2014-205777. Epub 2014 Jul 29.
4. Identification of polymorphisms in human interleukin-27 and their association with asthma in a Korean population. Chae SC, etal., J Hum Genet. 2007;52(4):355-61. Epub 2007 Feb 22.
5. Cytomegalovirus-Specific IL-10-Producing CD4+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence. Clement M, etal., PLoS Pathog. 2016 Dec 7;12(12):e1006050. doi: 10.1371/journal.ppat.1006050. eCollection 2016 Dec.
6. A spontaneous model of spondyloarthropathies that develops bone loss and pathological bone formation: A process regulated by IL27RA-/- and mutant-p53. Dibra D, etal., PLoS One. 2018 Mar 1;13(3):e0193485. doi: 10.1371/journal.pone.0193485. eCollection 2018.
7. Association of Interleukin-27 rs 153109 Single Nucleotide Polymorphism with Spontaneous Resolution of Hepatitis C Virus - Genotype 4a Infection in Egyptian Patients. Fawzy MM, etal., Asian Pac J Cancer Prev. 2016;17(4):2093-7. doi: 10.7314/apjcp.2016.17.4.2093.
8. Interleukin-27 exhibited anti-inflammatory activity during Plasmodium berghei infection in mice. Fazalul Rahiman SS, etal., Trop Biomed. 2013 Dec;30(4):663-80.
9. Production of both IL-27 and IFN-gamma after the treatment with a ligand for invariant NK T cells is responsible for the suppression of Th2 response and allergic inflammation in a mouse experimental asthma model. Fujita H, etal., J Immunol. 2009 Jul 1;183(1):254-60.
10. Human Immunodeficiency Virus Type-1 Myeloid Derived Suppressor Cells Inhibit Cytomegalovirus Inflammation through Interleukin-27 and B7-H4. Garg A, etal., Sci Rep. 2017 Mar 24;7:44485. doi: 10.1038/srep44485.
11. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
12. The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology. Hall AO, etal.
13. Interleukin-27: a novel biomarker in predicting bacterial infection among the critically ill. Hanna WJ, etal., Crit Care. 2015 Oct 30;19:378. doi: 10.1186/s13054-015-1095-2.
14. Interleukin-27R Signaling Mediates Early Viral Containment and Impacts Innate and Adaptive Immunity after Chronic Lymphocytic Choriomeningitis Virus Infection. Harker JA, etal., J Virol. 2018 May 29;92(12). pii: JVI.02196-17. doi: 10.1128/JVI.02196-17. Print 2018 Jun 15.
15. Relationship of IL27 gene polymorphisms with the risk of pulmonary tuberculosis in Chinese Han population. He C and Liu J, Int J Clin Exp Pathol. 2018 Aug 1;11(8):4147-4152. eCollection 2018.
16. The interleukin-27 -964A>G polymorphism enhances sepsis-induced inflammatory responses and confers susceptibility to the development of sepsis. He J, etal., Crit Care. 2018 Sep 30;22(1):248. doi: 10.1186/s13054-018-2180-0.
17. Interleukin-27 is differentially associated with HIV viral load and CD4+ T cell counts in therapy-naïve HIV-mono-infected and HIV/HCV-co-infected Chinese. He L, etal., PLoS One. 2014 May 9;9(5):e96792. doi: 10.1371/journal.pone.0096792. eCollection 2014.
18. Interleukin 27 inhibits atherosclerosis via immunoregulation of macrophages in mice. Hirase T, etal., Am J Physiol Heart Circ Physiol. 2013 Aug 1;305(3):H420-9. doi: 10.1152/ajpheart.00198.2013. Epub 2013 May 31.
19. Interleukin-27 as a Novel Biomarker for Early Cardiopulmonary Failure in Enterovirus 71-Infected Children with Central Nervous System Involvement. Huang M, etal., Mediators Inflamm. 2016;2016:4025167. doi: 10.1155/2016/4025167. Epub 2016 Jun 15.
20. Association of interleukin (IL)-12 and IL-27 gene polymorphisms with chronic obstructive pulmonary disease in a Chinese population. Huang N, etal., DNA Cell Biol. 2008 Sep;27(9):527-31.
21. Circulating interleukin-27 levels in Helicobacter pylori-infected patients with gastric or duodenal ulcers, independent of the bacterial cytotoxin-associated gene A virulence factor. Jafarzadeh A, etal., J Dig Dis. 2011 Aug;12(4):302-7. doi: 10.1111/j.1751-2980.2011.00510.x.
22. Rather than interleukin-27, interleukin-6 expresses positive correlation with liver severity in naïve hepatitis B infection patients. Kao JT, etal., Liver Int. 2012 Jul;32(6):928-36. doi: 10.1111/j.1478-3231.2011.02742.x. Epub 2012 Jan 9.
23. Interleukin-27-Producing CD4(+) T Cells Regulate Protective Immunity during Malaria Parasite Infection. Kimura D, etal., Immunity. 2016 Mar 15;44(3):672-82. doi: 10.1016/j.immuni.2016.02.011. Epub 2016 Mar 8.
24. IL-27/IFN-gamma induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages. Li JJ, etal., J Immunol. 2010 Oct 1;185(7):4401-9. Epub 2010 Sep 3.
25. Diagnostic Accuracy of Interleukin-27 in Bronchoalveolar Lavage Fluids for Pulmonary Tuberculosis. Lin S, etal., Infect Drug Resist. 2019 Dec 2;12:3755-3763. doi: 10.2147/IDR.S231215. eCollection 2019.
26. Influenza A virus induces interleukin-27 through cyclooxygenase-2 and protein kinase A signaling. Liu L, etal., J Biol Chem. 2012 Apr 6;287(15):11899-910. doi: 10.1074/jbc.M111.308064. Epub 2012 Feb 16.
27. Impaired Interleukin-27-Mediated Control of CD4+ T Cell Function Impact on Ectopic Lymphoid Structure Formation in Patients With Sjögren's Syndrome. Lucchesi D, etal., Arthritis Rheumatol. 2020 Sep;72(9):1559-1570. doi: 10.1002/art.41289. Epub 2020 Jul 21.
28. Anti-inflammatory Activity of Caspian Cobra (Naja naja oxiana) Snake Venom on the Serum Level of Interleukin-27 and Histopathological Changes in Myelin Oligodendrocyte Glycoprotein-experimental Autoimmune Encephalomyelitisinduced Mice. Mohammadnejad L, etal., Arch Razi Inst. 2021 Jan;75(4):491-500. doi: 10.22092/ari.2019.126151.1333. Epub 2021 Jan 1.
29. Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses. Moro K, etal., Nat Immunol. 2016 Jan;17(1):76-86. doi: 10.1038/ni.3309. Epub 2015 Nov 23.
30. Interleukin-27 expression following infection with the murine gammaherpesvirus 68. Nelson DA, etal., Cytokine. 2010 Aug;51(2):184-94. doi: 10.1016/j.cyto.2010.04.015. Epub 2010 May 20.
31. The human response to infection is associated with distinct patterns of interleukin 23 and interleukin 27 expression. O'Dwyer MJ, etal., Intensive Care Med. 2008 Apr;34(4):683-91. doi: 10.1007/s00134-007-0968-5. Epub 2008 Jan 29.
32. Deficiency in the frequency and function of Tr1 cells in IgAV and the possible role of IL-27. Pan L, etal., Rheumatology (Oxford). 2020 Dec 6. pii: 6024785. doi: 10.1093/rheumatology/keaa752.
33. Impact of Interleukin-27p28 on T and B Cell Responses during Toxoplasmosis. Park J, etal., Infect Immun. 2019 Nov 18;87(12). pii: IAI.00455-19. doi: 10.1128/IAI.00455-19. Print 2019 Dec.
34. Genes related to antiviral activity, cell migration, and lysis are differentially expressed in CD4(+) T cells in human t cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis patients. Pinto MT, etal., AIDS Res Hum Retroviruses. 2014 Jun;30(6):610-22. doi: 10.1089/aid.2013.0109. Epub 2013 Oct 16.
35. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
36. Interleukin-27 (IL-27) Mediates Susceptibility to Visceral Leishmaniasis by Suppressing the IL-17-Neutrophil Response. Quirino GFS, etal., Infect Immun. 2016 Jul 21;84(8):2289-2298. doi: 10.1128/IAI.00283-16. Print 2016 Aug.
37. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. Production of interleukin-27 by human neutrophils regulates their function during bacterial infection. Rinchai D, etal., Eur J Immunol. 2012 Dec;42(12):3280-90. doi: 10.1002/eji.201242526. Epub 2012 Oct 25.
40. Interleukin-27 is abrogated in gastric cancer, but highly expressed in other Helicobacter pylori-associated gastroduodenal diseases. Rocha GA, etal., Helicobacter. 2020 Feb;25(1):e12667. doi: 10.1111/hel.12667. Epub 2019 Nov 8.
41. Elevated Levels of Interleukin-27 in Early Life Compromise Protective Immunity in a Mouse Model of Gram-Negative Neonatal Sepsis. Seman BG, etal., Infect Immun. 2020 Feb 20;88(3). pii: IAI.00828-19. doi: 10.1128/IAI.00828-19. Print 2020 Feb 20.
42. Interleukin-27 improves the ability of adenosine deaminase to rule out tuberculous pleural effusion regardless of pleural tuberculosis prevalence. Skouras VS, etal., Infect Dis (Lond). 2015 Jul;47(7):477-83. doi: 10.3109/23744235.2015.1019919. Epub 2015 Mar 10.
43. [Diagnostic value of interleukin-27 in tuberculous pleural effusion]. Sun M, etal., Zhonghua Yi Xue Za Zhi. 2014 Sep 16;94(34):2641-4.
44. IL-27 Suppresses Antimicrobial Activity in Human Leprosy. Teles RMB, etal., J Invest Dermatol. 2015 Oct;135(10):2410-2417. doi: 10.1038/jid.2015.195. Epub 2015 Jun 1.
45. Increased IL-27/IL-27R expression in association with the immunopathology of murine ocular toxoplasmosis. Tong X, etal., Parasitol Res. 2018 Jul;117(7):2255-2263. doi: 10.1007/s00436-018-5914-7. Epub 2018 May 19.
46. Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection. Torrado E, etal., J Exp Med. 2015 Aug 24;212(9):1449-63. doi: 10.1084/jem.20141520. Epub 2015 Aug 17.
47. Association between polymorphisms of cytokine genes and secretion of IL-12p70, IL-18, and IL-27 by dendritic cells in patients with pulmonary tuberculosis. Urazova OI, etal., Tuberculosis (Edinb). 2019 Mar;115:56-62. doi: 10.1016/j.tube.2019.02.003. Epub 2019 Feb 6.
48. Interleukin 27 could be useful in the diagnosis of tuberculous pleural effusions. Valdés L, etal., Respir Care. 2014 Mar;59(3):399-405. doi: 10.4187/respcare.02749. Epub 2013 Aug 20.
49. Modified adenine (9-benzyl-2-butoxy-8-hydroxyadenine) redirects Th2-mediated murine lung inflammation by triggering TLR7. Vultaggio A, etal., J Immunol. 2009 Jan 15;182(2):880-9.
50. The correlation between hepatitis B virus infection and IL-27. Wang HL, etal., Biomed Mater Eng. 2012;22(1-3):187-93. doi: 10.3233/BME-2012-0706.
51. IL-27/IL-27 Receptor Signaling Provides Protection in Clostridium difficile-Induced Colitis. Wang L, etal., J Infect Dis. 2018 Jan 4;217(2):198-207. doi: 10.1093/infdis/jix581.
52. Diagnostic accuracy of interleukin 27 for tuberculous pleural effusion: two prospective studies and one meta-analysis. Wang W, etal., Thorax. 2018 Mar;73(3):240-247. doi: 10.1136/thoraxjnl-2016-209718. Epub 2017 Aug 26.
53. Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27. Wirtz S, etal., J Exp Med. 2006 Aug 7;203(8):1875-81. doi: 10.1084/jem.20060471. Epub 2006 Jul 31.
54. Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells. Yan J, etal., J Hepatol. 2016 May;64(5):1128-1136. doi: 10.1016/j.jhep.2015.12.020. Epub 2016 Jan 6.
55. IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation. Yoshimoto T, etal., J Immunol. 2007 Oct 1;179(7):4415-23.
56. Elevated serum interleukin-27 levels in patients with systemic sclerosis: association with T cell, B cell and fibroblast activation. Yoshizaki A, etal., Ann Rheum Dis. 2011 Jan;70(1):194-200. Epub 2010 Aug 12.
57. Association of the Interleukin-27 Gene Expression and Hepatitis B Virus Infection in Liver Transplanted Patients. Zare A, etal., Exp Clin Transplant. 2017 Oct;15(5):554-560. doi: 10.6002/ect.2015.0243. Epub 2016 Feb 26.
58. Comparison of the interleukin 27 expression for the acute and chronic phase of mononucleosis in children. Zelazowska-Rutkowska B, etal., Cytokine. 2021 May;141:155395. doi: 10.1016/j.cyto.2020.155395. Epub 2021 Feb 8.
59. Interleukin-27 inhibits vaccine-enhanced pulmonary disease following respiratory syncytial virus infection by regulating cellular memory responses. Zeng R, etal., J Virol. 2012 Apr;86(8):4505-17. doi: 10.1128/JVI.07091-11. Epub 2012 Feb 1.
60. Elevated Serum IgG Levels Positively Correlated with IL-27 May Indicate Poor Outcome in Patients with HBV-Related Acute-On-Chronic Liver Failure. Zhang GL, etal., J Immunol Res. 2019 May 6;2019:1538439. doi: 10.1155/2019/1538439. eCollection 2019.
61. High level of IL-27 positively correlated with Th17 cells may indicate liver injury in patients infected with HBV. Zhang GL, etal., Liver Int. 2014 Feb;34(2):266-73. doi: 10.1111/liv.12268. Epub 2013 Jul 25.
62. Activation of IL-27 p28 gene transcription by interferon regulatory factor 8 in cooperation with interferon regulatory factor 1. Zhang J, etal., J Biol Chem. 2010 Jul 9;285(28):21269-81. doi: 10.1074/jbc.M110.100818. Epub 2010 Apr 30.
63. Hepatitis B virus enhances interleukin-27 expression both in vivo and in vitro. Zhu C, etal., Clin Immunol. 2009 Apr;131(1):92-7. doi: 10.1016/j.clim.2008.10.011. Epub 2008 Dec 9.
64. Interleukin-27 ameliorates coxsackievirus-B3-induced viral myocarditis by inhibiting Th17 cells. Zhu H, etal., Virol J. 2015 Nov 14;12:189. doi: 10.1186/s12985-015-0418-x.
Additional References at PubMed
PMID:12121660   PMID:12477932   PMID:12734330   PMID:14657353   PMID:14764690   PMID:15793300   PMID:16670296   PMID:16670765   PMID:16751375   PMID:17068156   PMID:17207965   PMID:17703412  
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Genomics

Comparative Map Data
IL27
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381628,499,362 - 28,506,834 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1628,499,362 - 28,512,051 (-)EnsemblGRCh38hg38GRCh38
GRCh371628,510,683 - 28,518,155 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361628,418,184 - 28,425,656 (-)NCBINCBI36Build 36hg18NCBI36
Build 341628,418,472 - 28,425,633NCBI
Celera1627,685,614 - 27,693,084 (+)NCBICelera
Cytogenetic Map16p12.1-p11.2NCBI
HuRef1626,536,601 - 26,544,073 (-)NCBIHuRef
CHM1_11629,522,293 - 29,529,765 (-)NCBICHM1_1
T2T-CHM13v2.01628,869,090 - 28,896,415 (+)NCBIT2T-CHM13v2.0
Il27
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,188,181 - 126,194,197 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,188,182 - 126,194,113 (-)EnsemblGRCm39 Ensembl
GRCm387126,589,009 - 126,595,035 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7126,589,010 - 126,594,941 (-)EnsemblGRCm38mm10GRCm38
MGSCv377133,732,809 - 133,738,424 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367126,380,443 - 126,386,058 (-)NCBIMGSCv36mm8
Celera7126,438,423 - 126,444,039 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.18NCBI
Il27
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,603,684 - 190,609,292 (-)NCBIGRCr8
mRatBN7.21181,173,108 - 181,178,720 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,173,372 - 181,178,582 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01198,003,615 - 198,010,112 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,003,683 - 198,008,893 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01204,981,789 - 204,987,782 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,730,394 - 185,735,604 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1178,831,320 - 178,837,817 (-)NCBICelera
Cytogenetic Map1q36NCBI
Il27
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554936,712,005 - 6,717,417 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554936,712,005 - 6,717,417 (-)NCBIChiLan1.0ChiLan1.0
IL27
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21831,104,366 - 31,111,861 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11634,982,084 - 34,989,328 (+)NCBINHGRI_mPanPan1
PanPan1.11628,979,717 - 28,984,655 (-)NCBIpanpan1.1PanPan1.1panPan2
IL27
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1618,243,988 - 18,248,369 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl618,244,040 - 18,247,635 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,822,685 - 19,827,046 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0618,380,027 - 18,384,391 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl618,380,086 - 18,384,093 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1618,179,035 - 18,183,396 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0618,094,139 - 18,098,496 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0618,410,212 - 18,414,571 (+)NCBIUU_Cfam_GSD_1.0
Il27
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344123,875,494 - 123,879,941 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650111,973,385 - 11,976,583 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650111,972,715 - 11,978,152 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL27
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl318,421,981 - 18,427,915 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1318,421,962 - 18,427,916 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IL27
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1526,348,559 - 26,358,028 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl526,348,848 - 26,356,360 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660683,217,584 - 3,222,518 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il27
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478213,009,564 - 13,015,440 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478213,009,450 - 13,015,548 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in IL27
24 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16p12.2-11.2(chr16:21463739-29249579)x3 copy number gain See cases [RCV000051829] Chr16:21463739..29249579 [GRCh38]
Chr16:21475060..29260900 [GRCh37]
Chr16:21382561..29168401 [NCBI36]
Chr16:16p12.2-11.2		 pathogenic
GRCh38/hg38 16p12.2-11.2(chr16:21602183-29314373)x3 copy number gain See cases [RCV000051842] Chr16:21602183..29314373 [GRCh38]
Chr16:21613504..29325694 [GRCh37]
Chr16:21521005..29233195 [NCBI36]
Chr16:16p12.2-11.2		 pathogenic
GRCh38/hg38 16p12.2-11.2(chr16:23047969-30632245)x3 copy number gain See cases [RCV000052401] Chr16:23047969..30632245 [GRCh38]
Chr16:23059290..30643566 [GRCh37]
Chr16:22966791..30551067 [NCBI36]
Chr16:16p12.2-11.2		 pathogenic
GRCh38/hg38 16p12.1-11.2(chr16:28456967-30295107)x1 copy number loss See cases [RCV000052520] Chr16:28456967..30295107 [GRCh38]
Chr16:28468288..30306428 [GRCh37]
Chr16:28375789..30213929 [NCBI36]
Chr16:16p12.1-11.2		 pathogenic
GRCh38/hg38 16p12.1-11.2(chr16:28293803-29531653)x3 copy number gain See cases [RCV000053118] Chr16:28293803..29531653 [GRCh38]
Chr16:28305124..29542974 [GRCh37]
Chr16:28212625..29450475 [NCBI36]
Chr16:16p12.1-11.2		 uncertain significance
GRCh38/hg38 16p12.1-11.2(chr16:28492482-30179247)x1 copy number loss See cases [RCV000054252] Chr16:28492482..30179247 [GRCh38]
Chr16:28503803..30190568 [GRCh37]
Chr16:28411304..30098069 [NCBI36]
Chr16:16p12.1-11.2		 pathogenic|uncertain significance|conflicting data from submitters
GRCh38/hg38 16p12.1-11.2(chr16:28366111-30183432)x3 copy number gain See cases [RCV000054346] Chr16:28366111..30183432 [GRCh38]
Chr16:28377432..30194753 [GRCh37]
Chr16:28284933..30102254 [NCBI36]
Chr16:16p12.1-11.2		 pathogenic|uncertain significance
GRCh38/hg38 16p12.1-11.2(chr16:28061312-28584375)x3 copy number gain See cases [RCV000053862] Chr16:28061312..28584375 [GRCh38]
Chr16:28072633..28595696 [GRCh37]
Chr16:27980134..28503197 [NCBI36]
Chr16:16p12.1-11.2		 uncertain significance
NM_145659.3(IL27):c.209A>G (p.Glu70Gly) single nucleotide variant Malignant melanoma [RCV000071070] Chr16:28503789 [GRCh38]
Chr16:28515110 [GRCh37]
Chr16:28422611 [NCBI36]
Chr16:16p11.2		 not provided
GRCh38/hg38 16p13.3-11.2(chr16:4644892-29170820)x3 copy number gain See cases [RCV000133809] Chr16:4644892..29170820 [GRCh38]
Chr16:4694893..29182141 [GRCh37]
Chr16:4634894..29089642 [NCBI36]
Chr16:16p13.3-11.2		 pathogenic
GRCh38/hg38 16p12.1-11.2(chr16:28492482-29320029)x3 copy number gain See cases [RCV000135755] Chr16:28492482..29320029 [GRCh38]
Chr16:28503803..29331350 [GRCh37]
Chr16:28411304..29238851 [NCBI36]
Chr16:16p12.1-11.2		 uncertain significance
GRCh38/hg38 16p12.1-11.2(chr16:28492482-29170875)x1 copy number loss See cases [RCV000135759] Chr16:28492482..29170875 [GRCh38]
Chr16:28503803..29182196 [GRCh37]
Chr16:28411304..29089697 [NCBI36]
Chr16:16p12.1-11.2		 likely pathogenic
GRCh38/hg38 16p12.1-11.2(chr16:28492482-30179247)x3 copy number gain See cases [RCV000135765] Chr16:28492482..30179247 [GRCh38]
Chr16:28503803..30190568 [GRCh37]
Chr16:28411304..30098069 [NCBI36]
Chr16:16p12.1-11.2		 pathogenic|uncertain significance
GRCh38/hg38 16p12.2-11.2(chr16:22634385-29227323)x3 copy number gain See cases [RCV000135594] Chr16:22634385..29227323 [GRCh38]
Chr16:22645706..29238644 [GRCh37]
Chr16:22553207..29146145 [NCBI36]
Chr16:16p12.2-11.2		 likely pathogenic
GRCh38/hg38 16p12.1-11.2(chr16:28487211-29202837)x3 copy number gain See cases [RCV000137571] Chr16:28487211..29202837 [GRCh38]
Chr16:28498532..29214158 [GRCh37]
Chr16:28406033..29121659 [NCBI36]
Chr16:16p12.1-11.2		 uncertain significance
GRCh38/hg38 16p12.1-11.2(chr16:28392832-30186020)x1 copy number loss See cases [RCV000137580] Chr16:28392832..30186020 [GRCh38]
Chr16:28404153..30197341 [GRCh37]
Chr16:28311654..30104842 [NCBI36]
Chr16:16p12.1-11.2		 pathogenic
GRCh38/hg38 16p12.1-11.2(chr16:28392832-29342070)x1 copy number loss See cases [RCV000137949] Chr16:28392832..29342070 [GRCh38]
Chr16:28404153..29353391 [GRCh37]
Chr16:28311654..29260892 [NCBI36]
Chr16:16p12.1-11.2		 pathogenic
GRCh38/hg38 16p12.1-11.2(chr16:28327346-29342070)x1 copy number loss See cases [RCV000137848] Chr16:28327346..29342070 [GRCh38]
Chr16:28338667..29353391 [GRCh37]
Chr16:28246168..29260892 [NCBI36]
Chr16:16p12.1-11.2		 pathogenic
GRCh38/hg38 16p12.1-11.2(chr16:28392026-29170879)x3 copy number gain See cases [RCV000139217] Chr16:28392026..29170879 [GRCh38]
Chr16:28403347..29182200 [GRCh37]
Chr16:28310848..29089701 [NCBI36]
Chr16:16p12.1-11.2		 uncertain significance
GRCh38/hg38 16p12.1-11.2(chr16:28392832-30320693)x1 copy number loss See cases [RCV000139916] Chr16:28392832..30320693 [GRCh38]
Chr16:28404153..30332014 [GRCh37]
Chr16:28311654..30239515 [NCBI36]
Chr16:16p12.1-11.2		 pathogenic
GRCh38/hg38 16p12.2-11.2(chr16:21350622-29202837)x3 copy number gain See cases [RCV000140235] Chr16:21350622..29202837 [GRCh38]
Chr16:21361943..29214158 [GRCh37]
Chr16:21269444..29121659 [NCBI36]
Chr16:16p12.2-11.2		 likely pathogenic
GRCh38/hg38 16p12.1-11.2(chr16:27311746-31193406)x3 copy number gain See cases [RCV000140341] Chr16:27311746..31193406 [GRCh38]
Chr16:27323067..31204727 [GRCh37]
Chr16:27230568..31112228 [NCBI36]
Chr16:16p12.1-11.2		 pathogenic
GRCh38/hg38 16p12.1-11.2(chr16:28392832-29320029)x1 copy number loss See cases [RCV000139466] Chr16:28392832..29320029 [GRCh38]
Chr16:28404153..29331350 [GRCh37]
Chr16:28311654..29238851 [NCBI36]
Chr16:16p12.1-11.2		 pathogenic
GRCh38/hg38 16p12.2-11.2(chr16:23752047-31943755)x3 copy number gain See cases [RCV000141141] Chr16:23752047..31943755 [GRCh38]
Chr16:23763368..31955076 [GRCh37]
Chr16:23670869..31862577 [NCBI36]
Chr16:16p12.2-11.2		 pathogenic
GRCh38/hg38 16p12.1-11.2(chr16:28392832-29170875)x1 copy number loss See cases [RCV000140694] Chr16:28392832..29170875 [GRCh38]
Chr16:28404153..29182196 [GRCh37]
Chr16:28311654..29089697 [NCBI36]
Chr16:16p12.1-11.2		 pathogenic
GRCh38/hg38 16p12.1-11.2(chr16:28320366-29415078)x3 copy number gain See cases [RCV000141716] Chr16:28320366..29415078 [GRCh38]
Chr16:28331687..29426399 [GRCh37]
Chr16:28239188..29333900 [NCBI36]
Chr16:16p12.1-11.2		 uncertain significance
GRCh38/hg38 16p12.1-11.2(chr16:28492482-29170875)x3 copy number gain See cases [RCV000142569] Chr16:28492482..29170875 [GRCh38]
Chr16:28503803..29182196 [GRCh37]
Chr16:28411304..29089697 [NCBI36]
Chr16:16p12.1-11.2		 uncertain significance
GRCh38/hg38 16p12.1-11.2(chr16:28492482-30179247)x1 copy number loss See cases [RCV000148148] Chr16:28492482..30179247 [GRCh38]
Chr16:28503803..30190568 [GRCh37]
Chr16:28411304..30098069 [NCBI36]
Chr16:16p12.1-11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:28484556-29043450)x1 copy number loss See cases [RCV000258804] Chr16:28484556..29043450 [GRCh37]
Chr16:16p11.2		 pathogenic
GRCh37/hg19 16p12.3-11.2(chr16:19590412-29814175)x3 copy number gain Breast ductal adenocarcinoma [RCV000207226] Chr16:19590412..29814175 [GRCh37]
Chr16:16p12.3-11.2		 uncertain significance
GRCh37/hg19 16p13.3-11.2(chr16:1279324-31926800)x3 copy number gain Breast ductal adenocarcinoma [RCV000207053] Chr16:1279324..31926800 [GRCh37]
Chr16:16p13.3-11.2		 uncertain significance
GRCh37/hg19 16p11.2(chr16:28486693-29043960)x1 copy number loss See cases [RCV000240493] Chr16:28486693..29043960 [GRCh37]
Chr16:16p11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:28483631-29332591)x3 copy number gain not provided [RCV001270661] Chr16:28483631..29332591 [GRCh37]
Chr16:16p11.2		 uncertain significance
GRCh37/hg19 16p12.3-11.2(chr16:19424115-30142220)x3 copy number gain See cases [RCV000449403] Chr16:19424115..30142220 [GRCh37]
Chr16:16p12.3-11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:28486693-28578470)x3 copy number gain See cases [RCV000446894] Chr16:28486693..28578470 [GRCh37]
Chr16:16p11.2		 likely benign
GRCh37/hg19 16p11.2(chr16:28486693-30197290)x1 copy number loss See cases [RCV000447001] Chr16:28486693..30197290 [GRCh37]
Chr16:16p11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:28486693-29048572)x1 copy number loss See cases [RCV000447021] Chr16:28486693..29048572 [GRCh37]
Chr16:16p11.2		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
NC_000016.10:g.(?_28370872)_(29324276_?)del deletion Schizophrenia [RCV000416901] Chr16:28370872..29324276 [GRCh38]
Chr16:28382193..29335597 [GRCh37]
Chr16:28289694..29243098 [NCBI36]
Chr16:16p12.1-11.2		 likely pathogenic
GRCh37/hg19 16p11.2(chr16:28384463-29343462)x1 copy number loss See cases [RCV000510329] Chr16:28384463..29343462 [GRCh37]
Chr16:16p11.2		 pathogenic
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3		 uncertain significance
GRCh37/hg19 16p11.2(chr16:28441538-30178406)x1 copy number loss See cases [RCV000511533] Chr16:28441538..30178406 [GRCh37]
Chr16:16p11.2		 pathogenic
GRCh37/hg19 16p12.2-11.2(chr16:22718350-28858721)x4 copy number gain See cases [RCV000511587] Chr16:22718350..28858721 [GRCh37]
Chr16:16p12.2-11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:28371467-29426399)x4 copy number gain See cases [RCV000511109] Chr16:28371467..29426399 [GRCh37]
Chr16:16p11.2		 uncertain significance
NC_000016.10:g.(?_28487456)_(28595930_?)del deletion Neuronal ceroid lipofuscinosis [RCV000708291] Chr16:28487456..28595930 [GRCh38]
Chr16:28498777..28607251 [GRCh37]
Chr16:16p12.1-11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:28466730-29427247)x1 copy number loss See cases [RCV000510933] Chr16:28466730..29427247 [GRCh37]
Chr16:16p11.2		 pathogenic
GRCh37/hg19 16p12.2-11.2(chr16:21596299-30399167)x1 copy number loss See cases [RCV000511271] Chr16:21596299..30399167 [GRCh37]
Chr16:16p12.2-11.2		 pathogenic
maternal UPD(16p) complex Hemimegalencephaly [RCV000494707] Chr16:1280042..33710558 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p12.3-11.2(chr16:18238275-30177240)x3 copy number gain See cases [RCV000512428] Chr16:18238275..30177240 [GRCh37]
Chr16:16p12.3-11.2		 pathogenic
GRCh37/hg19 16p12.2-11.2(chr16:21379628-29351826)x3 copy number gain See cases [RCV000512478] Chr16:21379628..29351826 [GRCh37]
Chr16:16p12.2-11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:28389576-29438326)x1 copy number loss not provided [RCV000683798] Chr16:28389576..29438326 [GRCh37]
Chr16:16p11.2		 pathogenic
GRCh37/hg19 16p12.2-11.2(chr16:21379628-29379768)x1 copy number loss not provided [RCV000683786] Chr16:21379628..29379768 [GRCh37]
Chr16:16p12.2-11.2		 pathogenic
NC_000016.9:g.21530207_29332245del deletion not provided [RCV001030428] Chr16:21530207..29332245 [GRCh37]
Chr16:16p12.2-11.2		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
NC_000016.10:g.(?_28351819)_(29325073_?)del deletion Schizophrenia [RCV000754181] Chr16:28351819..29325073 [GRCh38]
Chr16:16p12.1-11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:28349949-29342589) copy number loss Distal 16p11.2 microdeletion syndrome [RCV002280653] Chr16:28349949..29342589 [GRCh37]
Chr16:16p11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:28371467-29416001)x3 copy number gain not provided [RCV000846620] Chr16:28371467..29416001 [GRCh37]
Chr16:16p11.2		 pathogenic
GRCh37/hg19 16p12.2-11.2(chr16:21576802-29351826)x3 copy number gain not provided [RCV001006786] Chr16:21576802..29351826 [GRCh37]
Chr16:16p12.2-11.2		 pathogenic
GRCh37/hg19 16p12.2-11.2(chr16:21475039-29043958)x1 copy number loss Chromosome 16p12.2-p11.2 deletion syndrome [RCV003315282] Chr16:21475039..29043958 [GRCh37]
Chr16:16p12.2-11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:28466730-30177916)x1 copy number loss not provided [RCV000848428] Chr16:28466730..30177916 [GRCh37]
Chr16:16p11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:28466730-28585574)x3 copy number gain not provided [RCV000849661] Chr16:28466730..28585574 [GRCh37]
Chr16:16p11.2		 uncertain significance
GRCh37/hg19 16p12.2-11.2(chr16:21312200-29646379)x3 copy number gain not provided [RCV001249228] Chr16:21312200..29646379 [GRCh37]
Chr16:16p12.2-11.2		 not provided
GRCh37/hg19 16p11.2(chr16:28466730-30191848)x1 copy number loss not provided [RCV000846340] Chr16:28466730..30191848 [GRCh37]
Chr16:16p11.2		 pathogenic
NC_000016.9:g.(?_27441393)_(28899063_?)del deletion not provided [RCV003105580] Chr16:27441393..28899063 [GRCh37]
Chr16:16p12.1-11.2		 uncertain significance
GRCh37/hg19 16p11.2(chr16:28466731-30321320)x1 copy number loss not provided [RCV002472634] Chr16:28466731..30321320 [GRCh37]
Chr16:16p11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:28466730-30178406)x1 copy number loss not provided [RCV001006789] Chr16:28466730..30178406 [GRCh37]
Chr16:16p11.2		 pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:5805001-34230001) copy number gain Microcephaly [RCV001252948] Chr16:5805001..34230001 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:2959279-30190593)x3 copy number gain See cases [RCV001263169] Chr16:2959279..30190593 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic|likely pathogenic
GRCh37/hg19 16p11.2(chr16:28336673-29358712)x1 copy number loss not provided [RCV001258615] Chr16:28336673..29358712 [GRCh37]
Chr16:16p11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:28384463-29343462)x3 copy number gain not provided [RCV001258621] Chr16:28384463..29343462 [GRCh37]
Chr16:16p11.2		 uncertain significance
GRCh37/hg19 16p11.2(chr16:28488319-30178406)x1 copy number loss not provided [RCV001258616] Chr16:28488319..30178406 [GRCh37]
Chr16:16p11.2		 pathogenic
NC_000016.9:g.(?_28488827)_(28950294_?)del deletion Neuronal ceroid lipofuscinosis [RCV001387099] Chr16:28488827..28950294 [GRCh37]
Chr16:16p11.2		 pathogenic
NM_145659.3(IL27):c.175T>G (p.Ser59Ala) single nucleotide variant not provided [RCV001679094] Chr16:28503907 [GRCh38]
Chr16:28515228 [GRCh37]
Chr16:16p11.2		 benign
GRCh37/hg19 16p12.2-11.2(chr16:21594997-29625302)x1 copy number loss not provided [RCV001795549] Chr16:21594997..29625302 [GRCh37]
Chr16:16p12.2-11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:28353878-29478115)x3 copy number gain Distal 16p11.2 microdeletion syndrome [RCV001801190] Chr16:28353878..29478115 [GRCh37]
Chr16:16p11.2		 likely pathogenic
GRCh37/hg19 16p11.2(chr16:28485883-29589674)x1 copy number loss not provided [RCV001834285] Chr16:28485883..29589674 [GRCh37]
Chr16:16p11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:28485883-29416001)x1 copy number loss not provided [RCV001829191] Chr16:28485883..29416001 [GRCh37]
Chr16:16p11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:28384465-29351826)x3 copy number gain not provided [RCV001827743] Chr16:28384465..29351826 [GRCh37]
Chr16:16p11.2		 uncertain significance
NC_000016.9:g.(?_28488837)_(28511261_?)dup duplication Neuronal ceroid lipofuscinosis [RCV001916254] Chr16:28488837..28511261 [GRCh37]
Chr16:16p11.2		 uncertain significance
NC_000016.9:g.(?_27441393)_(29001333_?)del deletion Neuronal ceroid lipofuscinosis [RCV003122400] Chr16:27441393..29001333 [GRCh37]
Chr16:16p12.1-11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:28483659-29341550)x1 copy number loss not provided [RCV002291542] Chr16:28483659..29341550 [GRCh37]
Chr16:16p11.2		 pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:4380767-30445350)x3 copy number gain not provided [RCV002472599] Chr16:4380767..30445350 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:28486929-29351826)x1 copy number loss not provided [RCV002472640] Chr16:28486929..29351826 [GRCh37]
Chr16:16p11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:28384464-29432245)x3 copy number gain not provided [RCV002474709] Chr16:28384464..29432245 [GRCh37]
Chr16:16p11.2		 uncertain significance
GRCh37/hg19 16p12.2-11.2(chr16:21576803-30177240)x3 copy number gain not provided [RCV002474541] Chr16:21576803..30177240 [GRCh37]
Chr16:16p12.2-11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:28490480-29379768)x1 copy number loss not provided [RCV002472918] Chr16:28490480..29379768 [GRCh37]
Chr16:16p11.2		 pathogenic
NM_145659.3(IL27):c.206C>T (p.Ala69Val) single nucleotide variant not specified [RCV004192162] Chr16:28503792 [GRCh38]
Chr16:28515113 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_145659.3(IL27):c.416C>A (p.Ala139Asp) single nucleotide variant not specified [RCV004125177] Chr16:28502022 [GRCh38]
Chr16:28513343 [GRCh37]
Chr16:16p11.2		 uncertain significance
GRCh37/hg19 16p11.2(chr16:28371468-29342589)x3 copy number gain not provided [RCV002475767] Chr16:28371468..29342589 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_145659.3(IL27):c.296G>A (p.Arg99His) single nucleotide variant not specified [RCV004201297] Chr16:28503702 [GRCh38]
Chr16:28515023 [GRCh37]
Chr16:16p11.2		 likely benign
NM_145659.3(IL27):c.488C>T (p.Pro163Leu) single nucleotide variant not specified [RCV004212160] Chr16:28499895 [GRCh38]
Chr16:28511216 [GRCh37]
Chr16:16p12.1		 uncertain significance
NM_145659.3(IL27):c.562G>A (p.Ala188Thr) single nucleotide variant not specified [RCV004090493] Chr16:28499821 [GRCh38]
Chr16:28511142 [GRCh37]
Chr16:16p12.1		 uncertain significance
NM_145659.3(IL27):c.11C>A (p.Thr4Lys) single nucleotide variant not specified [RCV004358064] Chr16:28506801 [GRCh38]
Chr16:28518122 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_145659.3(IL27):c.131G>A (p.Arg44Gln) single nucleotide variant not specified [RCV004363908] Chr16:28503951 [GRCh38]
Chr16:28515272 [GRCh37]
Chr16:16p11.2		 likely benign
GRCh37/hg19 16p11.2(chr16:28441539-29351827)x3 copy number gain not provided [RCV003485107] Chr16:28441539..29351827 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_145659.3(IL27):c.204+5G>A single nucleotide variant not provided [RCV003426643] Chr16:28503873 [GRCh38]
Chr16:28515194 [GRCh37]
Chr16:16p11.2		 uncertain significance
GRCh37/hg19 16p11.2(chr16:28371467-29379768)x1 copy number loss not specified [RCV003987151] Chr16:28371467..29379768 [GRCh37]
Chr16:16p11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:28486928-29438326)x1 copy number loss not specified [RCV003987144] Chr16:28486928..29438326 [GRCh37]
Chr16:16p11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:28485883-29347116)x1 copy number loss not specified [RCV003987198] Chr16:28485883..29347116 [GRCh37]
Chr16:16p11.2		 pathogenic
NM_145659.3(IL27):c.217C>G (p.Leu73Val) single nucleotide variant not specified [RCV004405217] Chr16:28503781 [GRCh38]
Chr16:28515102 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_145659.3(IL27):c.511G>A (p.Glu171Lys) single nucleotide variant not specified [RCV004405218] Chr16:28499872 [GRCh38]
Chr16:28511193 [GRCh37]
Chr16:16p12.1		 uncertain significance
NM_145659.3(IL27):c.554T>C (p.Leu185Pro) single nucleotide variant not specified [RCV004405219] Chr16:28499829 [GRCh38]
Chr16:28511150 [GRCh37]
Chr16:16p12.1		 likely benign
NM_145659.3(IL27):c.687C>G (p.His229Gln) single nucleotide variant not specified [RCV004405220] Chr16:28499696 [GRCh38]
Chr16:28511017 [GRCh37]
Chr16:16p12.1		 uncertain significance
NM_145659.3(IL27):c.70G>C (p.Ala24Pro) single nucleotide variant not specified [RCV004405221] Chr16:28504012 [GRCh38]
Chr16:28515333 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_145659.3(IL27):c.726G>C (p.Gln242His) single nucleotide variant not specified [RCV004405222] Chr16:28499657 [GRCh38]
Chr16:28510978 [GRCh37]
Chr16:16p12.1		 uncertain significance
NC_000016.9:g.(?_28488837)_(29001333_?)del deletion Brody myopathy [RCV004582649] Chr16:28488837..29001333 [GRCh37]
Chr16:16p11.2		 pathogenic
NM_145659.3(IL27):c.608C>T (p.Thr203Ile) single nucleotide variant not specified [RCV004628035] Chr16:28499775 [GRCh38]
Chr16:28511096 [GRCh37]
Chr16:16p12.1		 uncertain significance
NM_145659.3(IL27):c.697C>T (p.Pro233Ser) single nucleotide variant not specified [RCV004628036] Chr16:28499686 [GRCh38]
Chr16:28511007 [GRCh37]
Chr16:16p12.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:506
Count of miRNA genes:372
Interacting mature miRNAs:394
Transcripts:ENST00000356897, ENST00000568075
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406959169GWAS608145_Hankylosing spondylitis, psoriasis, ulcerative colitis, Crohn's disease, sclerosing cholangitis QTL GWAS608145 (human)3e-29ankylosing spondylitis, psoriasis, ulcerative colitis, Crohn's disease, sclerosing cholangitis162850638828506389Human
407083490GWAS732466_Hobsolete_red blood cell distribution width QTL GWAS732466 (human)1e-10obsolete_red blood cell distribution widthred blood cell distribution width- standard deviation (CMO:0003232)162850105028501051Human
407249927GWAS898903_Hinflammatory bowel disease QTL GWAS898903 (human)2e-13inflammatory bowel disease162850105028501051Human
407108416GWAS757392_Hplatelet crit QTL GWAS757392 (human)2e-20platelet critplateletcrit (CMO:0001349)162850208228502083Human
406892612GWAS541588_Hinterleukin-27 measurement QTL GWAS541588 (human)9e-12interleukin-27 measurement162850353328503534Human
407383151GWAS1032127_Hobsolete_red blood cell distribution width QTL GWAS1032127 (human)2e-15obsolete_red blood cell distribution widthred blood cell distribution width- standard deviation (CMO:0003232)162850208228502083Human
407255726GWAS904702_Hgenomic measurement QTL GWAS904702 (human)2e-08genomic measurement162850208228502083Human
407033577GWAS682553_Hulcerative colitis QTL GWAS682553 (human)0.000001ulcerative colitis162850638828506389Human
407361354GWAS1010330_Hbilirubin measurement QTL GWAS1010330 (human)2e-17bilirubin measurementserum total bilirubin level (CMO:0000376)162850105028501051Human
407049326GWAS698302_Hbody mass index QTL GWAS698302 (human)5e-09body mass indexbody mass index (BMI) (CMO:0000105)162850253228502533Human
407383192GWAS1032168_Hobsolete_red blood cell distribution width QTL GWAS1032168 (human)6e-12obsolete_red blood cell distribution widthred blood cell distribution width- standard deviation (CMO:0003232)162850220928502210Human
407029490GWAS678466_Hinflammatory bowel disease QTL GWAS678466 (human)1e-21inflammatory bowel disease162850638828506389Human
406925906GWAS574882_Hbody height QTL GWAS574882 (human)9e-11body height (VT:0001253)body height (CMO:0000106)162850208228502083Human
407385884GWAS1034860_Hobsolete_red blood cell distribution width QTL GWAS1034860 (human)3e-14obsolete_red blood cell distribution widthred blood cell distribution width- standard deviation (CMO:0003232)162850105028501051Human
407030677GWAS679653_HCrohn's disease QTL GWAS679653 (human)1e-22Crohn's disease162850638828506389Human
407258172GWAS907148_Hgenomic measurement QTL GWAS907148 (human)0.000001genomic measurement162850208228502083Human
407115833GWAS764809_Hmean corpuscular volume QTL GWAS764809 (human)7e-30mean corpuscular volumemean corpuscular volume (CMO:0000038)162850180828501809Human


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1110 1877 2026 1720 3462 1526 1996 4 563 1677 446 1573 5703 5329 12 2773 610 1351 1330 121

Sequence


Ensembl Acc Id: ENST00000356897   ⟹   ENSP00000349365
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1628,499,362 - 28,506,834 (-)Ensembl
Ensembl Acc Id: ENST00000568075   ⟹   ENSP00000455990
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1628,501,974 - 28,512,051 (-)Ensembl
RefSeq Acc Id: NM_145659   ⟹   NP_663634
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381628,499,362 - 28,506,834 (-)NCBI
GRCh371628,510,683 - 28,518,155 (-)ENTREZGENE
Build 361628,418,184 - 28,425,656 (-)NCBI Archive
HuRef1626,536,601 - 26,544,073 (-)ENTREZGENE
CHM1_11629,522,293 - 29,529,765 (-)NCBI
T2T-CHM13v2.01628,888,944 - 28,896,415 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054379989   ⟹   XP_054235964
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01628,869,090 - 28,896,415 (+)NCBI
RefSeq Acc Id: NP_663634   ⟸   NM_145659
- Peptide Label: precursor
- UniProtKB: A0N0L2 (UniProtKB/Swiss-Prot),   Q6P676 (UniProtKB/Swiss-Prot),   Q8NEV9 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000349365   ⟸   ENST00000356897
Ensembl Acc Id: ENSP00000455990   ⟸   ENST00000568075
RefSeq Acc Id: XP_054235964   ⟸   XM_054379989
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8NEV9-F1-model_v2 AlphaFold Q8NEV9 1-243 view protein structure

Promoters
RGD ID:6793191
Promoter ID:HG_KWN:23397
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:NM_145659
Position:
Human AssemblyChrPosition (strand)Source
Build 361628,425,626 - 28,426,202 (-)MPROMDB
RGD ID:7231721
Promoter ID:EPDNEW_H21607
Type:initiation region
Name:IL27_1
Description:interleukin 27
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H21609  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381628,506,834 - 28,506,894EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:19157 AgrOrtholog
COSMIC IL27 COSMIC
Ensembl Genes ENSG00000197272 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000356897 ENTREZGENE
  ENST00000356897.1 UniProtKB/Swiss-Prot
  ENST00000568075.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot
GTEx ENSG00000197272 GTEx
HGNC ID HGNC:19157 ENTREZGENE
Human Proteome Map IL27 Human Proteome Map
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  IL-27_alpha UniProtKB/Swiss-Prot
KEGG Report hsa:246778 UniProtKB/Swiss-Prot
NCBI Gene 246778 ENTREZGENE
OMIM 608273 OMIM
PANTHER INTERLEUKIN-27 SUBUNIT ALPHA UniProtKB/Swiss-Prot
  PTHR20879 UniProtKB/Swiss-Prot
PharmGKB PA134870478 PharmGKB
UniProt A0N0L2 ENTREZGENE
  H3BQY2_HUMAN UniProtKB/TrEMBL
  IL27A_HUMAN UniProtKB/Swiss-Prot
  Q6P676 ENTREZGENE
  Q8NEV9 ENTREZGENE
UniProt Secondary A0N0L2 UniProtKB/Swiss-Prot
  Q6P676 UniProtKB/Swiss-Prot