Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:estrogen receptor signaling pathway
go back to main search page
Accession:GO:0030520 term browser browse the term
Definition:A nuclear receptor-mediated signaling pathway initiated by an estrogen binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: estrogen receptor signalling pathway;   intracellular estrogen receptor signaling pathway;   nuclear receptor-mediated estrogen signaling pathway


show annotations for term's descendants           Sort by:
estrogen receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor IDA RGD PMID:26372666 RGD:407419879 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ar androgen receptor involved_in
acts_upstream_of		 ISO
IEA		 (PMID:10428808)
MGI:2687199 (PMID:14676301)
GO_REF:0000107		 RGD
Ensembl		 PMID:10428808 PMID:14676301 GO_REF:0000107 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Carm1 coactivator-associated arginine methyltransferase 1 acts_upstream_of_or_within ISO MGI:1352467 (PMID:12756295) RGD PMID:12756295 NCBI chr 8:20,097,262...20,141,950
Ensembl chr 8:20,097,254...20,147,689 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
MGI:2182328 (PMID:12370428)		 Ensembl
RGD		 PMID:12370428 GO_REF:0000107 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698 		JBrowse link
G Ddx17 DEAD-box helicase 17 involved_in ISO (PMID:24275493) RGD PMID:24275493 NCBI chr 7:111,091,127...111,109,353
Ensembl chr 7:111,089,445...111,109,193 		JBrowse link
G Ddx5 DEAD-box helicase 5 involved_in ISO (PMID:24275493) RGD PMID:24275493 NCBI chr10:91,723,508...91,732,210
Ensembl chr10:91,723,508...91,732,283 		JBrowse link
G Esr1 estrogen receptor 1 involved_in IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
(PMID:15831516), (PMID:9338790), (PMID:9841876)		 Ensembl
GO_Central
RGD		 PMID:9338790 PMID:9841876 PMID:15831516 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 involved_in
acts_upstream_of_or_within		 TAS
IBA
ISO
IEA		 GO_REF:0000033
MGI:2152217 (PMID:12370428)
(PMID:24033289)
GO_REF:0000002		 GO_Central
RGD
InterPro		 PMID:12370428 PMID:24033289 PMID:9600083 GO_REF:0000002 GO_REF:0000033, RGD:728646 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 IMP RGD PMID:20445128 RGD:4892084 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 involved_in ISO (PMID:7481822) RGD PMID:7481822 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Padi2 peptidyl arginine deiminase 2 involved_in ISO
IEA		 (PMID:22853951)
GO_REF:0000107		 RGD
Ensembl		 PMID:22853951 GO_REF:0000107 NCBI chr 5:153,209,053...153,251,632
Ensembl chr 5:153,209,053...153,251,632 		JBrowse link
G Phb2 prohibitin 2 involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
MGI:3574361 (PMID:17065319)		 Ensembl
RGD		 PMID:17065319 GO_REF:0000107 NCBI chr 4:157,517,662...157,522,268
Ensembl chr 4:157,517,577...157,522,272 		JBrowse link
G Pou4f2 POU class 4 homeobox 2 involved_in ISO (PMID:21241485) RGD PMID:21241485 NCBI chr19:29,486,686...29,490,327
Ensembl chr19:29,486,686...29,490,327 		JBrowse link
G Ppargc1b PPARG coactivator 1 beta involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:11854298)		 UniProt
Ensembl
RGD		 PMID:11854298 GO_REF:0000024 GO_REF:0000107 NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194 		JBrowse link
G Rbfox2 RNA binding fox-1 homolog 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:11875103)		 UniProt
RGD		 PMID:11875103 GO_REF:0000024 NCBI chr 7:108,810,627...109,054,420
Ensembl chr 7:108,810,628...109,054,691 		JBrowse link
G Safb scaffold attachment factor B involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:3577076 (PMID:15798188)		 GO_Central
RGD		 PMID:15798188 GO_REF:0000033 NCBI chr 9:1,417,449...1,438,408
Ensembl chr 9:1,417,525...1,438,644 		JBrowse link
G Taf7 TATA-box binding protein associated factor 7 acts_upstream_of_or_within ISO (PMID:10438527) RGD PMID:10438527 NCBI chr18:29,459,937...29,462,086
Ensembl chr18:29,452,943...29,462,134 		JBrowse link
G Trip4 thyroid hormone receptor interactor 4 involved_in ISO (PMID:25219498) RGD PMID:25219498 NCBI chr 8:66,351,861...66,439,679
Ensembl chr 8:66,353,248...66,439,774 		JBrowse link
negative regulation of intracellular estrogen receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca1 BRCA1, DNA repair associated involved_in ISO
IEA		 (PMID:17505062)
GO_REF:0000107		 RGD
Ensembl		 PMID:17505062 GO_REF:0000107 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Cnot1 CCR4-NOT transcription complex, subunit 1 involved_in ISO (PMID:16778766) RGD PMID:16778766 NCBI chr19:9,255,190...9,346,574
Ensembl chr19:9,255,194...9,346,574 		JBrowse link
G Cnot2 CCR4-NOT transcription complex, subunit 2 involved_in ISO (PMID:16778766) RGD PMID:16778766 NCBI chr 7:52,130,445...52,222,338
Ensembl chr 7:52,130,441...52,223,575 		JBrowse link
G Cnot9 CCR4-NOT transcription complex subunit 9 involved_in ISS
ISO		 GO_REF:0000024
(PMID:16778766)		 UniProt
RGD		 PMID:16778766 GO_REF:0000024 NCBI chr 9:76,084,269...76,109,111
Ensembl chr 9:76,084,334...76,109,100 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2182328 (PMID:12370428)		 Ensembl
RGD		 PMID:12370428 GO_REF:0000107 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698 		JBrowse link
G Foxh1 forkhead box H1 involved_in ISO (PMID:16120611) RGD PMID:16120611 NCBI chr 7:108,387,969...108,391,566
Ensembl chr 7:108,387,969...108,390,049 		JBrowse link
G Isl1 ISL LIM homeobox 1 involved_in IDA PMID:11043578 BHF-UCL PMID:11043578 RGD:8554127 NCBI chr 2:48,079,412...48,090,704
Ensembl chr 2:48,080,522...48,095,584 		JBrowse link
G Kank2 KN motif and ankyrin repeat domains 2 involved_in ISO
IBA
IEA		 (PMID:17476305)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:17476305 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:20,311,676...20,341,107
Ensembl chr 8:20,311,676...20,340,900 		JBrowse link
G Lbh LBH regulator of WNT signaling pathway involved_in ISO (PMID:25655704) RGD PMID:25655704 NCBI chr 6:22,569,238...22,593,056
Ensembl chr 6:22,568,834...22,593,079 		JBrowse link
G Phb2 prohibitin 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1351663|MGI:3574361 (PMID:17065319), (PMID:17785450)		 Ensembl
RGD		 PMID:17065319 PMID:17785450 GO_REF:0000107 NCBI chr 4:157,517,662...157,522,268
Ensembl chr 4:157,517,577...157,522,272 		JBrowse link
G Strn3 striatin 3 involved_in IMP
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:18434427 GO_REF:0000033, RGD:2311258 NCBI chr 6:69,047,776...69,134,102
Ensembl chr 6:69,047,776...69,134,102 		JBrowse link
G Tp63 tumor protein p63 involved_in ISO (PMID:25655704) RGD PMID:25655704 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398 		JBrowse link
G Vps11 VPS11 core subunit of CORVET and HOPS complexes involved_in ISO UniProtKB:Q9P253 (PMID:31015428) RGD PMID:31015428 NCBI chr 8:44,684,129...44,698,568
Ensembl chr 8:44,684,127...44,698,568 		JBrowse link
G Vps18 VPS18 core subunit of CORVET and HOPS complexes involved_in ISO UniProtKB:Q9H270 (PMID:31015428) RGD PMID:31015428 NCBI chr 3:106,279,444...106,290,298
Ensembl chr 3:106,279,425...106,291,964 		JBrowse link
G Zfp366 zinc finger protein 366 involved_in ISO
IBA		 (PMID:17085477)
GO_REF:0000033		 RGD
GO_Central		 PMID:17085477 GO_REF:0000033 NCBI chr 2:30,578,552...30,640,546
Ensembl chr 2:30,578,715...30,642,182 		JBrowse link
positive regulation of intracellular estrogen receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2687199 (PMID:14676301)		 Ensembl
RGD		 PMID:14676301 GO_REF:0000107 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Foxa1 forkhead box A1 involved_in ISO
IEA		 (PMID:16087863)
GO_REF:0000107		 RGD
Ensembl		 PMID:16087863 GO_REF:0000107 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188 		JBrowse link
G Fshr follicle stimulating hormone receptor acts_upstream_of_or_within ISO MGI:2384087 (PMID:11089565) RGD PMID:11089565 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785 		JBrowse link
G Kmt2d lysine methyltransferase 2D involved_in ISO (PMID:16603732) RGD PMID:16603732 NCBI chr 7:129,980,744...130,022,088
Ensembl chr 7:129,962,887...130,020,325 		JBrowse link
G Med1 mediator complex subunit 1 acts_upstream_of_or_within ISO MGI:4443002 (PMID:20351249) RGD PMID:20351249 NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 IDA RGD PMID:11713241 RGD:727330 NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594 		JBrowse link
G Pagr1 Paxip1-associated glutamate-rich protein 1 involved_in ISO
IBA		 (PMID:19039327)
GO_REF:0000033		 RGD
GO_Central		 PMID:19039327 GO_REF:0000033 NCBI chr 1:181,622,698...181,625,024 JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 involved_in ISO
ISS		 (PMID:16278681)
GO_REF:0000024		 RGD
UniProt		 PMID:16278681 GO_REF:0000024 NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 IMP RGD PMID:23493398 RGD:10413906 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Skp2 S-phase kinase associated protein 2 acts_upstream_of_or_within ISO MGI:102520 (PMID:17785450) RGD PMID:17785450 NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338 		JBrowse link
G Srarp steroid receptor associated and regulated protein involved_in ISO (PMID:27125460) RGD PMID:27125460 NCBI chr 5:153,740,973...153,745,077
Ensembl chr 5:153,740,975...153,744,998 		JBrowse link
G Wbp2 WW domain binding protein 2 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:16772533)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:16772533 GO_REF:0000024 GO_REF:0000107 NCBI chr10:101,312,476...101,320,775
Ensembl chr10:101,312,446...101,320,736 		JBrowse link
regulation of intracellular estrogen receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carm1 coactivator-associated arginine methyltransferase 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:19843527)		 UniProt
RGD		 PMID:19843527 GO_REF:0000024 NCBI chr 8:20,097,262...20,141,950
Ensembl chr 8:20,097,254...20,147,689 		JBrowse link
G Ddrgk1 DDRGK domain containing 1 involved_in ISO (PMID:25219498) RGD PMID:25219498 NCBI chr 3:117,861,916...117,882,680
Ensembl chr 3:117,861,653...117,882,680 		JBrowse link
G Dnaaf4 dynein axonemal assembly factor 4 involved_in ISO
ISS		 (PMID:19423554)
GO_REF:0000024		 RGD
UniProt		 PMID:19423554 GO_REF:0000024 NCBI chr 8:73,696,394...73,711,315
Ensembl chr 8:73,698,103...73,711,292 		JBrowse link
G Fshr follicle stimulating hormone receptor acts_upstream_of_or_within ISO MGI:2384087 (PMID:18063689), (PMID:18676690) RGD PMID:18063689 PMID:18676690 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785 		JBrowse link
G Lats1 large tumor suppressor kinase 1 involved_in ISO (PMID:28068668) RGD PMID:28068668 NCBI chr 1:2,160,411...2,193,640
Ensembl chr 1:2,160,411...2,193,640 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:1857247 (PMID:16007215) RGD PMID:16007215 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Uba5 ubiquitin-like modifier activating enzyme 5 involved_in ISO
ISS		 (PMID:25219498)
GO_REF:0000024		 RGD
UniProt		 PMID:25219498 GO_REF:0000024 NCBI chr 8:104,665,241...104,680,915
Ensembl chr 8:104,665,046...104,680,894 		JBrowse link
G Ufl1 Ufm1-specific ligase 1 involved_in ISO
ISS		 (PMID:25219498)
GO_REF:0000024		 RGD
UniProt		 PMID:25219498 GO_REF:0000024 NCBI chr 5:38,962,721...38,995,134
Ensembl chr 5:38,962,171...38,995,199 		JBrowse link
G Ufm1 ubiquitin-fold modifier 1 involved_in ISO
ISS		 (PMID:25219498)
GO_REF:0000024		 RGD
UniProt		 PMID:25219498 GO_REF:0000024 NCBI chr 2:137,969,476...137,977,620
Ensembl chr 2:137,966,678...137,978,089
Ensembl chr 2:137,966,678...137,978,089 		JBrowse link
G Ufsp2 UFM1-specific peptidase 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:25219498)		 UniProt
RGD		 PMID:25219498 GO_REF:0000024 NCBI chr16:46,272,016...46,291,080
Ensembl chr16:46,272,016...46,291,059 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20069
    cellular process 19150
      signal transduction 7181
        hormone-mediated signaling pathway 215
          steroid hormone receptor signaling pathway 136
            nuclear receptor-mediated steroid hormone signaling pathway 123
              estrogen receptor signaling pathway 50
                negative regulation of intracellular estrogen receptor signaling pathway 15
                positive regulation of intracellular estrogen receptor signaling pathway 12
                regulation of intracellular estrogen receptor signaling pathway + 36
Path 2
Term Annotations click to browse term
  biological_process 20069
    biological regulation 13554
      regulation of biological process 13131
        regulation of cellular process 12768
          signal transduction 7181
            intracellular signal transduction 3074
              intracellular receptor signaling pathway 392
                nuclear receptor-mediated signaling pathway 188
                  nuclear receptor-mediated steroid hormone signaling pathway 123
                    estrogen receptor signaling pathway 50
                      negative regulation of intracellular estrogen receptor signaling pathway 15
                      positive regulation of intracellular estrogen receptor signaling pathway 12
                      regulation of intracellular estrogen receptor signaling pathway + 36
paths to the root