Carm1 (coactivator-associated arginine methyltransferase 1)

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Gene: Carm1 (coactivator-associated arginine methyltransferase 1) Rattus norvegicus

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Symbol:

Carm1

Name:

coactivator-associated arginine methyltransferase 1

RGD ID:

1305879

Description:

Predicted to enable several functions, including lysine-acetylated histone binding activity; nuclear receptor coactivator activity; and protein-arginine N-methyltransferase activity. Involved in negative regulation of dendrite development; positive regulation of cell population proliferation; and response to cAMP. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nuclear replication fork. Biomarker of asthma; hepatocellular adenoma; and hepatocellular carcinoma. Orthologous to human CARM1 (coactivator associated arginine methyltransferase 1); PARTICIPATES IN androgen signaling pathway; estrogen signaling pathway; histone modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

coactivator-associated arginine methyltransferase 1 variant 5; histone-arginine methyltransferase CARM1; LOC363026; Prmt4; protein arginine N-methyltransferase 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	28,373,370 - 28,418,056 (+)	NCBI		GRCr8
mRatBN7.2	8	20,097,262 - 20,141,950 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	20,097,254 - 20,147,689 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	24,129,207 - 24,174,060 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	22,424,760 - 22,469,612 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	20,326,894 - 20,371,582 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	22,577,723 - 22,622,555 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	22,577,715 - 22,622,560 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	22,631,828 - 22,676,509 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	20,650,468 - 20,695,147 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	20,650,600 - 20,695,147 (+)	NCBI
Celera	8	21,488,633 - 21,533,257 (+)	NCBI		Celera
Cytogenetic Map	8	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alpha-mannosidosis (ISO)

asthma (IEP)

Charcot-Marie-Tooth disease dominant intermediate B (ISO)

episodic ataxia type 2 (ISO)

estrogen-receptor positive breast cancer (ISO)

familial hypercholesterolemia (ISO)

glutaric acidemia I (ISO)

hepatocellular adenoma (IEP)

hepatocellular carcinoma (IEP)

Neurodevelopmental Disorders (ISO)

prostate carcinoma in situ (ISO)

Prostatic Neoplasms (ISO)

psoriasis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2-butoxyethanol (ISO)

3',5'-cyclic AMP (ISO)

3-chloropropane-1,2-diol (EXP)

4-amino-2,6-dinitrotoluene (EXP)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

C60 fullerene (EXP)

cadmium atom (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

cocaine (EXP)

diarsenic trioxide (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

ethyl methanesulfonate (ISO)

fenthion (ISO)

flutamide (EXP)

fulvestrant (ISO)

genistein (ISO)

ivermectin (ISO)

L-methionine (ISO)

lead(0) (ISO)

linsidomine (EXP)

methapyrilene (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

paracetamol (EXP,ISO)

pentachlorophenol (ISO)

perfluorohexanesulfonic acid (ISO)

ribavirin (ISO)

S-adenosyl-L-homocysteine (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

thimerosal (ISO)

thioacetamide (EXP)

thiram (ISO)

triptonide (ISO)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell population proliferation (ISO)

chromatin remodeling (IBA)

endochondral bone morphogenesis (ISO)

estrogen receptor signaling pathway (ISO)

mRNA processing (IEA)

negative regulation of dendrite development (IMP)

nuclear receptor-mediated steroid hormone signaling pathway (ISO)

peptidyl-arginine methylation (IEA)

positive regulation of cell population proliferation (IMP,ISO)

positive regulation of epithelial cell apoptotic process (ISO)

positive regulation of fat cell differentiation (ISO,ISS)

positive regulation of NF-kappaB transcription factor activity (ISO)

positive regulation of transcription by RNA polymerase I (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

protein insertion into mitochondrial inner membrane (IBA)

protein localization to chromatin (ISO)

protein methylation (ISO)

regulation of DNA-templated transcription (ISO)

regulation of growth plate cartilage chondrocyte proliferation (ISO)

regulation of intracellular estrogen receptor signaling pathway (ISO,ISS)

regulation of mRNA binding (IMP)

replication fork reversal (ISO,ISS)

response to cAMP (IDA)

RNA splicing (IEA)

Cellular Component

chromosome (IEA)

cytoplasm (ISO)

cytosol (ISO,ISS)

nuclear replication fork (ISO,ISS)

nucleoplasm (IEA,ISO)

nucleus (IEA,ISO)

protein-containing complex (ISO)

RNA polymerase II transcription regulator complex (ISO)

TIM22 mitochondrial import inner membrane insertion complex (IBA)

Molecular Function

DNA-binding transcription factor binding (ISO)

histone arginine N-methyltransferase activity (ISO)

histone H3R17 methyltransferase activity (ISO,ISS)

histone H3R2 methyltransferase activity (IBA,ISO,ISS)

histone H3R26 methyltransferase activity (ISO,ISS)

histone methyltransferase activity (ISO,ISS)

lysine-acetylated histone binding (ISO,ISS)

nuclear receptor coactivator activity (ISO,ISS)

protein binding (IPI,ISO)

protein homodimerization activity (ISO)

protein methyltransferase activity (ISO)

protein-arginine N-methyltransferase activity (IEA,ISO,ISS)

protein-arginine omega-N asymmetric methyltransferase activity (ISO,ISS)

transcription cis-regulatory region binding (ISO,ISS)

transcription coactivator activity (ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

androgen signaling pathway (ISO)

estrogen signaling pathway (ISO)

histone modification pathway (ISO)

homocysteine metabolic pathway (ISO)

methionine cycle/metabolic pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Arginine methylation an emerging regulator of protein function.	Bedford MT and Richard S, Mol Cell 2005 Apr 29;18(3):263-72.
2.	Androgen receptor coregulators and their involvement in the development and progression of prostate cancer.	Chmelar R, etal., Int J Cancer. 2007 Feb 15;120(4):719-33.
3.	Histone arginine methylation.	Di Lorenzo A and Bedford MT, FEBS Lett. 2011 Jul 7;585(13):2024-31. doi: 10.1016/j.febslet.2010.11.010. Epub 2010 Nov 11.
4.	CARM1 regulates proliferation of PC12 cells by methylating HuD.	Fujiwara T, etal., Mol Cell Biol. 2006 Mar;26(6):2273-85.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Readers of histone methylarginine marks.	Gayatri S and Bedford MT, Biochim Biophys Acta. 2014 Aug;1839(8):702-710. doi: 10.1016/j.bbagrm.2014.02.015. Epub 2014 Feb 28.
7.	The oestrogen receptor coactivator CARM1 has an oncogenic effect and is associated with poor prognosis in breast cancer.	Habashy HO, etal., Breast Cancer Res Treat. 2013 Jul;140(2):307-16. doi: 10.1007/s10549-013-2614-y. Epub 2013 Jul 26.
8.	Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting.	Hall JM and McDonnell DP, Mol Interv. 2005 Dec;5(6):343-57.
9.	Tissue-specific and age-dependent expression of protein arginine methyltransferases (PRMTs) in male rat tissues.	Hong E, etal., Biogerontology. 2012 Jun;13(3):329-36. doi: 10.1007/s10522-012-9379-2. Epub 2012 Apr 7.
10.	Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status.	Hong H, etal., Cancer. 2004 Jul 1;101(1):83-9.
11.	Signal-dependent control of gluconeogenic key enzyme genes through coactivator-associated arginine methyltransferase 1.	Krones-Herzig A, etal., J Biol Chem. 2006 Feb 10;281(6):3025-9. Epub 2005 Dec 5.
12.	Protein kinase C stimulates HuD-mediated mRNA stability and protein expression of neurotrophic factors and enhances dendritic maturation of hippocampal neurons in culture.	Lim CS and Alkon DL, Hippocampus. 2012 Dec;22(12):2303-19. doi: 10.1002/hipo.22048. Epub 2012 Jun 27.
13.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
14.	Elevated expression of coactivator-associated arginine methyltransferase 1 is associated with early hepatocarcinogenesis.	Osada S, etal., Oncol Rep. 2013 Oct;30(4):1669-74. doi: 10.3892/or.2013.2651. Epub 2013 Aug 2.
15.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
16.	[Expression of protein arginine N-methyltransferases in E3 rat models of acute asthma].	Sun QZ, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2010 Apr;30(4):716-9.
17.	Requirement for multiple domains of the protein arginine methyltransferase CARM1 in its transcriptional coactivator function.	Teyssier C, etal., J Biol Chem 2002 Nov 29;277(48):46066-72. Epub 2002 Sep 25.

Additional References at PubMed

PMID:10381882	PMID:11341840	PMID:12756295	PMID:14690606	PMID:15616592	PMID:15944154	PMID:17882261	PMID:17882262	PMID:17898714	PMID:18188184	PMID:18495660	PMID:19405910
PMID:19725955	PMID:19843527	PMID:22977234	PMID:23980157	PMID:24726896	PMID:25072916	PMID:28264928	PMID:31627895	PMID:33415686

Genomics

Comparative Map Data

Carm1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	28,373,370 - 28,418,056 (+)	NCBI		GRCr8
mRatBN7.2	8	20,097,262 - 20,141,950 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	20,097,254 - 20,147,689 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	24,129,207 - 24,174,060 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	22,424,760 - 22,469,612 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	20,326,894 - 20,371,582 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	22,577,723 - 22,622,555 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	22,577,715 - 22,622,560 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	22,631,828 - 22,676,509 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	20,650,468 - 20,695,147 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	20,650,600 - 20,695,147 (+)	NCBI
Celera	8	21,488,633 - 21,533,257 (+)	NCBI		Celera
Cytogenetic Map	8	q13	NCBI

CARM1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	10,871,553 - 10,923,075 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	10,871,553 - 10,923,075 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	10,982,229 - 11,033,751 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	10,843,253 - 10,894,448 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	19	10,877,096 - 10,928,289 (+)	NCBI		Celera
Cytogenetic Map	19	p13.2	NCBI
HuRef	19	10,560,608 - 10,611,342 (+)	NCBI		HuRef
CHM1_1	19	10,983,387 - 11,034,611 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	10,998,565 - 11,050,086 (+)	NCBI		T2T-CHM13v2.0

Carm1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	21,458,163 - 21,500,763 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	21,458,190 - 21,503,919 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	21,546,894 - 21,589,467 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	21,546,894 - 21,592,623 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	21,351,338 - 21,393,911 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	21,297,388 - 21,339,864 (+)	NCBI		MGSCv36	mm8
Celera	9	18,815,851 - 18,859,087 (+)	NCBI		Celera
Cytogenetic Map	9	A3	NCBI

Carm1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	1,983,599 - 2,002,174 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	1,983,599 - 2,002,174 (+)	NCBI	ChiLan1.0	ChiLan1.0

CARM1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	15,791,553 - 15,843,400 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	14,790,172 - 14,841,771 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	10,424,993 - 10,476,702 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	11,144,733 - 11,195,948 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	11,144,733 - 11,195,948 (+)	Ensembl	panpan1.1		panPan2

CARM1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	50,328,466 - 50,371,845 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	50,331,030 - 50,348,195 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	50,201,812 - 50,245,875 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	50,850,535 - 50,894,856 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	20	50,059,887 - 50,103,936 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	50,487,176 - 50,531,447 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	50,728,777 - 50,772,884 (-)	NCBI		UU_Cfam_GSD_1.0

Carm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	209,233,788 - 209,263,420 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936659	1,090,164 - 1,123,920 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936659	1,071,883 - 1,120,917 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CARM1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	69,602,136 - 69,644,854 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	69,602,121 - 69,644,862 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	70,036,152 - 70,078,743 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CARM1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	9,866,715 - 9,915,655 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	9,866,534 - 9,914,682 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666074	10,028,808 - 10,078,493 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Carm1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	2,832,769 - 2,871,167 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624828	2,833,011 - 2,872,281 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Carm1
240 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	338
Count of miRNA genes:	98
Interacting mature miRNAs:	133
Transcripts:	ENSRNOT00000041577, ENSRNOT00000048245
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1558646	Swd5	Spike wave discharge measurement QTL 5	3.45	0.00036	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge frequency (CMO:0001742)	8	14906751	59906751	Rat
1357398	Slep3	Serum leptin concentration QTL 3	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	9712463	41866876	Rat
2317030	Wbc5	White blood cell count QTL 5	3.21	0.005	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	8	8736635	53736635	Rat
731182	Uae24	Urinary albumin excretion QTL 24	6.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	19331152	93965294	Rat
12880044	Am9	Aortic mass QTL 9		0.007	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	2097640	47097640	Rat
2317032	Ginf2	Gastrointestinal inflammation QTL 2	3.21	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	8	4705810	49705810	Rat
2301416	Bp315	Blood pressure QTL 315		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	7670578	52670578	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
631271	Lecl1	Lens clarity QTL 1		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	8	18984168	84531599	Rat
2317036	Livw3	Liver weight QTL 3	2.43	0.01	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	8	4705810	49705810	Rat
1598824	Memor4	Memory QTL 4	2.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	8	9712220	53356647	Rat
12880023	Bw184	Body weight QTL 184		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	2097640	47097640	Rat
9590084	Insglur5	Insulin/glucose ratio QTL 5	18.54	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	8	1	24597739	Rat
1354595	Despr4	Despair related QTL 4	2.16	0.0036	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	8	7688955	52688955	Rat
1354627	Despr14	Despair related QTL 14		0.0056	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	7688955	52688955	Rat
12880028	Cm103	Cardiac mass QTL 103		0.02	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	2097640	47097640	Rat
2317051	Aia18	Adjuvant induced arthritis QTL 18	2.42		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	8	8736635	53736635	Rat
2317882	Alcrsp24	Alcohol response QTL 24	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	8	1	25902202	Rat
2317048	Ginf1	Gastrointestinal inflammation QTL 1	3.52	0.005	cecum mucosa thickness (VT:0010234)	enterocolitis severity score (CMO:0002138)	8	4705810	49705810	Rat
2302367	Slep5	Serum leptin concentration QTL 5	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	9712463	41866876	Rat
12880025	Cm102	Cardiac mass QTL 102		0.044	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	8	2097640	47097640	Rat
61373	Mcs4	Mammary carcinoma susceptibility QTL 4	1.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	8	16290444	61290444	Rat

Markers in Region

RH132083

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	20,141,659 - 20,141,845 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	22,622,270 - 22,622,455	NCBI	Rnor6.0
Rnor_5.0	8	22,676,224 - 22,676,409	UniSTS	Rnor5.0
RGSC_v3.4	8	20,694,862 - 20,695,047	UniSTS	RGSC3.4
Celera	8	21,532,972 - 21,533,157	UniSTS
RH 3.4 Map	8	180.7	UniSTS
Cytogenetic Map	8	q13	UniSTS

RH135268

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	20,095,479 - 20,095,664 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	22,575,938 - 22,576,122	NCBI	Rnor6.0
Rnor_5.0	8	22,630,047 - 22,630,231	UniSTS	Rnor5.0
RGSC_v3.4	8	20,648,309 - 20,648,493	UniSTS	RGSC3.4
Celera	8	21,486,650 - 21,486,834	UniSTS
RH 3.4 Map	8	205.8	UniSTS
Cytogenetic Map	8	q13	UniSTS

RH133576

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	20,141,434 - 20,141,616 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	22,622,045 - 22,622,226	NCBI	Rnor6.0
Rnor_5.0	8	22,675,999 - 22,676,180	UniSTS	Rnor5.0
RGSC_v3.4	8	20,694,637 - 20,694,818	UniSTS	RGSC3.4
Celera	8	21,532,747 - 21,532,928	UniSTS
RH 3.4 Map	8	181.3	UniSTS
Cytogenetic Map	8	q13	UniSTS

RH141547

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	20,133,673 - 20,133,858 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	22,614,284 - 22,614,468	NCBI	Rnor6.0
Rnor_5.0	8	22,668,238 - 22,668,422	UniSTS	Rnor5.0
RGSC_v3.4	8	20,686,876 - 20,687,060	UniSTS	RGSC3.4
Celera	8	21,524,986 - 21,525,170	UniSTS
RH 3.4 Map	8	207.81	UniSTS
Cytogenetic Map	8	q13	UniSTS

Carm1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	20,141,241 - 20,141,716 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	22,621,852 - 22,622,326	NCBI	Rnor6.0
Rnor_5.0	8	22,675,806 - 22,676,280	UniSTS	Rnor5.0
RGSC_v3.4	8	20,694,444 - 20,694,918	UniSTS	RGSC3.4
Celera	8	21,532,554 - 21,533,028	UniSTS
Cytogenetic Map	8	q13	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	21	117	152	102	48	102	15	24	232	97	145	55	3
Low		24	75	45	21	45	21	21	18	18			21
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001030041	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001034088	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB201114	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB201115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB201116	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB201117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC120728	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473993	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KJ672502	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000012269 ⟹ ENSRNOP00000012270

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	20,097,254 - 20,147,689 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000041577 ⟹ ENSRNOP00000049428

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	20,097,254 - 20,141,950 (+)	Ensembl
Rnor_6.0 Ensembl	8	22,577,715 - 22,622,560 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000048245 ⟹ ENSRNOP00000042739

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	20,097,254 - 20,141,950 (+)	Ensembl
Rnor_6.0 Ensembl	8	22,577,715 - 22,622,560 (+)	Ensembl

RefSeq Acc Id:

NM_001030041 ⟹ NP_001025212

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	28,373,370 - 28,418,056 (+)	NCBI
mRatBN7.2	8	20,097,262 - 20,141,950 (+)	NCBI
Rnor_6.0	8	22,577,723 - 22,622,555 (+)	NCBI
Rnor_5.0	8	22,631,828 - 22,676,509 (+)	NCBI
RGSC_v3.4	8	20,650,468 - 20,695,147 (+)	RGD
Celera	8	21,488,633 - 21,533,257 (+)	RGD

Sequence:

show sequence

GAATTCGGCACGAGCGGCGGCGGCGGCCTGGGCCCGGGTGCGGCGGTGGCGGTGGCGGTGGTGG
CAGCGGGGCCTGGAGCCGGACCTAAGATGGCAGCGGCGGCAGCGACGGCGGTGGGGCCGGGTGC
GGGGAGCGCTGGGGTGGCGGGCCCGGGCGGCGCGGGGCCCTGCGCGACAGTGTCGGTGTTCCCC
GGCGCCCGCCTCCTCACTATCGGCGACGCGAACGGCGAGATCCAGCGGCACGCGGAGCAGCAGG
CGCTGCGCCTCGAGGTGCGCGCCGGACCAGACGCGGCGGGCATCGCCCTCTACAGCCATGAAGA
TGTGTGTGTGTTCAAGTGCTCAGTGTCCCGAGAGACAGAGTGCAGCCGTGTGGGCAGGCAGTCC
TTCATCATCACACTGGGCTGCAACAGCGTCCTCATCCAGTTCGCCACACCCCACGATTTCTGTT
CTTTCTACAACATCCTGAAAACCTGCCGGGGCCACACACTGGAGCGCTCTGTGTTCAGTGAGCG
AACAGAGGAGTCCTCAGCTGTGCAGTACTTCCAGTTTTATGGCTACCTGTCCCAGCAGCAGAAC
ATGATGCAGGACTATGTGCGAACAGGCACCTACCAGCGTGCAATCCTGCAGAACCACACCGACT
TCAAGGACAAGATCGTTCTAGATGTGGGCTGTGGCTCTGGGATCCTGTCATTCTTTGCTGCTCA
AGCAGGAGCCAGGAAAATTTACGCAGTGGAAGCCAGCACCATGGCTCAGCATGCCGAGGTCCTG
GTGAAGAGTAACAATCTGACAGACCGCATCGTGGTCATCCCTGGCAAAGTAGAGGAGGTCTCAT
TGCCTGAGCAAGTGGACATTATCATCTCAGAGCCCATGGGCTACATGCTCTTCAACGAACGTAT
GCTTGAGAGCTACCTCCATGCCAAAAAGTACCTGAAGCCCAGCGGCAACATGTTCCCCACCATT
GGTGATGTTCACCTTGCACCCTTCACTGATGAACAGCTCTACATGGAACAGTTCACCAAAGCCA
ACTTCTGGTACCAGCCATCCTTCCATGGAGTGGACCTGTCAGCCCTCCGAGGTGCCGCTGTGGA
TGAGTACTTCCGGCAACCTGTGGTGGACACATTTGACATCCGGATCCTGATGGCCAAATCTGTC
AAGTACACAGTGAACTTCCTAGAAGCCAAAGAAGGCGATTTGCACAGGATAGAAATCCCATTCA
AATTCCACATGCTGCATTCAGGGCTGGTCCACGGCTTGGCCTTCTGGTTCGATGTTGCTTTCAT
TGGCTCCATAATGACCGTGTGGCTCTCCACAGCCCCAACAGAGCCCCTGACCCACTGGTACCAG
GTCCGGTGCCTCTTCCAGTCACCGTTGTTTGCCAAGGCCGGGGACACGCTCTCAGGGACATGTC
TGCTTATTGCCAACAAAAGACAGAGCTATGACATCAGTATTGTGGCACAGGTGGACCAGACAGG
CTCCAAATCCAGTAACCTGCTGGATCTAAAGAACCCCTTCTTCAGGTACACAGGTACAACCCCA
TCACCCCCGCCTGGCTCACACTACACGTCTCCCTCGGAGAATATGTGGAATACGGGAAGCACCT
ACAATCTCAGCAGCGGGGTGGCTGTGGCTGGAATGCCTACTGCCTACGACCTGAGCAGTGTTAT
TGCTGGCGGCTCCAGCGTGGGTCACAACAACCTGATTCCCTTAGCCAACACAGGGATTGTCAAT
CACACCCACTCCCGGATGGGCTCCATAATGAGCACGGGCATTGTCCAAGGCTCCTCAGGTGCCC
AGGGAGGCGGCGGTAGCTCCAGTGCCCACTATGCAGTCAACAACCAGTTCACCATGGGTGGCCC
TGCCATCTCTATGGCCTCGCCCATGTCCATCCCGACCAACACCATGCACTATGGGAGTTAGGTG
CCTCCAGCCGCGACAGCACTGCGCACTGACAGCACCAGGAAACCAAATGAAGTCCAGGCCCGGC
ACAGCCGGTGGCTGTCCCCCTTGTTCTGGAGAAGCGTGAACACCCGGTCACAGCCCTCTTTGCT
ATGGGAACTTGGACACTTTTGTACACGATGTCGCCGCTGCCCTCAAGTACCCCCAGCCCAATCT
TTGGTCCCGAGCGAGTGTTGCTGCCATACTTTACATGAGATCCTGTTGGGGCAGCCCTCATCCT
GTTCTGTATCTCCACTCTGACCTGGCTTTGACATCTGCTGGAAGAGGCAAATCCCACCCCCACC
CCACAGCTGCACCTGACCAGGCAGGAGGAGGCCAGCAGCTGCCACCACAGACCTGGCAGCACCC
ACCCCACAACCCGTCCTTGCACCTCCCCTCACCTGGGGTGGCAGCACAGCCAGCTGGACCTCTC
CTTCAACTACCAGGCCACATGGTCACCATGGGCGTGACATGCTGCTTTTTTTAATTTTATTTTT
TTACGAAAAGAACCAGTGTCAACCCACAGACCCTCTGAGAAACCCGGCTGGCCGGGCCAAGCCA
GCAGCCCTGTCCCTAGGCCCAGAGGTTCTAGGTGAGGGGTGGCCCTGCCGAGCCTTCAGGGTGG
GCGAAGCCCCCTCCCACCAAAGGGTTCACCTCAAACTTGAATGTACAAACCACCCAGCTGTCCA
AAGGCCTAGCCCCTGCTTTCTGCTACTGTCCTGTCCTGAGCCTTGAAGGTCCCCTCCGTCAAAA
GCTGGAACAGGCAGCTCAGAGTGAGTAACCCTGGGCTACTGTGGCAAACAAGAGACCTCAAAGA
TCTATCACAAGGAAGGCATTCTGTCCTGATAGCTAGCATAGGCCTGTGTGTTCCCTCCACATTC
ATGTTCCACTCAACTCCTCTCAAGACAGCATCCCTGGGAAGGGGCCTAGCAGGGACCTCTCCCC
AGACGAAAATAAAAGCAAACAAGGAAGGGTGACTAATAAGCACAGGCAGTTTCCAGTCTCTTCC
CCTGTCCCCTTGCCCTAGAGTCCCCACCTTAATGGCCACAGCTCAAGCTGGGCTCCTGCCCACC
ACAGGTACCCTCTGGCAAAGGCTGGAGCTGCTCTGTGCCACCCTCCTGACCTGTCAGGGAATCA
AAGGGCCCTCAGGCGACTGGGAAACCAGGCTCTCTCCTGTCCATCAGTAATACTCCCTGCTTGG
CTGCCCCTCCCCACCTTTATATAAATTCTCTGGATCACCTTTGCATAGAAAATAAAAGTGTTTG
CTTTGTAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_001034088 ⟹ NP_001029260

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	28,373,370 - 28,418,056 (+)	NCBI
mRatBN7.2	8	20,097,262 - 20,141,950 (+)	NCBI
Rnor_6.0	8	22,577,723 - 22,622,555 (+)	NCBI
Rnor_5.0	8	22,631,828 - 22,676,509 (+)	NCBI
RGSC_v3.4	8	20,650,468 - 20,695,147 (+)	RGD
Celera	8	21,488,633 - 21,533,257 (+)	RGD

Sequence:

show sequence

GAATTCGGCACGAGCGGCGGCGGCGGCCTGGGCCCGGGTGCGGCGGTGGCGGTGGCGGTGGTGG
CAGCGGGGCCTGGAGCCGGACCTAAGATGGCAGCGGCGGCAGCGACGGCGGTGGGGCCGGGTGC
GGGGAGCGCTGGGGTGGCGGGCCCGGGCGGCGCGGGGCCCTGCGCGACAGTGTCGGTGTTCCCC
GGCGCCCGCCTCCTCACTATCGGCGACGCGAACGGCGAGATCCAGCGGCACGCGGAGCAGCAGG
CGCTGCGCCTCGAGGTGCGCGCCGGACCAGACGCGGCGGGCATCGCCCTCTACAGCCATGAAGA
TGTGTGTGTGTTCAAGTGCTCAGTGTCCCGAGAGACAGAGTGCAGCCGTGTGGGCAGGCAGTCC
TTCATCATCACACTGGGCTGCAACAGCGTCCTCATCCAGTTCGCCACACCCCACGATTTCTGTT
CTTTCTACAACATCCTGAAAACCTGCCGGGGCCACACACTGGAGCGCTCTGTGTTCAGTGAGCG
AACAGAGGAGTCCTCAGCTGTGCAGTACTTCCAGTTTTATGGCTACCTGTCCCAGCAGCAGAAC
ATGATGCAGGACTATGTGCGAACAGGCACCTACCAGCGTGCAATCCTGCAGAACCACACCGACT
TCAAGGACAAGATCGTTCTAGATGTGGGCTGTGGCTCTGGGATCCTGTCATTCTTTGCTGCTCA
AGCAGGAGCCAGGAAAATTTACGCAGTGGAAGCCAGCACCATGGCTCAGCATGCCGAGGTCCTG
GTGAAGAGTAACAATCTGACAGACCGCATCGTGGTCATCCCTGGCAAAGTAGAGGAGGTCTCAT
TGCCTGAGCAAGTGGACATTATCATCTCAGAGCCCATGGGCTACATGCTCTTCAACGAACGTAT
GCTTGAGAGCTACCTCCATGCCAAAAAGTACCTGAAGCCCAGCGGCAACATGTTCCCCACCATT
GGTGATGTTCACCTTGCACCCTTCACTGATGAACAGCTCTACATGGAACAGTTCACCAAAGCCA
ACTTCTGGTACCAGCCATCCTTCCATGGAGTGGACCTGTCAGCCCTCCGAGGTGCCGCTGTGGA
TGAGTACTTCCGGCAACCTGTGGTGGACACATTTGACATCCGGATCCTGATGGCCAAATCTGTC
AAGTACACAGTGAACTTCCTAGAAGCCAAAGAAGGCGATTTGCACAGGATAGAAATCCCATTCA
AATTCCACATGCTGCATTCAGGGCTGGTCCACGGCTTGGCCTTCTGGTTCGATGTTGCTTTCAT
TGGCTCCATAATGACCGTGTGGCTCTCCACAGCCCCAACAGAGCCCCTGACCCACTGGTACCAG
GTCCGGTGCCTCTTCCAGTCACCGTTGTTTGCCAAGGCCGGGGACACGCTCTCAGGGACATGTC
TGCTTATTGCCAACAAAAGACAGAGCTATGACATCAGTATTGTGGCACAGGTGGACCAGACAGG
CTCCAAATCCAGTAACCTGCTGGATCTAAAGAACCCCTTCTTCAGGTACACAGGTACAACCCCA
TCACCCCCGCCTGGCTCACACTACACGTCTCCCTCGGAGAATATGTGGAATACGGGAAGCACCT
ACAATCTCAGCAGCGGGGTGGCTGTGGCTGGAATGCCTACTGCCTACGACCTGAGCAGTGTTAT
TGCTGGCGGCTCCAGCGTGGGTCACAACAACCTGATTCCCTTAGGCTCCTCAGGTGCCCAGGGA
GGCGGCGGTAGCTCCAGTGCCCACTATGCAGTCAACAACCAGTTCACCATGGGTGGCCCTGCCA
TCTCTATGGCCTCGCCCATGTCCATCCCGACCAACACCATGCACTATGGGAGTTAGGTGCCTCC
AGCCGCGACAGCACTGCGCACTGACAGCACCAGGAAACCAAATGAAGTCCAGGCCCGGCACAGC
CGGTGGCTGTCCCCCTTGTTCTGGAGAAGCGTGAACACCCGGTCACAGCCCTCTTTGCTATGGG
AACTTGGACACTTTTGTACACGATGTCGCCGCTGCCCTCAAGTACCCCCAGCCCAATCTTTGGT
CCCGAGCGAGTGTTGCTGCCATACTTTACATGAGATCCTGTTGGGGCAGCCCTCATCCTGTTCT
GTATCTCCACTCTGACCTGGCTTTGACATCTGCTGGAAGAGGCAAATCCCACCCCCACCCCACA
GCTGCACCTGACCAGGCAGGAGGAGGCCAGCAGCTGCCACCACAGACCTGGCAGCACCCACCCC
ACAACCCGTCCTTGCACCTCCCCTCACCTGGGGTGGCAGCACAGCCAGCTGGACCTCTCCTTCA
ACTACCAGGCCACATGGTCACCATGGGCGTGACATGCTGCTTTTTTTAATTTTATTTTTTTACG
AAAAGAACCAGTGTCAACCCACAGACCCTCTGAGAAACCCGGCTGGCCGGGCCAAGCCAGCAGC
CCTGTCCCTAGGCCCAGAGGTTCTAGGTGAGGGGTGGCCCTGCCGAGCCTTCAGGGTGGGCGAA
GCCCCCTCCCACCAAAGGGTTCACCTCAAACTTGAATGTACAAACCACCCAGCTGTCCAAAGGC
CTAGCCCCTGCTTTCTGCTACTGTCCTGTCCTGAGCCTTGAAGGTCCCCTCCGTCAAAAGCTGG
AACAGGCAGCTCAGAGTGAGTAACCCTGGGCTACTGTGGCAAACAAGAGACCTCAAAGATCTAT
CACAAGGAAGGCATTCTGTCCTGATAGCTAGCATAGGCCTGTGTGTTCCCTCCACATTCATGTT
CCACTCAACTCCTCTCAAGACAGCATCCCTGGGAAGGGGCCTAGCAGGGACCTCTCCCCAGACG
AAAATAAAAGCAAACAAGGAAGGGTGACTAATAAGCACAGGCAGTTTCCAGTCTCTTCCCCTGT
CCCCTTGCCCTAGAGTCCCCACCTTAATGGCCACAGCTCAAGCTGGGCTCCTGCCCACCACAGG
TACCCTCTGGCAAAGGCTGGAGCTGCTCTGTGCCACCCTCCTGACCTGTCAGGGAATCAAAGGG
CCCTCAGGCGACTGGGAAACCAGGCTCTCTCCTGTCCATCAGTAATACTCCCTGCTTGGCTGCC
CCTCCCCACCTTTATATAAATTCTCTGGATCACCTTTGCATAGAAAATAAAAGTGTTTGCTTTG
TAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001025212	(Get FASTA)	NCBI Sequence Viewer
	NP_001029260	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AID68328	(Get FASTA)	NCBI Sequence Viewer
	BAE16333	(Get FASTA)	NCBI Sequence Viewer
	BAE16334	(Get FASTA)	NCBI Sequence Viewer
	BAE16335	(Get FASTA)	NCBI Sequence Viewer
	BAE16336	(Get FASTA)	NCBI Sequence Viewer
	EDL78286	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000012270.6
	ENSRNOP00000042739.3
	ENSRNOP00000049428.5
	ENSRNOP00055018520
	ENSRNOP00060043837
	ENSRNOP00065015733
GenBank Protein	Q4AE70	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001025212 ⟸ NM_001030041
- Peptide Label:	isoform a
- UniProtKB:	A6JNT0 (UniProtKB/TrEMBL), A0A068FP44 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAAAATAVGPGAGSAGVAGPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEVRAG PDAAGIALYSHEDVCVFKCSVSRETECSRVGRQSFIITLGCNSVLIQFATPHDFCSFYNILKTC RGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDV GCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIII SEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFH GVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGL VHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQS YDISIVAQVDQTGSKSSNLLDLKNPFFRYTGTTPSPPPGSHYTSPSENMWNTGSTYNLSSGVAV AGMPTAYDLSSVIAGGSSVGHNNLIPLANTGIVNHTHSRMGSIMSTGIVQGSSGAQGGGGSSSA HYAVNNQFTMGGPAISMASPMSIPTNTMHYGS hide sequence

RefSeq Acc Id:	NP_001029260 ⟸ NM_001034088
- Peptide Label:	isoform b
- UniProtKB:	A0A068FP44 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAAAATAVGPGAGSAGVAGPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEVRAG PDAAGIALYSHEDVCVFKCSVSRETECSRVGRQSFIITLGCNSVLIQFATPHDFCSFYNILKTC RGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDV GCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIII SEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFH GVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGL VHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQS YDISIVAQVDQTGSKSSNLLDLKNPFFRYTGTTPSPPPGSHYTSPSENMWNTGSTYNLSSGVAV AGMPTAYDLSSVIAGGSSVGHNNLIPLGSSGAQGGGGSSSAHYAVNNQFTMGGPAISMASPMSI PTNTMHYGS hide sequence

Ensembl Acc Id:

ENSRNOP00000042739 ⟸ ENSRNOT00000048245

Ensembl Acc Id:

ENSRNOP00000049428 ⟸ ENSRNOT00000041577

Ensembl Acc Id:

ENSRNOP00000012270 ⟸ ENSRNOT00000012269

Protein Domains

Histone-arginine methyltransferase CARM1 N-terminal SAM-dependent MTase PRMT-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4AE70-F1-model_v2	AlphaFold	Q4AE70	1-651	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695783

Promoter ID:

EPDNEW_R6308

Type:

initiation region

Name:

Carm1_1

Description:

coactivator-associated arginine methyltransferase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	22,577,701 - 22,577,761	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305879	AgrOrtholog
BioCyc Gene	G2FUF-31415	BioCyc
Ensembl Genes	ENSRNOG00000031129	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055013317	UniProtKB/Swiss-Prot
	ENSRNOG00060030321	UniProtKB/Swiss-Prot
	ENSRNOG00065012588	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000012269.6	UniProtKB/TrEMBL
	ENSRNOT00000041577.5	UniProtKB/Swiss-Prot
	ENSRNOT00000048245.7	UniProtKB/Swiss-Prot
	ENSRNOT00055022848	UniProtKB/Swiss-Prot
	ENSRNOT00060052733	UniProtKB/Swiss-Prot
	ENSRNOT00065020480	UniProtKB/Swiss-Prot
Gene3D-CATH	2.30.29.30	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.50.150	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Hnrnp arginine n-methyltransferase1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Arg_MeTrfase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Histone-Arg_MeTrfase_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PH-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SAM-dependent_MTases	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:363026	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	363026	ENTREZGENE
PANTHER	HISTONE-ARGININE METHYLTRANSFERASE CARM1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11006	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	CARM1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PrmA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Carm1	PhenoGen
PROSITE	SAM_MT_PRMT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000031129	RatGTEx
	ENSRNOG00055013317	RatGTEx
	ENSRNOG00060030321	RatGTEx
	ENSRNOG00065012588	RatGTEx
Superfamily-SCOP	SSF53335	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A068FP44	ENTREZGENE, UniProtKB/TrEMBL
	A6JNT0	ENTREZGENE, UniProtKB/TrEMBL
	CARM1_RAT	UniProtKB/Swiss-Prot
	D3ZEG8_RAT	UniProtKB/TrEMBL
	Q4AE70	ENTREZGENE
UniProt Secondary	Q4AE68	UniProtKB/Swiss-Prot
	Q4AE69	UniProtKB/Swiss-Prot
	Q4AE71	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-05-21	Carm1	coactivator-associated arginine methyltransferase 1	Prmt4	protein arginine N-methyltransferase 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Prmt4	protein arginine N-methyltransferase 4	Carm1	coactivator-associated arginine methyltransferase 1	Symbol and Name updated	1299863	APPROVED
2005-12-06	Carm1	coactivator-associated arginine methyltransferase 1	Carm1_predicted	coactivator-associated arginine methyltransferase 1 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Carm1_predicted	coactivator-associated arginine methyltransferase 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations