Zfp366 (zinc finger protein 366) - Rat Genome Database

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Gene: Zfp366 (zinc finger protein 366) Rattus norvegicus
Analyze
Symbol: Zfp366
Name: zinc finger protein 366
RGD ID: 2322904
Description: Predicted to enable several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; nuclear estrogen receptor binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of intracellular estrogen receptor signaling pathway; negative regulation of transcription by RNA polymerase II; and response to estrogen. Predicted to be located in nucleoplasm. Orthologous to human ZNF366 (zinc finger protein 366); INTERACTS WITH Monobutylphthalate; N,N-diethyl-m-toluamide; permethrin.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC100360041; LOC310024; Znf366
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8232,312,712 - 32,376,996 (+)NCBIGRCr8
mRatBN7.2230,578,552 - 30,640,546 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl230,578,715 - 30,642,182 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0229,410,169 - 29,498,661 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl229,410,579 - 29,498,664 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0248,576,559 - 48,660,393 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4230,218,990 - 30,237,606 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1230,137,487 - 30,157,975 (+)NCBI
Celera226,604,286 - 26,666,157 (+)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleoplasm  (IEA,ISO)
nucleus  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16522745   PMID:17085477  


Genomics

Comparative Map Data
Zfp366
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8232,312,712 - 32,376,996 (+)NCBIGRCr8
mRatBN7.2230,578,552 - 30,640,546 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl230,578,715 - 30,642,182 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0229,410,169 - 29,498,661 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl229,410,579 - 29,498,664 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0248,576,559 - 48,660,393 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4230,218,990 - 30,237,606 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1230,137,487 - 30,157,975 (+)NCBI
Celera226,604,286 - 26,666,157 (+)NCBICelera
Cytogenetic Map2q12NCBI
ZNF366
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38572,439,903 - 72,507,410 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl572,439,903 - 72,507,410 (-)EnsemblGRCh38hg38GRCh38
GRCh37571,735,730 - 71,803,237 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36571,774,990 - 71,839,005 (-)NCBINCBI36Build 36hg18NCBI36
Build 34571,774,989 - 71,839,005NCBI
Celera567,634,623 - 67,698,641 (-)NCBICelera
Cytogenetic Map5q13.2NCBI
HuRef566,944,930 - 67,008,953 (-)NCBIHuRef
CHM1_1571,171,929 - 71,235,948 (-)NCBICHM1_1
T2T-CHM13v2.0572,921,070 - 72,988,558 (-)NCBIT2T-CHM13v2.0
Zfp366
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391399,321,331 - 99,383,540 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1399,321,331 - 99,387,164 (+)EnsemblGRCm39 Ensembl
GRCm381399,184,823 - 99,247,032 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1399,184,823 - 99,250,656 (+)EnsemblGRCm38mm10GRCm38
MGSCv371399,954,778 - 100,016,987 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613100,284,980 - 100,347,189 (+)NCBIMGSCv36mm8
Celera13102,837,329 - 102,899,644 (+)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1352.25NCBI
Znf366
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555751,223,781 - 1,289,855 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555751,223,834 - 1,289,668 (-)NCBIChiLan1.0ChiLan1.0
ZNF366
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2442,806,844 - 42,871,861 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1540,960,468 - 41,028,156 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0542,805,429 - 42,873,109 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1543,404,795 - 43,471,873 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl543,404,640 - 43,471,868 (+)Ensemblpanpan1.1panPan2
ZNF366
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1255,455,419 - 55,511,302 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl255,458,702 - 55,526,228 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha252,423,544 - 52,470,405 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0255,971,474 - 56,018,284 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl255,972,245 - 56,041,849 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1253,031,675 - 53,078,543 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0253,799,790 - 53,855,696 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0254,690,488 - 54,712,316 (-)NCBIUU_Cfam_GSD_1.0
Znf366
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213186,801,802 - 186,868,147 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365493,991,123 - 4,057,165 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365493,991,181 - 4,057,150 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZNF366
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1648,708,610 - 48,780,941 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11648,708,604 - 49,048,767 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21652,692,109 - 52,712,905 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZNF366
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1466,779,113 - 66,844,839 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl466,776,547 - 66,843,905 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604915,516,471 - 15,601,333 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znf366
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249051,526,693 - 1,544,301 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249051,523,205 - 1,590,722 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zfp366
477 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:83
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000023180
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22699957143154682Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 5
Low 2 33 39 23 16 23 8 11 74 35 34 6 8
Below cutoff 1 10 18 18 18 6

Sequence


RefSeq Acc Id: ENSRNOT00000023180   ⟹   ENSRNOP00000023180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl230,578,715 - 30,642,182 (+)Ensembl
Rnor_6.0 Ensembl229,410,579 - 29,498,664 (+)Ensembl
RefSeq Acc Id: XM_039103477   ⟹   XP_038959405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8232,312,712 - 32,376,996 (+)NCBI
mRatBN7.2230,578,552 - 30,639,143 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038959405 (Get FASTA)   NCBI Sequence Viewer  
  XP_226715 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023180
  ENSRNOP00000023180.5
RefSeq Acc Id: ENSRNOP00000023180   ⟸   ENSRNOT00000023180
RefSeq Acc Id: XP_038959405   ⟸   XM_039103477
- UniProtKB: D4A715 (UniProtKB/TrEMBL)
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A715-F1-model_v2 AlphaFold D4A715 1-743 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691102
Promoter ID:EPDNEW_R1620
Type:single initiation site
Name:Zfp366_1
Description:zinc finger protein 366
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0229,410,676 - 29,410,736EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2322904 AgrOrtholog
BioCyc Gene G2FUF-54700 BioCyc
Ensembl Genes ENSRNOG00000017249 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023180.7 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
NCBI Gene 100360041 ENTREZGENE
PANTHER PR DOMAIN ZINC FINGER PROTEIN UniProtKB/TrEMBL
  PR DOMAIN ZINC FINGER PROTEIN 1 UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
  zf-C2H2_6 UniProtKB/TrEMBL
PhenoGen Zfp366 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017249 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt D4A715 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-08-22 Zfp366  zinc finger protein 366  LOC100360041  zinc finger protein 366  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-31 LOC100360041  zinc finger protein 366  Zfp366  zinc finger protein 366  Data merged from RGD:1306170 737654 APPROVED
2010-05-06 LOC100360041  zinc finger protein 366      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Zfp366  zinc finger protein 366   Zfp366_predicted  zinc finger protein 366 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Zfp366_predicted  zinc finger protein 366 (predicted)  Znf366_predicted    Symbol updated 1299863 APPROVED
2005-01-12 Znf366_predicted  zinc finger protein 366 (predicted)      Symbol and Name status set to approved 70820 APPROVED