Ufsp2 (UFM1-specific peptidase 2) - Rat Genome Database

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Gene: Ufsp2 (UFM1-specific peptidase 2) Rattus norvegicus
Analyze
Symbol: Ufsp2
Name: UFM1-specific peptidase 2
RGD ID: 1311161
Description: Predicted to enable deUFMylase activity and thiolester hydrolase activity. Predicted to be involved in proteolysis and regulation of intracellular estrogen receptor signaling pathway. Predicted to be located in endoplasmic reticulum and nucleus. Human ortholog(s) of this gene implicated in Beukes hip dysplasia and developmental and epileptic encephalopathy. Orthologous to human UFSP2 (UFM1 specific peptidase 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC361151; RGD1311161; similar to RIKEN cDNA 1810047C23; ufm1-specific protease 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21646,272,016 - 46,291,080 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1646,272,016 - 46,291,059 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1651,673,351 - 51,692,467 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01655,042,523 - 55,061,333 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01650,312,726 - 50,331,842 (-)NCBIRnor_WKY
Rnor_6.01649,465,958 - 49,484,975 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1649,465,968 - 49,484,985 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01649,192,524 - 49,211,689 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41649,552,474 - 49,571,471 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11649,552,551 - 49,571,546 (-)NCBI
Celera1644,270,417 - 44,289,211 (-)NCBICelera
Cytogenetic Map16q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO,ISS)
endoplasmic reticulum  (ISO,ISS)
nucleus  (ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:17182609   PMID:21228277   PMID:25219498  


Genomics

Comparative Map Data
Ufsp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21646,272,016 - 46,291,080 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1646,272,016 - 46,291,059 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1651,673,351 - 51,692,467 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01655,042,523 - 55,061,333 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01650,312,726 - 50,331,842 (-)NCBIRnor_WKY
Rnor_6.01649,465,958 - 49,484,975 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1649,465,968 - 49,484,985 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01649,192,524 - 49,211,689 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41649,552,474 - 49,571,471 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11649,552,551 - 49,571,546 (-)NCBI
Celera1644,270,417 - 44,289,211 (-)NCBICelera
Cytogenetic Map16q11NCBI
UFSP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384185,399,537 - 185,425,964 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4185,399,537 - 185,425,979 (-)EnsemblGRCh38hg38GRCh38
GRCh374186,320,691 - 186,347,118 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364186,558,437 - 186,584,062 (-)NCBINCBI36Build 36hg18NCBI36
Celera4183,646,881 - 183,673,344 (-)NCBICelera
Cytogenetic Map4q35.1NCBI
HuRef4182,074,147 - 182,100,608 (-)NCBIHuRef
CHM1_14186,297,123 - 186,323,567 (-)NCBICHM1_1
T2T-CHM13v2.04188,742,869 - 188,769,306 (-)NCBIT2T-CHM13v2.0
Ufsp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39846,428,551 - 46,449,995 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl846,428,565 - 46,449,995 (+)EnsemblGRCm39 Ensembl
GRCm38845,975,515 - 45,996,958 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl845,975,528 - 45,996,958 (+)EnsemblGRCm38mm10GRCm38
MGSCv37847,060,893 - 47,082,214 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36847,474,350 - 47,495,677 (+)NCBIMGSCv36mm8
Celera848,658,421 - 48,679,785 (+)NCBICelera
Cytogenetic Map8B1.1NCBI
Ufsp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540323,634,924 - 23,655,429 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540323,634,967 - 23,655,429 (+)NCBIChiLan1.0ChiLan1.0
UFSP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14189,779,242 - 189,805,572 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4189,779,242 - 189,805,572 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04177,562,642 - 177,589,312 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
UFSP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11645,208,741 - 45,230,041 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1645,208,863 - 45,229,996 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1645,696,365 - 45,717,679 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01647,424,777 - 47,446,091 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1647,424,825 - 47,446,091 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11645,392,610 - 45,413,913 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01646,005,444 - 46,026,743 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01646,136,811 - 46,158,137 (+)NCBIUU_Cfam_GSD_1.0
Ufsp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494334,164,685 - 34,184,002 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365543,925,982 - 3,948,450 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365543,926,046 - 3,945,575 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UFSP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1546,448,904 - 46,470,572 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11546,448,918 - 46,470,616 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21553,234,748 - 53,252,218 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UFSP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17131,352,140 - 131,375,558 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7131,350,251 - 131,375,549 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037111,613,032 - 111,637,249 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ufsp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476916,254,446 - 16,281,025 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476916,254,446 - 16,281,099 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ufsp2
106 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:62
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000016723
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
631833Sach2Saccharin preference QTL 240.01consumption behavior trait (VT:0002069)calculated saccharin drink intake rate (CMO:0001613)164302484250166018Rat

Markers in Region
RH137983  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21646,272,101 - 46,273,449 (+)MAPPERmRatBN7.2
Rnor_6.01649,466,044 - 49,467,391NCBIRnor6.0
Rnor_5.01649,192,610 - 49,193,957UniSTSRnor5.0
RGSC_v3.41649,552,555 - 49,553,902UniSTSRGSC3.4
Celera1644,270,498 - 44,271,845UniSTS
RH 3.4 Map16457.2UniSTS
Cytogenetic Map16q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016723   ⟹   ENSRNOP00000016723
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1646,272,023 - 46,291,059 (-)Ensembl
Rnor_6.0 Ensembl1649,465,968 - 49,484,985 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113258   ⟹   ENSRNOP00000096031
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1646,272,016 - 46,287,454 (-)Ensembl
RefSeq Acc Id: NM_001014142   ⟹   NP_001014164
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21646,272,021 - 46,291,022 (-)NCBI
Rnor_6.01649,465,963 - 49,484,960 (-)NCBI
Rnor_5.01649,192,524 - 49,211,689 (-)NCBI
RGSC_v3.41649,552,474 - 49,571,471 (-)RGD
Celera1644,270,417 - 44,289,211 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253159   ⟹   XP_006253221
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21646,272,016 - 46,291,037 (-)NCBI
Rnor_6.01649,465,958 - 49,484,975 (-)NCBI
Rnor_5.01649,192,524 - 49,211,689 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771265   ⟹   XP_008769487
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21646,272,016 - 46,290,920 (-)NCBI
Rnor_6.01649,465,958 - 49,484,876 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039094640   ⟹   XP_038950568
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21646,272,016 - 46,291,080 (-)NCBI
RefSeq Acc Id: XM_039094641   ⟹   XP_038950569
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21646,272,016 - 46,286,511 (-)NCBI
RefSeq Acc Id: XM_039094642   ⟹   XP_038950570
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21646,272,016 - 46,291,042 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001014164   ⟸   NM_001014142
- UniProtKB: Q5XIB4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006253221   ⟸   XM_006253159
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008769487   ⟸   XM_008771265
- Peptide Label: isoform X1
- UniProtKB: Q5XIB4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016723   ⟸   ENSRNOT00000016723
RefSeq Acc Id: XP_038950568   ⟸   XM_039094640
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038950570   ⟸   XM_039094642
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038950569   ⟸   XM_039094641
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000096031   ⟸   ENSRNOT00000113258

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIB4-F1-model_v2 AlphaFold Q5XIB4 1-461 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700104
Promoter ID:EPDNEW_R10627
Type:initiation region
Name:Ufsp2_1
Description:UFM1-specific peptidase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01649,484,982 - 49,485,042EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311161 AgrOrtholog
BioCyc Gene G2FUF-11331 BioCyc
Ensembl Genes ENSRNOG00000012087 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000016723 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000096031.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016723 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000113258.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7193395 IMAGE-MGC_LOAD
InterPro Peptidase_C78_UfSP1/2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:361151 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94722 IMAGE-MGC_LOAD
NCBI Gene 361151 ENTREZGENE
Pfam Peptidase_C78 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ufsp2 PhenoGen
UniProt A0A8I6AQ70_RAT UniProtKB/TrEMBL
  Q5XIB4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-31 Ufsp2  UFM1-specific peptidase 2  RGD1311161  similar to RIKEN cDNA 1810047C23  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1311161  similar to RIKEN cDNA 1810047C23  RGD1311161_predicted  similar to RIKEN cDNA 1810047C23 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1311161_predicted  similar to RIKEN cDNA 1810047C23 (predicted)  LOC361151_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC361151_predicted  similar to RIKEN cDNA 1810047C23 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL