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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:herpes simplex
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Accession:DOID:8566 term browser browse the term
Definition:A viral infectious disease that results_in_formation_of lesions, located_in mouth, located_in face, located_in genitalia, or located_in hands, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, which are transmitted_by direct contact with an active lesion or body fluid of an infected person. (DO)
Synonyms:exact_synonym: Herpesvirus hominis disease
 related_synonym: Herpes simplex virus 2 seropositivity
 xref: EFO:0009339;   EFO:1002022;   ICD10CM:B00.9;   ICD9CM:054;   MESH:D006561;   MONDO:0004609;   NCI:C155871
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
herpes simplex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E ISO RGD PMID:17101197 RGD:7771596 NCBI chr 1:110,525,717...110,528,534
Ensembl chr 1:110,525,722...110,528,440 		JBrowse link
G C3 complement C3 ISO RGD PMID:11509581 RGD:7401276 NCBI chr20:53,566,226...53,598,365
Ensembl chr20:53,566,261...53,598,761 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO mRNA:increased expression:cornea (mouse) RGD PMID:9544579 RGD:8549472 NCBI chr 9:39,008,187...39,009,932 JBrowse link
G CD1D CD1d molecule exacerbates ISO RGD PMID:18614643 RGD:127345112 NCBI chr38:23,489,169...23,491,712 JBrowse link
G CD274 CD274 molecule ISO RGD PMID:29669784 RGD:41412169 NCBI chr 1:93,461,735...93,605,772
Ensembl chr 1:93,585,518...93,603,522 		JBrowse link
G CD40LG CD40 ligand ISO RGD PMID:11134274 RGD:8547770 NCBI chr  X:107,001,421...107,023,007
Ensembl chr  X:107,010,890...107,023,006 		JBrowse link
G CD8A CD8 subunit alpha ISO mRNA:increased expression:trigeminal ganglion (mouse) RGD PMID:19151393 RGD:124715454 NCBI chr17:38,396,022...38,400,508
Ensembl chr17:38,369,414...38,400,508 		JBrowse link
G DOCK8 dedicator of cytokinesis 8 severity ISO RGD PMID:25776845 RGD:11055046 NCBI chr 1:89,152,456...89,379,203
Ensembl chr 1:89,150,856...89,378,013 		JBrowse link
G IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 ISO RGD PMID:30050136 RGD:40902865 NCBI chr 9:25,199,287...25,240,693
Ensembl chr 9:25,198,805...25,240,578 		JBrowse link
G IL18 interleukin 18 treatment ISO RGD PMID:9971824 RGD:8655923 NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348 		JBrowse link
G IL21 interleukin 21 treatment ISO mRNA:increased expression:spleen (mouse) RGD PMID:16406655 PMID:19233474 RGD:127285367 RGD:127285372 NCBI chr19:17,641,833...17,651,275
Ensembl chr19:17,641,833...17,651,266 		JBrowse link
G IL32 interleukin 32 ISO associated with human immunodeficiency virus infectious disease; protein,mRNA:decreased expression:CD4-positive��helper��T��cell��(human) RGD PMID:28007920 RGD:150340722 NCBI chr 6:38,119,287...38,122,979 JBrowse link
G IL33 interleukin 33 ISO protein:increased expression:skin RGD PMID:26872602 RGD:39939003 NCBI chr11:27,219,878...27,256,723
Ensembl chr11:27,219,878...27,256,721 		JBrowse link
G IRF5 interferon regulatory factor 5 susceptibility ISO associated with multiple sclerosis;DNA:SNP: :rs3807306 (human) RGD PMID:20861862 RGD:40924643 NCBI chr14:7,724,168...7,734,976
Ensembl chr14:7,724,780...7,742,795 		JBrowse link
G MBL1 mannose binding lectin 1 disease_progression
susceptibility		 ISO DNA:polymorphism:cds: RGD PMID:15498041 PMID:19480845 RGD:8693725 RGD:8693727 NCBI chr 4:29,419,886...29,424,377 JBrowse link
G NECTIN1 nectin cell adhesion molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10729168 NCBI chr 5:14,228,197...14,292,825
Ensembl chr 5:14,228,197...14,315,060 		JBrowse link
G NECTIN2 nectin cell adhesion molecule 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10729168 PMID:11602758 PMID:30319691 NCBI chr 1:110,543,140...110,569,168
Ensembl chr 1:110,543,247...110,569,143 		JBrowse link
G RIPK3 receptor interacting serine/threonine kinase 3 exacerbates ISO RGD PMID:25316792 PMID:30050136 RGD:127229943 RGD:40902865 NCBI chr 8:4,304,167...4,309,514
Ensembl chr 8:4,305,250...4,309,325 		JBrowse link
G RPL30 ribosomal protein L30 ISO protein:increased serine phosphorylation:ribosome RGD PMID:7588575 RGD:11039399 NCBI chr13:301,263...304,854 JBrowse link
eczema herpeticum term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IDO1 indoleamine 2,3-dioxygenase 1 severity ISO associated with atopic dermatitis; protein:increased activity:serum (human) RGD PMID:26198597 RGD:11528429 NCBI chr16:25,391,759...25,407,161
Ensembl chr16:25,391,754...25,407,048 		JBrowse link
G IFNG interferon gamma susceptibility ISO DNA:haplotype::
mRNA,protein:decreased expression:peripheral mononuclear cell:		 RGD PMID:21458658 RGD:6480259 NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698 		JBrowse link
genital herpes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL5 C-C motif chemokine ligand 5 ISO RGD PMID:12502811 RGD:4890015 NCBI chr 9:37,817,409...37,823,852
Ensembl chr 9:37,817,305...37,823,852 		JBrowse link
G IFNAR1 interferon alpha and beta receptor subunit 1 exacerbates ISO RGD PMID:28264883 RGD:125093738 NCBI chr31:28,854,765...28,876,399 JBrowse link
G IFNG interferon gamma ISO protein:increased expression:vaginal secretion: RGD PMID:10366565 RGD:8158034 NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698 		JBrowse link
G IL21 interleukin 21 treatment ISO RGD PMID:24358128 RGD:127285365 NCBI chr19:17,641,833...17,651,275
Ensembl chr19:17,641,833...17,651,266 		JBrowse link
G IL3 interleukin 3 ISO RNA: increased expression RGD PMID:21175248 RGD:5686876 NCBI chr11:20,330,480...20,332,668
Ensembl chr11:20,330,480...20,332,668 		JBrowse link
G IRF9 interferon regulatory factor 9 exacerbates ISO RGD PMID:28264883 RGD:125093738 NCBI chr 8:4,152,146...4,157,201 JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 ameliorates ISO RGD PMID:31555293 RGD:42722615 NCBI chr36:20,989,205...21,087,044
Ensembl chr36:20,989,360...21,012,524 		JBrowse link
G RNASEL ribonuclease L severity ISO RGD PMID:17157346 RGD:40902623 NCBI chr 7:15,978,055...16,001,604
Ensembl chr 7:15,856,151...16,001,569 		JBrowse link
G STAT4 signal transducer and activator of transcription 4 severity
treatment		 ISO DNA:SNPs, haplotype: :multiple
DNA:SNP:intron:rs7572482 (human)		 RGD PMID:22718836 RGD:8661697 NCBI chr37:1,566,563...1,685,378
Ensembl chr37:1,566,585...1,829,894 		JBrowse link
Herpes Simplex Encephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E susceptibility ISO DNA:polymorphism:exon: RGD PMID:11118260 RGD:7771554 NCBI chr 1:110,525,717...110,528,534
Ensembl chr 1:110,525,722...110,528,440 		JBrowse link
G AQP4 aquaporin 4 ISO RGD PMID:17454447 RGD:8698664 NCBI chr 7:61,855,617...61,868,953
Ensembl chr 7:61,855,744...61,865,089 		JBrowse link
G CALCR calcitonin receptor treatment ISO RGD PMID:22761571 RGD:7240516 NCBI chr14:18,923,116...19,074,904
Ensembl chr14:18,923,116...19,074,904 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO RGD PMID:22377584 RGD:8661752 NCBI chr20:42,305,344...42,313,258
Ensembl chr20:42,307,580...42,308,698 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 ISO RGD PMID:23391218 RGD:8551839 NCBI chr20:42,293,288...42,297,952
Ensembl chr20:42,294,996...42,297,952 		JBrowse link
G CRSP-3 calcitonin receptor-stimulating peptide 3 treatment ISO RGD PMID:22761571 RGD:7240516 NCBI chr21:37,676,841...37,680,643
Ensembl chr21:37,676,841...37,680,645 		JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 ISO RGD PMID:22377584 RGD:8661752 NCBI chr23:8,937,069...8,954,738
Ensembl chr23:8,938,906...8,952,808 		JBrowse link
G GDNF glial cell derived neurotrophic factor ISO mRNA:increased expression:brain: RGD PMID:15950786 RGD:8657070 NCBI chr 4:70,966,694...70,991,860
Ensembl chr 4:70,971,432...70,989,714 		JBrowse link
G IL1RL1 interleukin 1 receptor like 1 severity ISO RGD PMID:26872602 RGD:39939003 NCBI chr10:40,658,191...40,732,097
Ensembl chr10:40,659,041...40,677,357 		JBrowse link
G IRF3 interferon regulatory factor 3 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr 1:106,875,016...106,879,065
Ensembl chr 1:106,875,118...106,879,065 		JBrowse link
G LTA lymphotoxin alpha ISO RGD PMID:11145686 RGD:8548806 NCBI chr12:1,070,608...1,073,053
Ensembl chr12:1,071,192...1,073,067 		JBrowse link
G MMP2 matrix metallopeptidase 2 ISO protein:increased activity:brain RGD PMID:15364410 RGD:8547868 NCBI chr 2:60,471,092...60,492,991
Ensembl chr 2:60,471,257...60,494,113 		JBrowse link
G MMP9 matrix metallopeptidase 9 treatment ISO protein:increased activity:brain RGD PMID:15364410 PMID:20483026 RGD:8547867 RGD:8547868 NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293 		JBrowse link
G STAT4 signal transducer and activator of transcription 4 susceptibility ISO RGD PMID:17266445 RGD:8661706 NCBI chr37:1,566,563...1,685,378
Ensembl chr37:1,566,585...1,829,894 		JBrowse link
G TICAM1 TIR domain containing adaptor molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr20:54,948,237...54,961,996
Ensembl chr20:54,959,525...54,961,780 		JBrowse link
G TLR2 toll like receptor 2 disease_progression ISO RGD PMID:14739339 PMID:20806060 RGD:5130178 RGD:8553026 NCBI chr15:51,454,557...51,465,429
Ensembl chr15:51,454,695...51,465,241 		JBrowse link
G TLR3 toll like receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr16:44,617,012...44,633,591
Ensembl chr16:44,550,846...44,653,247 		JBrowse link
G TLR4 toll like receptor 4 ISO RGD PMID:20806060 RGD:5130178 NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165 		JBrowse link
G TLR9 toll like receptor 9 resistance ISO mRNA:increased expression:cheek (rat) RGD PMID:20806060 RGD:5130178 NCBI chr20:37,529,322...37,547,117
Ensembl chr20:37,542,340...37,547,114
Ensembl chr20:37,542,340...37,547,114 		JBrowse link
G TRAF3 TNF receptor associated factor 3 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr 8:70,739,389...70,794,448
Ensembl chr 8:70,739,417...70,790,645 		JBrowse link
G UNC93B1 unc-93 homolog B1, TLR signaling regulator ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr18:49,826,044...49,835,417
Ensembl chr18:49,826,026...49,882,461 		JBrowse link
Herpes Simplex Encephalitis 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANKRD37 ankyrin repeat domain 37 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr16:45,230,095...45,233,411
Ensembl chr16:45,230,096...45,233,418 		JBrowse link
G CCDC110 coiled-coil domain containing 110 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr16:45,158,092...45,180,280
Ensembl chr16:45,159,502...45,193,767 		JBrowse link
G CFAP96 cilia and flagella associated protein 96 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr16:45,175,351...45,208,647
Ensembl chr16:45,192,032...45,207,964 		JBrowse link
G CFAP97 cilia and flagella associated protein 97 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr16:45,412,156...45,446,514
Ensembl chr16:45,418,785...45,453,500 		JBrowse link
G CYP4V2 cytochrome P450 family 4 subfamily V member 2 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr16:44,523,583...44,541,781 JBrowse link
G F11 coagulation factor XI ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr16:44,469,609...44,492,833
Ensembl chr16:44,469,632...44,540,292 		JBrowse link
G FAM149A family with sequence similarity 149 member A ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr16:44,550,726...44,603,466
Ensembl chr16:44,550,846...44,653,247 		JBrowse link
G FAT1 FAT atypical cadherin 1 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr16:44,113,621...44,241,187
Ensembl chr16:44,128,386...44,241,192 		JBrowse link
G KLKB1 kallikrein B1 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr16:44,492,735...44,517,854
Ensembl chr16:44,469,632...44,540,292 		JBrowse link
G LRP2BP LRP2 binding protein ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr16:45,243,317...45,271,479
Ensembl chr16:45,243,342...45,271,361 		JBrowse link
G MTNR1A melatonin receptor 1A ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr16:44,258,239...44,286,761 JBrowse link
G PDLIM3 PDZ and LIM domain 3 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr16:45,111,358...45,141,444
Ensembl chr16:45,111,372...45,140,895 		JBrowse link
G SLC25A4 solute carrier family 25 member 4 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr16:45,454,660...45,458,606
Ensembl chr16:45,411,810...45,542,162 		JBrowse link
G SNX25 sorting nexin 25 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr16:45,269,434...45,411,890
Ensembl chr16:45,269,412...45,403,719 		JBrowse link
G SORBS2 sorbin and SH3 domain containing 2 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr16:44,847,384...45,063,218
Ensembl chr16:44,717,052...45,061,337 		JBrowse link
G TBK1 TANK binding kinase 1 ISO ClinVar Annotator: match by term: HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 1 ClinVar PMID:25700176 PMID:25803835 PMID:26476236 PMID:26581300 PMID:28492532 NCBI chr10:7,169,664...7,208,890
Ensembl chr10:7,168,007...7,208,899 		JBrowse link
G TLR3 toll like receptor 3 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis 1 | ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:9536098 PMID:15042513 PMID:16199547 PMID:17434873 PMID:17576681 More... NCBI chr16:44,617,012...44,633,591
Ensembl chr16:44,550,846...44,653,247 		JBrowse link
G UFSP2 UFM1 specific peptidase 2 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr16:45,208,741...45,230,041
Ensembl chr16:45,208,863...45,229,996 		JBrowse link
G UNC93B1 unc-93 homolog B1, TLR signaling regulator susceptibility ISO ClinVar Annotator: match by term: Herpes simplex encephalitis 1 | ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 OMIM
ClinVar		 PMID:9536098 PMID:16199547 PMID:16973841 PMID:17576681 PMID:24033266 More... NCBI chr18:49,826,044...49,835,417
Ensembl chr18:49,826,026...49,882,461 		JBrowse link
Herpes Simplex Encephalitis 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADSS1 adenylosuccinate synthase 1 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:72,288,246...72,305,479
Ensembl chr 8:72,288,323...72,305,479 		JBrowse link
G AHNAK2 AHNAK nucleoprotein 2 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:72,423,322...72,446,388 JBrowse link
G AKT1 AKT serine/threonine kinase 1 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:72,317,399...72,335,686
Ensembl chr 8:72,317,869...72,335,193 		JBrowse link
G AMN amnion associated transmembrane protein ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:70,800,435...70,807,835 JBrowse link
G ANKRD9 ankyrin repeat domain 9 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:70,441,493...70,445,555
Ensembl chr 8:70,441,587...70,443,987 		JBrowse link
G ASPG asparaginase ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:71,747,319...71,764,570
Ensembl chr 8:71,753,164...71,765,349 		JBrowse link
G ATP5MJ ATP synthase membrane subunit j ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:71,600,422...71,605,615 JBrowse link
G BAG5 BAG cochaperone 5 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:71,318,730...71,324,743
Ensembl chr 8:71,321,625...71,322,992 		JBrowse link
G BRF1 BRF1 RNA polymerase III transcription initiation factor subunit ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:72,588,578...72,632,259
Ensembl chr 8:72,588,693...72,632,263 		JBrowse link
G BTBD6 BTB domain containing 6 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:72,605,715...72,607,189
Ensembl chr 8:72,605,516...72,607,023 		JBrowse link
G C8H14orf180 chromosome 8 C14orf180 homolog ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:72,165,757...72,176,235
Ensembl chr 8:72,165,810...72,176,264 		JBrowse link
G CDC42BPB CDC42 binding protein kinase beta ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:70,809,943...70,915,922
Ensembl chr 8:70,811,023...71,033,324 		JBrowse link
G CDCA4 cell division cycle associated 4 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:72,457,671...72,465,630
Ensembl chr 8:72,458,160...72,465,767 		JBrowse link
G CEP170B centrosomal protein 170B ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:72,374,536...72,399,714 JBrowse link
G CINP cyclin dependent kinase 2 interacting protein ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:70,307,464...70,332,838
Ensembl chr 8:70,307,586...70,332,845 		JBrowse link
G CLBA1 clathrin binding box of aftiphilin containing 1 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:72,448,580...72,454,685
Ensembl chr 8:72,443,323...72,454,191 		JBrowse link
G COA8 cytochrome c oxidase assembly factor 8 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:71,324,271...71,357,468
Ensembl chr 8:71,318,244...71,357,466 		JBrowse link
G DYNC1H1 dynein cytoplasmic 1 heavy chain 1 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:69,997,021...70,064,886
Ensembl chr 8:69,997,145...70,064,825 		JBrowse link
G EIF5 eukaryotic translation initiation factor 5 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:71,102,628...71,111,971
Ensembl chr 8:71,102,690...71,270,399 		JBrowse link
G EXOC3L4 exocyst complex component 3 like 4 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:70,943,515...70,956,211
Ensembl chr 8:70,946,994...70,955,867 		JBrowse link
G GPR132 G protein-coupled receptor 132 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:72,478,585...72,493,165
Ensembl chr 8:72,479,905...72,493,609 		JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:70,091,203...70,096,107
Ensembl chr 8:70,092,217...70,095,243 		JBrowse link
G INF2 inverted formin 2 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:72,275,209...72,284,991 JBrowse link
G JAG2 jagged canonical Notch ligand 2 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:72,535,539...72,553,531
Ensembl chr 8:72,535,107...72,550,322 		JBrowse link
G KIF26A kinesin family member 26A ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:71,789,024...71,827,794
Ensembl chr 8:71,788,821...71,827,804 		JBrowse link
G KLC1 kinesin light chain 1 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:71,401,795...71,444,056
Ensembl chr 8:71,400,003...71,444,062 		JBrowse link
G LOC100855552 creatine kinase B-type ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:71,284,104...71,287,379 JBrowse link
G MARK3 microtubule affinity regulating kinase 3 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:71,148,263...71,269,717
Ensembl chr 8:71,102,690...71,270,399 		JBrowse link
G MOK MOK protein kinase ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:70,209,211...70,270,065
Ensembl chr 8:70,211,746...70,269,884 		JBrowse link
G NUDT14 nudix hydrolase 14 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:72,562,314...72,568,542
Ensembl chr 8:72,562,314...72,567,057 		JBrowse link
G PACS2 phosphofurin acidic cluster sorting protein 2 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:72,672,861...72,721,655
Ensembl chr 8:72,673,472...72,721,215 		JBrowse link
G PLD4 phospholipase D family member 4 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:72,410,076...72,417,681
Ensembl chr 8:72,416,637...72,417,384 		JBrowse link
G PPP1R13B protein phosphatase 1 regulatory subunit 13B ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:71,462,338...71,518,918
Ensembl chr 8:71,463,270...71,553,692 		JBrowse link
G PPP2R5C protein phosphatase 2 regulatory subunit B'gamma ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:69,846,311...69,969,409
Ensembl chr 8:69,846,446...69,967,578 		JBrowse link
G RCOR1 REST corepressor 1 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:70,586,259...70,637,453
Ensembl chr 8:70,585,567...70,627,158 		JBrowse link
G RD3L RD3 like ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:71,618,412...71,620,928
Ensembl chr 8:71,618,838...71,620,005 		JBrowse link
G SIVA1 SIVA1 apoptosis inducing factor ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:72,309,400...72,313,726
Ensembl chr 8:72,309,447...72,313,640 		JBrowse link
G TDRD9 tudor domain containing 9 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:71,610,653...71,717,772
Ensembl chr 8:71,610,711...71,717,199 		JBrowse link
G TECPR2 tectonin beta-propeller repeat containing 2 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:70,332,934...70,435,558
Ensembl chr 8:70,344,063...70,434,218 		JBrowse link
G TMEM179 transmembrane protein 179 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:72,177,054...72,188,324
Ensembl chr 8:72,179,141...72,188,917 		JBrowse link
G TNFAIP2 TNF alpha induced protein 2 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:70,965,776...70,977,807
Ensembl chr 8:70,967,741...70,976,396 		JBrowse link
G TRAF3 TNF receptor associated factor 3 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 | ClinVar Annotator: match by term: TRAF3 haploinsufficiency | ClinVar Annotator: match by term: TRAF3 related condition ClinVar
OMIM		 PMID:9536098 PMID:17576681 PMID:20832341 PMID:25741868 PMID:28492532 More... NCBI chr 8:70,739,389...70,794,448
Ensembl chr 8:70,739,417...70,790,645 		JBrowse link
G TRMT61A tRNA methyltransferase 61A ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:71,294,129...71,300,679
Ensembl chr 8:71,294,303...71,300,687 		JBrowse link
G WDR20 WD repeat domain 20 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:70,150,090...70,208,683
Ensembl chr 8:70,146,967...70,199,975 		JBrowse link
G XRCC3 X-ray repair cross complementing 3 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:71,441,732...71,452,922
Ensembl chr 8:71,442,429...71,449,408 		JBrowse link
G ZBTB42 zinc finger and BTB domain containing 42 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:72,339,038...72,346,109 JBrowse link
G ZFYVE21 zinc finger FYVE-type containing 21 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:71,451,968...71,462,244
Ensembl chr 8:71,451,999...71,461,938 		JBrowse link
G ZNF839 zinc finger protein 839 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532 NCBI chr 8:70,285,289...70,302,355
Ensembl chr 8:70,285,326...70,302,218 		JBrowse link
Herpes Simplex Encephalitis 4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TICAM1 TIR domain containing adaptor molecule 1 susceptibility ISO ClinVar Annotator: match by term: ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 6 | ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 4 OMIM
ClinVar		 PMID:22105173 PMID:24033266 PMID:25741868 PMID:26513235 PMID:28492532 NCBI chr20:54,948,237...54,961,996
Ensembl chr20:54,959,525...54,961,780 		JBrowse link
Herpes Simplex Encephalitis 7 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IRF3 interferon regulatory factor 3 susceptibility ISO ClinVar Annotator: match by term: Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 7 | ClinVar Annotator: match by term: IRF3-related condition OMIM
ClinVar		 PMID:25741868 PMID:26216125 PMID:26513235 PMID:28492532 NCBI chr 1:106,875,016...106,879,065
Ensembl chr 1:106,875,118...106,879,065 		JBrowse link
herpes simplex virus keratitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E treatment ISO RGD PMID:18515564 RGD:7771550 NCBI chr 1:110,525,717...110,528,534
Ensembl chr 1:110,525,722...110,528,440 		JBrowse link
G ATM ATM serine/threonine kinase ameliorates ISO RGD PMID:24370835 RGD:126781690 NCBI chr 5:24,180,129...24,297,207
Ensembl chr 5:24,182,135...24,297,207 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 severity ISO associated with Herpes Simplex, Type 1 RGD PMID:16997857 RGD:8548890 NCBI chr 9:39,008,187...39,009,932 JBrowse link
G CCL20 C-C motif chemokine ligand 20 ISO RGD PMID:15287366 RGD:7483593 NCBI chr25:40,506,385...40,509,903
Ensembl chr25:40,506,753...40,509,709 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 ISO RGD PMID:16476970 PMID:18798077 RGD:8551819 RGD:8551837 NCBI chr20:42,293,288...42,297,952
Ensembl chr20:42,294,996...42,297,952 		JBrowse link
G CCR6 C-C motif chemokine receptor 6 ISO RGD PMID:15287366 RGD:7483593 NCBI chr 1:54,932,798...54,960,646
Ensembl chr 1:54,932,690...54,959,740 		JBrowse link
G CD274 CD274 molecule ISO RGD PMID:16253242 RGD:41410794 NCBI chr 1:93,461,735...93,605,772
Ensembl chr 1:93,585,518...93,603,522 		JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 ISO RGD PMID:18798077 RGD:8551819 NCBI chr  X:55,882,433...55,884,582
Ensembl chr  X:55,882,433...55,884,582 		JBrowse link
G EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 treatment ISO RGD PMID:15670795 RGD:40902819 NCBI chr17:29,494,641...29,537,933
Ensembl chr17:29,496,128...29,537,933 		JBrowse link
G IFNB1 interferon beta 1 treatment ISO RGD PMID:15670795 RGD:40902819 NCBI chr11:40,668,295...40,668,855
Ensembl chr11:40,668,295...40,668,855 		JBrowse link
G IFNG interferon gamma ISO RGD PMID:12162877 RGD:8157603 NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698 		JBrowse link
G IL10 interleukin 10 treatment ISO RGD PMID:22467659 RGD:7364834 NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057 		JBrowse link
G IL1B interleukin 1 beta ISO mRNA:increased expression:cornea RGD PMID:10624423 RGD:7401196 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458 		JBrowse link
G IL1RN interleukin 1 receptor antagonist treatment ISO human protein in a mouse model RGD PMID:15258192 RGD:8549793 NCBI chr17:37,236,690...37,250,424
Ensembl chr17:37,212,751...37,249,329 		JBrowse link
G IL21 interleukin 21 treatment ISO RGD PMID:21204603 PMID:29370719 RGD:127285376 RGD:127285545 NCBI chr19:17,641,833...17,651,275
Ensembl chr19:17,641,833...17,651,266 		JBrowse link
G IL23A interleukin 23 subunit alpha ISO mRNA;increased expression:trigeminal ganglion (mouse) RGD PMID:12162874 RGD:39457946 NCBI chr10:635,384...640,715
Ensembl chr10:638,719...640,359 		JBrowse link
G KDR kinase insert domain receptor treatment ISO protein:increased expression:cornea: RGD PMID:16951377 RGD:8549742 NCBI chr13:47,442,861...47,484,574
Ensembl chr13:47,442,764...47,485,042 		JBrowse link
G RNASEL ribonuclease L treatment ISO RGD PMID:15670795 RGD:40902819 NCBI chr 7:15,978,055...16,001,604
Ensembl chr 7:15,856,151...16,001,569 		JBrowse link
G STAT4 signal transducer and activator of transcription 4 susceptibility ISO RGD PMID:17266445 RGD:8661706 NCBI chr37:1,566,563...1,685,378
Ensembl chr37:1,566,585...1,829,894 		JBrowse link
G TLR2 toll like receptor 2 ISO RGD PMID:17686871 RGD:7794851 NCBI chr15:51,454,557...51,465,429
Ensembl chr15:51,454,695...51,465,241 		JBrowse link
G TLR4 toll like receptor 4 ISO mRNA:increased expression:cornea: RGD PMID:17667620 PMID:17686871 RGD:7794851 RGD:8552970 NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165 		JBrowse link
G TLR9 toll like receptor 9 ISO RGD PMID:17686871 RGD:7794851 NCBI chr20:37,529,322...37,547,117
Ensembl chr20:37,542,340...37,547,114
Ensembl chr20:37,542,340...37,547,114 		JBrowse link
G TNF tumor necrosis factor ISO mRNA:increased expression:cornea RGD PMID:10624423 PMID:12162877 RGD:7401196 RGD:8157603 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425 		JBrowse link
Immunodeficiency 83 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TLR3 toll like receptor 3 susceptibility ISO ClinVar Annotator: match by term: Immunodeficiency 83, susceptibility to viral infections ClinVar
OMIM		 PMID:17872438 PMID:19625408 PMID:20472559 PMID:20855885 PMID:21911422 More... NCBI chr16:44,617,012...44,633,591
Ensembl chr16:44,550,846...44,653,247 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15757
    disease by infectious agent 2168
      viral infectious disease 1663
        Viral Skin Diseases 157
          herpes simplex 123
            Febrile Ulceronecrotic Mucha-Habermann Disease 0
            Herpes Labialis 0
            Herpes Simplex Encephalitis + 85
            Herpetic Stomatitis 0
            Neonatal Herpes 0
            eczema herpeticum 2
            genital herpes 9
            herpes simplex virus keratitis + 23
            herpetic whitlow 0
Path 2
Term Annotations click to browse term
  disease 15757
    Pathological Conditions, Signs and Symptoms 12323
      Signs and Symptoms 10318
        Neurologic Manifestations 9993
          sensory system disease 7033
            skin disease 4107
              Infectious Skin Diseases 287
                Viral Skin Diseases 157
                  herpes simplex 123
                    Febrile Ulceronecrotic Mucha-Habermann Disease 0
                    Herpes Labialis 0
                    Herpes Simplex Encephalitis + 85
                    Herpetic Stomatitis 0
                    Neonatal Herpes 0
                    eczema herpeticum 2
                    genital herpes 9
                    herpes simplex virus keratitis + 23
                    herpetic whitlow 0
paths to the root