JAG2 (jagged canonical Notch ligand 2) - Rat Genome Database

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Gene: JAG2 (jagged canonical Notch ligand 2) Canis lupus familiaris
Analyze
Symbol: JAG2
Name: jagged canonical Notch ligand 2
RGD ID: 12375852
Description: ENCODES a protein that exhibits calcium ion binding (inferred); growth factor activity (inferred); Notch binding (inferred); INVOLVED IN epithelial cell apoptotic process involved in palatal shelf morphogenesis (ortholog); in utero embryonic development (ortholog); male gonad development (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 27 (ortholog); Breast Neoplasms (ortholog); Charcot-Marie-Tooth disease axonal type 2O (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: jagged 2; protein jagged-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1872,535,539 - 72,553,531 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl872,535,107 - 72,550,322 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha872,047,599 - 72,068,957 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0872,823,360 - 72,848,984 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl872,822,931 - 72,856,860 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1872,503,851 - 72,525,225 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0872,554,984 - 72,576,363 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0872,944,852 - 72,966,232 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
JAG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1872,535,539 - 72,553,531 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl872,535,107 - 72,550,322 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha872,047,599 - 72,068,957 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0872,823,360 - 72,848,984 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl872,822,931 - 72,856,860 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1872,503,851 - 72,525,225 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0872,554,984 - 72,576,363 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0872,944,852 - 72,966,232 (-)NCBIUU_Cfam_GSD_1.0
JAG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814105,140,995 - 105,168,776 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14105,140,982 - 105,168,824 (-)EnsemblGRCh38hg38GRCh38
GRCh3714105,607,332 - 105,635,113 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614104,679,121 - 104,706,206 (-)NCBINCBI36Build 36hg18NCBI36
Build 3414104,679,120 - 104,706,206NCBI
Celera1485,661,503 - 85,688,392 (-)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1485,798,697 - 85,815,481 (-)NCBIHuRef
CHM1_114105,545,299 - 105,572,922 (-)NCBICHM1_1
T2T-CHM13v2.01499,382,854 - 99,410,701 (-)NCBIT2T-CHM13v2.0
Jag2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912112,871,439 - 112,893,437 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12112,871,439 - 112,893,396 (-)EnsemblGRCm39 Ensembl
GRCm3812112,907,803 - 112,929,812 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12112,907,819 - 112,929,776 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712114,146,801 - 114,167,706 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612113,356,398 - 113,377,303 (-)NCBIMGSCv36mm8
Celera12114,118,903 - 114,139,458 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.37NCBI
Jag2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,804,133 - 137,826,738 (-)NCBIGRCr8
mRatBN7.26131,983,059 - 132,005,665 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6131,983,056 - 132,005,818 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6132,152,615 - 132,174,787 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,442,522 - 132,464,547 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,817,423 - 131,839,474 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,711,144 - 137,733,331 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,711,155 - 137,733,026 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06146,707,326 - 146,729,504 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46137,909,633 - 137,931,120 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16137,916,169 - 137,936,985 (-)NCBI
Celera6129,521,212 - 129,543,266 (-)NCBICelera
Cytogenetic Map6q32NCBI
Jag2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555383,421,685 - 3,433,842 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555383,421,685 - 3,433,829 (-)NCBIChiLan1.0ChiLan1.0
JAG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215106,321,986 - 106,348,518 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114105,538,488 - 105,565,020 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01485,785,586 - 85,812,056 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114105,569,837 - 105,604,408 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14105,569,837 - 105,585,878 (-)Ensemblpanpan1.1panPan2
Jag2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086401,534,532 - 1,551,659 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936621366,616 - 380,618 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936621363,489 - 380,616 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JAG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.27131,225,201 - 131,245,220 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JAG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12483,050,412 - 83,081,982 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2483,051,368 - 83,076,820 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605370,482,903 - 70,500,481 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Jag2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624734308,375 - 327,604 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624734308,371 - 327,496 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in JAG2
446 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000029230   ⟹   ENSCAFP00000027180
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl872,535,107 - 72,550,322 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845040047   ⟹   ENSCAFP00845031359
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl872,822,931 - 72,845,127 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845040253   ⟹   ENSCAFP00845031532
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl872,822,931 - 72,845,127 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845040481   ⟹   ENSCAFP00845031696
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl872,837,576 - 72,856,860 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845040536   ⟹   ENSCAFP00845031734
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl872,849,792 - 72,856,860 (-)Ensembl
RefSeq Acc Id: XM_038484386   ⟹   XP_038340314
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1872,503,851 - 72,525,225 (-)NCBI
RefSeq Acc Id: XM_038545932   ⟹   XP_038401860
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0872,944,852 - 72,966,232 (-)NCBI
RefSeq Acc Id: XM_038597065   ⟹   XP_038452993
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha872,047,599 - 72,068,957 (-)NCBI
RefSeq Acc Id: XM_038609990   ⟹   XP_038465918
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0872,554,984 - 72,576,363 (-)NCBI
RefSeq Acc Id: XM_038673017   ⟹   XP_038528945
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0872,823,360 - 72,848,984 (-)NCBI
Ensembl Acc Id: ENSCAFP00000027180   ⟸   ENSCAFT00000029230
RefSeq Acc Id: XP_038340314   ⟸   XM_038484386
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038465918   ⟸   XM_038609990
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038528945   ⟸   XM_038673017
- Peptide Label: isoform X1
- UniProtKB: A0A8I3PPX5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038452993   ⟸   XM_038597065
- Peptide Label: isoform X5
- UniProtKB: A0A8P0NJU2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038401860   ⟸   XM_038545932
- Peptide Label: isoform X4
- UniProtKB: A0A8P0NJU2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845031359   ⟸   ENSCAFT00845040047
Ensembl Acc Id: ENSCAFP00845031734   ⟸   ENSCAFT00845040536
Ensembl Acc Id: ENSCAFP00845031532   ⟸   ENSCAFT00845040253
Ensembl Acc Id: ENSCAFP00845031696   ⟸   ENSCAFT00845040481
Protein Domains
DSL   EGF-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018401 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030005048 UniProtKB/TrEMBL
  ENSCAFG00845022668 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000029230.6 UniProtKB/TrEMBL
  ENSCAFT00000094870.1 UniProtKB/TrEMBL
  ENSCAFT00030009545.1 UniProtKB/TrEMBL
  ENSCAFT00030009638.1 UniProtKB/TrEMBL
  ENSCAFT00030009734.1 UniProtKB/TrEMBL
  ENSCAFT00845040047 ENTREZGENE
  ENSCAFT00845040047.1 UniProtKB/TrEMBL
  ENSCAFT00845040253.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.25.140 UniProtKB/TrEMBL
  2.60.40.3510 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro DSL UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Jagged/Serrate UniProtKB/TrEMBL
  Notch_ligand_N UniProtKB/TrEMBL
  Notch_signaling UniProtKB/TrEMBL
  VWF_dom UniProtKB/TrEMBL
NCBI Gene JAG2 ENTREZGENE
PANTHER NOTCH LIGAND FAMILY MEMBER UniProtKB/TrEMBL
  PROTEIN JAGGED-2 UniProtKB/TrEMBL
Pfam DL-JAG_EGF-like UniProtKB/TrEMBL
  DSL UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  hEGF UniProtKB/TrEMBL
  MNNL UniProtKB/TrEMBL
PRINTS EGFBLOOD UniProtKB/TrEMBL
  JAGGEDFAMILY UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  DSL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
SMART DSL UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  VWC_out UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A8C0MGY3_CANLF UniProtKB/TrEMBL
  A0A8C0ML10_CANLF UniProtKB/TrEMBL
  A0A8C0RD38_CANLF UniProtKB/TrEMBL
  A0A8I3PL42_CANLF UniProtKB/TrEMBL
  A0A8I3PPX5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NJU2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PKJ1_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:42173 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-15 JAG2  jagged canonical Notch ligand 2    jagged 2  Symbol and/or name change 5135510 APPROVED