JAG2 (jagged canonical Notch ligand 2) - Rat Genome Database

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Gene: JAG2 (jagged canonical Notch ligand 2) Canis lupus familiaris
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Symbol: JAG2
Name: jagged canonical Notch ligand 2
RGD ID: 12375852
Description: ENCODES a protein that exhibits growth factor activity (ortholog); Notch binding (ortholog); INVOLVED IN auditory receptor cell fate commitment (ortholog); brain development (ortholog); cell differentiation (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); Craniofacial Abnormalities (ortholog); glioblastoma (ortholog); FOUND IN integral component of plasma membrane (ortholog); membrane (ortholog); perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: jagged 2; LOW QUALITY PROTEIN: protein jagged-2; protein jagged-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1872,535,539 - 72,553,531 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl872,535,107 - 72,550,322 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha872,047,599 - 72,068,957 (-)NCBI
ROS_Cfam_1.0872,823,360 - 72,848,984 (-)NCBI
UMICH_Zoey_3.1872,503,851 - 72,525,225 (-)NCBI
UNSW_CanFamBas_1.0872,554,984 - 72,576,363 (-)NCBI
UU_Cfam_GSD_1.0872,944,852 - 72,966,232 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
JAG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1872,535,539 - 72,553,531 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl872,535,107 - 72,550,322 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha872,047,599 - 72,068,957 (-)NCBI
ROS_Cfam_1.0872,823,360 - 72,848,984 (-)NCBI
UMICH_Zoey_3.1872,503,851 - 72,525,225 (-)NCBI
UNSW_CanFamBas_1.0872,554,984 - 72,576,363 (-)NCBI
UU_Cfam_GSD_1.0872,944,852 - 72,966,232 (-)NCBI
JAG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl14105,140,982 - 105,168,824 (-)EnsemblGRCh38hg38GRCh38
GRCh3814105,140,981 - 105,168,776 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3714105,607,332 - 105,635,113 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614104,679,121 - 104,706,206 (-)NCBINCBI36hg18NCBI36
Build 3414104,679,120 - 104,706,206NCBI
Celera1485,661,503 - 85,688,392 (-)NCBI
Cytogenetic Map14q32.33NCBI
HuRef1485,798,697 - 85,815,481 (-)NCBIHuRef
CHM1_114105,545,299 - 105,572,922 (-)NCBICHM1_1
Jag2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912112,871,423 - 112,893,432 (-)NCBIGRCm39mm39
GRCm39 Ensembl12112,871,439 - 112,893,396 (-)Ensembl
GRCm3812112,907,803 - 112,929,812 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12112,907,819 - 112,929,776 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712114,146,801 - 114,167,706 (-)NCBIGRCm37mm9NCBIm37
MGSCv3612113,356,398 - 113,377,303 (-)NCBImm8
Celera12114,118,903 - 114,139,458 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.37NCBI
Jag2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26131,983,056 - 132,005,359 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl6131,983,056 - 132,005,818 (-)Ensembl
Rnor_6.06137,711,144 - 137,733,331 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,711,155 - 137,733,026 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06146,707,326 - 146,729,504 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46137,909,633 - 137,931,120 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16137,916,169 - 137,936,985 (-)NCBI
Celera6129,521,212 - 129,543,266 (-)NCBICelera
Cytogenetic Map6q32NCBI
Jag2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555383,421,685 - 3,433,842 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555383,421,685 - 3,433,829 (-)NCBIChiLan1.0ChiLan1.0
JAG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.114105,569,837 - 105,604,408 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14105,569,837 - 105,585,878 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01485,785,586 - 85,812,056 (-)NCBIMhudiblu_PPA_v0panPan3
Jag2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086401,534,532 - 1,551,659 (+)NCBI
SpeTri2.0NW_004936621363,489 - 380,616 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JAG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.27131,225,201 - 131,245,220 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JAG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12483,050,412 - 83,081,982 (-)NCBI
ChlSab1.1 Ensembl2483,051,368 - 83,076,820 (-)Ensembl
Vero_WHO_p1.0NW_02366605370,482,903 - 70,500,481 (-)NCBI
Jag2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624734308,371 - 327,496 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 4 1 6 6 9 4
Low 5 17 5 5 5 6 6 8 1 2
Below cutoff 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000029230   ⟹   ENSCAFP00000027180
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl872,535,107 - 72,550,322 (-)Ensembl
RefSeq Acc Id: XM_022422427   ⟹   XP_022278135
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1872,535,539 - 72,553,531 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038484386   ⟹   XP_038340314
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1872,503,851 - 72,525,225 (-)NCBI
RefSeq Acc Id: XM_038545932   ⟹   XP_038401860
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0872,944,852 - 72,966,232 (-)NCBI
RefSeq Acc Id: XM_038597065   ⟹   XP_038452993
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha872,047,599 - 72,068,957 (-)NCBI
RefSeq Acc Id: XM_038609990   ⟹   XP_038465918
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0872,554,984 - 72,576,363 (-)NCBI
RefSeq Acc Id: XM_038673017   ⟹   XP_038528945
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0872,823,360 - 72,848,984 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_022278135   ⟸   XM_022422427
- Sequence:
RefSeq Acc Id: ENSCAFP00000027180   ⟸   ENSCAFT00000029230
RefSeq Acc Id: XP_038340314   ⟸   XM_038484386
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038465918   ⟸   XM_038609990
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038528945   ⟸   XM_038673017
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038452993   ⟸   XM_038597065
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038401860   ⟸   XM_038545932
- Peptide Label: isoform X4


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018401 Ensembl, ENTREZGENE
NCBI Gene JAG2 ENTREZGENE
VGNC ID VGNC:42173 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-15 JAG2  jagged canonical Notch ligand 2    jagged 2  Symbol and/or name change 5135510 APPROVED