GDNF (glial cell derived neurotrophic factor) - Rat Genome Database

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Gene: GDNF (glial cell derived neurotrophic factor) Canis lupus familiaris
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Symbol: GDNF
Name: glial cell derived neurotrophic factor
RGD ID: 12301711
Description: ENCODES a protein that exhibits glial cell-derived neurotrophic factor receptor binding (ortholog); growth factor activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN branching involved in ureteric bud morphogenesis (ortholog); cell population proliferation (ortholog); cellular response to dexamethasone stimulus (ortholog); ASSOCIATED WITH hereditary sensory neuropathy; acoustic neuroma (ortholog); Alzheimer's disease (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog); Golgi apparatus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: glial cell line-derived neurotrophic factor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1470,966,694 - 70,991,860 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl470,971,432 - 70,989,714 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0471,483,108 - 71,516,105 (+)NCBI
UMICH_Zoey_3.1471,230,252 - 71,263,217 (+)NCBI
UNSW_CanFamBas_1.0471,343,690 - 71,376,610 (+)NCBI
UU_Cfam_GSD_1.0471,882,215 - 71,915,204 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
branching involved in ureteric bud morphogenesis  (ISO)
cell population proliferation  (ISO)
cellular response to dexamethasone stimulus  (ISO)
commissural neuron axon guidance  (ISO)
dorsal spinal cord development  (ISO)
embryonic organ development  (ISO)
enteric nervous system development  (ISO)
male gonad development  (ISO)
mesenchymal to epithelial transition involved in metanephros morphogenesis  (ISO)
metanephros development  (ISO)
midbrain development  (ISO)
mRNA stabilization  (ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of neuron apoptotic process  (ISO)
nervous system development  (ISO)
neural crest cell migration  (ISO)
neuron differentiation  (ISO)
neuron projection development  (ISO)
organ induction  (ISO)
peripheral nervous system development  (ISO)
peristalsis  (ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  (ISO)
positive regulation of monooxygenase activity  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of ureteric bud formation  (ISO)
postganglionic parasympathetic fiber development  (ISO)
postsynaptic membrane organization  (ISO)
regulation of dopamine uptake involved in synaptic transmission  (ISO)
regulation of gene expression  (ISO)
regulation of morphogenesis of a branching structure  (ISO)
regulation of semaphorin-plexin signaling pathway  (ISO)
regulation of ureteric bud formation  (ISO)
response to wounding  (ISO)
retina development in camera-type eye  (ISO)
sympathetic nervous system development  (ISO)
ureteric bud development  (ISO)
ureteric bud formation  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:28033318  


Genomics

Comparative Map Data
GDNF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1470,966,694 - 70,991,860 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl470,971,432 - 70,989,714 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0471,483,108 - 71,516,105 (+)NCBI
UMICH_Zoey_3.1471,230,252 - 71,263,217 (+)NCBI
UNSW_CanFamBas_1.0471,343,690 - 71,376,610 (+)NCBI
UU_Cfam_GSD_1.0471,882,215 - 71,915,204 (+)NCBI
GDNF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl537,812,677 - 37,840,041 (-)EnsemblGRCh38hg38GRCh38
GRCh38537,812,677 - 37,840,044 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37537,812,779 - 37,840,143 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36537,851,510 - 37,875,539 (-)NCBINCBI36hg18NCBI36
Build 34537,851,509 - 37,870,655NCBI
Celera537,699,155 - 37,726,173 (-)NCBI
Cytogenetic Map5p13.2NCBI
HuRef537,765,313 - 37,792,316 (-)NCBIHuRef
CHM1_1537,814,804 - 37,841,806 (-)NCBICHM1_1
Gdnf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39157,839,529 - 7,867,061 (+)NCBIGRCm39mm39
GRCm39 Ensembl157,840,327 - 7,867,056 (+)Ensembl
GRCm38157,810,048 - 7,837,580 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl157,810,846 - 7,837,575 (+)EnsemblGRCm38mm10GRCm38
MGSCv37157,761,011 - 7,787,575 (+)NCBIGRCm37mm9NCBIm37
MGSCv36157,758,226 - 7,784,790 (+)NCBImm8
Celera157,656,819 - 7,683,345 (+)NCBICelera
Cytogenetic Map15A1NCBI
Gdnf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2256,893,992 - 56,919,935 (+)NCBI
Rnor_6.0 Ensembl256,887,987 - 56,910,238 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0256,884,181 - 56,912,964 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0276,896,991 - 76,922,471 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4257,399,312 - 57,424,030 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1257,327,544 - 57,352,263 (+)NCBI
Celera252,510,468 - 52,532,694 (+)NCBICelera
Cytogenetic Map2q16NCBI
Gdnf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542622,386,450 - 22,412,324 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542622,386,613 - 22,412,324 (-)NCBIChiLan1.0ChiLan1.0
GDNF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1577,573,466 - 77,600,478 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl577,577,313 - 77,601,362 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0572,539,374 - 72,566,918 (+)NCBIMhudiblu_PPA_v0panPan3
Gdnf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213227,058,585 - 227,083,871 (-)NCBI
SpeTri2.0NW_0049365184,291,391 - 4,310,752 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GDNF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1622,936,601 - 22,965,886 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11622,936,602 - 22,965,929 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21624,176,604 - 24,179,641 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GDNF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1436,662,033 - 36,691,761 (-)NCBI
ChlSab1.1 Ensembl436,665,009 - 36,684,257 (-)Ensembl
Vero_WHO_p1.0NW_02366607127,015,956 - 27,043,442 (-)NCBI
Gdnf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475917,263,570 - 17,290,046 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2
Low 5 3 4 4 3
Below cutoff 18 5 5 2 6 9 8 10 6

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005619379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038474164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038474165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038474166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038535281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038535282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038535283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038599553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038599554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038599555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038663888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038663889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038663890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_546342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005324788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005324789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005324790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005358563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005358564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005358565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005393059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005393060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005393061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005426179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005426180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005426181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAAHUQ010000052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000043302   ⟹   ENSCAFP00000042228
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl470,971,432 - 70,989,714 (+)Ensembl
RefSeq Acc Id: XM_005619379   ⟹   XP_005619436
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1470,966,696 - 70,991,860 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038474164   ⟹   XP_038330092
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1471,234,366 - 71,255,385 (+)NCBI
RefSeq Acc Id: XM_038474165   ⟹   XP_038330093
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1471,230,252 - 71,255,385 (+)NCBI
RefSeq Acc Id: XM_038474166   ⟹   XP_038330094
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1471,230,253 - 71,255,385 (+)NCBI
RefSeq Acc Id: XM_038535281   ⟹   XP_038391209
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0471,886,331 - 71,907,365 (+)NCBI
RefSeq Acc Id: XM_038535282   ⟹   XP_038391210
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0471,882,215 - 71,907,365 (+)NCBI
RefSeq Acc Id: XM_038535283   ⟹   XP_038391211
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0471,882,216 - 71,907,365 (+)NCBI
RefSeq Acc Id: XM_038599553   ⟹   XP_038455481
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0471,347,766 - 71,368,784 (+)NCBI
RefSeq Acc Id: XM_038599554   ⟹   XP_038455482
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0471,343,690 - 71,368,784 (+)NCBI
RefSeq Acc Id: XM_038599555   ⟹   XP_038455483
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0471,343,691 - 71,368,784 (+)NCBI
RefSeq Acc Id: XM_038663888   ⟹   XP_038519816
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0471,487,224 - 71,508,253 (+)NCBI
RefSeq Acc Id: XM_038663889   ⟹   XP_038519817
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0471,483,108 - 71,508,253 (+)NCBI
RefSeq Acc Id: XM_038663890   ⟹   XP_038519818
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0471,483,109 - 71,508,253 (+)NCBI
RefSeq Acc Id: XM_546342   ⟹   XP_546342
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1470,966,694 - 70,991,860 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005324788
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1471,256,735 - 71,263,217 (+)NCBI
RefSeq Acc Id: XR_005324789
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1471,234,948 - 71,263,217 (+)NCBI
RefSeq Acc Id: XR_005324790
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1471,230,438 - 71,263,217 (+)NCBI
RefSeq Acc Id: XR_005358563
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0471,908,723 - 71,915,204 (+)NCBI
RefSeq Acc Id: XR_005358564
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0471,886,921 - 71,915,204 (+)NCBI
RefSeq Acc Id: XR_005358565
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0471,882,401 - 71,915,204 (+)NCBI
RefSeq Acc Id: XR_005393059
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0471,370,127 - 71,376,610 (+)NCBI
RefSeq Acc Id: XR_005393060
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0471,348,348 - 71,376,610 (+)NCBI
RefSeq Acc Id: XR_005393061
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0471,343,876 - 71,376,610 (+)NCBI
RefSeq Acc Id: XR_005426179
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0471,509,614 - 71,516,105 (+)NCBI
RefSeq Acc Id: XR_005426180
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0471,487,809 - 71,516,105 (+)NCBI
RefSeq Acc Id: XR_005426181
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0471,483,294 - 71,516,105 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_546342   ⟸   XM_546342
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005619436   ⟸   XM_005619379
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000042228   ⟸   ENSCAFT00000043302
RefSeq Acc Id: XP_038330093   ⟸   XM_038474165
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038330094   ⟸   XM_038474166
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038330092   ⟸   XM_038474164
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038455482   ⟸   XM_038599554
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038455483   ⟸   XM_038599555
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038455481   ⟸   XM_038599553
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038519817   ⟸   XM_038663889
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038519818   ⟸   XM_038663890
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038519816   ⟸   XM_038663888
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038391210   ⟸   XM_038535282
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038391211   ⟸   XM_038535283
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038391209   ⟸   XM_038535281
- Peptide Label: isoform X1
Protein Domains
TGF_BETA_2

Promoters
RGD ID:13683054
Promoter ID:EPDNEW_C1124
Type:single initiation site
Name:GDNF_1
Description:glial cell derived neurotrophic factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1470,966,137 - 70,966,197EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000029135 Ensembl, ENTREZGENE
NCBI Gene GDNF ENTREZGENE
VGNC ID VGNC:41166 ENTREZGENE