RGD Reference Report - The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat. - Rat Genome Database

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The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat.

Authors: Abdelmagid, N  Bereczky-Veress, B  Guerreiro-Cacais, AO  Bergman, P  Luhr, KM  Bergstrom, T  Skoldenberg, B  Piehl, F  Olsson, T  Diez, M 
Citation: Abdelmagid N, etal., PLoS Pathog. 2012;8(6):e1002753. doi: 10.1371/journal.ppat.1002753. Epub 2012 Jun 28.
RGD ID: 7240516
Pubmed: PMID:22761571   (View Abstract at PubMed)
PMCID: PMC3386237   (View Article at PubMed Central)
DOI: DOI:10.1371/journal.ppat.1002753   (Journal Full-text)

Herpes simplex encephalitis (HSE) is a fatal infection of the central nervous system (CNS) predominantly caused by Herpes simplex virus type 1. Factors regulating the susceptibility to HSE are still largely unknown. To identify host gene(s) regulating HSE susceptibility we performed a genome-wide linkage scan in an intercross between the susceptible DA and the resistant PVG rat. We found one major quantitative trait locus (QTL), Hse1, on rat chromosome 4 (confidence interval 24.3-31 Mb; LOD score 29.5) governing disease susceptibility. Fine mapping of Hse1 using recombinants, haplotype mapping and sequencing, as well as expression analysis of all genes in the interval identified the calcitonin receptor gene (Calcr) as the main candidate, which also is supported by functional studies. Thus, using unbiased genetic approach variability in Calcr was identified as potentially critical for infection and viral spread to the CNS and subsequent HSE development.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bw143RatBody Weight Changes  IAGP  RGD 
Bw144RatBody Weight Changes  IAGP  RGD 
Bw145RatBody Weight Changes  IAGP  RGD 
CALCAHumanHerpes Simplex Encephalitis treatmentISOCalca (Rattus norvegicus) RGD 
CALCRHumanHerpes Simplex Encephalitis treatmentISOCalcr (Rattus norvegicus) RGD 
CalcaRatHerpes Simplex Encephalitis treatmentIDA  RGD 
CalcaMouseHerpes Simplex Encephalitis treatmentISOCalca (Rattus norvegicus) RGD 
CalcrMouseHerpes Simplex Encephalitis treatmentISOCalcr (Rattus norvegicus) RGD 
CalcrRatHerpes Simplex Encephalitis treatmentIDA  RGD 
DA.PVG.1AV1-(D4Got211-D4Mit12)/KiniRatHerpes Simplex Encephalitis MODEL: inducedIAGPHerpes simplex virus type 1as compared to control strain PVG.1AV1/Kini and neurovirulent Herpes simplex type 1 virus (HSV-1 strain I-2762)RGD 
DA.PVG.1AV1-(D4Kiru12-D4Kiru55)/KiruRatHerpes Simplex Encephalitis MODEL: inducedIAGPHerpes simplex virus type 1as compared to control strain PVG.1AV1/Kini and neurovirulent Herpes simplex type 1 virus (HSV-1 strain I-2762)RGD 
DA.PVG.1AV1-(D4Rat103-D4Mit12)/KiniRatHerpes Simplex Encephalitis MODEL: inducedIAGPHerpes simplex virus type 1as compared to control strain PVG.1AV1/Kini and neurovirulent Herpes simplex type 1 virus (HSV-1 strain I-2762)RGD 
DA.PVG.1AV1-(D4Rat23-D4Rat108)/KiniRatHerpes Simplex Encephalitis MODEL: inducedIAGPHerpes simplex virus type 1as compared to control strain PVG.1AV1/Kini and neurovirulent Herpes simplex type 1 virus (HSV-1 strain I-2762)RGD 
DA/ZtmKiniRatHerpes Simplex Encephalitis MODEL: inducedIAGPHerpes simplex virus type 1 RGD 
DA/ZtmKiniRatHerpes Simplex Encephalitis MODEL: treatmentIAGPpeptide/proteintreated with rat Calca (8-32)RGD 
Vie1RatHerpes Simplex Encephalitis  IAGP  RGD 
Vie2RatHerpes Simplex Encephalitis  IAGP  RGD 
Vie3RatHerpes Simplex Encephalitis  IAGP  RGD 
Vie4RatHerpes Simplex Encephalitis  IAGP  RGD 
Vie5RatHerpes Simplex Encephalitis  IAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bw143Ratabnormal body weight  IDA  RGD 
Bw144Ratabnormal body weight  IDA  RGD 
Bw145Ratabnormal body weight  IDA  RGD 
Vie1Ratbrain inflammation  IDA  RGD 
Vie2Ratbrain inflammation  IDA  RGD 
Vie3Ratbrain inflammation  IDA  RGD 
Vie4Ratbrain inflammation  IDA  RGD 
Vie5Ratbrain inflammation  IDA  RGD 
Objects Annotated

Genes (Rattus norvegicus)
Calca  (calcitonin-related polypeptide alpha)
Calcr  (calcitonin receptor)

Genes (Mus musculus)
Calca  (calcitonin/calcitonin-related polypeptide, alpha)
Calcr  (calcitonin receptor)

Genes (Homo sapiens)
CALCA  (calcitonin related polypeptide alpha)
CALCR  (calcitonin receptor)

QTLs
Bw143  (Body weight QTL 143)
Bw144  (Body weight QTL 144)
Bw145  (Body weight QTL 145)
Vie1  (Viral induced encephalitis QTL 1)
Vie2  (Viral induced encephalitis QTL 2)
Vie3  (Viral induced encephalitis QTL 3)
Vie4  (Viral induced encephalitis QTL 4)
Vie5  (Viral induced encephalitis QTL 5)

Objects referenced in this article
Marker D4Kini3 D4Kini3 Rattus norvegicus
Marker D4Kini4 D4Kini4 Rattus norvegicus
Marker D4Kini5 D4Kini5 Rattus norvegicus
Marker D4Kini6 D4Kini6 Rattus norvegicus
Marker D4Kini7 D4Kini7 Rattus norvegicus
Marker D4Kini8 D4Kini8 Rattus norvegicus
Marker D4Kini9 D4Kini9 Rattus norvegicus
Marker D4Kini10 D4Kini10 Rattus norvegicus
Marker D4Kini11 D4Kini11 Rattus norvegicus
Marker D4Kini12 D4Kini12 Rattus norvegicus
Marker D4Kini13 D4Kini13 Rattus norvegicus
Marker D4Kini14 D4Kini14 Rattus norvegicus
Marker D4Kini15 D4Kini15 Rattus norvegicus
Marker D4Kini16 D4Kini16 Rattus norvegicus
Marker D4Kini17 D4Kini17 Rattus norvegicus
Marker D4Kini18 D4Kini18 Rattus norvegicus
Strain DA.PVG.1AV1-(D4Kini3-D4Mgh14)/Kini null Rattus norvegicus
Strain DA.PVG.1AV1-(D4Kini3-D4Rat177)/Kini null Rattus norvegicus

Additional Information