RGD Reference Report - Differential mRNA expression of neurotrophic factors GDNF, BDNF, and NT-3 in experimental herpes simplex virus encephalitis. - Rat Genome Database

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Differential mRNA expression of neurotrophic factors GDNF, BDNF, and NT-3 in experimental herpes simplex virus encephalitis.

Authors: Sellner, J  Lenhard, T  Haas, J  Einsiedel, RV  Meyding-Lamade, U 
Citation: Sellner J, etal., Brain Res Mol Brain Res. 2005 Jun 13;137(1-2):267-71. Epub 2005 Apr 22.
RGD ID: 8657070
Pubmed: PMID:15950786   (View Abstract at PubMed)
DOI: DOI:10.1016/j.molbrainres.2005.03.011   (Journal Full-text)

Glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) mRNA levels were studied in the course of murine herpes simplex virus encephalitis. Induction of GNDF and NT-3 (both P < 0.05) was found during acute encephalitis. Despite absence of clinical impairment, both neurotrophic factors were overexpressed 2 months (NT-3) and 6 months (GDNF) following infection (both P < 0.05). Neurotrophic factors play an important role in neuronal survival and recovery after acute injury to the central nervous system (CNS) and may represent an additional therapeutic target for treatment of viral encephalitis.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
GDNFHumanHerpes Simplex Encephalitis  ISOGdnf (Mus musculus)mRNA:increased expression:brain:RGD 
GdnfRatHerpes Simplex Encephalitis  ISOGdnf (Mus musculus)mRNA:increased expression:brain:RGD 
GdnfMouseHerpes Simplex Encephalitis  IEP mRNA:increased expression:brain:RGD 


Genes (Rattus norvegicus)
Gdnf  (glial cell derived neurotrophic factor)

Genes (Mus musculus)
Gdnf  (glial cell line derived neurotrophic factor)

Genes (Homo sapiens)
GDNF  (glial cell derived neurotrophic factor)