IL33 (interleukin 33) - Rat Genome Database

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Pathways
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Gene: IL33 (interleukin 33) Canis lupus familiaris
Analyze
Symbol: IL33
Name: interleukin 33
RGD ID: 12333507
Description: ENCODES a protein that exhibits interleukin-33 receptor binding (ortholog); INVOLVED IN cellular response to mechanical stimulus (ortholog); defense response to virus (ortholog); extrinsic apoptotic signaling pathway (ortholog); ASSOCIATED WITH acute myocardial infarction (ortholog); Alzheimer's disease (ortholog); angiostrongyliasis (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DVS27; IL-33; interleukin-33
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11127,219,878 - 27,256,723 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1127,219,878 - 27,256,721 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1125,988,860 - 26,025,714 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01128,069,676 - 28,106,564 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1128,069,663 - 28,108,194 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11126,788,250 - 26,825,127 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01126,610,673 - 26,647,647 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01127,281,817 - 27,318,668 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myocardial infarction  (ISO)
Alzheimer's disease  (ISO)
angiostrongyliasis  (ISO)
aortic atherosclerosis  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
candidiasis  (ISO)
Cardiomegaly  (ISO)
Cardiovirus Infections  (ISO)
cerebral malaria  (ISO)
chromosome 9p deletion syndrome  (ISO)
Chronic Hepatitis B  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Periodontitis  (ISO)
clonorchiasis  (ISO)
Clostridium difficile colitis  (ISO)
colitis  (ISO)
colon cancer  (ISO)
common cold  (ISO)
cryptococcosis  (ISO)
dengue disease  (ISO)
diabetes mellitus  (ISO)
Experimental Arthritis  (ISO)
Experimental Colitis  (ISO)
Experimental Liver Cirrhosis  (ISO)
familial hemophagocytic lymphohistiocytosis 2  (ISO)
Fungal Lung Diseases  (ISO)
genetic disease  (ISO)
gout  (ISO)
Hantavirus hemorrhagic fever with renal syndrome  (ISO)
Helicobacter Infections  (ISO)
Hemolysis  (ISO)
herpes simplex  (ISO)
Hookworm Infections  (ISO)
Hyperalgesia  (ISO)
Immediate Hypersensitivity  (ISO)
inflammatory bowel disease  (ISO)
influenza  (ISO)
Intervertebral Disc Displacement  (ISO)
irritable bowel syndrome  (ISO)
kidney disease  (ISO)
listeriosis  (ISO)
liver cirrhosis  (ISO)
malaria  (ISO)
Nematode Infections  (ISO)
paracoccidioidomycosis  (ISO)
parasitic helminthiasis infectious disease  (ISO)
peptic ulcer disease  (ISO)
periodontitis  (ISO)
pleural tuberculosis  (ISO)
pneumocystosis  (ISO)
pneumonia  (ISO)
prostate cancer  (ISO)
Pseudomonas Infections  (ISO)
pulmonary edema  (ISO)
pulmonary tuberculosis  (ISO)
respiratory allergy  (ISO)
respiratory syncytial virus infectious disease  (ISO)
schistosomiasis  (ISO)
Schistosomiasis Japonica  (ISO)
Sepsis  (ISO)
Staphylococcal Pneumonia  (ISO)
Staphylococcal Skin Infections  (ISO)
Strongylida Infections  (ISO)
Superinfection  (ISO)
tongue squamous cell carcinoma  (ISO)
tuberculosis  (ISO)
ulcerative colitis  (ISO)
Viral Bronchiolitis  (ISO)
viral encephalitis  (ISO)
Viral Myocarditis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to mechanical stimulus  (ISO)
defense response to virus  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
gene expression  (ISO)
interleukin-33-mediated signaling pathway  (ISO)
macrophage activation involved in immune response  (ISO)
macrophage differentiation  (ISS)
microglial cell activation involved in immune response  (ISO)
microglial cell proliferation  (ISO)
negative regulation of immunoglobulin production  (ISO)
negative regulation of inflammatory response to wounding  (IEA)
negative regulation of leukocyte migration  (ISO)
negative regulation of macrophage proliferation  (ISO)
negative regulation of T-helper 1 type immune response  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
negative regulation of type II interferon production  (ISO)
positive regulation of CD80 production  (ISO)
positive regulation of CD86 production  (ISO)
positive regulation of cellular defense response  (ISO)
positive regulation of chemokine production  (IEA)
positive regulation of cytokine production  (IBA,IEA)
positive regulation of gene expression  (ISO)
positive regulation of immunoglobulin production  (ISO)
positive regulation of inflammatory response  (IBA,IEA)
positive regulation of interleukin-13 production  (ISO)
positive regulation of interleukin-4 production  (ISO)
positive regulation of interleukin-5 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of macrophage activation  (IEA,ISO)
positive regulation of MHC class I biosynthetic process  (ISO)
positive regulation of MHC class II biosynthetic process  (ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (ISO)
positive regulation of oligodendrocyte differentiation  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type 2 immune response  (ISO)
protein import into nucleus  (ISO)
signal transduction  (IEA)
type 2 immune response  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:10566975   PMID:22301074   PMID:30032202   PMID:34519392  


Genomics

Comparative Map Data
IL33
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11127,219,878 - 27,256,723 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1127,219,878 - 27,256,721 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1125,988,860 - 26,025,714 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01128,069,676 - 28,106,564 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1128,069,663 - 28,108,194 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11126,788,250 - 26,825,127 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01126,610,673 - 26,647,647 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01127,281,817 - 27,318,668 (+)NCBIUU_Cfam_GSD_1.0
IL33
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3896,215,149 - 6,257,983 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl96,215,786 - 6,257,983 (+)EnsemblGRCh38hg38GRCh38
GRCh3796,215,149 - 6,257,983 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3696,231,678 - 6,247,982 (+)NCBINCBI36Build 36hg18NCBI36
Build 3496,231,677 - 6,247,982NCBI
Celera96,179,137 - 6,195,439 (+)NCBICelera
Cytogenetic Map9p24.1NCBI
HuRef96,171,374 - 6,213,493 (+)NCBIHuRef
CHM1_196,216,394 - 6,258,768 (+)NCBICHM1_1
T2T-CHM13v2.096,220,289 - 6,263,045 (+)NCBIT2T-CHM13v2.0
Il33
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391929,902,513 - 29,938,118 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1929,902,514 - 29,938,118 (+)EnsemblGRCm39 Ensembl
GRCm381929,925,113 - 29,960,718 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1929,925,114 - 29,960,718 (+)EnsemblGRCm38mm10GRCm38
MGSCv371929,999,604 - 30,035,205 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361930,015,647 - 30,026,715 (+)NCBIMGSCv36mm8
Celera1930,700,532 - 30,736,141 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1924.56NCBI
Il33
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81237,115,478 - 237,149,897 (+)NCBIGRCr8
mRatBN7.21227,701,964 - 227,736,374 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1227,721,435 - 227,736,373 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,123,222 - 236,138,166 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,052,907 - 243,067,851 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,869,667 - 235,884,579 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01248,112,611 - 248,147,030 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,132,090 - 248,147,029 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01255,382,760 - 255,397,661 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41233,670,801 - 233,685,798 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11233,834,823 - 233,849,820 (+)NCBI
Celera1224,871,607 - 224,886,518 (+)NCBICelera
Cytogenetic Map1q52NCBI
Il33
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543410,171,812 - 10,188,948 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543410,145,449 - 10,187,595 (+)NCBIChiLan1.0ChiLan1.0
IL33
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211118,322,326 - 118,364,362 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19118,328,274 - 118,370,309 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v096,027,014 - 6,069,540 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.196,208,479 - 6,250,433 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl96,234,178 - 6,248,624 (+)Ensemblpanpan1.1panPan2
Il33
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947142,170,523 - 142,338,788 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936539623,248 - 791,470 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936539763,755 - 791,461 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL33
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1215,899,436 - 215,941,840 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11215,899,830 - 215,941,944 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21241,454,091 - 241,496,130 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL33
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11273,235,585 - 73,283,665 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1273,237,406 - 73,252,436 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603861,612,048 - 61,659,928 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il33
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473610,764,486 - 10,784,864 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473610,733,944 - 10,786,188 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in IL33
420 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 11 6 6 6 6 1 7 6
Low 2 5 11 4 10 3
Below cutoff 2 1 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000002106   ⟹   ENSCAFP00000001950
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1127,219,878 - 27,256,721 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845042417   ⟹   ENSCAFP00845033256
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1128,069,663 - 28,108,194 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845042502   ⟹   ENSCAFP00845033314
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1128,069,663 - 28,108,194 (+)Ensembl
RefSeq Acc Id: NM_001003180   ⟹   NP_001003180
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11127,219,878 - 27,256,721 (+)NCBI
Dog10K_Boxer_Tasha1125,988,860 - 26,025,714 (+)NCBI
ROS_Cfam_1.01128,069,676 - 28,106,564 (+)NCBI
UMICH_Zoey_3.11126,788,250 - 26,825,127 (+)NCBI
UNSW_CanFamBas_1.01126,610,673 - 26,647,647 (+)NCBI
UU_Cfam_GSD_1.01127,281,817 - 27,318,668 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038680904   ⟹   XP_038536832
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01128,090,213 - 28,106,421 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001003180   ⟸   NM_001003180
- UniProtKB: O97863 (UniProtKB/Swiss-Prot),   A0A8C0JHB9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000001950   ⟸   ENSCAFT00000002106
RefSeq Acc Id: XP_038536832   ⟸   XM_038680904
- Peptide Label: isoform X1
- UniProtKB: A0A8I3PZM8 (UniProtKB/TrEMBL),   A0A8P0S7C1 (UniProtKB/TrEMBL),   A0A8C0JHB9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845033256   ⟸   ENSCAFT00845042417
RefSeq Acc Id: ENSCAFP00845033314   ⟸   ENSCAFT00845042502

Promoters
RGD ID:13685197
Promoter ID:EPDNEW_C3265
Type:single initiation site
Name:IL33_2
Description:interleukin 33
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_C3266  
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11127,219,863 - 27,219,923EPDNEW
RGD ID:13685198
Promoter ID:EPDNEW_C3266
Type:single initiation site
Name:IL33_1
Description:interleukin 33
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_C3265  
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11127,240,486 - 27,240,546EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000030105 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030014936 UniProtKB/TrEMBL
  ENSCAFG00040010108 UniProtKB/Swiss-Prot
  ENSCAFG00845024013 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000002106.6 UniProtKB/TrEMBL
  ENSCAFT00030027644.1 UniProtKB/TrEMBL
  ENSCAFT00030027761.1 UniProtKB/TrEMBL
  ENSCAFT00030027832.1 UniProtKB/TrEMBL
  ENSCAFT00040018732.1 UniProtKB/Swiss-Prot
  ENSCAFT00845042417 ENTREZGENE
  ENSCAFT00845042417.1 UniProtKB/TrEMBL
  ENSCAFT00845042502.1 UniProtKB/TrEMBL
Gene3D-CATH 2.80.10.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IL-33 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403810 UniProtKB/Swiss-Prot
NCBI Gene IL33 ENTREZGENE
PANTHER INTERLEUKIN-33 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR21114 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL33 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0JHB9 ENTREZGENE
  A0A8C0NIU1_CANLF UniProtKB/TrEMBL
  A0A8C0NLA6_CANLF UniProtKB/TrEMBL
  A0A8C0RKN0_CANLF UniProtKB/TrEMBL
  A0A8I3PGF0_CANLF UniProtKB/TrEMBL
  A0A8I3PZM8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0S7C1 ENTREZGENE, UniProtKB/TrEMBL
  IL33_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:41982 ENTREZGENE