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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:chronic conjunctivitis
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Accession:DOID:2475 term browser browse the term
Definition:Long term inflammation of the conjunctiva, caused by a variety of agents.
Synonyms:xref: ICD10CM:H10.4;   ICD9CM:372.1;   NCI:C35197
For additional species annotation, visit the Alliance of Genome Resources.


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chronic conjunctivitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fas Fas cell surface death receptor ISO protein:increased expression:conjunctival epithelial cell (human) RGD PMID:9990333 RGD:8662412 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 IMP in hemizygote mutant male (LAMP2y/-) RGD PMID:29720683 RGD:13703117 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522 		JBrowse link
G Lamp2em1 lysosomal-associated membrane protein 2; TALEN induced mutant1 IMP in hemizygote mutant male (LAMP2y/-) RGD PMID:29720683 RGD:13703117
allergic conjunctivitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl11 C-C motif chemokine ligand 11 IEP mRNA:increased expression:conjunctiva RGD PMID:12682842 RGD:2307196 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO RGD PMID:19553621 RGD:8548840 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IEP mRNA:increased expression:conjunctiva RGD PMID:12682842 RGD:2307196 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 ISO protein:increased expression:conjunctiva RGD PMID:11090473 RGD:6483824 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303 		JBrowse link
G Ccr3 C-C motif chemokine receptor 3 ISO RGD PMID:18658092 RGD:6893389 NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO RGD PMID:8766745 RGD:8547686 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma IDA
ISO		 RGD PMID:12234900 PMID:16123425 RGD:8142386, RGD:8142391 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 treatment ISO protein:increased expression:tear RGD PMID:22092652 PMID:16914468 PMID:15144463 PMID:19060266 RGD:7364837, RGD:11041889, RGD:7365076, RGD:7365027 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13 interleukin 13 ISO associated with Allergic Rhinitis;DNA:SNPs, haplotype:promoter, exon:-1112C>T (rs1800925), p.R130Q (rs20541) (human) RGD PMID:9191598 PMID:22023794 RGD:8549533, RGD:8549595 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il1b interleukin 1 beta treatment ISO RGD PMID:9326725 RGD:7401198 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment ISO human protein in a mouse model RGD PMID:10549671 RGD:8549802 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il4r interleukin 4 receptor susceptibility ISO associated with rhinitis; DNA:SNP: : rs2107356 (human) RGD PMID:20002627 RGD:4890389 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980 		JBrowse link
G Irf1 interferon regulatory factor 1 IEP RGD PMID:14605445 RGD:5128787 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase IDA protein:increased phosphorylation:T cell RGD PMID:14507881 RGD:1600225 NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794 		JBrowse link
G Muc1 mucin 1, cell surface associated severity ISO RGD PMID:17177679 RGD:7349351 NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733 		JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming severity ISO RGD PMID:17177679 RGD:7349351 NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756 		JBrowse link
G Muc4 mucin 4, cell surface associated severity ISO RGD PMID:17177679 PMID:11581187 RGD:7349351, RGD:7349400 NCBI chr11:68,008,245...68,053,242 JBrowse link
G Pla2g2a phospholipase A2 group IIA ISO protein:increased expression:body fluid or substance RGD PMID:21042565 RGD:6482725 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 treatment ISO RGD PMID:16914468 RGD:11041889 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tlr2 toll-like receptor 2 ISO associated with Staphylococcal Infections; RGD PMID:19358332 RGD:8552826 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 ISO mRNA,protein:increased expression:conjunctiva: RGD PMID:21820713 PMID:16023216 PMID:21391988 RGD:7777131, RGD:7794849, RGD:7794770 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tlr9 toll-like receptor 9 ISO mRNA,protein:decreased expression:conjunctiva: RGD PMID:16023216 RGD:7794849 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
G Tnc tenascin C ISO DNA:SNPs: :multiple (human) RGD PMID:18305139 RGD:4889589 NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624 		JBrowse link
Allergic Rhinoconjunctivitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 treatment ISO associated with Eosinophilic Esophagitis; DNA:polymorphisms:: RGD PMID:26416193 RGD:11352743 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Il3 interleukin 3 susceptibility ISO DNA:SNP: :rs40401(human) RGD PMID:23953855 RGD:13506915 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19057
    sensory system disease 7250
      eye disease 3729
        conjunctival disease 60
          conjunctivitis 46
            chronic conjunctivitis 29
              allergic conjunctivitis + 25
              chronic follicular conjunctivitis 0
              parasitic conjunctivitis 0
              simple chronic conjunctivitis 0
              vernal conjunctivitis 0
Path 2
Term Annotations click to browse term
  disease 19057
    disease of anatomical entity 18393
      nervous system disease 14266
        Neurologic Manifestations 10339
          sensory system disease 7250
            eye disease 3729
              conjunctival disease 60
                conjunctivitis 46
                  chronic conjunctivitis 29
                    allergic conjunctivitis + 25
                    chronic follicular conjunctivitis 0
                    parasitic conjunctivitis 0
                    simple chronic conjunctivitis 0
                    vernal conjunctivitis 0
paths to the root