RGD Reference Report - IL3 SNP rs40401 variant is a risk factor for rhinoconjunctivitis in Japanese women: the Kyushu Okinawa maternal and child health study. - Rat Genome Database

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IL3 SNP rs40401 variant is a risk factor for rhinoconjunctivitis in Japanese women: the Kyushu Okinawa maternal and child health study.

Authors: Miyake, Yoshihiro  Tanaka, Keiko  Arakawa, Masashi 
Citation: Miyake Y, etal., Cytokine. 2013 Oct;64(1):86-9. doi: 10.1016/j.cyto.2013.07.020. Epub 2013 Aug 15.
RGD ID: 13506915
Pubmed: PMID:23953855   (View Abstract at PubMed)
DOI: DOI:10.1016/j.cyto.2013.07.020   (Journal Full-text)


BACKGROUND: No studies have investigated the relationship between IL3 single nucleotide polymorphism (SNP) rs40401 and allergic rhinitis. We performed a case-control study to examine this issue and to assess interactions between the SNP and smoking or older siblings in young adult Japanese women.
METHODS: Included were 393 women who met the criteria of the International Study of Asthma and Allergies in Childhood (ISAAC) for rhinoconjunctivitis. Controls were 767 women without rhinoconjunctivitis according to the ISAAC criteria who had not been diagnosed with allergic rhinitis by a doctor.
RESULTS: Compared with women with the TT genotype of SNP rs40401, those with the CC genotype had a significantly increased risk of rhinoconjunctivitis: the adjusted OR was 1.52 (95% CI: 1.05-2.19). This positive relationship was significant under the additive model: the adjusted OR was 1.23 (95% CI: 1.02-1.47). The positive association fell just short of the significance level under the dominant or recessive model. There was no significant interaction between SNP rs40401 and smoking with respect to rhinoconjunctivitis. Compared with subjects with the TT or TC genotype of IL3 SNP rs40401 who had one or more older siblings, those with the CC genotype who had no older siblings had a 2.33-fold increased risk of rhinoconjunctivitis; nevertheless, the interaction was not significant.
CONCLUSION: This is the first study to show a significant positive association between IL3 SNP rs40401 variant and the risk of rhinoconjunctivitis. We could not find evidence for interactions between SNP rs40401 and smoking or older siblings affecting rhinoconjunctivitis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Allergic Rhinoconjunctivitis susceptibilityIAGP 13506915DNA:SNP: :rs40401(human)RGD 
Allergic Rhinoconjunctivitis susceptibilityISOIL3 (Homo sapiens)13506915; 13506915DNA:SNP: :rs40401(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il3  (interleukin 3)

Genes (Mus musculus)
Il3  (interleukin 3)

Genes (Homo sapiens)
IL3  (interleukin 3)


Additional Information