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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:menaquinone
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Accession:CHEBI:16374 term browser browse the term
Definition:Any member of the class of menaquinones that is 2-methyl-1,4-naphthoquinone with an unsaturated isoprenoid chain at the 3-position.
Synonyms:related_synonym: Formula=(C5H8)nC11H8O2;   MK-n;   Menatetrenone;   a menaquinone;   menaquinone-n;   vitamin K2
 alt_id: CHEBI:14582;   CHEBI:25184;   CHEBI:6749
 xref: CAS:11032-49-8;   KEGG:C00828
 xref_mesh: MESH:D024482
 xref: Wikipedia:Vitamin_K2


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menaquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased phosphorylation of AKT1 protein] CTD PMID:27212383 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases expression
multiple interactions		 EXP Vitamin K 2 results in increased expression of ALPL protein
PTH protein promotes the reaction [Vitamin K 2 results in increased expression of ALPL protein]; Vitamin K 2 affects the reaction [PTH protein results in increased expression of ALPL protein]		 CTD PMID:30639440 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Axl Axl receptor tyrosine kinase multiple interactions EXP Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of AXL protein] CTD PMID:27212383 NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of BCL2 protein] CTD PMID:27212383 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions
increases secretion
decreases expression		 ISO
EXP		 Vitamin K 2 inhibits the reaction [IL1B protein results in decreased expression of BGLAP protein modified form]
PTH protein promotes the reaction [Vitamin K 2 results in increased carboxylation of BGLAP protein]; PTH protein promotes the reaction [Vitamin K 2 results in increased secretion of BGLAP protein modified form]; Vitamin K 2 promotes the reaction [PTH protein results in increased carboxylation of BGLAP protein]; Vitamin K 2 promotes the reaction [PTH protein results in increased secretion of BGLAP protein modified form]; Vitamin K 2 results in increased carboxylation of and results in decreased secretion of BGLAP protein
Vitamin K 2 results in decreased expression of BGLAP mRNA		 CTD PMID:19675304 PMID:20460758 PMID:30639440 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Vitamin K 2 results in decreased expression of BIRC5 protein CTD PMID:29432837 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions EXP Vitamin K 2 affects the reaction [PTH protein results in increased expression of BMP2 protein] CTD PMID:30639440 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage		 ISO [Vitamin K 2 co-treated with arsenic trioxide] results in increased expression of CASP3; Acetylcysteine inhibits the reaction [[Vitamin K 2 co-treated with arsenic trioxide] results in increased expression of CASP3]
Vitamin K 2 results in increased cleavage of CASP3 protein		 CTD PMID:24273890 PMID:29432837 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases cleavage ISO Vitamin K 2 results in increased cleavage of CASP7 protein CTD PMID:29432837 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Vitamin K 2 results in decreased expression of CDK4 mRNA CTD PMID:16010434 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Vitamin K 2 results in increased expression of CDKN1A protein CTD PMID:29432837 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO Vitamin K 2 results in increased expression of CDKN2A mRNA CTD PMID:16010434 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO Vitamin K 2 results in decreased expression of COL1A1 mRNA CTD PMID:19675304 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G F10 coagulation factor X multiple interactions EXP [Phenobarbital co-treated with Vitamin K 2] results in increased activity of F10 protein CTD PMID:19952496 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141 		JBrowse link
G F7 coagulation factor VII multiple interactions EXP [Phenobarbital co-treated with Vitamin K 2] results in increased activity of F7 protein CTD PMID:19952496 NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610 		JBrowse link
G Gas6 growth arrest specific 6 multiple interactions EXP Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of GAS6 protein] CTD PMID:27212383 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO Vitamin K 2 results in increased phosphorylation of H2AX protein CTD PMID:29432837 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression ISO Vitamin K 2 results in decreased expression of HSPA5 protein CTD PMID:29432837 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases response to substance		 ISO Vitamin K 2 inhibits the reaction [IL1B protein results in decreased expression of BGLAP protein modified form]; Warfarin inhibits the reaction [Vitamin K 2 results in decreased susceptibility to IL1B protein] CTD PMID:20460758 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity		 ISO PROX1 protein inhibits the reaction [Vitamin K 2 results in increased activity of NR1I2 protein] CTD PMID:22023334 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Vitamin K 2 results in increased cleavage of PARP1 protein CTD PMID:29432837 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Prox1 prospero homeobox 1 multiple interactions ISO PROX1 protein inhibits the reaction [Vitamin K 2 results in increased activity of NR1I2 protein] CTD PMID:22023334 NCBI chr13:101,669,184...101,719,804
Ensembl chr13:101,669,184...101,711,183 		JBrowse link
G Pth parathyroid hormone multiple interactions EXP PTH protein promotes the reaction [Vitamin K 2 results in increased carboxylation of BGLAP protein]; PTH protein promotes the reaction [Vitamin K 2 results in increased expression of ALPL protein]; PTH protein promotes the reaction [Vitamin K 2 results in increased expression of RUNX2 protein]; PTH protein promotes the reaction [Vitamin K 2 results in increased expression of SP7 protein]; PTH protein promotes the reaction [Vitamin K 2 results in increased secretion of BGLAP protein modified form]; Vitamin K 2 affects the reaction [PTH protein results in increased expression of ALPL protein]; Vitamin K 2 affects the reaction [PTH protein results in increased expression of BMP2 protein]; Vitamin K 2 affects the reaction [PTH protein results in increased expression of RUNX2 protein]; Vitamin K 2 affects the reaction [PTH protein results in increased expression of SP7 protein]; Vitamin K 2 promotes the reaction [PTH protein results in increased carboxylation of BGLAP protein]; Vitamin K 2 promotes the reaction [PTH protein results in increased secretion of BGLAP protein modified form] CTD PMID:30639440 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530 		JBrowse link
G Rb1 RB transcriptional corepressor 1 increases expression ISO Vitamin K 2 results in increased expression of RB1 mRNA CTD PMID:16010434 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression
multiple interactions		 EXP Vitamin K 2 results in increased expression of RUNX2 protein
PTH protein promotes the reaction [Vitamin K 2 results in increased expression of RUNX2 protein]; Vitamin K 2 affects the reaction [PTH protein results in increased expression of RUNX2 protein]		 CTD PMID:30639440 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Rxra retinoid X receptor alpha multiple interactions
decreases phosphorylation		 ISO [Vitamin K 2 co-treated with 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid] results in decreased phosphorylation of RXRA protein
Vitamin K 2 results in decreased phosphorylation of RXRA protein		 CTD PMID:17270033 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Sp7 Sp7 transcription factor increases expression
multiple interactions		 EXP Vitamin K 2 results in increased expression of SP7 protein
PTH protein promotes the reaction [Vitamin K 2 results in increased expression of SP7 protein]; Vitamin K 2 affects the reaction [PTH protein results in increased expression of SP7 protein]		 CTD PMID:30639440 NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847 		JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression ISO Vitamin K 2 results in decreased expression of TNFSF11 mRNA CTD PMID:19675304 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
menaquinone-4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated increases activity ISO menatetrenone results in increased activity of ALPL protein CTD PMID:11113387 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression
multiple interactions
increases carboxylation		 ISO menatetrenone results in increased expression of BGLAP mRNA
Warfarin inhibits the reaction [menatetrenone results in increased carboxylation of BGLAP protein]		 CTD PMID:11113387 PMID:31173816 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions
increases expression
increases response to substance		 ISO Coumestrol inhibits the reaction [menatetrenone promotes the reaction [Phosphates results in increased expression of BMP2 mRNA]]; Coumestrol inhibits the reaction [menatetrenone results in increased expression of BMP2 mRNA]; Coumestrol inhibits the reaction [menatetrenone results in increased susceptibility to BMP2 protein]; Coumestrol inhibits the reaction [Phosphates promotes the reaction [menatetrenone results in increased expression of BMP2 mRNA]]; Ketoconazole inhibits the reaction [menatetrenone promotes the reaction [Phosphates results in increased expression of BMP2 mRNA]]; Ketoconazole inhibits the reaction [Phosphates promotes the reaction [menatetrenone results in increased expression of BMP2 mRNA]]; menatetrenone promotes the reaction [Phosphates results in increased expression of BMP2 mRNA]; Phosphates promotes the reaction [menatetrenone results in increased expression of BMP2 mRNA] CTD PMID:31843813 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO menatetrenone results in increased activity of NR1I2 protein CTD PMID:31843813 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression ISO menatetrenone results in increased expression of TNFRSF11B mRNA CTD PMID:31173816 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO menatetrenone inhibits the reaction [Calcitriol results in increased expression of TNFSF11 mRNA] CTD PMID:11113387 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Ubiad1 UbiA prenyltransferase domain containing 1 multiple interactions ISO [UBIAD1 protein results in increased metabolism of Vitamin K metabolite] which results in increased chemical synthesis of menatetrenone CTD PMID:20953171 NCBI chr 5:158,856,582...158,880,490
Ensembl chr 5:158,868,672...158,880,271 		JBrowse link
menaquinone-7 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bglap bone gamma-carboxyglutamate protein multiple interactions
increases carboxylation		 ISO Warfarin inhibits the reaction [menaquinone 7 results in increased carboxylation of BGLAP protein] CTD PMID:31173816 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression ISO menaquinone 7 results in increased expression of TNFRSF11B mRNA CTD PMID:31173816 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19890
    role 19839
      biological role 19858
        biochemical role 19566
          vitamin (role) 14025
            fat-soluble vitamin (role) 11261
              vitamin K 1259
                menaquinone 30
                  menaquinone-4 + 7
                  menaquinone-7 2
                  menaquinone-8 0
                  menaquinone-9 + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19890
    subatomic particle 19867
      composite particle 19888
        hadron 19888
          baryon 19888
            nucleon 19867
              atomic nucleus 19888
                atom 19888
                  main group element atom 19806
                    p-block element atom 19806
                      carbon group element atom 19746
                        carbon atom 19743
                          organic molecular entity 19743
                            heteroorganic entity 19502
                              organochalcogen compound 19264
                                organooxygen compound 19180
                                  carbonyl compound 18920
                                    ketone 17269
                                      cyclic ketone 15901
                                        quinone 9905
                                          p-quinones 8557
                                            prenylquinone 151
                                              prenylnaphthoquinone 30
                                                menaquinones 30
                                                  menaquinone 30
                                                    menaquinone-4 + 7
                                                    menaquinone-7 2
                                                    menaquinone-8 0
                                                    menaquinone-9 + 0
paths to the root