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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:prenylquinone
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Accession:CHEBI:26255 term browser browse the term
Definition:A quinone substituted by a polyprenyl-derived side-chain. Prenylquinones occur in all living cells. Due to their amphiphilic character, they are mainly located in biological membranes where they function as electron and proton carriers in the photosynthetic and respiratory electron transport chains. Some prenylquinones also perform more specialised roles sucy as antioxidants and enzyme cofactors. Prenylquinones are classified according to ring structure: the main classes are menaquinones, phylloquinones, ubiquinones and plastoquinones.
Synonyms:related_synonym: polyprenylquinone;   polyprenylquinones;   prenylquinones
 alt_id: CHEBI:72751
 xref: PMID:19928587;   PMID:21777468;   PMID:21844348;   PMID:22371323;   PMID:3985624



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coenzyme Q10 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in decreased phosphorylation of AKT1 protein]; [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased cleavage of AKT1 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in decreased phosphorylation of AKT1 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased cleavage of AKT1 protein]; coenzyme Q10 inhibits the reaction [Atorvastatin results in decreased phosphorylation of AKT1 protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein] CTD PMID:27087047 PMID:27345130 PMID:32383521 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of APAF1 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of APAF1 protein CTD PMID:33754447 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G App amyloid beta precursor protein multiple interactions
decreases response to substance
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [coenzyme Q10 results in decreased susceptibility to APP protein]; [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]; coenzyme Q10 inhibits the reaction [APP protein results in decreased expression of PIK3R1 protein]; coenzyme Q10 inhibits the reaction [APP protein results in decreased phosphorylation of GSK3B protein]; coenzyme Q10 inhibits the reaction [APP protein results in increased cleavage of CASP3 protein] CTD PMID:22186599 PMID:32383521 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Arap2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of ARAP2 mRNA] CTD PMID:21370964 NCBI chr14:46,717,657...46,917,326
Ensembl chr14:46,718,760...46,917,154
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased phosphorylation of BAD protein] CTD PMID:27087047 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of BAK1 protein] CTD PMID:27087047 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO
[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased expression of BAX protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of BAX mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of BAX protein]
[coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of BAX mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of BAX protein; coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]
CTD PMID:27087047 PMID:32116774 PMID:33393703 PMID:33754447 PMID:34186417 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
EXP
ISO
coenzyme Q10 results in increased expression of BCL2 mRNA
[coenzyme Q10 co-treated with TNFSF11 protein] results in decreased expression of BCL2 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in decreased expression of BCL2 protein; coenzyme Q10 inhibits the reaction [bisphenol A results in decreased expression of BCL2 mRNA]
[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of BCL2 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of BCL2 protein]
CTD PMID:18817789 PMID:27087047 PMID:32116774 PMID:33393703 PMID:33754447 More... NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased expression of BCL2L1 protein] CTD PMID:27087047 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G C1qa complement C1q A chain decreases expression ISO coenzyme Q10 results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
JBrowse link
G C4b complement C4B decreases expression ISO coenzyme Q10 results in decreased expression of C4B mRNA CTD PMID:19555370 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; coenzyme Q10 inhibits the reaction [APP protein results in increased cleavage of CASP3 protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased activity of CASP3 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of CASP3 mRNA]; coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of CASP3 protein]
[coenzyme Q10 co-treated with TNFSF11 protein] results in increased cleavage of CASP3 protein; coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of CASP3 mRNA]; coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]
CTD PMID:20510337 PMID:22186599 PMID:27087047 PMID:32116774 PMID:33393703 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP8 protein] CTD PMID:27087047 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP9 protein] CTD PMID:27087047 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions EXP
ISO
[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; [Quercetin co-treated with coenzyme Q10] inhibits the reaction [Streptozocin results in increased activity of CAT protein]; [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; [Vitamin E co-treated with coenzyme Q10] results in increased activity of CAT protein; coenzyme Q10 inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [Dichlorvos results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of CAT mRNA]
[coenzyme Q10 co-treated with TNFSF11 protein] affects the activity of CAT protein; [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the activity of CAT protein]; coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of CAT mRNA]
CTD PMID:12242689 PMID:19958828 PMID:25382014 PMID:29143438 PMID:29948670 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CCN2 protein] CTD PMID:27087047 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO coenzyme Q10 results in increased expression of CCND1 protein CTD PMID:34668565 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of COL1A1 protein] CTD PMID:27087047 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO coenzyme Q10 inhibits the reaction [Acetaminophen affects the phosphorylation of and affects the localization of CTNNB1 protein] CTD PMID:34668565 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsb cathepsin B multiple interactions ISO coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of and affects the localization of CTSB protein]; coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of CTSB mRNA] CTD PMID:34186417 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Ctsd cathepsin D multiple interactions ISO coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of and affects the localization of CTSD protein]; coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of CTSD mRNA] CTD PMID:34186417 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Ctss cathepsin S decreases expression ISO coenzyme Q10 results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of CYCS mRNA] CTD PMID:33856607 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lamivudine results in increased secretion of EDN1 protein]; coenzyme Q10 inhibits the reaction [Tenofovir results in increased secretion of EDN1 protein]; coenzyme Q10 inhibits the reaction [Zidovudine results in increased secretion of EDN1 protein] CTD PMID:23640862 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Eps15 epidermal growth factor receptor pathway substrate 15 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of EPS15 mRNA] CTD PMID:21370964 NCBI chr 5:124,045,865...124,146,221
Ensembl chr 5:124,045,926...124,146,221
JBrowse link
G Etv3 ETS variant transcription factor 3 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of ETV3 mRNA] CTD PMID:21370964 NCBI chr 2:172,965,461...172,980,320
Ensembl chr 2:172,965,588...172,980,314
JBrowse link
G Fadd Fas associated via death domain multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of FADD protein] CTD PMID:27087047 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Faslg Fas ligand multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of FASLG protein] CTD PMID:27087047 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fshr follicle stimulating hormone receptor multiple interactions ISO coenzyme Q10 inhibits the reaction [Cyclophosphamide results in decreased expression of FSHR mRNA] CTD PMID:31557371 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP [Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]; [Taurine co-treated with coenzyme Q10] results in increased activity of G6PD protein; coenzyme Q10 inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein] CTD PMID:33548410 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
multiple interactions
ISO
EXP
coenzyme Q10 results in decreased expression of GFAP mRNA
[Oxygen co-treated with coenzyme Q10] results in decreased expression of GFAP protein
CTD PMID:19555370 PMID:35212449 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GGT1 protein] CTD PMID:27387968 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GOT1 protein] CTD PMID:27387968 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO
[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased activity of GPT protein]; coenzyme Q10 inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GPT protein]; coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of GPT protein]
Chloroquine inhibits the reaction [coenzyme Q10 inhibits the reaction [Acetaminophen results in increased activity of GPT protein]]; coenzyme Q10 inhibits the reaction [Acetaminophen results in increased activity of GPT protein]
CTD PMID:27174133 PMID:27387968 PMID:33271250 PMID:33393703 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO
EXP
coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of GPX1 mRNA]
coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of GPX1 mRNA]
CTD PMID:32116774 PMID:33271250 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP
ISO
coenzyme Q10 inhibits the reaction [APP protein results in decreased phosphorylation of GSK3B protein]
coenzyme Q10 promotes the reaction [Acetaminophen results in increased phosphorylation of GSK3B protein]
CTD PMID:22186599 PMID:34668565 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases expression
EXP [epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in decreased activity of GSR protein]; [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; [Vitamin E co-treated with coenzyme Q10] results in increased activity of GSR protein; coenzyme Q10 inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased activity of GSR protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of GSR mRNA]
coenzyme Q10 results in increased expression of GSR mRNA
CTD PMID:19958828 PMID:32116774 PMID:33393703 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of HMOX1 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of HMOX1 protein]; coenzyme Q10 inhibits the reaction [sodium arsenite results in decreased expression of HMOX1 mRNA] CTD PMID:27174133 PMID:32116774 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
ISO
EXP
[Valproic Acid co-treated with coenzyme Q10] inhibits the reaction [Benzene results in increased expression of IL10 protein]
coenzyme Q10 results in increased expression of IL10 mRNA; coenzyme Q10 results in increased expression of IL10 protein
coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of IL10 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of IL10 protein]
CTD PMID:32116774 PMID:35090963 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of IL1B mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of IL1B protein]; coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of IL1B protein] CTD PMID:32116774 PMID:32383521 PMID:34939713 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of IL6 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of IL6 protein] CTD PMID:32383521 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein] CTD PMID:32383521 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 decreases abundance ISO KCNJ6 gene mutant form results in decreased abundance of coenzyme Q10 CTD PMID:15256069 NCBI chr11:34,061,702...34,308,758
Ensembl chr11:34,061,708...34,308,758
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions ISO coenzyme Q10 inhibits the reaction [bisphenol A results in decreased expression of LAMP2 protein] CTD PMID:34186417 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522
JBrowse link
G Ldhc lactate dehydrogenase C multiple interactions
increases activity
EXP [Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]; [Taurine co-treated with coenzyme Q10] results in increased activity of LDHC protein; coenzyme Q10 inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]
coenzyme Q10 results in increased activity of LDHC protein
CTD PMID:33548410 NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein] CTD PMID:27087047 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of MMP9 protein] CTD PMID:27087047 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [Melatonin co-treated with coenzyme Q10 co-treated with vinpocetine] inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein]; coenzyme Q10 inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein] CTD PMID:26519479 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mt3 metallothionein 3 multiple interactions EXP coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of MT3 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of MT3 protein] CTD PMID:33856607 NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of NCOA2 mRNA] CTD PMID:21370964 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
JBrowse link
G Ndufb6 NADH:ubiquinone oxidoreductase subunit B6 increases expression
multiple interactions
ISO coenzyme Q10 results in increased expression of NDUFB6 protein
coenzyme Q10 inhibits the reaction [Galactosamine results in decreased expression of NDUFB6 mRNA]
CTD PMID:19523936 NCBI chr 5:55,400,543...55,410,110
Ensembl chr 5:55,400,543...55,410,181
JBrowse link
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 increases expression ISO coenzyme Q10 results in increased expression of NDUFS7 protein CTD PMID:19523936 NCBI chr 7:9,452,556...9,460,135
Ensembl chr 7:9,450,392...9,460,195
JBrowse link
G Nefl neurofilament light chain multiple interactions EXP coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of NEFL protein] CTD PMID:34939713 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of NFATC1 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of NFATC1 protein; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 protein] CTD PMID:33754447 NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
EXP
ISO
coenzyme Q10 inhibits the reaction [lead acetate affects the localization of NFE2L2 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of NFE2L2 mRNA]; coenzyme Q10 inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 mRNA]; coenzyme Q10 inhibits the reaction [Vincristine results in decreased expression of NFE2L2 mRNA]
coenzyme Q10 results in increased expression of NFE2L2 mRNA
coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of NFE2L2 mRNA]
CTD PMID:27174133 PMID:32116774 PMID:33271250 PMID:34939713 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of NOS2 protein]
coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of NOS2 mRNA]
CTD PMID:20510337 PMID:32116774 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lamivudine results in decreased phosphorylation of NOS3 protein]; coenzyme Q10 inhibits the reaction [Tenofovir results in decreased phosphorylation of NOS3 protein]; coenzyme Q10 inhibits the reaction [Zidovudine results in decreased phosphorylation of NOS3 protein] CTD PMID:23640862 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Oscar osteoclast associated Ig-like receptor multiple interactions ISO [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of OSCAR mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of OSCAR protein; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of OSCAR mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of OSCAR protein] CTD PMID:33754447 NCBI chr 1:65,607,214...65,615,395
Ensembl chr 1:65,607,410...65,613,758
JBrowse link
G Pah phenylalanine hydroxylase decreases expression ISO coenzyme Q10 results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
increases expression
ISO coenzyme Q10 inhibits the reaction [Cyclophosphamide results in decreased expression of PCNA mRNA]
coenzyme Q10 results in increased expression of PCNA protein
CTD PMID:31557371 PMID:34668565 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [APP protein results in decreased expression of PIK3R1 protein] CTD PMID:22186599 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PINK1 protein]]; coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PINK1 protein] CTD PMID:33271250 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Pou2f1 POU class 2 homeobox 1 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of POU2F1 mRNA] CTD PMID:21370964 NCBI chr13:78,120,617...78,263,306
Ensembl chr13:78,130,685...78,263,363
JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of PPP2R5C mRNA] CTD PMID:21370964 NCBI chr 6:129,461,689...129,598,344
Ensembl chr 6:129,461,648...129,598,346
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PRKN protein]]; coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PRKN protein] CTD PMID:33271250 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
JBrowse link
G Psd3 pleckstrin and Sec7 domain containing 3 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of PSD3 mRNA] CTD PMID:21370964 NCBI chr16:21,465,643...22,035,846
Ensembl chr16:21,465,639...22,034,547
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of RELA protein] CTD PMID:34939713 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sarm1 sterile alpha and TIR motif containing 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of SARM1 mRNA] CTD PMID:34939713 NCBI chr10:63,369,456...63,393,016
Ensembl chr10:63,369,456...63,392,822
JBrowse link
G Skap2 src kinase associated phosphoprotein 2 decreases expression ISO coenzyme Q10 results in decreased expression of SKAP2 mRNA CTD PMID:19555370 NCBI chr 4:80,948,832...81,100,900
Ensembl chr 4:80,950,580...81,100,891
JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of SMAD3 mRNA] CTD PMID:27174133 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Snca synuclein alpha multiple interactions ISO
EXP
coenzyme Q10 inhibits the reaction [1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline results in increased expression of SNCA protein]
coenzyme Q10 inhibits the reaction [Dichlorvos promotes the reaction [SNCA protein binds to SNCA protein]]
[coenzyme Q10 co-treated with Creatine] results in decreased expression of SNCA protein
CTD PMID:15114628 PMID:19476553 PMID:21843543 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Sod2 superoxide dismutase 2 affects expression
increases expression
multiple interactions
EXP
ISO
coenzyme Q10 affects the expression of SOD2 protein
coenzyme Q10 results in increased expression of SOD2 mRNA
coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of SOD2 mRNA]
coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of SOD2 mRNA]
coenzyme Q10 inhibits the reaction [Acrolein results in increased expression of SOD2 protein]
CTD PMID:22083459 PMID:24008411 PMID:32116774 PMID:33271250 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in decreased expression of SQSTM1 protein]]; coenzyme Q10 promotes the reaction [Acetaminophen results in decreased expression of SQSTM1 protein] CTD PMID:33271250 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of TGFB1 mRNA] CTD PMID:27087047 PMID:27174133 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of TNF protein]
[Melatonin co-treated with coenzyme Q10 co-treated with vinpocetine] inhibits the reaction [Chlorpyrifos results in increased secretion of TNF protein]; coenzyme Q10 inhibits the reaction [Chlorpyrifos results in increased secretion of TNF protein]
[Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of TNF mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of TNF protein]; coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of TNF protein]
CTD PMID:20510337 PMID:26519479 PMID:32116774 PMID:32383521 PMID:34939713 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO [coenzyme Q10 co-treated with TNFSF11 protein] affects the activity of CAT protein; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of NFATC1 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of NFATC1 protein; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of OSCAR mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of OSCAR protein; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of TRAF2 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of TRAF2 protein; [coenzyme Q10 co-treated with TNFSF11 protein] results in decreased expression of BCL2 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in decreased expression of BCL2 protein; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased cleavage of CASP3 protein; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of APAF1 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of APAF1 protein; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of BAX mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of BAX protein; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the activity of CAT protein]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 protein]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of OSCAR mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of OSCAR protein]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of TRAF2 mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of TRAF2 protein] CTD PMID:33754447 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO
EXP
coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of TRP53 protein]
[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased phosphorylation of TP53 protein]
CTD PMID:20510337 PMID:33393703 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Traf2 Tnf receptor-associated factor 2 multiple interactions ISO [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of TRAF2 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of TRAF2 protein; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of TRAF2 mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of TRAF2 protein] CTD PMID:33754447 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
JBrowse link
Ilimaquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO ilimaquinone results in decreased expression of BCL2 protein CTD PMID:24930757 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO ilimaquinone results in decreased expression of BCL2L1 protein CTD PMID:24930757 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO [ilimaquinone results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of CASP3 protein; ilimaquinone promotes the reaction [TNFSF10 protein results in increased cleavage of CASP3 protein]
ilimaquinone results in increased cleavage of CASP3 protein
CTD PMID:24930757 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases cleavage ISO ilimaquinone results in increased cleavage of CASP8 protein CTD PMID:24930757 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ilimaquinone results in increased expression of DDIT3 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ilimaquinone results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [ilimaquinone results in increased expression of DDIT3 mRNA] CTD PMID:24930757 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO ilimaquinone results in increased phosphorylation of MAPK1 protein CTD PMID:24930757 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO ilimaquinone results in increased phosphorylation of MAPK3 protein CTD PMID:24930757 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [ilimaquinone results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of PARP1 protein; ilimaquinone promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]
ilimaquinone results in increased cleavage of PARP1 protein
CTD PMID:24930757 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pld2 phospholipase D2 multiple interactions
increases activity
ISO 1-Butanol inhibits the reaction [ilimaquinone results in increased activity of PLD2 protein] CTD PMID:17897952 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A protein]; Acetylcysteine inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A mRNA]
ilimaquinone results in increased expression of TNFRSF10A mRNA; ilimaquinone results in increased expression of TNFRSF10A protein
CTD PMID:24930757 NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [ilimaquinone results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of CASP3 protein; [ilimaquinone results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of PARP1 protein; ilimaquinone promotes the reaction [TNFSF10 protein results in increased cleavage of CASP3 protein]; ilimaquinone promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein] CTD PMID:24930757 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
menaquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased phosphorylation of AKT1 protein] CTD PMID:27212383 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases expression
multiple interactions
EXP Vitamin K 2 results in increased expression of ALPL protein
PTH protein promotes the reaction [Vitamin K 2 results in increased expression of ALPL protein]; Vitamin K 2 affects the reaction [PTH protein results in increased expression of ALPL protein]
CTD PMID:30639440 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Axl Axl receptor tyrosine kinase multiple interactions EXP Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of AXL protein] CTD PMID:27212383 NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of BCL2 protein] CTD PMID:27212383 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions
increases secretion
decreases expression
ISO
EXP
Vitamin K 2 inhibits the reaction [IL1B protein results in decreased expression of BGLAP protein modified form]
PTH protein promotes the reaction [Vitamin K 2 results in increased carboxylation of BGLAP protein]; PTH protein promotes the reaction [Vitamin K 2 results in increased secretion of BGLAP protein modified form]; Vitamin K 2 promotes the reaction [PTH protein results in increased carboxylation of BGLAP protein]; Vitamin K 2 promotes the reaction [PTH protein results in increased secretion of BGLAP protein modified form]; Vitamin K 2 results in increased carboxylation of and results in decreased secretion of BGLAP protein
Vitamin K 2 results in decreased expression of BGLAP mRNA
CTD PMID:19675304 PMID:20460758 PMID:30639440 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Vitamin K 2 results in decreased expression of BIRC5 protein CTD PMID:29432837 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions EXP Vitamin K 2 affects the reaction [PTH protein results in increased expression of BMP2 protein] CTD PMID:30639440 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO [Vitamin K 2 co-treated with arsenic trioxide] results in increased expression of CASP3; Acetylcysteine inhibits the reaction [[Vitamin K 2 co-treated with arsenic trioxide] results in increased expression of CASP3]
Vitamin K 2 results in increased cleavage of CASP3 protein
CTD PMID:24273890 PMID:29432837 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases cleavage ISO Vitamin K 2 results in increased cleavage of CASP7 protein CTD PMID:29432837 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Vitamin K 2 results in decreased expression of CDK4 mRNA CTD PMID:16010434 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Vitamin K 2 results in increased expression of CDKN1A protein CTD PMID:29432837 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO Vitamin K 2 results in increased expression of CDKN2A mRNA CTD PMID:16010434 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO Vitamin K 2 results in decreased expression of COL1A1 mRNA CTD PMID:19675304 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G F10 coagulation factor X multiple interactions EXP [Phenobarbital co-treated with Vitamin K 2] results in increased activity of F10 protein CTD PMID:19952496 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141
JBrowse link
G F7 coagulation factor VII multiple interactions EXP [Phenobarbital co-treated with Vitamin K 2] results in increased activity of F7 protein CTD PMID:19952496 NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610
JBrowse link
G Gas6 growth arrest specific 6 multiple interactions EXP Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of GAS6 protein] CTD PMID:27212383 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO Vitamin K 2 results in increased phosphorylation of H2AX protein CTD PMID:29432837 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression ISO Vitamin K 2 results in decreased expression of HSPA5 protein CTD PMID:29432837 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases response to substance
ISO Vitamin K 2 inhibits the reaction [IL1B protein results in decreased expression of BGLAP protein modified form]; Warfarin inhibits the reaction [Vitamin K 2 results in decreased susceptibility to IL1B protein] CTD PMID:20460758 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO PROX1 protein inhibits the reaction [Vitamin K 2 results in increased activity of NR1I2 protein] CTD PMID:22023334 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Vitamin K 2 results in increased cleavage of PARP1 protein CTD PMID:29432837 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Prox1 prospero homeobox 1 multiple interactions ISO PROX1 protein inhibits the reaction [Vitamin K 2 results in increased activity of NR1I2 protein] CTD PMID:22023334 NCBI chr13:101,669,184...101,719,804
Ensembl chr13:101,669,184...101,711,183
JBrowse link
G Pth parathyroid hormone multiple interactions EXP PTH protein promotes the reaction [Vitamin K 2 results in increased carboxylation of BGLAP protein]; PTH protein promotes the reaction [Vitamin K 2 results in increased expression of ALPL protein]; PTH protein promotes the reaction [Vitamin K 2 results in increased expression of RUNX2 protein]; PTH protein promotes the reaction [Vitamin K 2 results in increased expression of SP7 protein]; PTH protein promotes the reaction [Vitamin K 2 results in increased secretion of BGLAP protein modified form]; Vitamin K 2 affects the reaction [PTH protein results in increased expression of ALPL protein]; Vitamin K 2 affects the reaction [PTH protein results in increased expression of BMP2 protein]; Vitamin K 2 affects the reaction [PTH protein results in increased expression of RUNX2 protein]; Vitamin K 2 affects the reaction [PTH protein results in increased expression of SP7 protein]; Vitamin K 2 promotes the reaction [PTH protein results in increased carboxylation of BGLAP protein]; Vitamin K 2 promotes the reaction [PTH protein results in increased secretion of BGLAP protein modified form] CTD PMID:30639440 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530
JBrowse link
G Rb1 RB transcriptional corepressor 1 increases expression ISO Vitamin K 2 results in increased expression of RB1 mRNA CTD PMID:16010434 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression
multiple interactions
EXP Vitamin K 2 results in increased expression of RUNX2 protein
PTH protein promotes the reaction [Vitamin K 2 results in increased expression of RUNX2 protein]; Vitamin K 2 affects the reaction [PTH protein results in increased expression of RUNX2 protein]
CTD PMID:30639440 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions
decreases phosphorylation
ISO [Vitamin K 2 co-treated with 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid] results in decreased phosphorylation of RXRA protein
Vitamin K 2 results in decreased phosphorylation of RXRA protein
CTD PMID:17270033 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Sp7 Sp7 transcription factor increases expression
multiple interactions
EXP Vitamin K 2 results in increased expression of SP7 protein
PTH protein promotes the reaction [Vitamin K 2 results in increased expression of SP7 protein]; Vitamin K 2 affects the reaction [PTH protein results in increased expression of SP7 protein]
CTD PMID:30639440 NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847
JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression ISO Vitamin K 2 results in decreased expression of TNFSF11 mRNA CTD PMID:19675304 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
JBrowse link
menaquinone-4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated increases activity ISO menatetrenone results in increased activity of ALPL protein CTD PMID:11113387 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression
multiple interactions
increases carboxylation
ISO menatetrenone results in increased expression of BGLAP mRNA
Warfarin inhibits the reaction [menatetrenone results in increased carboxylation of BGLAP protein]
CTD PMID:11113387 PMID:31173816 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions
increases expression
increases response to substance
ISO Coumestrol inhibits the reaction [menatetrenone promotes the reaction [Phosphates results in increased expression of BMP2 mRNA]]; Coumestrol inhibits the reaction [menatetrenone results in increased expression of BMP2 mRNA]; Coumestrol inhibits the reaction [menatetrenone results in increased susceptibility to BMP2 protein]; Coumestrol inhibits the reaction [Phosphates promotes the reaction [menatetrenone results in increased expression of BMP2 mRNA]]; Ketoconazole inhibits the reaction [menatetrenone promotes the reaction [Phosphates results in increased expression of BMP2 mRNA]]; Ketoconazole inhibits the reaction [Phosphates promotes the reaction [menatetrenone results in increased expression of BMP2 mRNA]]; menatetrenone promotes the reaction [Phosphates results in increased expression of BMP2 mRNA]; Phosphates promotes the reaction [menatetrenone results in increased expression of BMP2 mRNA] CTD PMID:31843813 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO menatetrenone results in increased activity of NR1I2 protein CTD PMID:31843813 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression ISO menatetrenone results in increased expression of TNFRSF11B mRNA CTD PMID:31173816 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO menatetrenone inhibits the reaction [Calcitriol results in increased expression of TNFSF11 mRNA] CTD PMID:11113387 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Ubiad1 UbiA prenyltransferase domain containing 1 multiple interactions ISO [UBIAD1 protein results in increased metabolism of Vitamin K metabolite] which results in increased chemical synthesis of menatetrenone CTD PMID:20953171 NCBI chr 5:158,856,582...158,880,490
Ensembl chr 5:158,868,672...158,880,271
JBrowse link
menaquinone-7 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bglap bone gamma-carboxyglutamate protein multiple interactions
increases carboxylation
ISO Warfarin inhibits the reaction [menaquinone 7 results in increased carboxylation of BGLAP protein] CTD PMID:31173816 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression ISO menaquinone 7 results in increased expression of TNFRSF11B mRNA CTD PMID:31173816 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
phylloquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Warfarin co-treated with Vitamin K 1] results in decreased phosphorylation of AKT1 protein; Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased phosphorylation of AKT1 protein] CTD PMID:27212383 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Axl Axl receptor tyrosine kinase multiple interactions EXP [Warfarin co-treated with Vitamin K 1] results in decreased expression of AXL protein; Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of AXL protein] CTD PMID:27212383 NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP
[sorafenib co-treated with Vitamin K 1] results in decreased expression of BCL2 protein
[Warfarin co-treated with Vitamin K 1] results in decreased expression of BCL2 protein; Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of BCL2 protein]
CTD PMID:20301194 PMID:27212383 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases carboxylation
multiple interactions
ISO Vitamin K 1 results in increased carboxylation of BGLAP protein
Warfarin inhibits the reaction [Vitamin K 1 results in increased carboxylation of BGLAP protein]
CTD PMID:31173816 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [sorafenib co-treated with Vitamin K 1] results in increased cleavage of BID protein CTD PMID:20301194 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions EXP [Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 mRNA; [Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 protein; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 mRNA]; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 protein] CTD PMID:27412937 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [sorafenib co-treated with Vitamin K 1] results in increased cleavage of CASP3 protein
[Warfarin co-treated with Vitamin K 1] results in increased cleavage of CASP3 protein
CTD PMID:20301194 PMID:23990204 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [sorafenib co-treated with Vitamin K 1] results in increased cleavage of CASP8 protein CTD PMID:20301194 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP Vitamin K 1 affects the reaction [Ethylene Glycol affects the expression of CCL2 mRNA] CTD PMID:31639794 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G F2 coagulation factor II, thrombin increases expression ISO Vitamin K 1 deficiency results in increased expression of F2 protein modified form CTD PMID:2821104 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G F9 coagulation factor IX multiple interactions ISO [VKORC1 protein results in increased reduction of Vitamin K 1] which results in increased carboxylation of and results in increased activity of F9 protein; [VKORC1L1 protein results in increased reduction of Vitamin K 1] which results in increased carboxylation of and results in increased activity of F9 protein CTD PMID:29581108 NCBI chr  X:138,352,334...138,396,835
Ensembl chr  X:138,352,298...138,396,835
JBrowse link
G Faslg Fas ligand multiple interactions ISO [sorafenib co-treated with Vitamin K 1] results in increased expression of FASLG protein; pyrazolanthrone inhibits the reaction [[sorafenib co-treated with Vitamin K 1] results in increased expression of FASLG protein] CTD PMID:20301194 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Vitamin K 1 results in increased expression of FOS mRNA CTD PMID:19273458 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gas6 growth arrest specific 6 multiple interactions EXP [Warfarin co-treated with Vitamin K 1] results in decreased expression of GAS6 protein; Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of GAS6 protein] CTD PMID:27212383 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Vitamin K 1 inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Vitamin K 1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:16636460 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [sorafenib co-treated with Vitamin K 1] results in increased phosphorylation of JUN protein; pyrazolanthrone inhibits the reaction [[sorafenib co-treated with Vitamin K 1] results in increased phosphorylation of JUN protein] CTD PMID:20301194 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [sorafenib co-treated with Vitamin K 1] results in decreased phosphorylation of MAPK1 protein CTD PMID:20301194 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [sorafenib co-treated with Vitamin K 1] results in decreased phosphorylation of MAPK3 protein CTD PMID:20301194 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mgp matrix Gla protein multiple interactions
increases expression
EXP
ISO
[Vitamin K 1 co-treated with Ethylene Glycol] results in increased expression of MGP protein; Vitamin K 1 results in increased expression of and results in increased secretion of MGP protein modified form; Warfarin inhibits the reaction [Vitamin K 1 results in increased expression of and results in increased secretion of MGP protein modified form]
Vitamin K 1 results in increased expression of MGP protein
[[Warfarin co-treated with Vitamin K 1] results in decreased carboxylation of MGP protein] which results in decreased activity of MGP protein; [Warfarin co-treated with Vitamin K 1] results in decreased activity of MGP protein; [Warfarin co-treated with Vitamin K 1] results in decreased carboxylation of MGP protein; [Warfarin co-treated with Vitamin K 1] results in decreased expression of MGP mRNA
CTD PMID:21705322 PMID:23990204 PMID:31639794 NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions EXP [Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 mRNA; [Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 protein; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 mRNA]; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 protein] CTD PMID:27412937 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO [Warfarin co-treated with Vitamin K 1] results in increased expression of SPP1 mRNA CTD PMID:23990204 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Tagln transgelin multiple interactions ISO [Warfarin co-treated with Vitamin K 1] results in decreased expression of TAGLN mRNA CTD PMID:23990204 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 multiple interactions
increases reduction
ISO 4-hydroxycoumarin inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]; [VKORC1 protein results in increased reduction of Vitamin K 1] which results in increased carboxylation of and results in increased activity of F9 protein; Acenocoumarol inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]; bromadiolone inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]; bromfenacoum inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]; coumachlor inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]; coumatetralyl inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]; Dicumarol inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]; ferulenol inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]; fluindione inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]; Phenindione inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]; Phenprocoumon inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]; Warfarin inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1] CTD PMID:29581108 NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008
JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 multiple interactions
increases reduction
ISO 4-hydroxycoumarin inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]; [VKORC1L1 protein results in increased reduction of Vitamin K 1] which results in increased carboxylation of and results in increased activity of F9 protein; Acenocoumarol inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]; bromadiolone inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]; bromfenacoum inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]; coumachlor inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]; coumatetralyl inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]; Dicumarol inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]; ferulenol inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]; fluindione inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]; Phenindione inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]; Phenprocoumon inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]; Warfarin inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1] CTD PMID:29581108 NCBI chr12:26,717,959...26,768,193
Ensembl chr12:26,623,976...26,768,225
JBrowse link
ubiquinone-0 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression ISO ubiquinone-O results in decreased expression of ALDH1 protein CTD PMID:36847822 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Casp1 caspase 1 decreases expression
multiple interactions
ISO ubiquinone-O results in decreased expression of CASP1 protein
ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein]
CTD PMID:36847822 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Cd24 CD24 molecule increases expression ISO ubiquinone-O results in increased expression of CD24 protein CTD PMID:36847822 NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662
JBrowse link
G Cd44 CD44 molecule decreases expression ISO ubiquinone-O results in decreased expression of CD44 protein CTD PMID:36847822 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cdh1 cadherin 1 increases expression ISO ubiquinone-O results in increased expression of CDH1 mRNA; ubiquinone-O results in increased expression of CDH1 protein CTD PMID:36847822 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO ubiquinone-O results in decreased expression of CDH2 mRNA; ubiquinone-O results in decreased expression of CDH2 protein CTD PMID:36847822 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression ISO ubiquinone-O results in decreased expression of HIF1A protein CTD PMID:36847822 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hk2 hexokinase 2 decreases expression ISO ubiquinone-O results in decreased expression of HK2 protein CTD PMID:36847822 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
JBrowse link
G Il18 interleukin 18 decreases expression
multiple interactions
ISO ubiquinone-O results in decreased expression of IL18 protein
ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein]
CTD PMID:36847822 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions
ISO ubiquinone-O results in decreased expression of IL1B protein
ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA]
CTD PMID:36847822 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO ubiquinone-O results in decreased expression of LDHA protein CTD PMID:36847822 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of MMP2 mRNA] CTD PMID:36847822 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of MMP9 mRNA] CTD PMID:36847822 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 decreases expression
multiple interactions
ISO ubiquinone-O results in decreased expression of NLRP3 protein
ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein]
CTD PMID:36847822 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
ISO ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NOS2 protein]
ubiquinone-O results in decreased expression of NOS2 protein
CTD PMID:36847822 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 decreases expression ISO ubiquinone-O results in decreased expression of PDK1 protein CTD PMID:36847822 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
JBrowse link
G Pkm pyruvate kinase M1/2 decreases expression ISO ubiquinone-O results in decreased expression of PKM protein CTD PMID:36847822 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
JBrowse link
G Pycard PYD and CARD domain containing decreases expression ISO ubiquinone-O results in decreased expression of PYCARD protein CTD PMID:36847822 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression ISO ubiquinone-O results in decreased expression of SLC2A1 mRNA; ubiquinone-O results in decreased expression of SLC2A1 protein CTD PMID:36847822 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Tlr4 toll-like receptor 4 decreases expression ISO ubiquinone-O results in decreased expression of TLR4 protein CTD PMID:36847822 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
ubiquinone-1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nqo2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 multiple interactions ISO [NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q1; [NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q1 CTD PMID:20399199 NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320
JBrowse link
ubiquinone-9 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 decreases abundance ISO KCNJ6 gene mutant form results in decreased abundance of ubiquinone 9 CTD PMID:15256069 NCBI chr11:34,061,702...34,308,758
Ensembl chr11:34,061,708...34,308,758
JBrowse link
ubiquinones term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase multiple interactions EXP Ubiquinone inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein] CTD PMID:20584200 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions ISO ubiquinones decrease 4-hydroxynonenal-Aldh2 protein adduct formation; decrease acylation, nitrosylation, S-nitrosylation, and nitration of Aldh2 protein in mouse liver RGD PMID:29156373 RGD:15036805 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
[Glutamic Acid co-treated with malic acid co-treated with Ubiquinone] inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; Ubiquinone inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; Ubiquinone inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA]
Ubiquinone inhibits the reaction [Dexamethasone results in increased activity of CASP3 protein]
CTD PMID:12880480 PMID:24732427 PMID:35866224 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase increases activity EXP Ubiquinone results in increased activity of CAT protein CTD PMID:20034476 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Coq8a coenzyme Q8A increases chemical synthesis ISO COQ8A protein results in increased chemical synthesis of Ubiquinone CTD PMID:18319072 NCBI chr13:91,904,731...91,933,588
Ensembl chr13:91,904,739...91,931,431
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) multiple interactions
increases metabolic processing
ISO
EXP
2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; teriflunomide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; X 910279 inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]
DHODH protein results in increased metabolism of Ubiquinone
2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; teriflunomide inhibits the reaction [DHODH protein results in increased metabolism of Ubiquinone]; teriflunomide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; X 910279 inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]
CTD PMID:9802339 PMID:11248707 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Ubiquinone inhibits the reaction [Dexamethasone results in increased activity of GPT protein] CTD PMID:35866224 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of IL1B protein] CTD PMID:17516992 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of IL6 protein] CTD PMID:17516992 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Ubiquinone inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of NOS3 mRNA]; Ubiquinone inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of NOS3 protein]; Ubiquinone inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of NOS3] CTD PMID:20020783 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [Niacin co-treated with Ubiquinone co-treated with Riboflavin] results in increased expression of PARP1 protein CTD PMID:18377693 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO PPARA protein affects the reaction [Diethylhexyl Phthalate affects the abundance of Ubiquinone] CTD PMID:10731415 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of TNF protein] CTD PMID:17516992 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 decreases reduction
decreases oxidation
ISO XRCC1 gene mutant form results in decreased reduction of Ubiquinone
XRCC1 results in decreased oxidation of Ubiquinone
CTD PMID:30998386 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    chemical entity 19916
      group 19875
        inorganic group 19454
          oxo group 18922
            organic oxo compound 18922
              carbonyl compound 18922
                ketone 17210
                  cyclic ketone 15715
                    quinone 8655
                      p-quinones 8563
                        prenylquinone 143
                          (+/-)-sclerotiorumin A 0
                          (7S,11S,12S,14R)-14-methoxyamentol quinone 0
                          12-hydroxytauranin 0
                          2-(3-methylbut-2-enyl)-5-(2-methylbut-3-en-2-yl)cyclohexa-2,5-diene-1,4-dione 0
                          2-Polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone 0
                          2-Polyprenyl-6-methoxy-1,4-benzoquinone 0
                          2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinone 0
                          2-nonaprenyl-6-methoxy-1,4-benzoquinone 0
                          3-[[(1S,2R,4As,8aR)-1,2,4a-trimethyl-5-methylidene-3,4,6,7,8,8a-hexahydro-2H-naphthalen-1-yl]methyl]-2-hydroxy-5-methoxycyclohexa-2,5-diene-1,4-dione 0
                          3-ketotauranin 0
                          3alpha-hydroxytauranin 0
                          5'-deoxyneomacrophorin IV 0
                          5-epi-ilimaquinone 0
                          Acrimine B 0
                          Asterriquinone B1 0
                          Asterriquinone I 0
                          Asterriquinone J 0
                          Asterriquinone K 0
                          Cristaquinone A 0
                          Demethylasterriquinone B1 0
                          Eerectquione B 0
                          F12509A 0
                          HU-331 0
                          Hinnuliquinone 0
                          Ilimaquinone 11
                          Myrothecol G 0
                          Myrothecol H 0
                          Penicilliumin A 0
                          Peniginsengin B 0
                          Plastoquinone 8 0
                          Plastoquinone-1 0
                          Purpurogemutantidin 0
                          Smenospongines B 0
                          Truncaquinone A 0
                          lignin cw compound-275 0
                          lignin cw compound-276 0
                          phylloquinones + 25
                          polyprenylbenzoquinone + 0
                          prenylnaphthoquinone + 30
                          rhodoquinones 0
                          tocopherolquinone 0
                          ubiquinones + 102
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      ketone 17210
                                        cyclic ketone 15715
                                          quinone 8655
                                            p-quinones 8563
                                              prenylquinone 143
                                                (+/-)-sclerotiorumin A 0
                                                (7S,11S,12S,14R)-14-methoxyamentol quinone 0
                                                12-hydroxytauranin 0
                                                2-(3-methylbut-2-enyl)-5-(2-methylbut-3-en-2-yl)cyclohexa-2,5-diene-1,4-dione 0
                                                2-Polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone 0
                                                2-Polyprenyl-6-methoxy-1,4-benzoquinone 0
                                                2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinone 0
                                                2-nonaprenyl-6-methoxy-1,4-benzoquinone 0
                                                3-[[(1S,2R,4As,8aR)-1,2,4a-trimethyl-5-methylidene-3,4,6,7,8,8a-hexahydro-2H-naphthalen-1-yl]methyl]-2-hydroxy-5-methoxycyclohexa-2,5-diene-1,4-dione 0
                                                3-ketotauranin 0
                                                3alpha-hydroxytauranin 0
                                                5'-deoxyneomacrophorin IV 0
                                                5-epi-ilimaquinone 0
                                                Acrimine B 0
                                                Asterriquinone B1 0
                                                Asterriquinone I 0
                                                Asterriquinone J 0
                                                Asterriquinone K 0
                                                Cristaquinone A 0
                                                Demethylasterriquinone B1 0
                                                Eerectquione B 0
                                                F12509A 0
                                                HU-331 0
                                                Hinnuliquinone 0
                                                Ilimaquinone 11
                                                Myrothecol G 0
                                                Myrothecol H 0
                                                Penicilliumin A 0
                                                Peniginsengin B 0
                                                Plastoquinone 8 0
                                                Plastoquinone-1 0
                                                Purpurogemutantidin 0
                                                Smenospongines B 0
                                                Truncaquinone A 0
                                                lignin cw compound-275 0
                                                lignin cw compound-276 0
                                                phylloquinones + 25
                                                polyprenylbenzoquinone + 0
                                                prenylnaphthoquinone + 30
                                                rhodoquinones 0
                                                tocopherolquinone 0
                                                ubiquinones + 102
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