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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:menaquinone-4
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Accession:CHEBI:78277 term browser browse the term
Definition:A menaquinone whose side-chain contains 4 isoprene units in an all-trans-configuration.
Synonyms:exact_synonym: 2-methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl]-1,4-naphthoquinone
 related_synonym: 2-Methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthoquinone;   2-Methyl-3-geranylgeranyl-1,4-naphthoquinone;   2-Methyl-3-trans-tetraprenyl-1,4-naphthoquinone;   Formula=C31H40O2;   InChI=1S/C31H40O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,12,14,16,18-20H,9-11,13,15,17,21H2,1-6H3/b23-14+,24-16+,25-20+;   InChIKey=DKHGMERMDICWDU-GHDNBGIDSA-N;   MK-4;   MK4;   Menaquinone K4;   SMILES=CC(C)=CCC\\C(C)=C\\CC\\C(C)=C\\CC\\C(C)=C\\CC1=C(C)C(=O)c2ccccc2C1=O;   Vitamin MK 4;   menatetrenona;   menatetrenone;   menatetrenonum;   vitamin K2(20)
 xref: CAS:863-61-6;   Chemspider:4445530;   DrugBank:DB12148;   Drug_Central:1685;   FooDB:FDB029792;   HMDB:HMDB0030017;   KEGG:D00100
 xref_mesh: MESH:C030814
 xref: MetaCyc:CPD-9726;   PMCID:PMC7259074;   PMID:22692649;   PMID:23169578;   PMID:23346882;   PMID:23702931;   PMID:23832575;   PMID:24085302;   PMID:24138531;   PMID:24342502;   PMID:24426779;   PMID:24489112;   PMID:24508562;   PMID:24630057;   PMID:24737747;   PMID:24841104;   PMID:24975215;   PMID:30753659;   PMID:31018587;   PMID:31083359;   PMID:31579595;   PMID:32086127;   PMID:32150581;   PMID:32412060;   PMID:32448576;   PMID:33051011;   PMID:33542347;   PMID:34202933;   Reaxys:2178866;   Wikipedia:Menatetrenone


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menaquinone-4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated increases activity ISO menatetrenone results in increased activity of ALPL protein CTD PMID:11113387 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression
multiple interactions
increases carboxylation		 ISO menatetrenone results in increased expression of BGLAP mRNA
Warfarin inhibits the reaction [menatetrenone results in increased carboxylation of BGLAP protein]		 CTD PMID:11113387 PMID:31173816 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions
increases expression
increases response to substance		 ISO Coumestrol inhibits the reaction [menatetrenone promotes the reaction [Phosphates results in increased expression of BMP2 mRNA]]; Coumestrol inhibits the reaction [menatetrenone results in increased expression of BMP2 mRNA]; Coumestrol inhibits the reaction [menatetrenone results in increased susceptibility to BMP2 protein]; Coumestrol inhibits the reaction [Phosphates promotes the reaction [menatetrenone results in increased expression of BMP2 mRNA]]; Ketoconazole inhibits the reaction [menatetrenone promotes the reaction [Phosphates results in increased expression of BMP2 mRNA]]; Ketoconazole inhibits the reaction [Phosphates promotes the reaction [menatetrenone results in increased expression of BMP2 mRNA]]; menatetrenone promotes the reaction [Phosphates results in increased expression of BMP2 mRNA]; Phosphates promotes the reaction [menatetrenone results in increased expression of BMP2 mRNA] CTD PMID:31843813 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO menatetrenone results in increased activity of NR1I2 protein CTD PMID:31843813 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression ISO menatetrenone results in increased expression of TNFRSF11B mRNA CTD PMID:31173816 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO menatetrenone inhibits the reaction [Calcitriol results in increased expression of TNFSF11 mRNA] CTD PMID:11113387 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Ubiad1 UbiA prenyltransferase domain containing 1 multiple interactions ISO [UBIAD1 protein results in increased metabolism of Vitamin K metabolite] which results in increased chemical synthesis of menatetrenone CTD PMID:20953171 NCBI chr 5:158,856,582...158,880,490
Ensembl chr 5:158,868,672...158,880,271 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      chemical role 19473
        antioxidant 16145
          menaquinone-4 7
            2,3-epoxymenatetrenone 0
            omega-hydroxymenaquinone-4 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            heteroorganic entity 19505
                              organochalcogen compound 19268
                                organooxygen compound 19184
                                  carbonyl compound 18908
                                    ketone 17258
                                      cyclic ketone 15908
                                        quinone 9901
                                          p-quinones 8557
                                            prenylquinone 151
                                              prenylnaphthoquinone 30
                                                menaquinones 30
                                                  menaquinone 30
                                                    menaquinone-4 7
                                                      2,3-epoxymenatetrenone 0
                                                      omega-hydroxymenaquinone-4 0
paths to the root