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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:menaquinone-4
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Accession:CHEBI:78277 term browser browse the term
Definition:A menaquinone whose side-chain contains 4 isoprene units in an all-trans-configuration.
Synonyms:exact_synonym: 2-methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl]-1,4-naphthoquinone
 related_synonym: 2-Methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthoquinone;   2-Methyl-3-geranylgeranyl-1,4-naphthoquinone;   2-Methyl-3-trans-tetraprenyl-1,4-naphthoquinone;   Formula=C31H40O2;   InChI=1S/C31H40O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,12,14,16,18-20H,9-11,13,15,17,21H2,1-6H3/b23-14+,24-16+,25-20+;   InChIKey=DKHGMERMDICWDU-GHDNBGIDSA-N;   MK-4;   MK4;   Menaquinone K4;   SMILES=CC(C)=CCC\\C(C)=C\\CC\\C(C)=C\\CC\\C(C)=C\\CC1=C(C)C(=O)c2ccccc2C1=O;   Vitamin MK 4;   menatetrenona;   menatetrenone;   menatetrenonum;   vitamin K2(20)
 xref: CAS:863-61-6;   Chemspider:4445530;   DrugBank:DB12148;   Drug_Central:1685;   FooDB:FDB029792;   HMDB:HMDB0030017;   KEGG:D00100
 xref_mesh: MESH:C030814
 xref: MetaCyc:CPD-9726;   PMCID:PMC7259074;   PMID:22692649;   PMID:23169578;   PMID:23346882;   PMID:23702931;   PMID:23832575;   PMID:24085302;   PMID:24138531;   PMID:24342502;   PMID:24426779;   PMID:24489112;   PMID:24508562;   PMID:24630057;   PMID:24737747;   PMID:24841104;   PMID:24975215;   PMID:30753659;   PMID:31018587;   PMID:31083359;   PMID:31579595;   PMID:32086127;   PMID:32150581;   PMID:32412060;   PMID:32448576;   PMID:33051011;   PMID:33542347;   PMID:34202933;   Reaxys:2178866;   Wikipedia:Menatetrenone



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menaquinone-4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated increases activity ISO menatetrenone results in increased activity of ALPL protein CTD PMID:11113387 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression
increases carboxylation
multiple interactions
ISO menatetrenone results in increased expression of BGLAP mRNA
menatetrenone results in increased carboxylation of BGLAP protein
Warfarin inhibits the reaction [menatetrenone results in increased carboxylation of BGLAP protein]
CTD PMID:11113387 PMID:31173816 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions
increases response to substance
increases expression
ISO Coumestrol inhibits the reaction [menatetrenone promotes the reaction [Phosphates results in increased expression of BMP2 mRNA]]; Coumestrol inhibits the reaction [menatetrenone results in increased expression of BMP2 mRNA]; Coumestrol inhibits the reaction [menatetrenone results in increased susceptibility to BMP2 protein]; Coumestrol inhibits the reaction [Phosphates promotes the reaction [menatetrenone results in increased expression of BMP2 mRNA]]; Ketoconazole inhibits the reaction [menatetrenone promotes the reaction [Phosphates results in increased expression of BMP2 mRNA]]; Ketoconazole inhibits the reaction [Phosphates promotes the reaction [menatetrenone results in increased expression of BMP2 mRNA]]; menatetrenone promotes the reaction [Phosphates results in increased expression of BMP2 mRNA]; Phosphates promotes the reaction [menatetrenone results in increased expression of BMP2 mRNA] CTD PMID:31843813 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO menatetrenone results in increased activity of NR1I2 protein CTD PMID:31843813 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression ISO menatetrenone results in increased expression of TNFRSF11B mRNA CTD PMID:31173816 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO menatetrenone inhibits the reaction [Calcitriol results in increased expression of TNFSF11 mRNA] CTD PMID:11113387 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Ubiad1 UbiA prenyltransferase domain containing 1 multiple interactions ISO [UBIAD1 protein results in increased metabolism of Vitamin K metabolite] which results in increased chemical synthesis of menatetrenone CTD PMID:20953171 NCBI chr 5:158,856,582...158,880,490
Ensembl chr 5:158,868,672...158,880,271
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20050
    role 20001
      chemical role 19530
        antioxidant 14499
          menaquinone-4 7
            2,3-epoxymenatetrenone 0
            omega-hydroxymenaquinone-4 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      carbon group element atom 19872
                        carbon atom 19863
                          organic molecular entity 19863
                            organic group 18937
                              organic divalent group 18922
                                organodiyl group 18922
                                  carbonyl group 18872
                                    carbonyl compound 18872
                                      ketone 17097
                                        cyclic ketone 15648
                                          quinone 8489
                                            p-quinones 8397
                                              prenylquinone 113
                                                prenylnaphthoquinone 30
                                                  menaquinones 30
                                                    menaquinone 30
                                                      menaquinone-4 7
                                                        2,3-epoxymenatetrenone 0
                                                        omega-hydroxymenaquinone-4 0
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