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ONTOLOGY REPORT - ANNOTATIONS

Term:tricarboxylic acid cycle
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Accession:GO:0006099 term browser browse the term
Definition:A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
Synonyms:exact_synonym: Krebs cycle;   TCA cycle;   citric acid cycle;   oxidative TCA cycle
 xref: MetaCyc:P105-PWY;   MetaCyc:PWY-5690;   MetaCyc:PWY-5913;   MetaCyc:PWY-6969;   MetaCyc:PWY-7254;   MetaCyc:PWY66-398;   MetaCyc:REDCITCYC;   MetaCyc:TCA;   MetaCyc:TCA-1;   Reactome:R-HSA-71403 "Citric acid cycle (TCA cycle)";   Wikipedia:Tricarboxylic_acid_cycle


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tricarboxylic acid cycle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 4933405O20Rikl RIKEN cDNA 4933405O20 gene like involved_in IEA
IBA 		GO_REF:0000002
GO_REF:0000033
GO_REF:0000117
GO_REF:0000043 		InterPro
GO_Central
UniProt		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 GO_REF:0000117 NCBI chr 1:109,436,262...109,437,732 JBrowse link
G Aco1 aconitase 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:60,055,895...60,111,920
Ensembl chr 5:60,055,866...60,112,600 		JBrowse link
G Aco2 aconitase 2 involved_in
acts_upstream_of_or_within 		IEA
ISO
IBA 		GO_REF:0000041
(PMID:9630632)
GO_REF:0000043
GO_REF:0000002
MGI:88529 (PMID:32212192)
GO_REF:0000033 		UniProt
RGD
InterPro
GO_Central		 PMID:9630632 PMID:32212192 GO_REF:0000002 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 NCBI chr 7:115,265,816...115,308,931
Ensembl chr 7:115,265,791...115,308,892 		JBrowse link
G Col6a1 collagen type VI alpha 1 chain acts_upstream_of_or_within ISO MGI:2153356 (PMID:23437220) RGD PMID:23437220 NCBI chr20:11,905,690...11,924,111
Ensembl chr20:11,905,457...11,924,107 		JBrowse link
G Cs citrate synthase involved_in IEA
IBA 		GO_REF:0000041
GO_REF:0000043
GO_REF:0000002
GO_REF:0000033 		UniProt
InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:1,342,942...1,375,938 		JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase involved_in ISS
IEA 		GO_REF:0000024
GO_REF:0000043 		UniProt GO_REF:0000024 GO_REF:0000043 NCBI chr 8:59,875,537...59,900,947
Ensembl chr 8:59,868,214...59,900,818
Ensembl chr 1:59,868,214...59,900,818 		JBrowse link
G Dld dihydrolipoamide dehydrogenase involved_in IEA
ISO 		GO_REF:0000107
MGI:2182403 (PMID:15356189) 		Ensembl
RGD		 PMID:15356189 GO_REF:0000107 NCBI chr 6:53,631,686...53,655,059
Ensembl chr 6:53,619,631...53,652,354 		JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase involved_in IEA
IBA
ISO
ISS 		GO_REF:0000041
GO_REF:0000033
MGI:4367457 (PMID:19660549), (PMID:22169199)
GO_REF:0000002
GO_REF:0000043
GO_REF:0000024
(PMID:30929736) 		UniProt
GO_Central
RGD
InterPro		 PMID:19660549 PMID:22169199 PMID:30929736 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 NCBI chr 6:110,489,576...110,512,841
Ensembl chr 6:110,489,392...110,514,357 		JBrowse link
G Fh fumarate hydratase involved_in IEA
IBA 		GO_REF:0000041
GO_REF:0000033
GO_REF:0000043
GO_REF:0000002 		UniProt
GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 NCBI chr13:90,056,565...90,082,450
Ensembl chr13:90,056,570...90,089,627 		JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 involved_in IEA
IBA 		GO_REF:0000043
GO_REF:0000033 		UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000043 NCBI chr 9:74,027,887...74,057,442
Ensembl chr 9:74,027,892...74,049,555 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 involved_in IEA
IBA 		GO_REF:0000043
GO_REF:0000033 		UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000043 NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:143,439,323...143,467,248 		JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha involved_in ISO
IEA
IBA 		(PMID:2252888)
(PMID:14555658)
GO_REF:0000114
GO_REF:0000104
GO_REF:0000043
GO_REF:0000002
GO_REF:0000107
MGI:5904256 (PMID:35985423)
GO_REF:0000033 		RGD
ComplexPortal
UniProt
InterPro
Ensembl
GO_Central		 PMID:2252888 PMID:14555658 PMID:35985423 GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 GO_REF:0000104 GO_REF:0000107 GO_REF:0000114 NCBI chr 8:63,867,882...63,887,223
Ensembl chr 8:63,867,820...63,887,223 		JBrowse link
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta involved_in ISO
IEA
IBA 		(PMID:14555658)
GO_REF:0000114
GO_REF:0000104
GO_REF:0000002
GO_REF:0000043
GO_REF:0000107
GO_REF:0000117
GO_REF:0000033 		RGD
ComplexPortal
UniProt
InterPro
Ensembl
GO_Central		 PMID:14555658 GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 GO_REF:0000104 GO_REF:0000107 GO_REF:0000114 GO_REF:0000117 NCBI chr 3:137,934,971...137,940,275
Ensembl chr 3:137,934,697...137,940,107 		JBrowse link
G Idh3g isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma involved_in TAS
ISO
IEA
IBA 		(PMID:14555658)
GO_REF:0000114
GO_REF:0000104
GO_REF:0000002
GO_REF:0000107
GO_REF:0000043
GO_REF:0000033 		RGD
ComplexPortal
UniProt
InterPro
Ensembl
GO_Central		 PMID:14555658 PMID:8240232 GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 GO_REF:0000104 GO_REF:0000107 GO_REF:0000114, RGD:633073 NCBI chr  X:156,666,573...156,675,482
Ensembl chr  X:156,666,577...156,675,799 		JBrowse link
G Kgd4 alpha-ketoglutarate dehydrogenase subunit 4 involved_in ISO (PMID:25165143) RGD PMID:25165143 NCBI chr 2:33,604,611...33,614,988
Ensembl chr 2:33,604,613...33,615,095 		JBrowse link
G Mdh1 malate dehydrogenase 1 involved_in IEA
IBA 		GO_REF:0000043
GO_REF:0000033 		UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000043 NCBI chr14:99,831,934...99,847,227
Ensembl chr14:99,831,615...99,847,232 		JBrowse link
G Mdh1b malate dehydrogenase 1B involved_in IBA
IEA 		GO_REF:0000033
GO_REF:0000043 		GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000043 NCBI chr 9:72,614,185...72,661,820
Ensembl chr 9:72,613,340...72,661,745 		JBrowse link
G Mdh2 malate dehydrogenase 2 involved_in IEA
ISO
IBA 		GO_REF:0000043
(PMID:37647199)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000002
(PMID:35063410) 		UniProt
RGD
GO_Central
Ensembl
InterPro		 PMID:35063410 PMID:37647199 GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 NCBI chr12:26,530,886...26,543,841
Ensembl chr12:26,530,881...26,543,841 		JBrowse link
G Ndp norrin cystine knot growth factor NDP acts_upstream_of_or_within ISO MGI:4414794 (PMID:30988181) RGD PMID:30988181 NCBI chr  X:8,379,569...8,404,019
Ensembl chr  X:8,379,569...8,406,802 		JBrowse link
G Ogdh oxoglutarate dehydrogenase involved_in IEA
IBA
ISO 		GO_REF:0000117
GO_REF:0000033
MGI:4367457 (PMID:19660549), (PMID:22169199)
GO_REF:0000107 		UniProt
GO_Central
RGD
Ensembl		 PMID:19660549 PMID:22169199 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr14:85,363,949...85,431,405
Ensembl chr14:85,364,014...85,432,271 		JBrowse link
G Ogdhl oxoglutarate dehydrogenase L involved_in IDA
IBA
IEA 		PMID:18783430
GO_REF:0000033
GO_REF:0000117 		GO_Central
UniProt		 PMID:18783430 GO_REF:0000033 GO_REF:0000117, RGD:42721998 NCBI chr16:7,584,666...7,610,705
Ensembl chr16:7,584,657...7,610,698 		JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr  X:38,509,158...38,522,986
Ensembl chr  X:38,509,084...38,522,536 		JBrowse link
G Pdha2 pyruvate dehydrogenase E1 subunit alpha 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:232,545,550...232,547,098
Ensembl chr 2:232,415,088...232,549,624 		JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr15:19,182,789...19,188,731
Ensembl chr15:19,181,208...19,188,976 		JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A involved_in IEA
NAS
ISO 		GO_REF:0000041
PMID:30030361
GO_REF:0000043
GO_REF:0000002
MGI:5805498 (PMID:31469588)
GO_REF:0000107 		UniProt
InterPro
RGD
Ensembl		 PMID:31469588 PMID:30030361 GO_REF:0000002 GO_REF:0000041 GO_REF:0000043 GO_REF:0000107, RGD:151356635 NCBI chr 1:30,764,553...30,789,523
Ensembl chr 1:30,764,590...30,790,121 		JBrowse link
G Sdhaf2 succinate dehydrogenase complex assembly factor 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:216,564,002...216,592,877
Ensembl chr 1:216,567,861...216,593,540 		JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B involved_in IEA
ISO
NAS 		GO_REF:0000041
GO_REF:0000107
MGI:5805498 (PMID:31469588)
GO_REF:0000002
GO_REF:0000043
PMID:30030361 		UniProt
Ensembl
RGD
InterPro		 PMID:31469588 PMID:30030361 GO_REF:0000002 GO_REF:0000041 GO_REF:0000043 GO_REF:0000107, RGD:151356635 NCBI chr 5:158,547,775...158,568,589
Ensembl chr 5:158,547,689...158,569,667 		JBrowse link
G Sdhc succinate dehydrogenase complex subunit C involved_in NAS
IEA
ISO 		PMID:30030361
GO_REF:0000107
MGI:5805498 (PMID:31469588)
GO_REF:0000043
GO_REF:0000002 		Ensembl
RGD
UniProt
InterPro		 PMID:31469588 PMID:30030361 GO_REF:0000002 GO_REF:0000043 GO_REF:0000107, RGD:151356635 NCBI chr13:86,077,133...86,098,025
Ensembl chr13:86,077,134...86,098,044 		JBrowse link
G Sdhd succinate dehydrogenase complex subunit D involved_in ISO
IEA
IBA
NAS 		(PMID:9533030)
GO_REF:0000107
GO_REF:0000033
MGI:5805498 (PMID:31469588)
PMID:30030361
GO_REF:0000043
GO_REF:0000041 		RGD
Ensembl
GO_Central
UniProt		 PMID:9533030 PMID:31469588 PMID:30030361 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 GO_REF:0000107, RGD:151356635 NCBI chr 8:59,841,090...59,850,641
Ensembl chr 8:59,841,090...59,850,641 		JBrowse link
G Sucla2 succinate-CoA ligase ADP-forming subunit beta involved_in IDA
IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
MGI:5585619 (PMID:24271779)
GO_REF:0000002
GO_REF:0000104
GO_REF:0000043
GO_REF:0000041 		GO_Central
Ensembl
RGD
InterPro
UniProt		 PMID:24271779 PMID:17403370 GO_REF:0000002 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 GO_REF:0000104 GO_REF:0000107, RGD:2306915 NCBI chr15:55,161,894...55,215,031
Ensembl chr15:55,161,868...55,215,029 		JBrowse link
G Suclg1 succinate-CoA ligase GDP/ADP-forming subunit alpha involved_in IDA
IEA
ISO
IBA 		GO_REF:0000041
GO_REF:0000104
GO_REF:0000043
MGI:5585619 (PMID:24271779)
GO_REF:0000107
GO_REF:0000033 		UniProt
RGD
Ensembl
GO_Central		 PMID:24271779 PMID:17403370 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 GO_REF:0000104 GO_REF:0000107, RGD:2306915 NCBI chr 4:106,866,329...106,895,686
Ensembl chr 4:106,866,114...106,895,689 		JBrowse link
G Suclg2 succinate-CoA ligase GDP-forming subunit beta involved_in IDA
IBA
IEA 		GO_REF:0000033
GO_REF:0000104
GO_REF:0000002
GO_REF:0000043
GO_REF:0000041 		GO_Central
UniProt
InterPro
RGD		 PMID:17403370 GO_REF:0000002 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 GO_REF:0000104, RGD:2306915 NCBI chr 4:129,623,833...129,893,937
Ensembl chr 4:129,623,834...129,937,296 		JBrowse link
2-oxoglutarate decarboxylation to succinyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dld dihydrolipoamide dehydrogenase involved_in ISO
IEA 		(PMID:15712224)
GO_REF:0000107 		RGD
Ensembl		 PMID:15712224 GO_REF:0000107 NCBI chr 6:53,631,686...53,655,059
Ensembl chr 6:53,619,631...53,652,354 		JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase involved_in ISO MGI:4367457 (PMID:19660549) RGD PMID:19660549 NCBI chr 6:110,489,576...110,512,841
Ensembl chr 6:110,489,392...110,514,357 		JBrowse link
G Ogdh oxoglutarate dehydrogenase involved_in IEA
ISO 		GO_REF:0000107
(PMID:22169199) 		Ensembl
RGD		 PMID:22169199 GO_REF:0000107 NCBI chr14:85,363,949...85,431,405
Ensembl chr14:85,364,014...85,432,271 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19688
    cellular process 18845
      metabolic process 11694
        primary metabolic process 10271
          tricarboxylic acid cycle 32
            2-oxoglutarate decarboxylation to succinyl-CoA 3
Path 2
Term Annotations click to browse term
  biological_process 19688
    cellular process 18845
      metabolic process 11694
        generation of precursor metabolites and energy 560
          energy derivation by oxidation of organic compounds 506
            cellular respiration 405
              aerobic respiration 326
                tricarboxylic acid cycle 32
                  2-oxoglutarate decarboxylation to succinyl-CoA 3
paths to the root