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Ontology Browser

Term:
tricarboxylic acid cycle (GO:0006099)
Annotations: Rat: (32) Mouse: (31) Human: (34) Chinchilla: (34) Bonobo: (34) Dog: (25) Squirrel: (1) Pig: (26)
Parent Terms Term With Siblings Child Terms
aerobic electron transport chain +   
aerobic respiration, using ammonia as electron donor 
aerobic respiration, using arsenite as electron donor 
aerobic respiration, using carbon monoxide as electron donor 
aerobic respiration, using ferrous ions as electron donor 
aerobic respiration, using hydrogen as electron donor 
aerobic respiration, using nitrite as electron donor 
aerobic respiration, using sulfur or sulfate as electron donor 
alternative respiration 
carbohydrate metabolic process +   
cellular amino acid metabolic process +   
lipid metabolic process +   
nucleobase-containing compound metabolic process +   
protein metabolic process +   
regulation of aerobic respiration +   
regulation of primary metabolic process +   
tricarboxylic acid cycle +   
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

Synonyms
Exact Synonyms: Krebs cycle ;   TCA cycle ;   citric acid cycle
Xrefs: MIPS_funcat:02.10 ;   MetaCyc:P105-PWY ;   MetaCyc:P42-PWY ;   MetaCyc:TCA ;   Wikipedia:Tricarboxylic_acid_cycle
Definition Sources: ISBN:0198506732

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.