RGD Reference Report - Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes. - Rat Genome Database

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Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes.

Authors: Signes, Alba  Fernandez-Vizarra, Erika 
Citation: Signes A and Fernandez-Vizarra E, Essays Biochem. 2018 Jul 20;62(3):255-270. doi: 10.1042/EBC20170098. Print 2018 Jul 20.
RGD ID: 151356635
Pubmed: PMID:30030361   (View Abstract at PubMed)
PMCID: PMC6056720   (View Article at PubMed Central)
DOI: DOI:10.1042/EBC20170098   (Journal Full-text)

The assembly of the five oxidative phosphorylation system (OXPHOS) complexes in the inner mitochondrial membrane is an intricate process. The human enzymes comprise core proteins, performing the catalytic activities, and a large number of 'supernumerary' subunits that play essential roles in assembly, regulation and stability. The correct addition of prosthetic groups as well as chaperoning and incorporation of the structural components require a large number of factors, many of which have been found mutated in cases of mitochondrial disease. Nowadays, the mechanisms of assembly for each of the individual complexes are almost completely understood and the knowledge about the assembly factors involved is constantly increasing. On the other hand, it is now well established that complexes I, III and IV interact with each other, forming the so-called respiratory supercomplexes or 'respirasomes', although the pathways that lead to their formation are still not completely clear. This review is a summary of our current knowledge concerning the assembly of complexes I-V and of the supercomplexes.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SdhaRatmitochondrial inner membrane part_ofNAS PMID:30030361ComplexPortal 
SdhbRatmitochondrial inner membrane part_ofNAS PMID:30030361ComplexPortal 
SdhcRatmitochondrial inner membrane part_ofNAS PMID:30030361ComplexPortal 
SdhdRatmitochondrial inner membrane part_ofNAS PMID:30030361ComplexPortal 

Objects Annotated

Genes (Rattus norvegicus)
Sdha  (succinate dehydrogenase complex flavoprotein subunit A)
Sdhb  (succinate dehydrogenase complex iron sulfur subunit B)
Sdhc  (succinate dehydrogenase complex subunit C)
Sdhd  (succinate dehydrogenase complex subunit D)


Additional Information