Idh3b (isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta) - Rat Genome Database

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Gene: Idh3b (isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta) Rattus norvegicus
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Symbol: Idh3b
Name: isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta
RGD ID: 621881
Description: Enables isocitrate dehydrogenase (NAD+) activity. Involved in NADH metabolic process; carboxylic acid metabolic process; and tricarboxylic acid cycle. Predicted to be part of mitochondrial isocitrate dehydrogenase complex (NAD+). Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in retinitis pigmentosa 46. Orthologous to human IDH3B (isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; mitochondrial complex II deficiency pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: isocitrate dehydrogenase (NAD(+)) 3 beta; isocitrate dehydrogenase 3 (NAD+) beta; isocitrate dehydrogenase [NAD] subunit beta, mitochondrial; isocitric dehydrogenase subunit beta; MGC94111; NAD(+)-specific ICDH subunit beta; NAD+-specific isocitrate dehydrogenase b subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83137,934,971 - 137,940,275 (-)NCBIGRCr8
mRatBN7.23117,481,845 - 117,486,909 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3117,481,845 - 117,486,982 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3121,379,896 - 121,384,925 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03129,975,515 - 129,980,544 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03127,636,012 - 127,641,041 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03122,808,564 - 122,813,638 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3122,808,564 - 122,813,583 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03129,308,279 - 129,313,315 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43117,892,614 - 117,897,633 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13117,798,468 - 117,800,065 (-)NCBI
Celera3116,298,150 - 116,303,169 (-)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Preparation and properties of mitochondria derived from synaptosomes. Lai JC and Clark JB, Biochem J. 1976 Feb 15;154(2):423-32.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Expression of NAD(+)-dependent isocitrate dehydrogenase in brown adipose tissue. Shinohara Y, etal., Biochem Biophys Res Commun 2001 Mar 2;281(3):634-8.
12. Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase. Soundar S, etal., J Biol Chem. 2003 Dec 26;278(52):52146-53. doi: 10.1074/jbc.M306178200. Epub 2003 Oct 10.
Additional References at PubMed
PMID:12477932   PMID:14651853   PMID:15489334   PMID:18614015   PMID:21630459   PMID:21700703   PMID:25931508   PMID:26316108   PMID:29476059  


Genomics

Comparative Map Data
Idh3b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83137,934,971 - 137,940,275 (-)NCBIGRCr8
mRatBN7.23117,481,845 - 117,486,909 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3117,481,845 - 117,486,982 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3121,379,896 - 121,384,925 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03129,975,515 - 129,980,544 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03127,636,012 - 127,641,041 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03122,808,564 - 122,813,638 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3122,808,564 - 122,813,583 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03129,308,279 - 129,313,315 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43117,892,614 - 117,897,633 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13117,798,468 - 117,800,065 (-)NCBI
Celera3116,298,150 - 116,303,169 (-)NCBICelera
Cytogenetic Map3q36NCBI
IDH3B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38202,658,395 - 2,664,216 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl202,658,395 - 2,664,219 (-)EnsemblGRCh38hg38GRCh38
GRCh37202,639,041 - 2,644,862 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36202,587,041 - 2,592,843 (-)NCBINCBI36Build 36hg18NCBI36
Build 34202,587,042 - 2,592,843NCBI
Celera202,703,504 - 2,709,306 (-)NCBICelera
Cytogenetic Map20p13NCBI
HuRef202,588,269 - 2,594,156 (-)NCBIHuRef
CHM1_1202,639,448 - 2,645,272 (-)NCBICHM1_1
T2T-CHM13v2.0202,688,862 - 2,694,697 (-)NCBIT2T-CHM13v2.0
Idh3b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392130,121,229 - 130,126,371 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2130,121,229 - 130,126,467 (-)EnsemblGRCm39 Ensembl
GRCm382130,279,309 - 130,284,451 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2130,279,309 - 130,284,547 (-)EnsemblGRCm38mm10GRCm38
MGSCv372130,105,045 - 130,110,187 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362129,970,753 - 129,983,751 (-)NCBIMGSCv36mm8
Celera2131,503,716 - 131,508,858 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.2NCBI
Idh3b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541513,643,168 - 13,649,463 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541513,642,804 - 13,649,023 (-)NCBIChiLan1.0ChiLan1.0
IDH3B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2213,647,477 - 3,677,553 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1203,644,302 - 3,674,378 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0202,766,598 - 2,772,571 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1202,529,510 - 2,559,894 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl202,529,510 - 2,535,570 (-)Ensemblpanpan1.1panPan2
IDH3B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12418,556,437 - 18,561,399 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2418,556,508 - 18,561,391 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2418,385,740 - 18,390,707 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02419,014,265 - 19,019,181 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2419,014,285 - 19,019,174 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12418,570,449 - 18,575,416 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02418,680,753 - 18,685,668 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02419,009,851 - 19,014,767 (+)NCBIUU_Cfam_GSD_1.0
Idh3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640167,601,899 - 167,606,729 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648516,033,128 - 16,042,821 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648516,033,287 - 16,038,097 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IDH3B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1732,955,101 - 32,960,104 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11732,955,061 - 32,960,110 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21737,446,330 - 37,451,309 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IDH3B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1253,875,991 - 53,882,069 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl253,875,390 - 53,881,716 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666087292,746 - 299,180 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Idh3b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247413,808,784 - 3,814,510 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247413,808,436 - 3,814,239 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Idh3b
20 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:19
Count of miRNA genes:17
Interacting mature miRNAs:19
Transcripts:ENSRNOT00000009681
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)3115638168135181505Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3115638168135181505Rat

Markers in Region
MARC_26079-26080:1032790967:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23117,482,203 - 117,483,037 (+)MAPPERmRatBN7.2
Rnor_6.03122,808,923 - 122,809,756NCBIRnor6.0
Rnor_5.03129,308,638 - 129,309,471UniSTSRnor5.0
RGSC_v3.43117,892,973 - 117,893,806UniSTSRGSC3.4
Celera3116,298,509 - 116,299,342UniSTS
Cytogenetic Map3q36UniSTS
MARC_26128-26129:1030370563:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23117,483,026 - 117,483,470 (+)MAPPERmRatBN7.2
mRatBN7.2795,301,953 - 95,302,102 (+)MAPPERmRatBN7.2
Rnor_6.07104,350,215 - 104,350,363NCBIRnor6.0
Rnor_6.03122,809,746 - 122,810,189NCBIRnor6.0
Rnor_5.07104,920,275 - 104,920,423UniSTSRnor5.0
Rnor_5.03129,309,461 - 129,309,904UniSTSRnor5.0
RGSC_v3.43117,893,796 - 117,894,239UniSTSRGSC3.4
RGSC_v3.47100,794,934 - 100,795,082UniSTSRGSC3.4
Celera791,915,100 - 91,915,248UniSTS
Celera3116,299,332 - 116,299,775UniSTS
Cytogenetic Map3q36UniSTS
Cytogenetic Map7q33UniSTS
RH78746  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23117,482,214 - 117,483,046 (+)MAPPERmRatBN7.2
Rnor_6.03122,808,934 - 122,809,765NCBIRnor6.0
Rnor_5.03129,308,649 - 129,309,480UniSTSRnor5.0
RGSC_v3.43117,892,984 - 117,893,815UniSTSRGSC3.4
Celera3116,298,520 - 116,299,351UniSTS
Cytogenetic Map3q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000009681   ⟹   ENSRNOP00000009681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3117,481,845 - 117,486,982 (-)Ensembl
Rnor_6.0 Ensembl3122,808,564 - 122,813,583 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112690   ⟹   ENSRNOP00000093884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3117,482,069 - 117,486,892 (-)Ensembl
RefSeq Acc Id: NM_053581   ⟹   NP_446033
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83137,934,971 - 137,939,990 (-)NCBI
mRatBN7.23117,481,845 - 117,486,865 (-)NCBI
Rnor_6.03122,808,564 - 122,813,583 (-)NCBI
Rnor_5.03129,308,279 - 129,313,315 (-)NCBI
RGSC_v3.43117,892,614 - 117,897,633 (-)RGD
Celera3116,298,150 - 116,303,169 (-)RGD
Sequence:
RefSeq Acc Id: XM_006235048   ⟹   XP_006235110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83137,934,974 - 137,940,275 (-)NCBI
mRatBN7.23117,481,848 - 117,486,909 (-)NCBI
Rnor_6.03122,808,567 - 122,813,638 (-)NCBI
Rnor_5.03129,308,279 - 129,313,315 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063284749   ⟹   XP_063140819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83137,934,974 - 137,940,275 (-)NCBI
RefSeq Acc Id: XM_063284750   ⟹   XP_063140820
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83137,934,974 - 137,937,374 (-)NCBI
RefSeq Acc Id: NP_446033   ⟸   NM_053581
- Peptide Label: precursor
- UniProtKB: Q68FX0 (UniProtKB/Swiss-Prot),   A6HQ80 (UniProtKB/TrEMBL),   A0A8I6AMM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235110   ⟸   XM_006235048
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AMM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009681   ⟸   ENSRNOT00000009681
RefSeq Acc Id: ENSRNOP00000093884   ⟸   ENSRNOT00000112690
RefSeq Acc Id: XP_063140819   ⟸   XM_063284749
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063140820   ⟸   XM_063284750
- Peptide Label: isoform X3
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q68FX0-F1-model_v2 AlphaFold Q68FX0 1-385 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692429
Promoter ID:EPDNEW_R2954
Type:multiple initiation site
Name:Idh3B_1
Description:isocitrate dehydrogenase 3 (NAD+) beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03122,813,581 - 122,813,641EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621881 AgrOrtholog
BioCyc Gene G2FUF-47863 BioCyc
BioCyc Pathway PWY-5690 [TCA cycle II (plants and fungi)] BioCyc
BioCyc Pathway Image PWY-5690 BioCyc
Ensembl Genes ENSRNOG00000007316 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009681 ENTREZGENE
  ENSRNOT00000009681.7 UniProtKB/TrEMBL
  ENSRNOT00000112690.1 UniProtKB/TrEMBL
Gene3D-CATH Isopropylmalate Dehydrogenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7126029 IMAGE-MGC_LOAD
InterPro IsoCit/isopropylmalate_DH_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Isocitrate_DH_NAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IsoPropMal-DH-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:94173 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:94111 IMAGE-MGC_LOAD
NCBI Gene 94173 ENTREZGENE
PANTHER DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Iso_dh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Idh3b PhenoGen
PROSITE IDH_IMDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007316 RatGTEx
SMART Iso_dh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Isocitrate/Isopropylmalate dehydrogenase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AMM2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q4B4_RAT UniProtKB/TrEMBL
  A6HQ80 ENTREZGENE, UniProtKB/TrEMBL
  IDH3B_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-08 Idh3b  isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta  Idh3b  isocitrate dehydrogenase (NAD(+)) 3 beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-04-29 Idh3b  isocitrate dehydrogenase (NAD(+)) 3 beta  Idh3B  isocitrate dehydrogenase 3 (NAD+) beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Idh3B  isocitrate dehydrogenase 3 (NAD+) beta  IDH3B  NAD+-specific isocitrate dehydrogenase b subunit  Name updated 1299863 APPROVED
2002-08-07 IDH3B  NAD+-specific isocitrate dehydrogenase b subunit      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the brown adipose tissue 70770