| 620957 | Ebp | EBP, cholestenol delta-isomerase | ENCODES a protein that exhibits C-8 sterol isomerase activity; cholestenol delta-isomerase activity (ortholog); cholesterol-5,6-oxide hydrolase activity (ortholog); INVOLVED IN cholesterol biosynthetic process; cholesterol biosynthetic process via desmosterol (ortholog); cholesterol biosynthetic pro cess via lathosterol (ortholog); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH autosomal recessive congenital ichthyosis (ortholog); chondrodysplasia punctata (ortholog); connective tissue disease (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); nuclear envelope (ortholog); INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine | X | 16971372 | 16977782 | Rat | 272 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 733162 | Ebp | EBP cholestenol delta-isomerase | This gene encodes a transmembrane protein that localizes to the endoplasmic reticulum. This protein catalyses the conversion of delta8 to delta7 sterols, an important step in sterol biosynthesis. Mutations in this gene are responsible for the mouse tattered mutant phenotype. Tattered males are embry onic lethal, while heterozygous females have developmental defects. Deficiency of the related gene in human causes X-linked dominant chondrodysplasia punctata. [provided by RefSeq, May 2015] | X | 8051568 | 8059751 | Mouse | 277 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, REVIEWED [RefSeq] |
| 1345811 | EBP | EBP cholestenol delta-isomerase | The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome). [provided by RefSeq, Jul 2008] | X | 48521808 | 48528716 | Human | 471 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8851291 | Ebp | EBP cholestenol delta-isomerase | ENCODES a protein that exhibits C-8 sterol isomerase activity (ortholog); cholestenol delta-isomerase activity (ortholog); cholesterol-5,6-oxide hydrolase activity (ortholog); INVOLVED IN cholesterol biosynthetic process (ortholog); cholesterol biosynthetic process via desmosterol (ortholog); choles terol biosynthetic process via lathosterol (ortholog); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH chondrodysplasia punctata (ortholog); connective tissue disease (ortholog); Desbuquois dysplasia (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); nuclear envelope (ortholog) | NW_004955543 | 92553 | 98370 | Chinchilla | 55 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11964038 | EBP | EBP cholestenol delta-isomerase | ENCODES a protein that exhibits C-8 sterol isomerase activity (ortholog); cholesterol-5,6-oxide hydrolase activity (ortholog); identical protein binding (ortholog); INVOLVED IN cholesterol biosynthetic process (ortholog); cholesterol biosynthetic process via desmosterol (ortholog); cholesterol biosy nthetic process via lathosterol (ortholog); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH chondrodysplasia punctata (ortholog); connective tissue disease (ortholog); Desbuquois dysplasia (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); nuclear envelope (ortholog); nuclear membrane (ortholog) | X | 40820042 | 40826957 | Bonobo | 61 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12140454 | EBP | cholestenol delta-isomerase | ENCODES a protein that exhibits C-8 sterol isomerase activity (ortholog); cholesterol-5,6-oxide hydrolase activity (ortholog); identical protein binding (ortholog); INVOLVED IN cholesterol biosynthetic process (ortholog); cholesterol biosynthetic process via desmosterol (ortholog); cholesterol biosy nthetic process via lathosterol (ortholog); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH chondrodysplasia punctata (ortholog); connective tissue disease (ortholog); Desbuquois dysplasia (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); nuclear envelope (ortholog) | X | 41774857 | 41779474 | Dog | 67 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12562084 | Ebp | EBP cholestenol delta-isomerase | ENCODES a protein that exhibits C-8 sterol isomerase activity (ortholog); INVOLVED IN cholesterol biosynthetic process (ortholog); hemopoiesis (ortholog); sterol biosynthetic process (ortholog); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH chondrodysplasia punctata (ortholog); connective tissue disease (ortholog); Desbuquois dysplasia (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred) | NW_004936721 | 508716 | 515968 | Squirrel | 66 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14087127 | EBP | EBP cholestenol delta-isomerase | ENCODES a protein that exhibits C-8 sterol isomerase activity (ortholog); INVOLVED IN cholesterol biosynthetic process (ortholog); hemopoiesis (ortholog); sterol biosynthetic process (ortholog); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH chondrodysplasia punctata (ortholog); connective tissue disease (ortholog); Desbuquois dysplasia (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred) | | | | Pig | 65 | symbol , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18454433 | EBP | EBP cholestenol delta-isomerase | ENCODES a protein that exhibits C-8 sterol isomerase activity (ortholog); INVOLVED IN cholesterol biosynthetic process (ortholog); hemopoiesis (ortholog); sterol biosynthetic process (ortholog); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH chondrodysplasia punctata (ortholog); connective tissue disease (ortholog); Desbuquois dysplasia (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred) | | | | Green Monkey | 66 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18910795 | Ebp | EBP cholestenol delta-isomerase | ENCODES a protein that exhibits C-8 sterol isomerase activity (ortholog); cholesterol-5,6-oxide hydrolase activity (ortholog); identical protein binding (ortholog); INVOLVED IN cholesterol biosynthetic process (ortholog); cholesterol biosynthetic process via desmosterol (ortholog); cholesterol biosy nthetic process via lathosterol (ortholog); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH chondrodysplasia punctata (ortholog); connective tissue disease (ortholog); Desbuquois dysplasia (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); nuclear envelope (ortholog); nuclear membrane (ortholog) | | | | Naked Mole-Rat | 62 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 626072599 | Ebp | EBP cholestenol delta-isomerase | ENCODES a protein that exhibits C-8 sterol isomerase activity (ortholog); cholestenol delta-isomerase activity (ortholog); cholesterol-5,6-oxide hydrolase activity (ortholog); INVOLVED IN cholesterol biosynthetic process (ortholog); cholesterol biosynthetic process via desmosterol (ortholog); choles terol biosynthetic process via lathosterol (ortholog); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH chondrodysplasia punctata (ortholog); connective tissue disease (ortholog); Desbuquois dysplasia (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); nuclear envelope (ortholog) | | | | Black Rat | 55 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 626174466 | ebp | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14375432 | ebp-1 | | | | | | Roundworm | | symbol | gene, null |
| 14374003 | ebp-2 | | | | | | Roundworm | | symbol | gene, null |
| 14374004 | ebp-3 | | | | | | Roundworm | | symbol | gene, null |
| 1313991 | Ebna1bp2 | EBNA1 binding protein 2 | Predicted to be involved in rRNA processing and ribosomal large subunit biogenesis. Predicted to be located in chromosome. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nuclear periphery and nucleolus. Orthologous to human EBNA1BP2 (EBNA1 binding protein 2). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 118477996 | 118484973 | Mouse | 128 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1347574 | GLB1 | galactosidase beta 1 | This gene encodes a member of the glycosyl hydrolase 35 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature lysosomal enzyme. This enzyme catalyzes the hydrolysis of a terminal beta-linked galactose residue from ganglioside substrates and other glycoconjugates. Mutations in this gene may result in GM1-gangliosidosis and Morquio B syndrome. [provided by RefSeq, Nov 2015] | 3 | 32961108 | 33097146 | Human | 931 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1332087 | Pa2g4 | proliferation-associated 2G4 | Predicted to enable nucleic acid binding activity; transcription corepressor activity; and ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of apoptotic process and positive regulation of cell differentiation. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleolus. Predicted to be part of ribonucleoprotein complex. Is expressed in brain; heart; jaw; limb; and lung mesenchyme. Orthologous to human PA2G4 (proliferation-associated 2G4). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 128393635 | 128401803 | Mouse | 198 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1605862 | SH3D19 | SH3 domain containing 19 | This gene encodes a multiple SH3 domain-containing protein, which interacts with other proteins, such as EBP and members of ADAM family, via the SH3 domains. This protein may be involved in suppression of Ras-induced cellular transformation and Ras-mediated acti vation of ELK1 by EBP, and regulation of ADAM proteins in the signaling of EGFR-ligand shedding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] | 4 | 151120281 | 151325605 | Human | 110 | description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 10325 | Cebpa | CCAAT/enhancer binding protein alpha | This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of t his protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. The use of alternative in-frame non-AUG (CUG) and AUG start codons results in several protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the CUG and the first AUG start codons. [provided by RefSeq, Sep 2014] | 7 | 34818718 | 34821353 | Mouse | 902 | symbol , old_gene_name , PhenoGen , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 10328 | Cebpe | CCAAT/enhancer binding protein epsilon | Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Acts upstream of or within macrophage differentiation; phagocytosis; and positive regu lation of gene expression. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in bone marrow; liver; lung; and spleen. Human ortholog(s) of this gene implicated in immunodeficiency 108. Orthologous to human CEBPE (CCAAT enhancer binding protein epsilon). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 54947823 | 54949604 | Mouse | 156 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 2330 | Cebpg | CCAAT/enhancer binding protein gamma | ENCODES a protein that exhibits DNA binding; double-stranded DNA binding; protein-containing complex binding; INVOLVED IN liver development; regulation of transcription by RNA polymerase II; B cell differentiation (ortholog); PARTICIPATES IN tuberculosis pathway; FOUND IN nucleoplasm (ortholog); nuc leus (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 1 | 96820981 | 96829736 | Rat | 186 | symbol , old_gene_name , PhenoGen , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 70498 | Nfkb1 | nuclear factor kappa B subunit 1 | ENCODES a protein that exhibits DNA binding; double-stranded DNA binding; heat shock protein binding; INVOLVED IN cellular response to brain-derived neurotrophic factor stimulus; cellular response to carbohydrate stimulus; cellular response to cytokine stimulus; PARTICIPATES IN pro-inflammatory cyto kine mediated pathway; adenosine signaling pathway; ceramide signaling pathway; ASSOCIATED WITH alcoholic hepatitis; Cerebral Hemorrhage; Chemical and Drug Induced Liver Injury; FOUND IN protein-containing complex; chromatin (ortholog); cytoplasm (ortholog); INTERACTS WITH (+)-catechin; (+)-taxifolin; (20S)-ginsenoside Rg3 | 2 | 226689745 | 226805897 | Rat | 1427 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 730892 | NFKB1 | nuclear factor kappa B subunit 1 | This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a tr anscription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Aug 2020] | 4 | 102501359 | 102617302 | Human | 1447 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 730893 | Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Enables several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; identical protein binding activity; and transcription coregulator activity. Involved in several processes, including B cell receptor signaling pathway; cellular response to virus; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to tumor necrosis factor; regulation of gene expression; and response to muscle stretch. Located in cytosol. Part of NF-kappaB p50/p65 complex and transcription regulator complex. Is active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Human ortholog(s) of this gene implicated in several diseases, including HTLV-1-associated myelopathy/tropical spastic paraparesis; carcinoma (multiple); common variable immunodeficiency 12; melanoma; and prostate cancer. Orthologous to human NFKB1 (nuclear factor kappa B subunit 1). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 135290416 | 135397422 | Mouse | 1593 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 732281 | Nherf1 | NHERF family PDZ scaffold protein 1 | Enables dopamine receptor binding activity and phosphatase binding activity. Involved in several processes, including bile acid secretion; maintenance of epithelial cell apical/basal polarity; and negative regulation of signal transduction. Acts upstream of or within several processes, including G p rotein-coupled dopamine receptor signaling pathway; auditory receptor cell stereocilium organization; and cerebrospinal fluid circulation. Located in several cellular components, including brush border membrane; sperm midpiece; and stereocilium tip. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; knee joint primordium; and sensory organ. Human ortholog(s) of this gene implicated in hypophosphatemic nephrolithiasis/osteoporosis 2. Orthologous to human NHERF1 (NHERF family PDZ scaffold protein 1). [provided by Alliance of Genome Resources, Apr 2025] | 11 | 115054138 | 115072009 | Mouse | 355 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 11420 | Nkx2-1 | NK2 homeobox 1 | Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and intronic transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including hypothalamus de velopment; positive regulation of circadian rhythm; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including lung development; nervous system development; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; brain; neural ectoderm; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in choreatic disease and papillary thyroid carcinoma. Orthologous to human NKX2-1 (NK2 homeobox 1). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 56578741 | 56583570 | Mouse | 354 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 732483 | NKX2-1 | NK2 homeobox 1 | This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Feb 2014] | 14 | 36516397 | 36520232 | Human | 351 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 10329 | Cebpg | CCAAT/enhancer binding protein gamma | Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in hemopoiesis; natural killer cell mediated cytotoxicity; and regulation of gene expression. Acts upstream of or within mRNA metabolic process. Located in nucleus. Is expressed in several structures, in cluding blood; central nervous system; genitourinary system; retina; and yolk sac. Orthologous to human CEBPG (CCAAT enhancer binding protein gamma). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 34745847 | 34755991 | Mouse | 194 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1350900 | FCN2 | ficolin 2 | The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has be en shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] | 9 | 134864144 | 134887523 | Human | 59 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 735927 | CEBPG | CCAAT enhancer binding protein gamma | The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2011] | 19 | 33373709 | 33382686 | Human | 197 | symbol , old_gene_name , COSMIC , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 2327 | Cebpb | CCAAT/enhancer binding protein beta | ENCODES a protein that exhibits DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor binding; INVOLVED IN cellular response to interleukin-1; cellular response to lipopolysaccharide; hepatocyte proliferation; PARTICIPATES IN forkhead class A signaling pathway; interleukin-3 signaling pathway; interleukin-4 signaling pathway; ASSOCIATED WITH Endotoxemia; neurodegenerative disease; Sepsis; FOUND IN CHOP-C/EBP complex; nuclear matrix; nucleus; INTERACTS WITH (-)-cotinine; (S)-nicotine; 1,2,4-trimethylbenzene | 3 | 176817005 | 176818436 | Rat | 799 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 736208 | CEBPB | CCAAT enhancer binding protein beta | This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013] | 20 | 50190583 | 50192690 | Human | 772 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 62391 | Ddit3 | DNA-damage inducible transcript 3 | ENCODES a protein that exhibits DNA binding; protein heterodimerization activity; sequence-specific DNA binding; INVOLVED IN cellular response to manganese ion; embryonic organ development; ER overload response; PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; mitogen activated protein kinase signaling pathway; ASSOCIATED WITH acute kidney failure; Acute Lung Injury; Acute-Phase Reaction; FOUND IN CHOP-C/EBP complex; nucleus; CHOP-ATF3 complex (ortholog); INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (R)-lipoic acid | 7 | 65001695 | 65006517 | Rat | 1687 | old_gene_name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 62396 | Ddit3 | DNA-damage inducible transcript 3 | Enables several functions, including DNA-binding transcription factor binding activity; protein heterodimerization activity; and transcription regulator activator activity. Involved in several processes, including blood vessel development; intracellular signal transduction; and regulation of transcr iption by RNA polymerase II. Acts upstream of or within several processes, including ER overload response; diaphragm contraction; and negative regulation of fat cell differentiation. Located in late endosome and nucleus. Part of CHOP-C/EBP complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in myxoid liposarcoma. Orthologous to human DDIT3 (DNA damage inducible transcript 3). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 127126662 | 127132160 | Mouse | 1691 | old_gene_name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 69165 | DDIT3 | DNA damage inducible transcript 3 | This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/... (more) an style='font-weight:700;'>EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010] | 12 | 57516588 | 57520517 | Human | 1635 | old_gene_name , description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 69121 | CEBPA | CCAAT enhancer binding protein alpha | This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of t his protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013] | 19 | 33299934 | 33302534 | Human | 1690 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 14220489 | CEBPA | CCAAT enhancer binding protein alpha | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription factor binding (ortholog); histone deacetylase binding (ortholog); INVOLVED IN acute-phase response (ortholog); animal organ regeneration (ortholog); brown fat cell differentiation (ortholog); PARTICIPATES IN forkhead class A signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); Acute-Phase Reaction (ortholog); FOUND IN CHOP-C/EBP complex (ortholog); nuclear matrix (ortholog); nucleolus (ortholog); INTERACTS WITH dexamethasone; glycerol 2-phosphate; L-ascorbic acid | | | | Pig | 158 | symbol , description , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 736554 | CEBPD | CCAAT enhancer binding protein delta | The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of g enes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11. [provided by RefSeq, Sep 2010] | 8 | 47736913 | 47738164 | Human | 344 | symbol , old_gene_name , COSMIC , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 733093 | CEBPE | CCAAT enhancer binding protein epsilon | The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008] | 14 | 23117306 | 23119255 | Human | 161 | symbol , old_gene_name , COSMIC , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1304571 | Ebpl | EBP like | ENCODES a protein that exhibits cholestenol delta-isomerase activity (inferred); INVOLVED IN sterol metabolic process (inferred); FOUND IN endoplasmic reticulum (ortholog); INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 15 | 39684140 | 39707537 | Rat | 79 | symbol , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1312086 | EBPL | EBP like | Predicted to enable cholestenol delta-isomerase activity. Predicted to be involved in sterol metabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025] | 13 | 49660674 | 49691487 | Human | 80 | symbol , COSMIC , name , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 8714095 | Ebpl | EBP like | FOUND IN endoplasmic reticulum (ortholog) | NW_004955431 | 3114160 | 3122448 | Chinchilla | 1 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 11895712 | EBPL | EBP like | ENCODES a protein that exhibits cholestenol delta-isomerase activity (inferred); INVOLVED IN sterol metabolic process (inferred); FOUND IN endoplasmic reticulum (inferred); membrane (inferred) | 13 | 30799832 | 30830670 | Bonobo | 7 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12195612 | EBPL | EBP like | ENCODES a protein that exhibits cholestenol delta-isomerase activity (inferred); INVOLVED IN sterol metabolic process (inferred); FOUND IN endoplasmic reticulum (ortholog); INTERACTS WITH masitinib | 22 | 2116588 | 2137935 | Dog | 8 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12456992 | Ebpl | EBP like | ENCODES a protein that exhibits cholestenol delta-isomerase activity (inferred); INVOLVED IN sterol metabolic process (inferred); FOUND IN endoplasmic reticulum (inferred); membrane (inferred) | NW_004936565 | 2706788 | 2731453 | Squirrel | 7 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 14029556 | EBPL | EBP like | ENCODES a protein that exhibits cholestenol delta-isomerase activity (inferred); INVOLVED IN sterol metabolic process (inferred); FOUND IN endoplasmic reticulum (inferred); membrane (inferred) | | | | Pig | 7 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18631143 | EBPL | EBP like | ENCODES a protein that exhibits cholestenol delta-isomerase activity (inferred); INVOLVED IN sterol metabolic process (inferred); FOUND IN endoplasmic reticulum (inferred); membrane (inferred) | | | | Green Monkey | 7 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18904242 | Ebpl | EBP like | ENCODES a protein that exhibits cholestenol delta-isomerase activity (inferred); INVOLVED IN sterol metabolic process (inferred); FOUND IN endoplasmic reticulum (inferred); membrane (inferred) | | | | Naked Mole-Rat | 6 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 625857847 | Ebpl | EBP like | FOUND IN endoplasmic reticulum (ortholog) | | | | Black Rat | 1 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 38621444 | LOC729217 | EBP like pseudogene | | 16 | 64260326 | 64261241 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 10326 | Cebpb | CCAAT/enhancer binding protein beta | Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and enzyme binding activity. Contributes to RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including li ver development; positive regulation of metabolic process; and response to bacterium. Acts upstream of or within several processes, including mammary gland epithelium development; positive regulation of osteoblast differentiation; and regulation of gene expression. Located in chromosome; cytoplasm; and nuclear matrix. Part of C/EBP complex. Is expressed in several structures, including adrenal gland; connective tissue; extraembryonic component; genitourinary system; and integumental system. Used to study osteochondrodysplasia and viral infectious disease. Orthologous to human CEBPB (CCAAT enhancer binding protein beta). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 167530835 | 167532352 | Mouse | 1011 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 2326 | Cebpa | CCAAT/enhancer binding protein alpha | ENCODES a protein that exhibits DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor binding; INVOLVED IN acute-phase response; animal organ regeneration; cell differentiation; PARTICIPATES IN forkhead class A signaling pathway; acut e myeloid leukemia pathway; ASSOCIATED WITH abnormal lipid level; ASSOCIATED WITH Acute-Phase Reaction; alcohol-associated liver disease; transient cerebral ischemia; FOUND IN CHOP-C/EBP complex; nuclear matrix; nucleolus; INTERACTS WITH (+)-pilocarpine; (-)-cotinine; (S)-nicotine | 1 | 96896584 | 96899256 | Rat | 722 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, REVIEWED [RefSeq] |
| 2328 | Cebpd | CCAAT/enhancer binding protein delta | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; INVOLVED IN positive regulation of transcription by RNA polymerase II; fat cell differentiat ion (ortholog); hematopoietic progenitor cell differentiation (ortholog); PARTICIPATES IN forkhead class A signaling pathway; interleukin-6 signaling pathway; ASSOCIATED WITH prolactinoma; Sepsis; acute myeloid leukemia (ortholog); FOUND IN nucleus (ortholog); INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate | 11 | 98268856 | 98269994 | Rat | 345 | symbol , old_gene_name , PhenoGen , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 10327 | Cebpd | CCAAT/enhancer binding protein delta | Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including fat cell differentiation; positive regulation of osteoblast differentiation; and regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including alimentary system; early embryo; genitourinary system; integumental system; and lung. Orthologous to human CEBPD (CCAAT enhancer binding protein delta). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 15705150 | 15707409 | Mouse | 371 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 2329 | Cebpe | CCAAT/enhancer binding protein epsilon | ENCODES a protein that exhibits DNA binding; identical protein binding; protein-containing complex binding; INVOLVED IN cellular response to lipopolysaccharide; myeloid cell differentiation; granulocyte differentiation (ortholog); ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute promye locytic leukemia (ortholog); genetic disease (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 15 | 32139716 | 32141476 | Rat | 114 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 733713 | Atf4 | activating transcription factor 4 | Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding protein binding activity; and promoter-specific chromatin binding activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specifi c. Involved in several processes, including cellular response to leucine starvation; intracellular signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including gluconeogenesis; positive regulation of sodium-dependent phosphate transport; and positive regulation of vascular associated smooth muscle cell apoptotic process. Located in cytoplasm and nucleus. Part of ATF1-ATF4 transcription factor complex and ATF4-CREB1 transcription factor complex. Is expressed in several structures, including central nervous system; embryo ectoderm; eye; genitourinary system; and long bone. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human ATF4 (activating transcription factor 4). [provided by Alliance of Genome Resources, Apr 2025] | 15 | 80139385 | 80141746 | Mouse | 1019 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1604587 | FAM117A | family with sequence similarity 117 member A | INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-deoxy-D-glucose | 17 | 49710332 | 49789110 | Human | 85 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 16552843 | PORCN-DT | PORCN divergent transcript | | X | 48506526 | 48508839 | Human | | old_gene_name | gene, ncrna, VALIDATED [RefSeq] |
| 10336166 | Cebpb | CCAAT enhancer binding protein beta | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN brown fat cell differentiation (ortholog); cellular response to amino acid stimulus (ortholog); cellular response to interleukin-1 (ortholog); PARTICIPATES IN forkhead class A signaling pathway; interleukin-3 signaling pathway; interleukin-4 signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Alzheimer's disease (ortholog); Bacteremia (ortholog); FOUND IN C/EBP complex (ortholog); CHOP-C/EBP complex (ortholog); chromatin (ortholog) | NW_004955445 | 8060432 | 8061289 | Chinchilla | 177 | symbol , old_gene_name , description | gene, protein-coding, MODEL [RefSeq] |
| 14025162 | CEBPB | CCAAT enhancer binding protein beta | ENCODES a protein that exhibits DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor binding (ortholog); INVOLVED IN positive regulation of DNA-templated transcription; cellular response to amino acid stimulus (ortholog); cel lular response to interleukin-1 (ortholog); PARTICIPATES IN forkhead class A signaling pathway; interleukin-3 signaling pathway; interleukin-4 signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Alzheimer's disease (ortholog); Bacteremia (ortholog); FOUND IN nucleus; C/EBP complex (ortholog); CHOP-C/EBP complex (ortholog) | | | | Pig | 172 | symbol , old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1312755 | CEBPZ | CCAAT enhancer binding protein zeta | This gene belongs to the CBF/Mak21 family. The encoded protein plays a role in cellular response to environmental stimuli through a transcriptional process that involves heat shock factors, conserved DNA elements (heat shock elements or HSEs) and CCAAT boxes. The protein acts as a DNA-binding transc riptional activator and regulates the heat-shock protein 70 (HSP70) promoter in a CCAAT-dependent manner. The protein is also involved in cell growth and differentiation, particularly, hematopoietic differentiation. [provided by RefSeq, Nov 2020] | 2 | 37201612 | 37231596 | Human | 83 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8765433 | Cebpz | CCAAT enhancer binding protein zeta | ENCODES a protein that exhibits DNA binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); FOUND IN CCAAT-binding factor complex (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | NW_004955441 | 5013144 | 5033830 | Chinchilla | 8 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 8951649 | Cebpa | CCAAT enhancer binding protein alpha | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN acute-phase response (ortholog); animal organ regeneration (ortholog); brown fat cell differentiation (ortholog); PARTICIPATES IN forkhead class A signaling pathway; AS SOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); Acute-Phase Reaction (ortholog); FOUND IN CHOP-C/EBP complex (ortholog); nuclear matrix (ortholog); nucleolus (ortholog) | NW_004955468 | 3046544 | 3049217 | Chinchilla | 189 | symbol , old_gene_name , description | gene, protein-coding, MODEL [RefSeq] |
| 8777367 | Cebpd | CCAAT enhancer binding protein delta | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); identical protein binding (ortholog); INVOLVED IN fat cell differentiation (ortholog); hematopoietic progenitor cell differentiation (ortholog); inner ear deve lopment (ortholog); PARTICIPATES IN forkhead class A signaling pathway; interleukin-6 signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); Experimental Liver Cirrhosis (ortholog); hepatocellular carcinoma (ortholog); FOUND IN nucleus (ortholog) | NW_004955454 | 7711010 | 7711680 | Chinchilla | 36 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 8933016 | Cebpg | CCAAT enhancer binding protein gamma | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN B cell differentiation (ortholog); enucleate erythrocyte differentiation (ortholog); immune r esponse (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog) | NW_004955468 | 3137106 | 3141733 | Chinchilla | 42 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12117454 | CEBPG | CCAAT enhancer binding protein gamma | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); double-stranded DNA binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN liver development (ortholog); mRNA metabolic process (ortholog); obsolete negative regulation of DNA-binding transc ription factor activity (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | 1 | 118777110 | 118784397 | Dog | 54 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 8999840 | Cebpe | CCAAT enhancer binding protein epsilon | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); granulocyte differentiation (ortholog); macrophage differ entiation (ortholog); ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute promyelocytic leukemia (ortholog); genetic disease (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog) | NW_004955409 | 37186282 | 37187914 | Chinchilla | 26 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1616773 | Cebpzos | CCAAT/enhancer binding protein zeta, opposite strand | Predicted to be located in mitochondrial membrane. Orthologous to human CEBPZOS (CEBPZ opposite strand). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 79223928 | 79228477 | Mouse | 35 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1312756 | Cebpz | CCAAT/enhancer binding protein zeta | Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of CCAAT-binding activity factor complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary sy stem; bone; brain; genitourinary system; and hemolymphoid system gland. Orthologous to human CEBPZ (CCAAT enhancer binding protein zeta). [provided by Alliance of Genome Resources, Apr 2025] | 17 | 79226432 | 79244499 | Mouse | 81 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1349693 | RETN | resistin | This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. The encoded protein also has an antimicrobial role in skin, displaying antibacterial activity against both Gram positive and Gram negative bacteria. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2020] | 19 | 7669049 | 7670455 | Human | 246 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1345045 | RETNLB | resistin like beta | Predicted to enable hormone activity. Involved in epithelial cell proliferation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025] | 3 | 108755638 | 108757410 | Human | 47 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 14374033 | EBP2 | | | | | | Yeast | | symbol | gene, null |
| 1312087 | Ebpl | emopamil binding protein-like | Predicted to enable cholestenol delta-isomerase activity. Predicted to be involved in sterol metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in central nervous system; retina; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human EBPL (EBP like). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 61577212 | 61597894 | Mouse | 81 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 155241115 | ebpl | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 11739234 | CEBPA | CCAAT enhancer binding protein alpha | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN acute-phase response (ortholog); animal organ regeneration (ortholog); brown fat cell differentiation (ortholog); PARTICIPATES IN forkhead class A signaling pathway; AS SOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); Acute-Phase Reaction (ortholog); FOUND IN CHOP-C/EBP complex (ortholog); nuclear matrix (ortholog); nucleolus (ortholog) | 19 | 30223567 | 30226204 | Bonobo | 189 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 12179653 | CEBPA | CCAAT enhancer binding protein alpha | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN acute-phase response (ortholog); animal organ regeneration (ortholog); brown fat cell differentiation (ortholog); PARTICIPATES IN forkhead class A signaling pathway; AS SOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); Acute-Phase Reaction (ortholog); FOUND IN CHOP-C/EBP complex (ortholog); nuclear matrix (ortholog); nucleolus (ortholog) | 1 | 118846252 | 118851045 | Dog | 189 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 12532631 | Cebpa | CCAAT enhancer binding protein alpha | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN acute-phase response (ortholog); animal organ regeneration (ortholog); brown fat cell differentiation (ortholog); PARTICIPATES IN forkhead class A signaling pathway; AS SOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); Acute-Phase Reaction (ortholog); FOUND IN CHOP-C/EBP complex (ortholog); nuclear matrix (ortholog); nucleolus (ortholog) | NW_004936570 | 2513561 | 2516213 | Squirrel | 189 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 18502792 | CEBPA | CCAAT enhancer binding protein alpha | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription factor binding (ortholog); histone deacetylase binding (ortholog); INVOLVED IN acute-phase response (ortholog); animal organ regeneration (ortholog); brown fat cell differentiation (ortholog); PARTICIPATES IN forkhead class A signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); Acute-Phase Reaction (ortholog); FOUND IN CHOP-C/EBP complex (ortholog); nuclear matrix (ortholog); nucleolus (ortholog) | | | | Green Monkey | 173 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 18932894 | Cebpa | CCAAT enhancer binding protein alpha | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN acute-phase response (ortholog); animal organ regeneration (ortholog); brown fat cell differentiation (ortholog); PARTICIPATES IN forkhead class A signaling pathway; AS SOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); Acute-Phase Reaction (ortholog); FOUND IN CHOP-C/EBP complex (ortholog); nuclear matrix (ortholog); nucleolus (ortholog) | | | | Naked Mole-Rat | 183 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 625936701 | Cebpa | CCAAT enhancer binding protein alpha | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN acute-phase response (ortholog); animal organ regeneration (ortholog); brown fat cell differentiation (ortholog); PARTICIPATES IN forkhead class A signaling pathway; AS SOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); Acute-Phase Reaction (ortholog); FOUND IN CHOP-C/EBP complex (ortholog); nuclear matrix (ortholog); nucleolus (ortholog) | | | | Black Rat | 186 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 12337530 | CEBPB | CCAAT enhancer binding protein beta | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor binding (ortholog); INVOLVED IN cellular response to amino acid stimulus (ortholog); cellular response to interleukin-1 (ortholog ); cellular response to lipopolysaccharide (ortholog); PARTICIPATES IN forkhead class A signaling pathway; interleukin-3 signaling pathway; interleukin-4 signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Alzheimer's disease (ortholog); Bacteremia (ortholog); FOUND IN C/EBP complex (ortholog); CHOP-C/EBP complex (ortholog); nuclear matrix (ortholog) | 24 | 36661294 | 36663162 | Dog | 170 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 18710288 | CEBPB | CCAAT enhancer binding protein beta | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor binding (ortholog); INVOLVED IN cellular response to amino acid stimulus (ortholog); cellular response to interleukin-1 (ortholog ); cellular response to lipopolysaccharide (ortholog); PARTICIPATES IN forkhead class A signaling pathway; interleukin-3 signaling pathway; interleukin-4 signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Alzheimer's disease (ortholog); Bacteremia (ortholog); FOUND IN C/EBP complex (ortholog); CHOP-C/EBP complex (ortholog); nuclear matrix (ortholog) | | | | Green Monkey | 171 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 18920043 | Cebpb | CCAAT enhancer binding protein beta | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN brown fat cell differentiation (ortholog); cellular response to amino acid stimulus (ortholog); cellular response to interleukin-1 (ortholog); PARTICIPATES IN forkhead class A signaling pathway; interleukin-3 signaling pathway; interleukin-4 signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Alzheimer's disease (ortholog); Bacteremia (ortholog); FOUND IN C/EBP complex (ortholog); CHOP-C/EBP complex (ortholog); chromatin (ortholog) | | | | Naked Mole-Rat | 175 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 32730256 | CEBPB | CCAAT enhancer binding protein beta | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN brown fat cell differentiation (ortholog); cellular response to amino acid stimulus (ortholog); cellular response to interleukin-1 (ortholog); PARTICIPATES IN forkhead class A signaling pathway; interleukin-3 signaling pathway; interleukin-4 signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Alzheimer's disease (ortholog); Bacteremia (ortholog); FOUND IN C/EBP complex (ortholog); CHOP-C/EBP complex (ortholog); chromatin (ortholog) | 20 | 46533163 | 46535282 | Bonobo | 177 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 625976732 | Cebpb | CCAAT enhancer binding protein beta | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN brown fat cell differentiation (ortholog); cellular response to amino acid stimulus (ortholog); cellular response to interleukin-1 (ortholog); PARTICIPATES IN forkhead class A signaling pathway; interleukin-3 signaling pathway; interleukin-4 signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Alzheimer's disease (ortholog); Bacteremia (ortholog); FOUND IN C/EBP complex (ortholog); CHOP-C/EBP complex (ortholog); chromatin (ortholog) | | | | Black Rat | 177 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 155241116 | ebpl.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1305762 | Ebna1bp2 | EBNA1 binding protein 2 | INVOLVED IN ribosome biogenesis (inferred); FOUND IN chromosome (ortholog); nucleolus (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 5 | 137433534 | 137438100 | Rat | 114 | old_gene_name , ensembl_full_name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1313990 | EBNA1BP2 | EBNA1 binding protein 2 | Enables RNA binding activity. Predicted to be involved in rRNA processing and ribosomal large subunit biogenesis. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Jul 2025] | 1 | 43164174 | 43172570 | Human | 116 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1302994 | Pa2g4 | proliferation-associated 2G4 | ENCODES a protein that exhibits nucleic acid binding (ortholog); transcription corepressor activity (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN negative regulation of apoptotic process; positive regulation of cell differentiation; negative regulation of DNA-templated transcr iption (ortholog); ASSOCIATED WITH Disease Progression (ortholog); Stomach Neoplasms (ortholog); FOUND IN cytoplasm; nucleolus; cytosol (ortholog); INTERACTS WITH (+)-schisandrin B; 2,4-dibromophenyl 2,4,5-tribromophenyl ether; 2,4-dinitrotoluene | 7 | 1569326 | 1576794 | Rat | 174 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1354307 | PA2G4 | proliferation-associated 2G4 | This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytop lasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008] | 12 | 56104559 | 56113910 | Human | 181 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 12149291 | PA2G4 | proliferation-associated 2G4 | ENCODES a protein that exhibits nucleic acid binding (inferred); RNA binding (inferred); transcription corepressor activity (inferred); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of DNA-templated transcription (ortholog); positive regulation of cell differen tiation (ortholog); ASSOCIATED WITH Disease Progression (ortholog); Stomach Neoplasms (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleolus (inferred) | 10 | 426074 | 437044 | Dog | 28 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 708538 | Nherf1 | NHERF family PDZ scaffold protein 1 | ENCODES a protein that exhibits gamma-aminobutyric acid transmembrane transporter activity; molecular adaptor activity; myosin II binding; INVOLVED IN gamma-aminobutyric acid import; import across plasma membrane; positive regulation of monoatomic ion transmembrane transport; PARTICIPATES IN eicosan oid signaling pathway; parathyroid hormone signaling pathway; platelet-derived growth factor signaling pathway; ASSOCIATED WITH hypertension; malignant renovascular hypertension; chronic kidney disease (ortholog); FOUND IN apical plasma membrane; cytoplasm; microvillus membrane; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl | 10 | 100902165 | 100919265 | Rat | 304 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1342625 | NHERF1 | NHERF family PDZ scaffold protein 1 | This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer.[provided by RefSeq, Sep 2009] | 17 | 74748628 | 74769353 | Human | 346 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 12154201 | NHERF1 | NHERF family PDZ scaffold protein 1 | ENCODES a protein that exhibits gamma-aminobutyric acid transmembrane transporter activity (ortholog); molecular adaptor activity (ortholog); myosin II binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); adenylate cyclase-activating dopamine receptor signaling pathway (orthol og); auditory receptor cell stereocilium organization (ortholog); PARTICIPATES IN eicosanoid signaling pathway; parathyroid hormone signaling pathway; platelet-derived growth factor signaling pathway; ASSOCIATED WITH chronic kidney disease (ortholog); genetic disease (ortholog); hypertension (ortholog); FOUND IN apical plasma membrane (ortholog); microvillus membrane (ortholog); nucleus (ortholog) | 9 | 5661792 | 5679783 | Dog | 139 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1552402 | Cldn18 | claudin 18 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel l sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is a downstream target gene regulated by the T/EBP/NKX2.1 homeodomain transcription factor. Four alternatively spliced transcript variants resulted from alternative promoters and alternative splicing have been identified, which encode two lung-specific isoforms and two stomach-specific isoforms respectively. This gene is also expressed in colons, inner ear and skin, and its expression is increased in both experimental colitis and ulcerative colitis. [provided by RefSeq, Aug 2010] | 9 | 99572849 | 99599320 | Mouse | 106 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1344050 | CLEC4E | C-type lectin domain family 4 member E | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The enco ded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008] | 12 | 8533275 | 8540905 | Human | 119 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 9004389 | Ddit3 | DNA damage inducible transcript 3 | ENCODES a protein that exhibits cAMP response element binding protein binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); apoptotic process (ortholog); artery de velopment (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); Acute-Phase Reaction (ortholog); FOUND IN CHOP-ATF3 complex (ortholog); CHOP-ATF4 complex (ortholog); CHOP-C/EBP complex (ortholog) | NW_004955458 | 5232979 | 5238513 | Chinchilla | 194 | description | gene, protein-coding, MODEL [RefSeq] |
| 11685790 | DDIT3 | DNA damage inducible transcript 3 | ENCODES a protein that exhibits cAMP response element binding protein binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); apoptotic process (ortholog); artery de velopment (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); Acute-Phase Reaction (ortholog); FOUND IN CHOP-ATF3 complex (ortholog); CHOP-ATF4 complex (ortholog); CHOP-C/EBP complex (ortholog) | 12 | 31406332 | 31410293 | Bonobo | 194 | description | gene, protein-coding, MODEL [RefSeq] |
| 598132437 | DDIT3 | DNA damage inducible transcript 3 | ENCODES a protein that exhibits cAMP response element binding protein binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN cell redox homeostasis (ortholog); negative regulation of interleukin-17 production (orth olog); negative regulation of interleukin-4 production (ortholog); ASSOCIATED WITH asbestosis (ortholog); Breast Neoplasms (ortholog); contact dermatitis (ortholog); FOUND IN CHOP-ATF3 complex (inferred); CHOP-ATF4 complex (inferred); CHOP-C/EBP complex (inferred) | | | | Green Monkey | 125 | description | gene, protein-coding, MODEL [RefSeq] |
| 625845025 | Ddit3 | DNA damage inducible transcript 3 | ENCODES a protein that exhibits cAMP response element binding protein binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); apoptotic process (ortholog); artery de velopment (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); Acute-Phase Reaction (ortholog); FOUND IN CHOP-ATF3 complex (ortholog); CHOP-ATF4 complex (ortholog); CHOP-C/EBP complex (ortholog) | | | | Black Rat | 194 | description | gene, protein-coding, MODEL [RefSeq] |
| 18779148 | LOC103238566 | DDIT3 upstream open reading frame protein | ENCODES a protein that exhibits cAMP response element binding protein binding (ortholog); DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); apoptotic process (ortholog); artery development (ortholog); ASSOCIATE D WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); Acute-Phase Reaction (ortholog); FOUND IN CHOP-C/EBP complex (ortholog); cytoplasm (ortholog); late endosome (ortholog) | | | | Green Monkey | 107 | description | gene, protein-coding, MODEL [RefSeq] |
| 329331850 | LOC129392969 | DDIT3 upstream open reading frame protein | ENCODES a protein that exhibits cAMP response element binding protein binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN anterior/posterior axis specification (inferred); apoptotic process (inferred); artery de velopment (inferred); FOUND IN CHOP-ATF3 complex (inferred); CHOP-ATF4 complex (inferred); CHOP-C/EBP complex (inferred) | | | | Bonobo | 80 | description | gene, protein-coding, MODEL [RefSeq] |
| 625965953 | LOC116901016 | probable rRNA-processing protein EBP2 | | | | | Black Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 40915216 | LOC119881744 | probable rRNA-processing protein EBP2 | INVOLVED IN ribosome biogenesis (inferred); FOUND IN nucleolus (inferred) | | | | Dog | 7 | name | gene, protein-coding, MODEL [RefSeq] |
| 16562875 | AC093536.1 | emopamil binding protein-like (EBPL) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 18924542 | LOC106007709 | probable rRNA-processing protein EBP2 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18920590 | LOC106008629 | probable rRNA-processing protein EBP2 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 11453203 | LOC108350483 | probable rRNA-processing protein EBP2 pseudogene | | 3 | 153613214 | 153614591 | Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 1347763 | STOML1 | stomatin like 1 | Predicted to enable ion channel inhibitor activity. Predicted to be involved in lipid transport. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025] | 15 | 73978926 | 73994622 | Human | 69 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1605322 | TBC1D10A | TBC1 domain family member 10A | Enables PDZ domain binding activity. Involved in positive regulation of proteolysis and retrograde transport, endosome to Golgi. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025] | 22 | 30291990 | 30326941 | Human | 89 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1553262 | Tbc1d10c | TBC1 domain family, member 10c | Predicted to enable GTPase activator activity. Acts upstream of or within negative regulation of B cell activation; negative regulation of ERK1 and ERK2 cascade; and negative regulation of calcineurin-NFAT signaling cascade. Predicted to be located in filopodium membrane. Is expressed in thymus prim ordium. Orthologous to human TBC1D10C (TBC1 domain family member 10C). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 4234356 | 4241194 | Mouse | 85 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1615771 | Tbc1d10a | TBC1 domain family, member 10a | Predicted to enable GTPase activator activity and PDZ domain binding activity. Predicted to be involved in positive regulation of proteolysis and retrograde transport, endosome to Golgi. Predicted to be located in plasma membrane. Is expressed in renal calyx and vibrissa. Orthologous to human TBC1D1 0A (TBC1 domain family member 10A). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 4136852 | 4167407 | Mouse | 96 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 8713605 | Ebna1bp2 | EBNA1 binding protein 2 | FOUND IN chromosome (ortholog); nucleolus (ortholog) | NW_004955537 | 2792295 | 2800249 | Chinchilla | 8 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11751290 | EBNA1BP2 | EBNA1 binding protein 2 | INVOLVED IN ribosomal large subunit biogenesis (inferred); ribosome biogenesis (inferred); rRNA processing (inferred); FOUND IN chromosome (inferred); nuclear periphery (inferred); nucleolus (inferred) | 1 | 42462907 | 42470949 | Bonobo | 15 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12329500 | EBNA1BP2 | EBNA1 binding protein 2 | INVOLVED IN ribosome biogenesis (inferred); FOUND IN chromosome (ortholog) | 15 | 16977855 | 16986208 | Dog | 14 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12437722 | Ebna1bp2 | EBNA1 binding protein 2 | INVOLVED IN ribosomal large subunit biogenesis (inferred); ribosome biogenesis (inferred); rRNA processing (inferred); FOUND IN chromosome (inferred); nuclear periphery (inferred); nucleolus (inferred) | NW_004936474 | 24583494 | 24595094 | Squirrel | 15 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14094669 | EBNA1BP2 | EBNA1 binding protein 2 | INVOLVED IN ribosome biogenesis (inferred); FOUND IN chromosome (inferred); nucleolus (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 16 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18432406 | EBNA1BP2 | EBNA1 binding protein 2 | INVOLVED IN ribosomal large subunit biogenesis (inferred); ribosome biogenesis (inferred); rRNA processing (inferred); FOUND IN chromosome (inferred); nuclear periphery (inferred); nucleolus (inferred) | | | | Green Monkey | 15 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18931330 | Ebna1bp2 | EBNA1 binding protein 2 | INVOLVED IN ribosomal large subunit biogenesis (inferred); ribosome biogenesis (inferred); rRNA processing (inferred); FOUND IN chromosome (ortholog) | | | | Naked Mole-Rat | 14 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 625968348 | Ebna1bp2 | EBNA1 binding protein 2 | FOUND IN chromosome (ortholog); nucleolus (ortholog) | | | | Black Rat | 8 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1351441 | TRIB2 | tribbles pseudokinase 2 | This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signa l transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009] | 2 | 12716936 | 12742734 | Human | 159 | description | gene, protein-coding, REVIEWED [RefSeq] |
