Ebpl (emopamil binding protein-like) - Rat Genome Database

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Gene: Ebpl (emopamil binding protein-like) Mus musculus
Analyze
Symbol: Ebpl
Name: emopamil binding protein-like
RGD ID: 1312087
MGI Page MGI
Description: Predicted to enable cholestenol delta-isomerase activity. Predicted to be involved in sterol metabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in central nervous system; retina; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human EBPL (EBP like).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5730442K12Rik; EBRP; emopamil binding related protein, delta8-delta7 sterol isomerase related protein; emopamil-binding protein-like; emopamil-binding-related protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391461,577,212 - 61,597,894 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1461,569,191 - 61,597,888 (-)EnsemblGRCm39 Ensembl
GRCm381461,339,763 - 61,360,445 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1461,331,742 - 61,360,439 (-)EnsemblGRCm38mm10GRCm38
MGSCv371461,958,600 - 61,979,282 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361460,294,860 - 60,314,549 (-)NCBIMGSCv36mm8
Celera1459,106,822 - 59,127,515 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1432.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12760743   PMID:14610273   PMID:15226823   PMID:15489334   PMID:16141072   PMID:16141073   PMID:18809582  
PMID:21267068   PMID:21873635   PMID:26272612  


Genomics

Comparative Map Data
Ebpl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391461,577,212 - 61,597,894 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1461,569,191 - 61,597,888 (-)EnsemblGRCm39 Ensembl
GRCm381461,339,763 - 61,360,445 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1461,331,742 - 61,360,439 (-)EnsemblGRCm38mm10GRCm38
MGSCv371461,958,600 - 61,979,282 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361460,294,860 - 60,314,549 (-)NCBIMGSCv36mm8
Celera1459,106,822 - 59,127,515 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1432.72NCBI
EBPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381349,660,674 - 49,691,487 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1349,660,674 - 49,691,486 (-)EnsemblGRCh38hg38GRCh38
GRCh371350,234,810 - 50,265,623 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361349,132,863 - 49,163,612 (-)NCBINCBI36Build 36hg18NCBI36
Build 341349,132,863 - 49,163,612NCBI
Celera1331,289,746 - 31,320,576 (-)NCBICelera
Cytogenetic Map13q14.2NCBI
HuRef1331,028,176 - 31,058,957 (-)NCBIHuRef
CHM1_11350,202,353 - 50,233,179 (-)NCBICHM1_1
T2T-CHM13v2.01348,879,582 - 48,910,398 (-)NCBIT2T-CHM13v2.0
Ebpl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81539,684,140 - 39,707,537 (-)NCBIGRCr8
mRatBN7.21535,508,074 - 35,531,472 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1535,508,074 - 35,531,472 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1537,372,859 - 37,396,078 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01538,523,505 - 38,546,724 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01536,968,764 - 36,992,161 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01541,668,119 - 41,691,518 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1541,668,119 - 41,691,518 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01545,472,241 - 45,495,631 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41540,484,464 - 40,506,451 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11540,500,163 - 40,522,151 (-)NCBI
Celera1535,205,464 - 35,228,861 (-)NCBICelera
Cytogenetic Map15p12NCBI
Ebpl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554313,112,134 - 3,121,780 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554313,114,160 - 3,122,448 (-)NCBIChiLan1.0ChiLan1.0
EBPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21451,074,227 - 51,130,358 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11349,751,192 - 49,782,032 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01330,799,832 - 30,830,670 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11349,548,230 - 49,578,820 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1349,548,230 - 49,578,820 (-)Ensemblpanpan1.1panPan2
EBPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1222,116,588 - 2,137,935 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl222,116,131 - 2,182,633 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha222,145,655 - 2,166,752 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0222,106,939 - 2,128,685 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl222,106,435 - 2,173,674 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1222,016,192 - 2,037,355 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0222,065,607 - 2,086,720 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0222,083,831 - 2,104,999 (+)NCBIUU_Cfam_GSD_1.0
Ebpl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945159,222,363 - 159,247,403 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365652,706,788 - 2,731,453 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365652,706,788 - 2,731,453 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EBPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1118,040,011 - 18,072,633 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11118,039,978 - 18,150,729 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21118,297,518 - 18,444,593 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EBPL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1327,576,087 - 27,606,770 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl327,576,329 - 27,606,684 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605716,276,627 - 16,307,505 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ebpl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247484,967,698 - 5,000,728 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247484,967,611 - 5,000,156 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ebpl
452 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:437
Count of miRNA genes:328
Interacting mature miRNAs:371
Transcripts:ENSMUST00000022494
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145393744087937440Mouse
10043889Cia52_mcollagen induced arthritis QTL 52 (mouse)Not determined145608238190082509Mouse
1301562Hwq1_mheart weight quantitative locus 1 (mouse)Not determined145654674590546941Mouse
1357565wrmod1_mwobbler modifier 1 (mouse)Not determined1458179640101859473Mouse
11039527Ccc2_mcolitis susceptibility in the Collaborative Cross 2 (mouse)145991861294138217Mouse
14695040Ifbl5_minterfrontal bone length 5 (mouse)146096082362006713Mouse
14695043Ifbw4_minterfrontal bone width 4 (mouse)146096082362006713Mouse

Markers in Region
UniSTS:237202  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381461,341,058 - 61,341,271UniSTSGRCm38
MGSCv371461,959,895 - 61,960,108UniSTSGRCm37
Celera1459,108,118 - 59,108,331UniSTS
Cytogenetic Map14D1UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000022494   ⟹   ENSMUSP00000022494
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1461,569,191 - 61,597,888 (-)Ensembl
GRCm38.p6 Ensembl1461,331,742 - 61,360,439 (-)Ensembl
RefSeq Acc Id: ENSMUST00000223560
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1461,577,214 - 61,597,769 (-)Ensembl
GRCm38.p6 Ensembl1461,339,765 - 61,360,320 (-)Ensembl
RefSeq Acc Id: ENSMUST00000225112
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1461,581,300 - 61,597,857 (-)Ensembl
GRCm38.p6 Ensembl1461,343,851 - 61,360,408 (-)Ensembl
RefSeq Acc Id: NM_026598   ⟹   NP_080874
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391461,577,212 - 61,597,894 (-)NCBI
GRCm381461,339,763 - 61,360,445 (-)ENTREZGENE
MGSCv371461,958,600 - 61,979,282 (-)RGD
Celera1459,106,822 - 59,127,515 (-)RGD
cM Map14 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_080874   ⟸   NM_026598
- UniProtKB: Q9CRQ2 (UniProtKB/Swiss-Prot),   Q3TQR1 (UniProtKB/Swiss-Prot),   Q9CY81 (UniProtKB/Swiss-Prot),   Q9D0P0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000022494   ⟸   ENSMUST00000022494
Protein Domains
EXPERA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9D0P0-F1-model_v2 AlphaFold Q9D0P0 1-206 view protein structure

Promoters
RGD ID:8682642
Promoter ID:EPDNEW_M19351
Type:initiation region
Name:Ebpl_1
Description:Mus musculus emopamil binding protein-like , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381461,360,431 - 61,360,491EPDNEW
RGD ID:6824851
Promoter ID:MM_KWN:17135
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_026598
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361461,978,996 - 61,980,077 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1915427 AgrOrtholog
Ensembl Genes ENSMUSG00000021928 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000022494 ENTREZGENE
  ENSMUST00000022494.10 UniProtKB/Swiss-Prot
InterPro EBP UniProtKB/Swiss-Prot
  EXPERA UniProtKB/Swiss-Prot
KEGG Report mmu:68177 UniProtKB/Swiss-Prot
MGD MGI:1915427 ENTREZGENE
NCBI Gene 68177 ENTREZGENE
PANTHER EMOPAMIL-BINDING PROTEIN-LIKE UniProtKB/Swiss-Prot
  PTHR14207 UniProtKB/Swiss-Prot
Pfam EBP UniProtKB/Swiss-Prot
PhenoGen Ebpl PhenoGen
PROSITE EXPERA UniProtKB/Swiss-Prot
UniProt EBPL_MOUSE UniProtKB/Swiss-Prot
  Q3TQR1 ENTREZGENE
  Q9CRQ2 ENTREZGENE
  Q9CY81 ENTREZGENE
  Q9D0P0 ENTREZGENE
UniProt Secondary Q3TQR1 UniProtKB/Swiss-Prot
  Q9CRQ2 UniProtKB/Swiss-Prot
  Q9CY81 UniProtKB/Swiss-Prot