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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:paracetamol drug pathway
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Accession:PW:0001524 term browser browse the term
Definition:The pharmacokinetics/pharmacodynamics of paracetamol, a widely used analgesic, known as acetaminophen (APAP). The analgesic effect is believed to be due to the inhibition of prostaglandins biosynthesis. Paracetamol overdose is associated with hepatic toxicity and a leading cause of liver failure. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.
Synonyms:exact_synonym: acetaminophen drug pathway
 related_synonym: SMP:00710
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paracetamol drug pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1C3 aldo-keto reductase family 1 member C3 EXP SMPDB SMP:00710 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686 		JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type EXP SMPDB SMP:00710 NCBI chr17:6,996,049...7,010,754
Ensembl chr17:6,996,049...7,010,754 		JBrowse link
G ALOX12B arachidonate 12-lipoxygenase, 12R type EXP SMPDB SMP:00710 NCBI chr17:8,072,636...8,087,716
Ensembl chr17:8,072,636...8,087,716 		JBrowse link
G ALOX15 arachidonate 15-lipoxygenase EXP SMPDB SMP:00710 NCBI chr17:4,630,919...4,641,678
Ensembl chr17:4,630,919...4,642,294 		JBrowse link
G ALOX15B arachidonate 15-lipoxygenase type B EXP SMPDB SMP:00710 NCBI chr17:8,039,059...8,049,134
Ensembl chr17:8,039,034...8,049,134 		JBrowse link
G ALOX5 arachidonate 5-lipoxygenase EXP SMPDB SMP:00710 NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119 		JBrowse link
G CBR1 carbonyl reductase 1 EXP SMPDB SMP:00710 NCBI chr21:36,070,024...36,073,164
Ensembl chr21:36,069,941...36,073,166 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 EXP SMPDB SMP:00710 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398 		JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 EXP SMPDB SMP:00710 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 EXP SMPDB SMP:00710 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G CYP2J2 cytochrome P450 family 2 subfamily J member 2 EXP SMPDB SMP:00710 NCBI chr 1:59,893,308...59,969,212
Ensembl chr 1:59,893,308...59,926,773 		JBrowse link
G CYP2U1 cytochrome P450 family 2 subfamily U member 1 EXP SMPDB SMP:00710 NCBI chr 4:107,931,549...107,953,461
Ensembl chr 4:107,931,549...107,953,461 		JBrowse link
G CYP4A11 cytochrome P450 family 4 subfamily A member 11 EXP SMPDB SMP:00710 NCBI chr 1:46,929,188...46,941,476
Ensembl chr 1:46,929,177...46,941,484 		JBrowse link
G CYP4F2 cytochrome P450 family 4 subfamily F member 2 EXP SMPDB SMP:00710 NCBI chr19:15,878,023...15,898,074
Ensembl chr19:15,878,023...15,898,077 		JBrowse link
G CYP4F3 cytochrome P450 family 4 subfamily F member 3 EXP SMPDB SMP:00710 NCBI chr19:15,640,897...15,662,825
Ensembl chr19:15,640,897...15,662,825 		JBrowse link
G CYP4F8 cytochrome P450 family 4 subfamily F member 8 EXP SMPDB SMP:00710 NCBI chr19:15,615,218...15,630,639
Ensembl chr19:15,615,218...15,630,639 		JBrowse link
G EPHX2 epoxide hydrolase 2 EXP SMPDB SMP:00710 NCBI chr 8:27,491,143...27,548,626
Ensembl chr 8:27,490,781...27,545,564 		JBrowse link
G GGT1 gamma-glutamyltransferase 1 EXP SMPDB SMP:00710 NCBI chr22:24,583,750...24,628,996
Ensembl chr22:24,594,811...24,629,005 		JBrowse link
G GPX1 glutathione peroxidase 1 EXP SMPDB SMP:00710 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605 		JBrowse link
G LTA4H leukotriene A4 hydrolase EXP SMPDB SMP:00710 NCBI chr12:96,000,753...96,043,520
Ensembl chr12:96,000,753...96,043,520 		JBrowse link
G LTC4S leukotriene C4 synthase EXP SMPDB SMP:00710 NCBI chr 5:179,793,986...179,796,647
Ensembl chr 5:179,793,980...179,796,647 		JBrowse link
G PLA2G4B phospholipase A2 group IVB EXP SMPDB SMP:00710 NCBI chr15:41,838,847...41,848,143
Ensembl chr15:41,837,775...41,848,147 		JBrowse link
G PRXL2B peroxiredoxin like 2B EXP SMPDB SMP:00710 NCBI chr 1:2,586,523...2,591,468
Ensembl chr 1:2,586,491...2,591,469 		JBrowse link
G PTGDS prostaglandin D2 synthase EXP SMPDB SMP:00710 NCBI chr 9:136,977,504...136,981,742
Ensembl chr 9:136,975,092...136,981,742 		JBrowse link
G PTGES prostaglandin E synthase EXP SMPDB SMP:00710 NCBI chr 9:129,738,349...129,753,042
Ensembl chr 9:129,738,331...129,753,042 		JBrowse link
G PTGIS prostaglandin I2 synthase EXP SMPDB SMP:00710 NCBI chr20:49,503,874...49,568,137
Ensembl chr20:49,503,874...49,568,137 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 TAS
EXP		 SMPDB
RGD		 PMID:23719833 SMP:00710, RGD:8552695 NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 TAS
EXP		 SMPDB
RGD		 PMID:23719833 SMP:00710, RGD:8552695 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G TBXAS1 thromboxane A synthase 1 EXP SMPDB SMP:00710 NCBI chr 7:139,778,242...140,020,293
Ensembl chr 7:139,777,051...140,020,325 		JBrowse link
paracetamol pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 EXP SMPDB SMP:00640 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) EXP SMPDB SMP:00640 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 TAS RGD PMID:23462933 RGD:8552693 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 TAS RGD PMID:23462933 RGD:8552693 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253 		JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 (PEL blood group) TAS
EXP		 SMPDB
RGD		 PMID:23462933 SMP:00640, RGD:8552693 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475 		JBrowse link
G ABCC5 ATP binding cassette subfamily C member 5 EXP SMPDB SMP:00640 NCBI chr 3:183,919,934...184,017,884
Ensembl chr 3:183,919,934...184,017,939 		JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) TAS
EXP		 SMPDB
RGD		 PMID:23462933 SMP:00640, RGD:8552693 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 EXP SMPDB SMP:00640 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 EXP SMPDB SMP:00640 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 EXP SMPDB SMP:00640 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 ISO
EXP		 SMPDB
RGD		 PMID:23462933 SMP:00640, RGD:8552693 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 EXP SMPDB SMP:00640 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 EXP SMPDB SMP:00640 NCBI chr 3:186,570,720...186,585,793
Ensembl chr 3:186,567,403...186,585,800 		JBrowse link
G ERP29 endoplasmic reticulum protein 29 EXP SMPDB SMP:00640 NCBI chr12:112,013,426...112,023,449
Ensembl chr12:112,013,348...112,023,449 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 EXP SMPDB SMP:00640 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
G GSTT1 glutathione S-transferase theta 1 EXP SMPDB SMP:00640
G HSP90B1 heat shock protein 90 beta family member 1 EXP SMPDB SMP:00640 NCBI chr12:103,930,410...103,947,926
Ensembl chr12:103,930,107...103,953,931 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 EXP SMPDB SMP:00640 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
G HYOU1 hypoxia up-regulated 1 EXP SMPDB SMP:00640 NCBI chr11:119,044,188...119,057,205
Ensembl chr11:119,044,188...119,057,227 		JBrowse link
G PDIA2 protein disulfide isomerase family A member 2 EXP SMPDB SMP:00640 NCBI chr16:283,164...287,215
Ensembl chr16:283,164...287,215 		JBrowse link
G PDIA4 protein disulfide isomerase family A member 4 EXP SMPDB SMP:00640 NCBI chr 7:149,003,051...149,028,505
Ensembl chr 7:149,003,062...149,028,662 		JBrowse link
G PDIA6 protein disulfide isomerase family A member 6 EXP SMPDB SMP:00640 NCBI chr 2:10,783,391...10,837,712
Ensembl chr 2:10,783,391...10,837,977 		JBrowse link
G PPIB peptidylprolyl isomerase B EXP SMPDB SMP:00640 NCBI chr15:64,155,817...64,163,022
Ensembl chr15:64,155,740...64,163,134 		JBrowse link
G SDF2L1 stromal cell derived factor 2 like 1 EXP SMPDB SMP:00640 NCBI chr22:21,642,302...21,644,299
Ensembl chr22:21,642,302...21,644,299 		JBrowse link
G SULT1A1 sulfotransferase family 1A member 1 TAS
EXP		 SMPDB
RGD		 PMID:23462933 SMP:00640, RGD:8552693 NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044 		JBrowse link
G SULT1A3 sulfotransferase family 1A member 3 TAS
EXP		 SMPDB
RGD		 PMID:23462933 SMP:00640, RGD:8552693 NCBI chr16:30,199,255...30,204,310
Ensembl chr16:30,199,228...30,204,310 		JBrowse link
G SULT1A4 sulfotransferase family 1A member 4 TAS RGD PMID:23462933 RGD:8552693 NCBI chr16:29,459,913...29,464,966
Ensembl chr16:29,459,913...29,464,966 		JBrowse link
G SULT1E1 sulfotransferase family 1E member 1 TAS
EXP		 SMPDB
RGD		 PMID:23462933 SMP:00640, RGD:8552693 NCBI chr 4:69,821,122...69,860,145
Ensembl chr 4:69,841,212...69,860,145 		JBrowse link
G SULT2A1 sulfotransferase family 2A member 1 EXP SMPDB SMP:00640 NCBI chr19:47,870,467...47,886,315
Ensembl chr19:47,870,467...47,886,315 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 TAS
EXP		 SMPDB
RGD		 PMID:23462933 SMP:00640, RGD:8552693 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G UGT1A6 UDP glucuronosyltransferase family 1 member A6 TAS
EXP		 SMPDB
RGD		 PMID:23462933 SMP:00640, RGD:8552693 NCBI chr 2:233,691,702...233,773,300
Ensembl chr 2:233,691,607...233,773,300 		JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 EXP SMPDB SMP:00640 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300 		JBrowse link
G UGT2B15 UDP glucuronosyltransferase family 2 member B15 EXP SMPDB SMP:00640 NCBI chr 4:68,646,597...68,670,652
Ensembl chr 4:68,646,597...68,670,652 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5956
    drug pathway 412
      nervous system drug pathway 196
        analgesic and/or antipyretic drug pathway 107
          paracetamol drug pathway 61
            paracetamol pharmacokinetics pathway 33
paths to the root