HSP90B1 (heat shock protein 90 beta family member 1) - Rat Genome Database

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Gene: HSP90B1 (heat shock protein 90 beta family member 1) Homo sapiens
Analyze
Symbol: HSP90B1
Name: heat shock protein 90 beta family member 1
RGD ID: 1321409
HGNC Page HGNC:12028
Description: Enables RNA binding activity; low-density lipoprotein particle receptor binding activity; and protein phosphatase binding activity. Involved in negative regulation of apoptotic process; response to hypoxia; and retrograde protein transport, ER to cytosol. Acts upstream of or within actin rod assembly and cellular response to ATP. Located in several cellular components, including endoplasmic reticulum; midbody; and perinuclear region of cytoplasm. Part of protein-containing complex. Biomarker of lung adenocarcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 94 kDa glucose-regulated protein; ECGP; endoplasmin; endothelial cell (HBMEC) glycoprotein; epididymis luminal protein 35; epididymis secretory sperm binding protein Li 125m; glucose regulated protein, 94 kDa; GP96; gp96 homolog; GRP-94; GRP94; heat shock protein 90 kDa beta member 1; heat shock protein 90kDa beta (Grp94), member 1; heat shock protein 90kDa beta family member 1; HEL-S-125m; HEL35; stress-inducible tumor rejection antigen gp96; TRA1; tumor rejection antigen (gp96) 1; tumor rejection antigen 1; Tumor rejection antigen-1 (gp96)
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: HSP90B2P   HSP90B3P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812103,930,410 - 103,947,926 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12103,930,107 - 103,953,931 (+)EnsemblGRCh38hg38GRCh38
GRCh3712104,324,188 - 104,341,704 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612102,848,319 - 102,865,833 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412102,826,655 - 102,844,170NCBI
Celera12103,987,945 - 104,005,473 (+)NCBICelera
Cytogenetic Map12q23.3NCBI
HuRef12101,383,834 - 101,401,444 (+)NCBIHuRef
CHM1_112104,290,083 - 104,307,660 (+)NCBICHM1_1
T2T-CHM13v2.012103,892,110 - 103,909,638 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (ISO)
1,4-dithiothreitol  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-deoxy-D-glucose  (EXP)
2-methoxyethanol  (ISO)
2-palmitoylglycerol  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-amino-2,6-dinitrotoluene  (ISO)
4-aminophenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-(N,N-hexamethylene)amiloride  (EXP)
6-propyl-2-thiouracil  (ISO)
acrolein  (ISO)
actinomycin D  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
aristolochic acid A  (EXP)
Aroclor 1254  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenic trichloride  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP,ISO)
azoxystrobin  (EXP)
benzatropine  (EXP)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP)
bleomycin A2  (ISO)
brefeldin A  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
cannabidiol  (EXP)
capsaicin  (EXP,ISO)
captan  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroacetic acid  (ISO)
chloropicrin  (EXP)
chlorpyrifos  (ISO)
cis-caffeic acid  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (EXP)
coumarin  (ISO)
coumestrol  (EXP,ISO)
Cuprizon  (EXP)
curcumin  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
D-glucose  (EXP,ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (ISO)
dicrotophos  (EXP)
Dienochlor  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
diuron  (EXP,ISO)
dopamine  (EXP)
elemental selenium  (EXP)
endosulfan  (EXP,ISO)
enzyme inhibitor  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
etoposide  (ISO)
fenofibrate  (ISO)
fenpyroximate  (EXP)
fenvalerate  (ISO)
folic acid  (ISO)
folpet  (ISO)
fulvestrant  (EXP,ISO)
geldanamycin  (EXP)
genistein  (EXP)
gentamycin  (ISO)
glafenine  (ISO)
glucose  (EXP,ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
Ibutilide  (ISO)
imidacloprid  (EXP)
inulin  (ISO)
iron dichloride  (EXP)
isoliquiritigenin  (ISO)
isoprenaline  (ISO)
isotretinoin  (EXP)
ivermectin  (EXP)
L-1,4-dithiothreitol  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
manganese(II) chloride  (ISO)
meglumine amidotrizoate  (ISO)
menadione  (ISO)
mercury dichloride  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methomyl  (EXP)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (EXP)
methylmercury chloride  (EXP,ISO)
methylparaben  (EXP)
methylseleninic acid  (EXP)
morphine  (ISO)
N,N-dimethylformamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosomorpholine  (ISO)
oxidopamine  (ISO)
p-menthan-3-ol  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
picoxystrobin  (EXP)
pirinixic acid  (ISO)
poly(propylene imine) macromolecule  (EXP)
potassium dichromate  (EXP)
procymidone  (ISO)
progesterone  (ISO)
Propiverine  (ISO)
prostaglandin A1  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP)
raloxifene  (EXP)
resveratrol  (EXP)
rotenone  (EXP,ISO)
selenium atom  (EXP)
serpentine asbestos  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
surfactin  (EXP)
surfactin C  (EXP)
T-2 toxin  (ISO)
tamibarotene  (EXP)
tamoxifen  (ISO)
temozolomide  (EXP)
testosterone enanthate  (EXP)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thapsigargin  (EXP,ISO)
titanium dioxide  (ISO)
trans-caffeic acid  (EXP)
triadimefon  (ISO)
trichostatin A  (EXP)
tungsten  (ISO)
tunicamycin  (EXP,ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vitamin E  (EXP)
vorinostat  (EXP)
zinc atom  (EXP)
zinc oxide  (ISO)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. LncRNA H19 inhibits ER stress induced apoptosis and improves diabetic cardiomyopathy by regulating PI3K/AKT/mTOR axis. Wang S, etal., Aging (Albany NY). 2022 Aug 30;14(16):6809-6828. doi: 10.18632/aging.204256. Epub 2022 Aug 30.
8. Suppression subtractive hybridization identified differentially expressed genes in lung adenocarcinoma: ERGIC3 as a novel lung cancer-related gene. Wu M, etal., BMC Cancer. 2013 Feb 1;13:44. doi: 10.1186/1471-2407-13-44.
Additional References at PubMed
PMID:1512535   PMID:1923827   PMID:2377606   PMID:2378869   PMID:2546060   PMID:2924290   PMID:7523574   PMID:7768954   PMID:8460400   PMID:8617772   PMID:9006956   PMID:9596688  
PMID:9694898   PMID:10049727   PMID:10497210   PMID:10887119   PMID:11557039   PMID:11584270   PMID:11726552   PMID:11861214   PMID:11907036   PMID:11912201   PMID:11958450   PMID:12167617  
PMID:12397072   PMID:12471035   PMID:12475965   PMID:12477932   PMID:12643545   PMID:12654781   PMID:12665801   PMID:12754519   PMID:14499622   PMID:14500642   PMID:14744259   PMID:15082718  
PMID:15107540   PMID:15166316   PMID:15192333   PMID:15257553   PMID:15489334   PMID:15620698   PMID:15637761   PMID:15728573   PMID:15845869   PMID:15952740   PMID:15962384   PMID:16015374  
PMID:16130169   PMID:16257961   PMID:16263699   PMID:16269234   PMID:16288044   PMID:16497268   PMID:16630554   PMID:16754684   PMID:17081065   PMID:17082602   PMID:17344063   PMID:17347446  
PMID:17431395   PMID:17545519   PMID:17558393   PMID:17612505   PMID:17726464   PMID:17805476   PMID:17936703   PMID:18029348   PMID:18155754   PMID:18178560   PMID:18190237   PMID:18239673  
PMID:18264092   PMID:18273841   PMID:18331622   PMID:18340425   PMID:18411291   PMID:18482745   PMID:18554719   PMID:18662321   PMID:18816836   PMID:18941243   PMID:19000834   PMID:19135240  
PMID:19199708   PMID:19212831   PMID:19299420   PMID:19343720   PMID:19578160   PMID:19615732   PMID:19697319   PMID:19724918   PMID:19752220   PMID:19875450   PMID:19895174   PMID:19913121  
PMID:19946888   PMID:20000738   PMID:20029029   PMID:20111909   PMID:20159978   PMID:20176102   PMID:20195357   PMID:20232284   PMID:20237496   PMID:20300187   PMID:20348541   PMID:20351288  
PMID:20352117   PMID:20458337   PMID:20467437   PMID:20510162   PMID:20562859   PMID:20599762   PMID:20628086   PMID:20704820   PMID:20721957   PMID:20811636   PMID:20839070   PMID:20936779  
PMID:21081666   PMID:21145461   PMID:21208614   PMID:21319273   PMID:21343306   PMID:21423176   PMID:21472681   PMID:21559462   PMID:21565611   PMID:21626137   PMID:21630459   PMID:21637029  
PMID:21642380   PMID:21708117   PMID:21739154   PMID:21774995   PMID:21873635   PMID:21900206   PMID:21988832   PMID:21992474   PMID:21998592   PMID:22013210   PMID:22079093   PMID:22119785  
PMID:22174317   PMID:22190034   PMID:22245095   PMID:22268729   PMID:22270544   PMID:22304920   PMID:22363530   PMID:22519731   PMID:22532561   PMID:22554506   PMID:22653265   PMID:22672426  
PMID:22689054   PMID:22724016   PMID:22777994   PMID:22863883   PMID:22934019   PMID:22938940   PMID:22939629   PMID:23035116   PMID:23097496   PMID:23109341   PMID:23182705   PMID:23190606  
PMID:23208072   PMID:23266770   PMID:23349634   PMID:23428871   PMID:23431407   PMID:23503679   PMID:23589305   PMID:23658023   PMID:23686814   PMID:23703321   PMID:23755898   PMID:23798571  
PMID:23829397   PMID:23979707   PMID:23995768   PMID:24146856   PMID:24204260   PMID:24244333   PMID:24457600   PMID:24511009   PMID:24618592   PMID:24711643   PMID:24816397   PMID:24899641  
PMID:24981860   PMID:24999993   PMID:25027323   PMID:25147182   PMID:25192599   PMID:25315684   PMID:25361076   PMID:25437307   PMID:25470779   PMID:25496667   PMID:25637791   PMID:25660456  
PMID:25737303   PMID:25796446   PMID:25798051   PMID:25803899   PMID:25852190   PMID:25880332   PMID:25898135   PMID:25921289   PMID:25959826   PMID:25963833   PMID:25973087   PMID:26108996  
PMID:26115722   PMID:26167512   PMID:26217791   PMID:26235316   PMID:26318431   PMID:26339394   PMID:26344197   PMID:26464709   PMID:26493996   PMID:26496610   PMID:26497551   PMID:26499835  
PMID:26511642   PMID:26618866   PMID:26638075   PMID:26641092   PMID:26718209   PMID:26719248   PMID:26760575   PMID:26816005   PMID:26831064   PMID:26872972   PMID:26910913   PMID:26945068  
PMID:26949251   PMID:26982636   PMID:27025967   PMID:27034005   PMID:27046189   PMID:27183126   PMID:27248496   PMID:27249023   PMID:27342126   PMID:27375898   PMID:27433848   PMID:27462432  
PMID:27580824   PMID:27599983   PMID:27609421   PMID:27662661   PMID:27684187   PMID:27751915   PMID:27777122   PMID:27880917   PMID:28000571   PMID:28065597   PMID:28186131   PMID:28298427  
PMID:28302793   PMID:28347227   PMID:28352659   PMID:28366632   PMID:28514442   PMID:28515276   PMID:28533407   PMID:28581483   PMID:28706421   PMID:29128334   PMID:29180619   PMID:29212245  
PMID:29229926   PMID:29298432   PMID:29328381   PMID:29368272   PMID:29447283   PMID:29467282   PMID:29507755   PMID:29509190   PMID:29511261   PMID:29725069   PMID:29729432   PMID:29768689  
PMID:29777862   PMID:29791485   PMID:29845934   PMID:29852388   PMID:29872149   PMID:29979702   PMID:30021884   PMID:30097533   PMID:30188326   PMID:30196744   PMID:30455355   PMID:30463901  
PMID:30503554   PMID:30550567   PMID:30559450   PMID:30575818   PMID:30711629   PMID:30719181   PMID:30809309   PMID:30833792   PMID:30855574   PMID:30860673   PMID:30948266   PMID:31046837  
PMID:31056421   PMID:31091453   PMID:31180492   PMID:31239290   PMID:31300519   PMID:31332168   PMID:31395819   PMID:31405213   PMID:31409639   PMID:31484937   PMID:31501420   PMID:31534518  
PMID:31536960   PMID:31578452   PMID:31586073   PMID:31615303   PMID:31620119   PMID:31637425   PMID:31659016   PMID:31665637   PMID:31669268   PMID:31685992   PMID:31904996   PMID:31956271  
PMID:31970893   PMID:31973538   PMID:31980649   PMID:31995728   PMID:32129710   PMID:32149426   PMID:32296183   PMID:32347575   PMID:32409323   PMID:32423001   PMID:32457219   PMID:32513696  
PMID:32529326   PMID:32572027   PMID:32698014   PMID:32707033   PMID:32788342   PMID:32807901   PMID:32812023   PMID:32814053   PMID:32877691   PMID:32888949   PMID:32929329   PMID:32941674  
PMID:32963011   PMID:32994395   PMID:33022573   PMID:33111431   PMID:33145341   PMID:33194618   PMID:33211673   PMID:33239621   PMID:33542414   PMID:33545068   PMID:33567341   PMID:33633110  
PMID:33644029   PMID:33658012   PMID:33671632   PMID:33766124   PMID:33916271   PMID:33957083   PMID:33961781   PMID:33967600   PMID:34026424   PMID:34061598   PMID:34079125   PMID:34196494  
PMID:34208855   PMID:34225486   PMID:34244482   PMID:34373451   PMID:34428256   PMID:34449539   PMID:34597346   PMID:34635651   PMID:34644545   PMID:34687203   PMID:34702444   PMID:34709727  
PMID:34728620   PMID:34780058   PMID:35007762   PMID:35013218   PMID:35063084   PMID:35122331   PMID:35124280   PMID:35256949   PMID:35271311   PMID:35338135   PMID:35343654   PMID:35356984  
PMID:35384245   PMID:35446349   PMID:35509820   PMID:35530310   PMID:35545034   PMID:35546148   PMID:35563538   PMID:35658213   PMID:35676659   PMID:35677655   PMID:35681168   PMID:35687106  
PMID:35696571   PMID:35831314   PMID:35831895   PMID:35850772   PMID:35905823   PMID:35914814   PMID:35944360   PMID:36030824   PMID:36114006   PMID:36168627   PMID:36180527   PMID:36215168  
PMID:36217030   PMID:36229750   PMID:36273042   PMID:36291587   PMID:36339263   PMID:36348010   PMID:36424410   PMID:36517590   PMID:36526897   PMID:36574265   PMID:36584595   PMID:36610398  
PMID:36762613   PMID:36768601   PMID:36779763   PMID:36880596   PMID:37120454   PMID:37156452   PMID:37204028   PMID:37515378   PMID:37689310   PMID:37827155   PMID:37931956   PMID:37932427  
PMID:38113892   PMID:38243263   PMID:38297188  


Genomics

Comparative Map Data
HSP90B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812103,930,410 - 103,947,926 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12103,930,107 - 103,953,931 (+)EnsemblGRCh38hg38GRCh38
GRCh3712104,324,188 - 104,341,704 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612102,848,319 - 102,865,833 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412102,826,655 - 102,844,170NCBI
Celera12103,987,945 - 104,005,473 (+)NCBICelera
Cytogenetic Map12q23.3NCBI
HuRef12101,383,834 - 101,401,444 (+)NCBIHuRef
CHM1_112104,290,083 - 104,307,660 (+)NCBICHM1_1
T2T-CHM13v2.012103,892,110 - 103,909,638 (+)NCBIT2T-CHM13v2.0
Hsp90b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391086,526,705 - 86,541,308 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1086,526,073 - 86,541,373 (-)EnsemblGRCm39 Ensembl
GRCm381086,690,841 - 86,705,444 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1086,690,209 - 86,705,509 (-)EnsemblGRCm38mm10GRCm38
MGSCv371086,153,586 - 86,168,189 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361086,120,640 - 86,135,243 (-)NCBIMGSCv36mm8
Celera1088,669,594 - 88,684,200 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1043.05NCBI
Hsp90b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8722,997,962 - 23,012,293 (-)NCBIGRCr8
mRatBN7.2721,110,431 - 21,124,762 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl721,110,457 - 21,124,788 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx723,085,224 - 23,099,540 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0725,247,933 - 25,262,249 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0725,025,008 - 25,039,326 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0727,226,570 - 27,240,533 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl727,226,569 - 27,240,533 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0727,345,730 - 27,359,757 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4723,332,986 - 23,347,525 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1723,353,261 - 23,367,796 (-)NCBI
Celera718,290,242 - 18,304,551 (-)NCBICelera
Cytogenetic Map7q13NCBI
Hsp90b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540538,629,691 - 38,645,202 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540538,629,691 - 38,645,202 (+)NCBIChiLan1.0ChiLan1.0
HSP90B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210111,992,374 - 112,010,769 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112111,988,771 - 112,007,166 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012101,506,845 - 101,524,407 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112104,901,997 - 104,919,592 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12104,901,997 - 104,919,329 (+)Ensemblpanpan1.1panPan2
HSP90B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11542,456,793 - 42,474,122 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1542,456,764 - 42,579,311 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1542,826,278 - 42,843,622 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01543,114,295 - 43,131,887 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1543,114,231 - 43,235,108 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11542,380,743 - 42,398,025 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01542,479,226 - 42,496,568 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01542,750,406 - 42,767,726 (+)NCBIUU_Cfam_GSD_1.0
Hsp90b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494517,503,494 - 17,517,769 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649210,513,908 - 10,528,285 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649210,513,908 - 10,528,281 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSP90B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl580,511,506 - 80,530,991 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1580,511,513 - 80,531,016 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2584,016,174 - 84,083,931 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSP90B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11199,119,268 - 99,139,988 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1199,119,224 - 99,139,722 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037145,859,568 - 145,877,331 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hsp90b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247504,737,894 - 4,752,221 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247504,738,563 - 4,752,227 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HSP90B1
27 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12q23.1-23.3(chr12:100670616-108583607)x1 copy number loss See cases [RCV000051320] Chr12:100670616..108583607 [GRCh38]
Chr12:101064394..108977383 [GRCh37]
Chr12:99588525..107501512 [NCBI36]
Chr12:12q23.1-23.3
pathogenic
NM_003299.2(HSP90B1):c.1802G>A (p.Ser601Asn) single nucleotide variant Malignant melanoma [RCV000062380] Chr12:103943231 [GRCh38]
Chr12:104337009 [GRCh37]
Chr12:102861139 [NCBI36]
Chr12:12q23.3
not provided
GRCh38/hg38 12q23.3(chr12:103500125-104726872)x1 copy number loss See cases [RCV000138809] Chr12:103500125..104726872 [GRCh38]
Chr12:103893903..105120650 [GRCh37]
Chr12:102418033..103644780 [NCBI36]
Chr12:12q23.3
uncertain significance
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh38/hg38 12q21.33-24.11(chr12:91044318-109133210)x3 copy number gain See cases [RCV000142447] Chr12:91044318..109133210 [GRCh38]
Chr12:91438095..109571015 [GRCh37]
Chr12:89962226..108055398 [NCBI36]
Chr12:12q21.33-24.11
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic|likely pathogenic
GRCh37/hg19 12q23.1-23.3(chr12:100580198-105804075)x3 copy number gain See cases [RCV000445929] Chr12:100580198..105804075 [GRCh37]
Chr12:12q23.1-23.3
uncertain significance
GRCh37/hg19 12q23.2-24.11(chr12:103044333-111639805)x1 copy number loss See cases [RCV000445832] Chr12:103044333..111639805 [GRCh37]
Chr12:12q23.2-24.11
likely pathogenic
GRCh37/hg19 12q23.3(chr12:103967623-104456149)x3 copy number gain See cases [RCV000448958] Chr12:103967623..104456149 [GRCh37]
Chr12:12q23.3
likely benign
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
NM_003299.3(HSP90B1):c.2204A>G (p.Tyr735Cys) single nucleotide variant Inborn genetic diseases [RCV003282790] Chr12:103946883 [GRCh38]
Chr12:104340661 [GRCh37]
Chr12:12q23.3
uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12q23.2-23.3(chr12:102414522-105845768)x1 copy number loss not provided [RCV000846678] Chr12:102414522..105845768 [GRCh37]
Chr12:12q23.2-23.3
uncertain significance
NM_003299.3(HSP90B1):c.219G>A (p.Ser73=) single nucleotide variant not provided [RCV000886227] Chr12:103932343 [GRCh38]
Chr12:104326121 [GRCh37]
Chr12:12q23.3
benign
GRCh37/hg19 12q23.2-23.3(chr12:103588380-105161579)x3 copy number gain not provided [RCV002472838] Chr12:103588380..105161579 [GRCh37]
Chr12:12q23.2-23.3
uncertain significance
GRCh37/hg19 12q23.3-24.12(chr12:104230462-111984801)x1 copy number loss not provided [RCV001834231] Chr12:104230462..111984801 [GRCh37]
Chr12:12q23.3-24.12
pathogenic
NM_003299.3(HSP90B1):c.2139T>G (p.Leu713=) single nucleotide variant not provided [RCV001816122] Chr12:103946818 [GRCh38]
Chr12:104340596 [GRCh37]
Chr12:12q23.3
likely benign
GRCh37/hg19 12q23.2-24.11(chr12:103044333-111639805) copy number loss not specified [RCV002053016] Chr12:103044333..111639805 [GRCh37]
Chr12:12q23.2-24.11
likely pathogenic
GRCh37/hg19 12q23.1-23.3(chr12:100580198-105804075) copy number gain not specified [RCV002053014] Chr12:100580198..105804075 [GRCh37]
Chr12:12q23.1-23.3
uncertain significance
NM_003299.3(HSP90B1):c.1444G>T (p.Asp482Tyr) single nucleotide variant Inborn genetic diseases [RCV002902633] Chr12:103942596 [GRCh38]
Chr12:104336374 [GRCh37]
Chr12:12q23.3
uncertain significance
NM_003299.3(HSP90B1):c.370A>G (p.Asn124Asp) single nucleotide variant Inborn genetic diseases [RCV002793514] Chr12:103932901 [GRCh38]
Chr12:104326679 [GRCh37]
Chr12:12q23.3
uncertain significance
NM_003299.3(HSP90B1):c.1879C>T (p.Leu627Phe) single nucleotide variant Inborn genetic diseases [RCV002728473] Chr12:103943308 [GRCh38]
Chr12:104337086 [GRCh37]
Chr12:12q23.3
uncertain significance
NM_003299.3(HSP90B1):c.937G>A (p.Glu313Lys) single nucleotide variant Inborn genetic diseases [RCV002930353] Chr12:103938421 [GRCh38]
Chr12:104332199 [GRCh37]
Chr12:12q23.3
uncertain significance
NM_003299.3(HSP90B1):c.2099G>A (p.Arg700Gln) single nucleotide variant Inborn genetic diseases [RCV002644848] Chr12:103946689 [GRCh38]
Chr12:104340467 [GRCh37]
Chr12:12q23.3
uncertain significance
NM_003299.3(HSP90B1):c.16G>T (p.Val6Leu) single nucleotide variant Inborn genetic diseases [RCV002698429] Chr12:103930531 [GRCh38]
Chr12:104324309 [GRCh37]
Chr12:12q23.3
uncertain significance
NM_003299.3(HSP90B1):c.643C>T (p.His215Tyr) single nucleotide variant Inborn genetic diseases [RCV002960139] Chr12:103934187 [GRCh38]
Chr12:104327965 [GRCh37]
Chr12:12q23.3
uncertain significance
NM_003299.3(HSP90B1):c.802G>A (p.Val268Ile) single nucleotide variant Inborn genetic diseases [RCV002961385] Chr12:103937753 [GRCh38]
Chr12:104331531 [GRCh37]
Chr12:12q23.3
uncertain significance
NM_003299.3(HSP90B1):c.1397G>A (p.Arg466His) single nucleotide variant Inborn genetic diseases [RCV002807777] Chr12:103942549 [GRCh38]
Chr12:104336327 [GRCh37]
Chr12:12q23.3
uncertain significance
NM_003299.3(HSP90B1):c.1846G>C (p.Glu616Gln) single nucleotide variant Inborn genetic diseases [RCV002655608] Chr12:103943275 [GRCh38]
Chr12:104337053 [GRCh37]
Chr12:12q23.3
uncertain significance
NM_003299.3(HSP90B1):c.200G>A (p.Arg67Lys) single nucleotide variant Inborn genetic diseases [RCV003211014] Chr12:103932324 [GRCh38]
Chr12:104326102 [GRCh37]
Chr12:12q23.3
uncertain significance
NM_003299.3(HSP90B1):c.74T>C (p.Val25Ala) single nucleotide variant Inborn genetic diseases [RCV003214562] Chr12:103931545 [GRCh38]
Chr12:104325323 [GRCh37]
Chr12:12q23.3
uncertain significance
NM_003299.3(HSP90B1):c.767C>T (p.Ser256Phe) single nucleotide variant Inborn genetic diseases [RCV003209852] Chr12:103937718 [GRCh38]
Chr12:104331496 [GRCh37]
Chr12:12q23.3
uncertain significance
NM_003299.3(HSP90B1):c.1195G>A (p.Asp399Asn) single nucleotide variant Inborn genetic diseases [RCV003266103] Chr12:103941512 [GRCh38]
Chr12:104335290 [GRCh37]
Chr12:12q23.3
uncertain significance
NM_003299.3(HSP90B1):c.177T>G (p.Asp59Glu) single nucleotide variant Inborn genetic diseases [RCV003355306] Chr12:103932301 [GRCh38]
Chr12:104326079 [GRCh37]
Chr12:12q23.3
uncertain significance
NM_003299.3(HSP90B1):c.511A>G (p.Thr171Ala) single nucleotide variant Inborn genetic diseases [RCV003386756] Chr12:103934055 [GRCh38]
Chr12:104327833 [GRCh37]
Chr12:12q23.3
uncertain significance
GRCh37/hg19 12q23.3(chr12:104255219-104417352)x1 copy number loss not provided [RCV003483170] Chr12:104255219..104417352 [GRCh37]
Chr12:12q23.3
uncertain significance
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR223hsa-miR-223-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23208072
MIR223hsa-miR-223-3pOncomiRDBexternal_infoNANA23208072

Predicted Target Of
Summary Value
Count of predictions:1061
Count of miRNA genes:653
Interacting mature miRNAs:736
Transcripts:ENST00000299767, ENST00000540297, ENST00000548462, ENST00000548622, ENST00000549334, ENST00000550479, ENST00000550595, ENST00000551983, ENST00000552051
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH67937  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371599,798,433 - 99,798,560UniSTSGRCh37
GRCh3712104,327,930 - 104,328,057UniSTSGRCh37
Build 3612102,852,060 - 102,852,187RGDNCBI36
Celera1576,217,405 - 76,217,532UniSTS
Celera12103,991,686 - 103,991,813RGD
Cytogenetic Map12q24.2-q24.3UniSTS
Cytogenetic Map15q26.3UniSTS
HuRef1575,927,993 - 75,928,120UniSTS
HuRef12101,387,652 - 101,387,779UniSTS
GDB:384824  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712104,323,734 - 104,323,977UniSTSGRCh37
Build 3612102,847,864 - 102,848,107RGDNCBI36
Celera12103,987,490 - 103,987,733RGD
Cytogenetic Map12q23.3UniSTS
Cytogenetic Map12q24.2-q24.3UniSTS
HuRef12101,383,456 - 101,383,699UniSTS
STS-H99801  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371599,799,106 - 99,799,340UniSTSGRCh37
GRCh3712104,335,463 - 104,336,451UniSTSGRCh37
Build 361597,616,629 - 97,616,863RGDNCBI36
Celera12103,999,235 - 104,000,221UniSTS
Celera1576,218,078 - 76,218,312RGD
Cytogenetic Map12q24.2-q24.3UniSTS
Cytogenetic Map15q26.3UniSTS
HuRef1575,928,666 - 75,928,900UniSTS
HuRef12101,395,201 - 101,396,187UniSTS
GeneMap99-GB4 RH Map15346.39UniSTS
TRA1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712104,336,867 - 104,337,062UniSTSGRCh37
GRCh371599,799,479 - 99,799,674UniSTSGRCh37
Build 3612102,860,997 - 102,861,192RGDNCBI36
Celera1576,218,451 - 76,218,646UniSTS
Celera12104,000,637 - 104,000,832UniSTS
Celera190,355,583 - 90,355,778RGD
HuRef1575,929,039 - 75,929,234UniSTS
HuRef12101,396,603 - 101,396,798UniSTS
HuRef190,227,537 - 90,227,732UniSTS
SHGC-12717  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712104,341,451 - 104,341,678UniSTSGRCh37
Build 3612102,865,581 - 102,865,808RGDNCBI36
Celera12104,005,221 - 104,005,448RGD
Cytogenetic Map12q24.2-q24.3UniSTS
HuRef12101,401,187 - 101,401,414UniSTS
Whitehead-YAC Contig Map15 UniSTS
RH17893  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712104,337,341 - 104,337,481UniSTSGRCh37
Build 3612102,861,471 - 102,861,611RGDNCBI36
Celera12104,001,111 - 104,001,251RGD
Cytogenetic Map12q24.2-q24.3UniSTS
HuRef12101,397,077 - 101,397,217UniSTS
GeneMap99-GB4 RH Map12409.83UniSTS
NCBI RH Map12689.3UniSTS
WI-15169  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712104,340,335 - 104,340,460UniSTSGRCh37
Build 3612102,864,465 - 102,864,590RGDNCBI36
Celera12104,004,105 - 104,004,230RGD
Cytogenetic Map12q24.2-q24.3UniSTS
HuRef12101,400,071 - 101,400,196UniSTS
GeneMap99-GB4 RH Map12409.52UniSTS
Whitehead-RH Map12501.5UniSTS
NCBI RH Map12689.3UniSTS
STS-X15187  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371599,800,106 - 99,800,315UniSTSGRCh37
GRCh3712104,341,110 - 104,341,531UniSTSGRCh37
Build 3612102,865,240 - 102,865,661RGDNCBI36
Celera12104,004,880 - 104,005,301RGD
Celera1576,219,078 - 76,219,287UniSTS
Cytogenetic Map15q26.3UniSTS
Cytogenetic Map12q24.2-q24.3UniSTS
HuRef1575,929,666 - 75,929,875UniSTS
HuRef12101,400,846 - 101,401,267UniSTS
GeneMap99-GB4 RH Map15352.9UniSTS
NCBI RH Map15733.7UniSTS
MARC_26038-26039:1032450563:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371599,798,061 - 99,798,210UniSTSGRCh37
GRCh3712104,326,128 - 104,326,694UniSTSGRCh37
Build 361597,615,584 - 97,615,733RGDNCBI36
Celera12103,989,884 - 103,990,450UniSTS
Celera1576,217,033 - 76,217,182RGD
HuRef1575,927,621 - 75,927,770UniSTS
HuRef12101,385,850 - 101,386,416UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 76 187 553 52 130 51 116 26 55 33 162 606 3 56 34 1
Medium 2356 2795 1171 570 1816 413 4239 2166 3654 385 1288 1003 168 1148 2754 3
Low 7 9 2 2 5 1 2 5 25 1 10 4 4 1 2 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_003299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB209534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC078819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF087988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH007363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ890084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK025459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK025862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY040226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA419931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS288589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU794608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ460515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ900941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M33716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X15187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000299767   ⟹   ENSP00000299767
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,410 - 103,947,926 (+)Ensembl
RefSeq Acc Id: ENST00000540297   ⟹   ENSP00000446266
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,363 - 103,936,519 (+)Ensembl
RefSeq Acc Id: ENST00000548462
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,438 - 103,947,927 (+)Ensembl
RefSeq Acc Id: ENST00000548622
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,382 - 103,932,176 (+)Ensembl
RefSeq Acc Id: ENST00000549334   ⟹   ENSP00000446748
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,107 - 103,932,929 (+)Ensembl
RefSeq Acc Id: ENST00000550479
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,938,238 - 103,941,768 (+)Ensembl
RefSeq Acc Id: ENST00000550595   ⟹   ENSP00000450215
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,332 - 103,953,931 (+)Ensembl
RefSeq Acc Id: ENST00000551983
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,941,834 - 103,943,467 (+)Ensembl
RefSeq Acc Id: ENST00000552051
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,941,753 - 103,947,726 (+)Ensembl
RefSeq Acc Id: ENST00000614327   ⟹   ENSP00000477660
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,358 - 103,947,858 (+)Ensembl
RefSeq Acc Id: ENST00000640977   ⟹   ENSP00000492386
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,363 - 103,938,535 (+)Ensembl
RefSeq Acc Id: ENST00000679377
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,383 - 103,936,616 (+)Ensembl
RefSeq Acc Id: ENST00000679538   ⟹   ENSP00000505687
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,411 - 103,947,922 (+)Ensembl
RefSeq Acc Id: ENST00000679779
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,358 - 103,947,922 (+)Ensembl
RefSeq Acc Id: ENST00000679861   ⟹   ENSP00000505440
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,684 - 103,947,922 (+)Ensembl
RefSeq Acc Id: ENST00000680242
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,432 - 103,936,426 (+)Ensembl
RefSeq Acc Id: ENST00000680281
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,358 - 103,947,922 (+)Ensembl
RefSeq Acc Id: ENST00000680316   ⟹   ENSP00000505046
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,600 - 103,947,922 (+)Ensembl
RefSeq Acc Id: ENST00000680370   ⟹   ENSP00000506084
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,410 - 103,947,922 (+)Ensembl
RefSeq Acc Id: ENST00000680391   ⟹   ENSP00000506292
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,351 - 103,948,015 (+)Ensembl
RefSeq Acc Id: ENST00000680478
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,941,753 - 103,947,912 (+)Ensembl
RefSeq Acc Id: ENST00000680653
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,356 - 103,947,922 (+)Ensembl
RefSeq Acc Id: ENST00000680663   ⟹   ENSP00000505000
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,363 - 103,947,922 (+)Ensembl
RefSeq Acc Id: ENST00000680762   ⟹   ENSP00000506150
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,358 - 103,947,379 (+)Ensembl
RefSeq Acc Id: ENST00000680899   ⟹   ENSP00000506602
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,351 - 103,948,136 (+)Ensembl
RefSeq Acc Id: ENST00000680989
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,358 - 103,947,912 (+)Ensembl
RefSeq Acc Id: ENST00000681172   ⟹   ENSP00000505280
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,363 - 103,947,922 (+)Ensembl
RefSeq Acc Id: ENST00000681174   ⟹   ENSP00000506032
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,410 - 103,947,922 (+)Ensembl
RefSeq Acc Id: ENST00000681245
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,936,677 - 103,947,922 (+)Ensembl
RefSeq Acc Id: ENST00000681698   ⟹   ENSP00000504931
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,413 - 103,947,922 (+)Ensembl
RefSeq Acc Id: ENST00000681704
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,383 - 103,947,912 (+)Ensembl
RefSeq Acc Id: ENST00000681861   ⟹   ENSP00000506419
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,332 - 103,947,695 (+)Ensembl
RefSeq Acc Id: ENST00000681910
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,383 - 103,947,922 (+)Ensembl
RefSeq Acc Id: ENST00000681941   ⟹   ENSP00000505039
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,376 - 103,947,922 (+)Ensembl
RefSeq Acc Id: ENST00000681949   ⟹   ENSP00000504951
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12103,930,358 - 103,947,912 (+)Ensembl
RefSeq Acc Id: NM_003299   ⟹   NP_003290
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812103,930,410 - 103,947,926 (+)NCBI
GRCh3712104,324,112 - 104,341,708 (+)NCBI
Build 3612102,848,319 - 102,865,833 (+)NCBI Archive
HuRef12101,383,834 - 101,401,444 (+)NCBI
CHM1_112104,290,083 - 104,307,660 (+)NCBI
T2T-CHM13v2.012103,892,110 - 103,909,638 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_003290 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA58621 (Get FASTA)   NCBI Sequence Viewer  
  AAA68201 (Get FASTA)   NCBI Sequence Viewer  
  AAD14161 (Get FASTA)   NCBI Sequence Viewer  
  AAH09195 (Get FASTA)   NCBI Sequence Viewer  
  AAH66656 (Get FASTA)   NCBI Sequence Viewer  
  AAK74072 (Get FASTA)   NCBI Sequence Viewer  
  ACJ13662 (Get FASTA)   NCBI Sequence Viewer  
  ACS44652 (Get FASTA)   NCBI Sequence Viewer  
  ADO22458 (Get FASTA)   NCBI Sequence Viewer  
  BAD92771 (Get FASTA)   NCBI Sequence Viewer  
  BAG58251 (Get FASTA)   NCBI Sequence Viewer  
  BAG61085 (Get FASTA)   NCBI Sequence Viewer  
  BAG62233 (Get FASTA)   NCBI Sequence Viewer  
  CAA33261 (Get FASTA)   NCBI Sequence Viewer  
  CAI64497 (Get FASTA)   NCBI Sequence Viewer  
  CAK18765 (Get FASTA)   NCBI Sequence Viewer  
  EAW97723 (Get FASTA)   NCBI Sequence Viewer  
  EAW97724 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000299767
  ENSP00000299767.4
  ENSP00000446748.1
  ENSP00000450215.2
  ENSP00000477660.2
  ENSP00000504931.1
  ENSP00000504951.1
  ENSP00000505000.1
  ENSP00000505039.1
  ENSP00000505046.1
  ENSP00000505280.1
  ENSP00000505440.1
  ENSP00000505687.1
  ENSP00000506032.1
  ENSP00000506084.1
  ENSP00000506150.1
  ENSP00000506292.1
  ENSP00000506419.1
  ENSP00000506602.1
GenBank Protein P14625 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_003290   ⟸   NM_003299
- Peptide Label: precursor
- UniProtKB: Q96A97 (UniProtKB/Swiss-Prot),   P14625 (UniProtKB/Swiss-Prot),   V9HWP2 (UniProtKB/TrEMBL),   Q5CAQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000446748   ⟸   ENST00000549334
RefSeq Acc Id: ENSP00000299767   ⟸   ENST00000299767
RefSeq Acc Id: ENSP00000477660   ⟸   ENST00000614327
RefSeq Acc Id: ENSP00000492386   ⟸   ENST00000640977
RefSeq Acc Id: ENSP00000450215   ⟸   ENST00000550595
RefSeq Acc Id: ENSP00000446266   ⟸   ENST00000540297
RefSeq Acc Id: ENSP00000506602   ⟸   ENST00000680899
RefSeq Acc Id: ENSP00000505280   ⟸   ENST00000681172
RefSeq Acc Id: ENSP00000506292   ⟸   ENST00000680391
RefSeq Acc Id: ENSP00000505046   ⟸   ENST00000680316
RefSeq Acc Id: ENSP00000505687   ⟸   ENST00000679538
RefSeq Acc Id: ENSP00000504951   ⟸   ENST00000681949
RefSeq Acc Id: ENSP00000506032   ⟸   ENST00000681174
RefSeq Acc Id: ENSP00000505000   ⟸   ENST00000680663
RefSeq Acc Id: ENSP00000504931   ⟸   ENST00000681698
RefSeq Acc Id: ENSP00000505440   ⟸   ENST00000679861
RefSeq Acc Id: ENSP00000506084   ⟸   ENST00000680370
RefSeq Acc Id: ENSP00000506150   ⟸   ENST00000680762
RefSeq Acc Id: ENSP00000506419   ⟸   ENST00000681861
RefSeq Acc Id: ENSP00000505039   ⟸   ENST00000681941
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14625-F1-model_v2 AlphaFold P14625 1-803 view protein structure

Promoters
RGD ID:6790213
Promoter ID:HG_KWN:16498
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000299767,   NR_027249,   UC001TJZ.2,   UC009ZUH.1,   UC009ZUI.1
Position:
Human AssemblyChrPosition (strand)Source
Build 3612102,846,911 - 102,848,452 (-)MPROMDB
RGD ID:6853488
Promoter ID:EP74570
Type:initiation region
Name:HS_TRA1
Description:Tumor rejection antigen (gp96) 1.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 3612102,848,318 - 102,848,378EPD
RGD ID:6810295
Promoter ID:HG_ACW:18540
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:HSP90B1.GAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 3612102,850,089 - 102,850,589 (+)MPROMDB
RGD ID:6810292
Promoter ID:HG_ACW:18541
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:HSP90B1.CAPR07,   HSP90B1.HAPR07-UNSPLICED
Position:
Human AssemblyChrPosition (strand)Source
Build 3612102,851,741 - 102,852,241 (+)MPROMDB
RGD ID:6810298
Promoter ID:HG_ACW:18542
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:HSP90B1.IAPR07-UNSPLICED
Position:
Human AssemblyChrPosition (strand)Source
Build 3612102,852,174 - 102,852,674 (+)MPROMDB
RGD ID:7225219
Promoter ID:EPDNEW_H18355
Type:initiation region
Name:HSP90B1_1
Description:heat shock protein 90 beta family member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812103,930,410 - 103,930,470EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:12028 AgrOrtholog
COSMIC HSP90B1 COSMIC
Ensembl Genes ENSG00000166598 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000299767 ENTREZGENE
  ENST00000299767.10 UniProtKB/Swiss-Prot
  ENST00000549334.5 UniProtKB/TrEMBL
  ENST00000550595.2 UniProtKB/TrEMBL
  ENST00000614327.2 UniProtKB/TrEMBL
  ENST00000679538.1 UniProtKB/TrEMBL
  ENST00000679861.1 UniProtKB/TrEMBL
  ENST00000680316.1 UniProtKB/TrEMBL
  ENST00000680370.1 UniProtKB/TrEMBL
  ENST00000680391.1 UniProtKB/TrEMBL
  ENST00000680663.1 UniProtKB/TrEMBL
  ENST00000680762.1 UniProtKB/TrEMBL
  ENST00000680899.1 UniProtKB/TrEMBL
  ENST00000681172.1 UniProtKB/TrEMBL
  ENST00000681174.1 UniProtKB/TrEMBL
  ENST00000681698.1 UniProtKB/TrEMBL
  ENST00000681861.1 UniProtKB/TrEMBL
  ENST00000681941.1 UniProtKB/TrEMBL
  ENST00000681949.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.790 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.230.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.11260 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000166598 GTEx
HGNC ID HGNC:12028 ENTREZGENE
Human Proteome Map HSP90B1 Human Proteome Map
InterPro HATPase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HATPase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heat_shock_protein_90_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP90_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp90_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp90_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:7184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 7184 ENTREZGENE
OMIM 191175 OMIM
PANTHER ENDOPLASMIN UniProtKB/Swiss-Prot
  ENDOPLASMIN UniProtKB/TrEMBL
  ENDOPLASMIN UniProtKB/TrEMBL
  PTHR11528 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HATPase_c_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA36705 PharmGKB
PIRSF Hsp90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS HEATSHOCK90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ER_TARGET UniProtKB/Swiss-Prot
  HSP90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HATPase_c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF110942 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54211 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55874 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WT78_HUMAN UniProtKB/TrEMBL
  A0A7P0T823_HUMAN UniProtKB/TrEMBL
  A0A7P0T885_HUMAN UniProtKB/TrEMBL
  A0A7P0T8C8_HUMAN UniProtKB/TrEMBL
  A0A7P0T8R3_HUMAN UniProtKB/TrEMBL
  A0A7P0T917_HUMAN UniProtKB/TrEMBL
  A0A7P0TAC2_HUMAN UniProtKB/TrEMBL
  A0A7P0TAE1_HUMAN UniProtKB/TrEMBL
  A0A7P0TAG4_HUMAN UniProtKB/TrEMBL
  A0A7P0TAT8_HUMAN UniProtKB/TrEMBL
  A0A7P0TAY2_HUMAN UniProtKB/TrEMBL
  A0A7P0TBC2_HUMAN UniProtKB/TrEMBL
  A0A7P0Z405_HUMAN UniProtKB/TrEMBL
  A0A7P0Z4B4_HUMAN UniProtKB/TrEMBL
  ENPL_HUMAN UniProtKB/Swiss-Prot
  F8W026_HUMAN UniProtKB/TrEMBL
  H0YIV0_HUMAN UniProtKB/TrEMBL
  P14625 ENTREZGENE
  Q5CAQ5 ENTREZGENE, UniProtKB/TrEMBL
  Q96A97 ENTREZGENE
  Q96GW1_HUMAN UniProtKB/TrEMBL
  V9HWP2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q96A97 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-28 HSP90B1  heat shock protein 90 beta family member 1    heat shock protein 90kDa beta family member 1  Symbol and/or name change 5135510 APPROVED
2015-11-24 HSP90B1  heat shock protein 90kDa beta family member 1    heat shock protein 90kDa beta (Grp94), member 1  Symbol and/or name change 5135510 APPROVED