Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:type 2 diabetes mellitus pathway
go back to main search page
Accession:PW:0000208 term browser browse the term
Definition:Diabetes mellitus is characterized by abnormally high levels of glucose in the blood. Hereditary and environmental factors are likely contributors but the exact mechanisms are not well understood. Type 2 diabetes mellitus, characterized by insulin resistance, involves alterations in insulin secretion and signaling and impaired glucose homeostasis pathways.
Synonyms:exact_synonym: NIDDM pathway;   T2D pathway;   non-insulin-dependent diabetes mellitus pathway
 related_synonym: KEGG:04930;   type II diabetes mellitus pathway
View Interactive Diagram


show annotations for term's descendants           Sort by:
type 2 diabetes mellitus pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC8 ATP binding cassette subfamily C member 8 IMP
IEA		 DNA:missense mutation::A1369S KEGG
RGD		 PMID:17259403 hsa:04930, RGD:2313628 NCBI chr11:17,392,498...17,476,845
Ensembl chr11:17,392,498...17,476,894 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing IEA KEGG hsa:04930 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G AKT2 AKT serine/threonine kinase 2 IMP RGD PMID:15166380 RGD:2313408 NCBI chr19:40,230,317...40,285,345
Ensembl chr19:40,230,317...40,285,536 		JBrowse link
G CACNA1A calcium voltage-gated channel subunit alpha1 A IEA KEGG hsa:04930 NCBI chr19:13,206,442...13,506,479
Ensembl chr19:13,206,442...13,624,489 		JBrowse link
G CACNA1B calcium voltage-gated channel subunit alpha1 B IEA KEGG hsa:04930 NCBI chr 9:137,877,782...138,124,619
Ensembl chr 9:137,877,782...138,124,624 		JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C IEA KEGG hsa:04930 NCBI chr12:1,970,780...2,697,950
Ensembl chr12:1,970,772...2,697,950 		JBrowse link
G CACNA1D calcium voltage-gated channel subunit alpha1 D IEA KEGG hsa:04930 NCBI chr 3:53,494,611...53,813,733
Ensembl chr 3:53,328,963...53,813,733 		JBrowse link
G CACNA1E calcium voltage-gated channel subunit alpha1 E IEA KEGG hsa:04930 NCBI chr 1:181,317,699...181,808,084
Ensembl chr 1:181,317,690...181,813,262 		JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G IEA KEGG hsa:04930 NCBI chr17:50,560,715...50,627,474
Ensembl chr17:50,560,715...50,627,474 		JBrowse link
G GCK glucokinase IEA KEGG hsa:04930 NCBI chr 7:44,143,213...44,189,439
Ensembl chr 7:44,143,213...44,198,170 		JBrowse link
G HK1 hexokinase 1 IEA KEGG hsa:04930 NCBI chr10:69,270,000...69,401,882
Ensembl chr10:69,269,984...69,401,884 		JBrowse link
G HK2 hexokinase 2 IEA KEGG hsa:04930 NCBI chr 2:74,834,127...74,893,359
Ensembl chr 2:74,834,127...74,893,359 		JBrowse link
G HK3 hexokinase 3 IEA KEGG hsa:04930 NCBI chr 5:176,880,869...176,899,346
Ensembl chr 5:176,880,869...176,899,346 		JBrowse link
G HKDC1 hexokinase domain containing 1 IEA KEGG hsa:04930 NCBI chr10:69,220,332...69,267,552
Ensembl chr10:69,220,332...69,267,552 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta IEA KEGG hsa:04930 NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460 		JBrowse link
G INS insulin TAS
IEA		 KEGG
RGD		 PMID:9809695 hsa:04930, RGD:2313694 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221 		JBrowse link
G INSR insulin receptor TAS
IEA		 KEGG
RGD		 PMID:9809695 hsa:04930, RGD:2313694 NCBI chr19:7,112,265...7,294,414
Ensembl chr19:7,112,255...7,294,414 		JBrowse link
G IRS1 insulin receptor substrate 1 IEA KEGG hsa:04930 NCBI chr 2:226,731,312...226,799,820
Ensembl chr 2:226,731,312...226,799,820 		JBrowse link
G IRS2 insulin receptor substrate 2 IEA KEGG hsa:04930 NCBI chr13:109,752,695...109,786,583
Ensembl chr13:109,752,695...109,786,583 		JBrowse link
G IRS4 insulin receptor substrate 4 IEA KEGG hsa:04930 NCBI chr  X:108,719,946...108,736,563
Ensembl chr  X:108,719,946...108,736,563 		JBrowse link
G KCNJ11 potassium inwardly rectifying channel subfamily J member 11 TAS
IEA
IMP		 polymorphisms in the gene are linked to altered insulin secretion; E23K polymorphism appears to confer susceptibility to diabetes type-2 in Caucasian population
DNA:missense mutation::p.E23K (human)		 KEGG
RGD		 PMID:15565284 PMID:17259403 hsa:04930, RGD:2313610, RGD:2313628 NCBI chr11:17,385,248...17,389,346
Ensembl chr11:17,365,172...17,389,331 		JBrowse link
G MAFA MAF bZIP transcription factor A IEA KEGG hsa:04930 NCBI chr 8:143,428,064...143,430,732
Ensembl chr 8:143,419,182...143,430,732 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 IEA KEGG hsa:04930 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK10 mitogen-activated protein kinase 10 IEA KEGG hsa:04930 NCBI chr 4:86,010,405...86,594,074
Ensembl chr 4:85,990,007...86,594,625 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 IEA KEGG hsa:04930 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 IEA KEGG hsa:04930 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 IEA KEGG hsa:04930 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099 		JBrowse link
G MTOR mechanistic target of rapamycin kinase IEA KEGG hsa:04930 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556 		JBrowse link
G PDX1 pancreatic and duodenal homeobox 1 IEA KEGG hsa:04930 NCBI chr13:27,920,000...27,926,313
Ensembl chr13:27,920,000...27,926,313 		JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha IEA KEGG hsa:04930 NCBI chr 3:179,148,126...179,240,093
Ensembl chr 3:179,148,114...179,240,093 		JBrowse link
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta IEA KEGG hsa:04930 NCBI chr 3:138,652,698...138,834,928
Ensembl chr 3:138,652,698...138,834,928 		JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta IEA KEGG hsa:04930 NCBI chr 1:9,627,258...9,729,114
Ensembl chr 1:9,629,889...9,729,114 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma IEA KEGG hsa:04930 NCBI chr 7:106,865,282...106,908,980
Ensembl chr 7:106,865,278...106,908,980 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 IEA KEGG hsa:04930 NCBI chr 5:68,215,756...68,301,821
Ensembl chr 5:68,215,740...68,301,821 		JBrowse link
G PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 IEA KEGG hsa:04930 NCBI chr19:18,153,163...18,170,532
Ensembl chr19:18,153,163...18,170,532 		JBrowse link
G PIK3R3 phosphoinositide-3-kinase regulatory subunit 3 IEA KEGG hsa:04930 NCBI chr 1:46,040,140...46,174,901
Ensembl chr 1:46,040,140...46,133,036 		JBrowse link
G PIK3R5 phosphoinositide-3-kinase regulatory subunit 5 IEA KEGG hsa:04930 NCBI chr17:8,878,916...8,965,707
Ensembl chr17:8,878,911...8,965,712 		JBrowse link
G PKLR pyruvate kinase L/R IEA KEGG hsa:04930 NCBI chr 1:155,289,293...155,308,654
Ensembl chr 1:155,289,293...155,301,438 		JBrowse link
G PRKCD protein kinase C delta IEA KEGG hsa:04930 NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717 		JBrowse link
G PRKCE protein kinase C epsilon IEA KEGG hsa:04930 NCBI chr 2:45,651,279...46,187,990
Ensembl chr 2:45,651,345...46,187,990 		JBrowse link
G PRKCZ protein kinase C zeta IEA KEGG hsa:04930 NCBI chr 1:2,048,504...2,185,395
Ensembl chr 1:2,050,411...2,185,395 		JBrowse link
G SLC2A2 solute carrier family 2 member 2 IEA KEGG hsa:04930 NCBI chr 3:170,996,347...171,026,720
Ensembl chr 3:170,996,347...171,026,743 		JBrowse link
G SLC2A4 solute carrier family 2 member 4 IEA KEGG hsa:04930 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257 		JBrowse link
G SOCS1 suppressor of cytokine signaling 1 IEA KEGG hsa:04930 NCBI chr16:11,254,417...11,256,204
Ensembl chr16:11,254,417...11,256,204 		JBrowse link
G SOCS2 suppressor of cytokine signaling 2 IEA KEGG hsa:04930 NCBI chr12:93,569,969...93,626,236
Ensembl chr12:93,569,814...93,583,487 		JBrowse link
G SOCS3 suppressor of cytokine signaling 3 IEA KEGG hsa:04930 NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077 		JBrowse link
G SOCS4 suppressor of cytokine signaling 4 IEA KEGG hsa:04930 NCBI chr14:55,027,236...55,049,489
Ensembl chr14:55,027,230...55,049,489 		JBrowse link
G TNF tumor necrosis factor IEA KEGG hsa:04930 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5958
    disease pathway 2076
      cardiovascular system disease pathway 237
        metabolic syndrome X pathway 49
          type 2 diabetes mellitus pathway 48
Path 2
Term Annotations click to browse term
  pathway 5958
    disease pathway 2076
      nutritional and metabolic disease pathway 694
        metabolic disease pathway 650
          glucose metabolism disease pathway 126
            diabetes mellitus pathway 112
              type 2 diabetes mellitus pathway 48
paths to the root