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Gene: CACNA1E (calcium voltage-gated channel subunit alpha1 E) Homo sapiens
Symbol: CACNA1E
Name: calcium voltage-gated channel subunit alpha1 E
Description: Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BII; brain calcium channel II; CACH6; CACNL1A6; calcium channel, L type, alpha-1 polypeptide, isoform 6; calcium channel, R type, alpha-1 polypeptide, isoform 6; calcium channel, voltage-dependent, alpha 1E subunit; calcium channel, voltage-dependent, l type, alpha 1e subunit; calcium channel, voltage-dependent, R type, alpha 1E subunit; calcium voltage-gated channel subunit alpha1 subunit E; Cav2.3; EIEE69; gm139; voltage-dependent calcium channel alpha 1E subunit; voltage-dependent R-type calcium channel subunit alpha-1E; voltage-gated calcium channel alpha 1E subunit; voltage-gated calcium channel alpha subunit Cav2.3; voltage-gated calcium channel subunit alpha Cav2.3
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381181,317,712 - 181,808,084 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371181,452,447 - 181,775,920 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361179,719,339 - 180,037,339 (+)NCBINCBI36hg18NCBI36
Build 341178,184,372 - 178,502,370NCBI
Celera1154,559,815 - 154,877,831 (+)NCBI
Cytogenetic Map1q25.3NCBI
HuRef1152,684,592 - 153,007,527 (+)NCBIHuRef
CHM1_11182,875,471 - 183,198,679 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CACNA1E
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733702
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.