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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:interleukin-1-mediated signaling pathway
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Accession:GO:0070498 term browser browse the term
Definition:The series of molecular signals initiated by interleukin-1 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: IL-1-mediated signaling pathway;   interleukin-1-mediated signalling pathway
 narrow_synonym: IL-1 alpha-mediated signaling pathway;   IL-1 beta-mediated signaling pathway;   interleukin-1 alpha-mediated signaling pathway;   interleukin-1 beta-mediated signaling pathway


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interleukin-1-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egr1 early growth response 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037 		JBrowse link
G Ikbkb inhibitor of kappaB kinase beta involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605 		JBrowse link
G Il1b interleukin 1 beta involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il1r1 interleukin 1 receptor, type I involved_in IDA
IBA
ISO		 (MGI:1889886|PMID:10854325) UniProt
GO_Central
MGI
RGD		 PMID:10854325 PMID:20967881 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:1889886 MGI:4417868 MGI:4834177 RGD:5130945 NCBI chr 1:40,261,651...40,355,361
Ensembl chr 1:40,264,240...40,356,417 		JBrowse link
G Il1rap interleukin 1 receptor accessory protein involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr16:26,400,259...26,548,878
Ensembl chr16:26,400,454...26,548,867 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 NOT|involved_in
acts_upstream_of_or_within		 ISO
IBA
IDA		 (PMID:11397809)
(PMID:12054681)
(MGI:1889886|PMID:10854325)		 UniProt
GO_Central
MGI
UniProt		 PMID:10854325 PMID:11397809 PMID:12054681 GO_REF:0000033 GO_REF:0000119 MGI:1889886 MGI:4834177 NCBI chr  X:73,057,520...73,067,527
Ensembl chr  X:73,057,520...73,067,524 		JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 6:113,615,428...113,671,987
Ensembl chr 6:113,615,428...113,671,987 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 involved_in
acts_upstream_of_or_within		 ISO
IDA
IBA		 (PMID:12054681) MGI
GO_Central		 PMID:12054681 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr10:119,977,553...120,038,035
Ensembl chr10:119,977,553...120,038,035 		JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr15:94,441,495...94,466,198
Ensembl chr15:94,441,524...94,479,696 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mir146 microRNA 146 involved_in ISO (PMID:20937840) ARUK-UCL PMID:20937840 NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288 		JBrowse link
G Myd88 myeloid differentiation primary response gene 88 involved_in IDA
ISO		 (MGI:1889886|PMID:10854325) UniProt
MGI		 PMID:10854325 GO_REF:0000119 MGI:1889886 MGI:4834177 NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Plcb1 phospholipase C, beta 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:134,628,084...135,317,178
Ensembl chr 2:134,627,987...135,317,178 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Rps6ka4 ribosomal protein S6 kinase, polypeptide 4 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr19:6,806,573...6,819,513
Ensembl chr19:6,806,578...6,818,004 		JBrowse link
G Rps6ka5 ribosomal protein S6 kinase, polypeptide 5 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr12:100,514,692...100,691,693
Ensembl chr12:100,514,698...100,693,242 		JBrowse link
G St18 suppression of tumorigenicity 18 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:6,557,455...6,931,164
Ensembl chr 1:6,557,455...6,931,164 		JBrowse link
G Tirap toll-interleukin 1 receptor (TIR) domain-containing adaptor protein NOT|involved_in IDA
NAS		 (MGI:2149909|PMID:11544529)
(MGI:3531416|PMID:12447442)		 BHF-UCL PMID:11544529 PMID:12447442 MGI:2149909 MGI:3531416 NCBI chr 9:35,095,687...35,111,587
Ensembl chr 9:35,095,847...35,111,587 		JBrowse link
G Tnip2 TNFAIP3 interacting protein 2 involved_in IMP (MGI:3656197|PMID:16633345) UniProt PMID:16633345 MGI:3656197 NCBI chr 5:34,653,440...34,671,323
Ensembl chr 5:34,653,431...34,671,335 		JBrowse link
G Tollip toll interacting protein involved_in IDA
ISO		 (MGI:1889886|PMID:10854325) UniProt
MGI		 PMID:10854325 GO_REF:0000119 MGI:1889886 MGI:4834177 NCBI chr 7:141,435,317...141,456,198
Ensembl chr 7:141,428,550...141,472,244 		JBrowse link
G Traf6 TNF receptor-associated factor 6 involved_in IMP
ISO		 (MGI:2181820|PMID:10421844) UniProt
MGI
RGD		 PMID:10421844 PMID:20967881 GO_REF:0000096 MGI:2181820 MGI:4417868 RGD:5130945 NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014 		JBrowse link
negative regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1r2 interleukin 1 receptor, type II acts_upstream_of_or_within IPI (PMID:23395675) MGI PMID:23395675 NCBI chr 1:40,123,872...40,164,390
Ensembl chr 1:40,113,239...40,164,391 		JBrowse link
G Il1rn interleukin 1 receptor antagonist involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506 		JBrowse link
G Il6 interleukin 6 involved_in IMP (MGI:5795829|PMID:11159963) BHF-UCL PMID:11159963 MGI:5795829 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Mir21a microRNA 21a acts_upstream_of_or_within ISO (PMID:25327529) BHF-UCL PMID:25327529 NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984 		JBrowse link
G Mir27a microRNA 27a involved_in ISO (PMID:25327529) BHF-UCL PMID:25327529 NCBI chr 8:84,935,301...84,935,387
Ensembl chr 8:84,935,301...84,935,387 		JBrowse link
G Otud4 OTU domain containing 4 involved_in IDA
IBA
ISO		 (MGI:6120140|PMID:29395066) UniProt
GO_Central
MGI		 PMID:29395066 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:6120140 NCBI chr 8:80,366,305...80,404,384
Ensembl chr 8:80,366,247...80,404,353 		JBrowse link
positive regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1r1 interleukin 1 receptor, type I acts_upstream_of_or_within IMP (PMID:23395675) MGI PMID:23395675 NCBI chr 1:40,261,651...40,355,361
Ensembl chr 1:40,264,240...40,356,417 		JBrowse link
regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vrk2 vaccinia related kinase 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:26,421,398...26,544,006
Ensembl chr11:26,421,322...26,543,999 		JBrowse link
G Zbp1 Z-DNA binding protein 1 involved_in IMP (MGI:6394181|PMID:31630209) UniProt PMID:31630209 MGI:6394181 NCBI chr 2:173,048,405...173,060,715
Ensembl chr 2:173,048,405...173,060,716 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    cellular process 17546
      signal transduction 6676
        cell surface receptor signaling pathway 2922
          cytokine-mediated signaling pathway 513
            interleukin-1-mediated signaling pathway 31
              negative regulation of interleukin-1-mediated signaling pathway 6
              positive regulation of interleukin-1-mediated signaling pathway 1
              regulation of interleukin-1-mediated signaling pathway + 9
Path 2
Term Annotations click to browse term
  biological_process 28573
    response to stimulus 10772
      response to chemical 5404
        response to organic substance 3914
          response to cytokine 1355
            cellular response to cytokine stimulus 1206
              cytokine-mediated signaling pathway 513
                interleukin-1-mediated signaling pathway 31
                  negative regulation of interleukin-1-mediated signaling pathway 6
                  positive regulation of interleukin-1-mediated signaling pathway 1
                  regulation of interleukin-1-mediated signaling pathway + 9
paths to the root