Tirap (toll-interleukin 1 receptor (TIR) domain-containing adaptor protein) - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Tirap (toll-interleukin 1 receptor (TIR) domain-containing adaptor protein) Mus musculus
Analyze
Symbol: Tirap
Name: toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
RGD ID: 1322403
MGI Page MGI
Description: Enables Toll-like receptor 2 binding activity; identical protein binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including positive regulation of B cell proliferation; positive regulation of NF-kappaB transcription factor activity; and regulation of cytokine production. Acts upstream of or within several processes, including I-kappaB kinase/NF-kappaB signaling; positive regulation of macrophage cytokine production; and response to bacterium. Located in endocytic vesicle and ruffle membrane. Is expressed in testis. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human TIRAP (TIR domain containing adaptor protein).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AA407980; adaptor protein Wyatt; C130027E04Rik; M; Mal; myD88 adapter-like protein; MyD88-adapter-like; TIR domain-containing adapter protein; Tlr4ap; Toll-like receptor 4 adaptor protein; toll/interleukin-1 receptor domain-containing adapter protein; wyat; Wyatt
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39935,095,687 - 35,111,587 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl935,095,847 - 35,111,587 (-)EnsemblGRCm39 Ensembl
GRCm38935,184,391 - 35,200,291 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl935,184,551 - 35,200,291 (-)EnsemblGRCm38mm10GRCm38
MGSCv37934,991,976 - 35,007,876 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36934,936,435 - 34,949,545 (-)NCBIMGSCv36mm8
Celera932,421,410 - 32,437,270 (-)NCBICelera
Cytogenetic Map9A4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
3'-UTR-mediated mRNA stabilization  (ISO)
activation of NF-kappaB-inducing kinase activity  (ISO)
cell surface receptor signaling pathway  (IPI,ISO)
cellular response to bacterial lipopeptide  (IMP)
cellular response to lipoteichoic acid  (IMP)
defense response to Gram-positive bacterium  (IMP)
I-kappaB kinase/NF-kappaB signaling  (IBA,IMP,ISO)
immune system process  (IEA)
inflammatory response  (IEA)
innate immune response  (IEA)
interleukin-1-mediated signaling pathway  (IDA,NAS)
myeloid cell differentiation  (IMP)
positive regulation of B cell proliferation  (IMP)
positive regulation of chemokine (C-X-C motif) ligand 1 production  (IMP)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (IBA,IMP)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IBA,ISO)
positive regulation of innate immune response  (IBA,IMP)
positive regulation of interleukin-12 production  (IMP)
positive regulation of interleukin-15 production  (ISO)
positive regulation of interleukin-6 production  (IDA,IMP,ISO)
positive regulation of interleukin-8 production  (IMP,ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of JUN kinase activity  (ISO)
positive regulation of macrophage cytokine production  (IMP)
positive regulation of neutrophil chemotaxis  (IMP)
positive regulation of NF-kappaB transcription factor activity  (IMP,ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of toll-like receptor 2 signaling pathway  (ISO)
positive regulation of toll-like receptor 3 signaling pathway  (IDA)
positive regulation of toll-like receptor 4 signaling pathway  (ISO)
positive regulation of tumor necrosis factor production  (IMP,ISO)
regulation of innate immune response  (NAS)
regulation of interferon-beta production  (IDA)
regulation of interleukin-15 production  (IMP)
regulation of stress-activated MAPK cascade  (IBA)
response to bacterium  (ISO)
response to lipopolysaccharide  (ISO)
signal transduction  (IEA)
TIRAP-dependent toll-like receptor 4 signaling pathway  (ISO)
toll-like receptor 4 signaling pathway  (ISO)
toll-like receptor 5 signaling pathway  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11526399   PMID:11544529   PMID:11923871   PMID:12072368   PMID:12421970   PMID:12447441   PMID:12447442  
PMID:12477932   PMID:12565889   PMID:14517278   PMID:14610273   PMID:14630816   PMID:14698224   PMID:15489334   PMID:15690042   PMID:15860593   PMID:16116224   PMID:16141072   PMID:16141073  
PMID:16210631   PMID:16236128   PMID:16301656   PMID:16415872   PMID:16461338   PMID:16751103   PMID:16785551   PMID:16832055   PMID:16886064   PMID:16980352   PMID:16980981   PMID:16983331  
PMID:17049055   PMID:17082602   PMID:17202370   PMID:17292937   PMID:17322885   PMID:17339472   PMID:17360653   PMID:17456769   PMID:17490432   PMID:17579078   PMID:17617611   PMID:17617634  
PMID:17916774   PMID:18039275   PMID:18287559   PMID:18292575   PMID:18295350   PMID:18297073   PMID:18492657   PMID:18583567   PMID:19009526   PMID:19296467   PMID:19378012   PMID:19454663  
PMID:19570822   PMID:19574958   PMID:19592497   PMID:19675137   PMID:19717524   PMID:19825525   PMID:19889726   PMID:19930040   PMID:20061547   PMID:20351694   PMID:20451243   PMID:20519121  
PMID:20617171   PMID:20802145   PMID:20826748   PMID:20957750   PMID:21057511   PMID:21098227   PMID:21148800   PMID:21267068   PMID:21303924   PMID:21308778   PMID:21398616   PMID:21430222  
PMID:21480215   PMID:21873635   PMID:21966468   PMID:22073274   PMID:22187460   PMID:22497726   PMID:22896628   PMID:23033384   PMID:23038756   PMID:23238562   PMID:23297396   PMID:23417039  
PMID:23612054   PMID:23728346   PMID:24012421   PMID:24035364   PMID:24084649   PMID:24391503   PMID:24478078   PMID:24529375   PMID:24603458   PMID:25515629   PMID:26095366   PMID:26885859  
PMID:26888676   PMID:27061018   PMID:27509078   PMID:27646001   PMID:27995997   PMID:28235196   PMID:28528205   PMID:30108181   PMID:30332431   PMID:31729371   PMID:31851971   PMID:31852751  
PMID:32220799   PMID:32325033   PMID:32554809   PMID:32698010   PMID:32839504   PMID:35089323   PMID:36792369   PMID:36888688  


Genomics

Comparative Map Data
Tirap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39935,095,687 - 35,111,587 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl935,095,847 - 35,111,587 (-)EnsemblGRCm39 Ensembl
GRCm38935,184,391 - 35,200,291 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl935,184,551 - 35,200,291 (-)EnsemblGRCm38mm10GRCm38
MGSCv37934,991,976 - 35,007,876 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36934,936,435 - 34,949,545 (-)NCBIMGSCv36mm8
Celera932,421,410 - 32,437,270 (-)NCBICelera
Cytogenetic Map9A4NCBI
TIRAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811126,283,093 - 126,294,933 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl11126,282,497 - 126,298,845 (+)EnsemblGRCh38hg38GRCh38
GRCh3711126,152,988 - 126,164,828 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611125,658,192 - 125,670,038 (+)NCBINCBI36Build 36hg18NCBI36
Celera11123,318,165 - 123,330,030 (+)NCBICelera
Cytogenetic Map11q24.2NCBI
HuRef11122,098,046 - 122,109,916 (+)NCBIHuRef
CHM1_111126,039,258 - 126,051,104 (+)NCBICHM1_1
T2T-CHM13v2.011126,314,493 - 126,326,362 (+)NCBIT2T-CHM13v2.0
Tirap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2833,531,724 - 33,548,508 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl833,531,725 - 33,547,432 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0836,382,029 - 36,399,625 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl836,385,353 - 36,388,224 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0836,400,673 - 36,406,908 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4834,966,856 - 34,969,727 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera834,950,692 - 34,968,852 (-)NCBICelera
Cytogenetic Map8q21NCBI
Tirap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541227,312,489 - 27,315,031 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541227,303,548 - 27,315,031 (+)NCBIChiLan1.0ChiLan1.0
TIRAP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111125,018,064 - 125,022,309 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11125,018,064 - 125,022,309 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011121,100,558 - 121,112,844 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TIRAP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.158,222,217 - 8,237,595 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl58,221,794 - 8,226,074 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha58,275,792 - 8,300,808 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.058,170,182 - 8,195,206 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl58,176,896 - 8,181,685 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.158,239,756 - 8,264,804 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.058,213,520 - 8,238,550 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.058,247,729 - 8,272,742 (-)NCBIUU_Cfam_GSD_1.0
Tirap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947108,511,610 - 108,526,005 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365725,924,158 - 5,938,658 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365725,926,193 - 5,938,621 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIRAP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl953,375,644 - 53,394,165 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1953,374,559 - 53,394,172 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2959,036,463 - 59,057,589 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TIRAP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11117,417,561 - 117,419,870 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660438,650,207 - 8,662,061 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tirap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624812439,319 - 446,646 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624812433,540 - 445,517 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2396
Count of miRNA genes:759
Interacting mature miRNAs:949
Transcripts:ENSMUST00000175765, ENSMUST00000176021, ENSMUST00000176531, ENSMUST00000176611, ENSMUST00000176685, ENSMUST00000177052, ENSMUST00000177129
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300849Sles4_msystemic lupus erythmatosus suppressor 4 (mouse)Not determined9910756237306370Mouse
13504833Bglu19_mblood glucose level 19 (mouse)9991076843910768Mouse
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91236997046370114Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91339117547391175Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91541175149411890Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91541175149411890Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91541175149411890Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91541175149411890Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91574962749749627Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91574962749749627Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91574962749749627Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91601129650011296Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91601129650011296Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91670964150709641Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91697884050978943Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined91994340653943525Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse
14700787Ncdq1_mnevus cell density QTL 1 (mouse)92811129636111296Mouse
1301000Obq5_mobesity QTL 5 (mouse)Not determined92850333341799326Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1558949Igan3_mIgA nephropathy 3 (mouse)Not determined93041469440565914Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
4142455Elnv_mepilepsy naive (mouse)Not determined93127155837306370Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
1357682Phdlc1_mplasma HDL cholesterol 1 (mouse)Not determined93410461942764866Mouse
1300868Tlf_mT lymphocyte fraction (mouse)Not determined93483774837306370Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse

Markers in Region
RH124653  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38935,184,593 - 35,184,839UniSTSGRCm38
GRCm385109,409,295 - 109,409,539UniSTSGRCm38
MGSCv37934,992,178 - 34,992,424UniSTSGRCm37
MGSCv375109,838,314 - 109,838,558UniSTSGRCm37
Celera932,421,613 - 32,421,859UniSTS
Cytogenetic Map9A5.3UniSTS
D10Mit157.2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6D1UniSTS
Cytogenetic Map16B4UniSTS
Cytogenetic Map18E2UniSTS
Cytogenetic Map4C3UniSTS
Cytogenetic Map7B2UniSTS
Cytogenetic Map4D2.3UniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map14E2.2UniSTS
Cytogenetic Map4C7UniSTS
Cytogenetic Map2H4UniSTS
Cytogenetic Map1FUniSTS
Cytogenetic Map6C3UniSTS
Cytogenetic Map11DUniSTS
Cytogenetic Map3G2UniSTS
Cytogenetic Map17A1UniSTS
Cytogenetic Map9F2UniSTS
Cytogenetic Map12F1UniSTS
Cytogenetic Map19C2UniSTS
Cytogenetic Map3BUniSTS
Cytogenetic Map8C1UniSTS
Cytogenetic Map18A2UniSTS
Cytogenetic Map3F2UniSTS
Cytogenetic Map14C3UniSTS
Cytogenetic Map8E1UniSTS
Cytogenetic Map8E2UniSTS
Cytogenetic Map5B1UniSTS
Cytogenetic Map18B1UniSTS
Cytogenetic Map9CUniSTS
Cytogenetic Map14C2UniSTS
Cytogenetic Map6A1UniSTS
Cytogenetic Map10B4UniSTS
Cytogenetic Map13D2.1UniSTS
Cytogenetic Map5E5UniSTS
Cytogenetic Map11B1.3UniSTS
Cytogenetic Map4D1UniSTS
Cytogenetic Map9A5.2UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map17E3UniSTS
Cytogenetic Map11B3UniSTS
Cytogenetic Map1H4UniSTS
Cytogenetic Map6A3UniSTS
Cytogenetic Map5E4-E5UniSTS
Cytogenetic Map15E1UniSTS
Cytogenetic Map13DUniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map14D1UniSTS
Cytogenetic Map7B4UniSTS
Cytogenetic Map8D3UniSTS
Cytogenetic MapXDUniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map7E2UniSTS
Cytogenetic Map1H2.3UniSTS
Cytogenetic Map7A2UniSTS
Cytogenetic Map7F3UniSTS
Cytogenetic Map9F1UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map4E2UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic Map8B3.3UniSTS
Cytogenetic Map8D2UniSTS
Cytogenetic Map3DUniSTS
Cytogenetic Map15D2UniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map7A3UniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map16B2UniSTS
Cytogenetic Map7CUniSTS
Cytogenetic Map3F2.1UniSTS
Cytogenetic Map6F3UniSTS
Cytogenetic Map1C4UniSTS
Cytogenetic Map11E2UniSTS
Cytogenetic Map11B5UniSTS
Cytogenetic Map9F3UniSTS
Cytogenetic Map2BUniSTS
Cytogenetic Map13B3UniSTS
Cytogenetic Map9A4UniSTS
Cytogenetic Map5A3UniSTS
Cytogenetic Map2H1UniSTS
Cytogenetic Map16B1UniSTS
Cytogenetic Map1A5UniSTS
Cytogenetic Map11CUniSTS
Cytogenetic Map9E1UniSTS
Cytogenetic Map6G1UniSTS
Cytogenetic MapXA2UniSTS
Cytogenetic Map13B1UniSTS
Cytogenetic Map5E2UniSTS
Cytogenetic Map12C1UniSTS
Cytogenetic Map5FUniSTS
Cytogenetic Map4D3UniSTS
Cytogenetic Map10C2UniSTS
Cytogenetic Map9BUniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map7F1UniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map10A4UniSTS
Cytogenetic Map8A2UniSTS
Cytogenetic Map18A1UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map1C2UniSTS
Cytogenetic Map11B2UniSTS
Cytogenetic Map6E3UniSTS
Cytogenetic Map5C3.3UniSTS
Cytogenetic Map1BUniSTS
Cytogenetic Map17A3.1UniSTS
Cytogenetic Map7A1UniSTS
Cytogenetic Map2E5UniSTS
Cytogenetic Map11A1UniSTS
Cytogenetic Map4B1UniSTS
Cytogenetic Map15A2UniSTS
Cytogenetic Map8C3UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map5G3UniSTS
Cytogenetic Map4A3UniSTS
Cytogenetic Map2H3UniSTS
Cytogenetic Map8A1UniSTS
Cytogenetic Map8A1.1UniSTS
Cytogenetic Map16A3UniSTS
Cytogenetic Map10B1UniSTS
Cytogenetic Map19AUniSTS
Cytogenetic Map10A1UniSTS
Cytogenetic Map13D1UniSTS
Cytogenetic Map4A1UniSTS
Cytogenetic Map9A3UniSTS
Cytogenetic Map17CUniSTS
Cytogenetic Map1DUniSTS
Cytogenetic Map5E3UniSTS
Cytogenetic Map15D3UniSTS
Cytogenetic Map2H2UniSTS
Cytogenetic Map7D3UniSTS
Cytogenetic Map2A1UniSTS
Cytogenetic Map14C1UniSTS
Cytogenetic Map14E5UniSTS
Cytogenetic Map10CUniSTS
Cytogenetic Map18B2UniSTS
Cytogenetic Map2F1UniSTS
Cytogenetic Map10D3UniSTS
Cytogenetic Map17A2UniSTS
Cytogenetic Map2C3UniSTS
Cytogenetic Map1C3UniSTS
Cytogenetic Map17B2UniSTS
Cytogenetic Map5B2UniSTS
Cytogenetic Map5G1UniSTS
Cytogenetic Map4C6UniSTS
Cytogenetic Map13C3UniSTS
Cytogenetic Map2E1UniSTS
Cytogenetic Map17A3.2-A3.3UniSTS
Cytogenetic Map19C3UniSTS
Cytogenetic Map7E3UniSTS
Cytogenetic Map13C1UniSTS
Cytogenetic Map9E3.1UniSTS
Cytogenetic Map15E3UniSTS
Cytogenetic Map6B1UniSTS
Cytogenetic MapXE3UniSTS
Cytogenetic Map4C4UniSTS
Cytogenetic Map3E3UniSTS
Cytogenetic Map11A4UniSTS
Cytogenetic Map4C5UniSTS
Cytogenetic Map18B3UniSTS
Cytogenetic Map9A2UniSTS
Cytogenetic Map7E1UniSTS
Cytogenetic Map5D-E1UniSTS
Cytogenetic Map5B3UniSTS
Cytogenetic Map13A2-A3UniSTS
Cytogenetic Map5A2UniSTS
Cytogenetic Map4B3UniSTS
Cytogenetic Map1E4UniSTS
Cytogenetic Map17E4UniSTS
Cytogenetic Map1G2UniSTS
Cytogenetic Map15B3.1UniSTS
Cytogenetic Map12EUniSTS
Cytogenetic MapXA5UniSTS
Cytogenetic Map6A3.3UniSTS
Cytogenetic Map6G3UniSTS
Cytogenetic Map6F2UniSTS
Cytogenetic Map5C1UniSTS
Cytogenetic Map4D2.1UniSTS
Cytogenetic Map4A5UniSTS
Cytogenetic Map3F2.2UniSTS
Cytogenetic Map1E3-E4UniSTS
Cytogenetic Map9F1-F3UniSTS
Cytogenetic Map1C1.1UniSTS
Cytogenetic Map14D2UniSTS
Cytogenetic Map12A2UniSTS
Cytogenetic Map17A3-BUniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map14A3UniSTS
Cytogenetic Map5G1.1UniSTS
Cytogenetic MapXF2-F4UniSTS
Cytogenetic Map7D2UniSTS
Cytogenetic Map2F3UniSTS
Cytogenetic Map10A3UniSTS
Cytogenetic MapXA7.3UniSTS
Cytogenetic Map9F1-F2UniSTS
Cytogenetic Map13A3.2UniSTS
Cytogenetic Map10A2UniSTS
Cytogenetic Map1C1UniSTS
Cytogenetic Map1A1UniSTS
Cytogenetic Map12D3UniSTS
Cytogenetic Map1A3-A5UniSTS
Cytogenetic Map2A2UniSTS
Cytogenetic Map3A1UniSTS
Cytogenetic MapXA3.3UniSTS
Cytogenetic Map16A-B1UniSTS
Cytogenetic Map1D2.3UniSTS
Cytogenetic Map6B2.3UniSTS
Cytogenetic Map2G3UniSTS
Cytogenetic MapXA2-A3.1UniSTS
Cytogenetic Map9A5.3UniSTS
Cytogenetic Map14A2-BUniSTS
Cytogenetic Map8E1-E2UniSTS
Cytogenetic Map8A3UniSTS
Cytogenetic Map1G3-H1UniSTS
Cytogenetic Map8B3-C1UniSTS
Cytogenetic Map19C1UniSTS
Cytogenetic Map8C5UniSTS
Cytogenetic Map8A4UniSTS
Cytogenetic Map15F3UniSTS
Cytogenetic Map14E4UniSTS
Cytogenetic Map4D2.2UniSTS
Cytogenetic MapXF5UniSTS
cM Map1040.0UniSTS
Whitehead Genetic1033.9UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001177845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001177846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001177847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_054096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030244028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC140448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF378130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF410784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK036431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY507516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY740695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY743490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000175765   ⟹   ENSMUSP00000135435
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl935,095,847 - 35,111,587 (-)Ensembl
GRCm38.p6 Ensembl935,184,551 - 35,200,291 (-)Ensembl
RefSeq Acc Id: ENSMUST00000176021   ⟹   ENSMUSP00000135738
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl935,100,025 - 35,111,179 (-)Ensembl
GRCm38.p6 Ensembl935,188,729 - 35,199,883 (-)Ensembl
RefSeq Acc Id: ENSMUST00000176531   ⟹   ENSMUSP00000135224
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl935,098,081 - 35,111,224 (-)Ensembl
GRCm38.p6 Ensembl935,186,785 - 35,199,928 (-)Ensembl
RefSeq Acc Id: ENSMUST00000176611   ⟹   ENSMUSP00000134984
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl935,100,322 - 35,102,696 (-)Ensembl
GRCm38.p6 Ensembl935,189,026 - 35,191,400 (-)Ensembl
RefSeq Acc Id: ENSMUST00000176685   ⟹   ENSMUSP00000135876
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl935,098,640 - 35,111,266 (-)Ensembl
GRCm38.p6 Ensembl935,187,344 - 35,199,970 (-)Ensembl
RefSeq Acc Id: ENSMUST00000177052   ⟹   ENSMUSP00000135429
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl935,102,333 - 35,110,795 (-)Ensembl
GRCm38.p6 Ensembl935,191,037 - 35,199,499 (-)Ensembl
RefSeq Acc Id: ENSMUST00000177129   ⟹   ENSMUSP00000135462
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl935,098,081 - 35,111,284 (-)Ensembl
GRCm38.p6 Ensembl935,186,785 - 35,199,988 (-)Ensembl
RefSeq Acc Id: NM_001177845   ⟹   NP_001171316
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39935,095,687 - 35,111,587 (-)NCBI
GRCm38935,184,391 - 35,200,291 (-)ENTREZGENE
MGSCv37934,991,976 - 35,007,876 (-)RGD
Celera932,421,410 - 32,437,270 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001177846   ⟹   NP_001171317
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39935,095,687 - 35,111,261 (-)NCBI
GRCm38935,184,391 - 35,199,965 (-)NCBI
MGSCv37934,991,976 - 35,007,876 (-)RGD
Celera932,421,410 - 32,437,270 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001177847   ⟹   NP_001171318
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39935,095,687 - 35,111,201 (-)NCBI
GRCm38935,184,391 - 35,199,905 (-)NCBI
MGSCv37934,991,976 - 35,007,876 (-)RGD
Celera932,421,410 - 32,437,270 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_054096   ⟹   NP_473437
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39935,095,687 - 35,111,261 (-)NCBI
GRCm38935,184,391 - 35,199,965 (-)NCBI
MGSCv37934,991,976 - 35,007,876 (-)RGD
Celera932,421,410 - 32,437,270 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030244028   ⟹   XP_030099888
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39935,095,693 - 35,111,240 (-)NCBI
GRCm38935,184,397 - 35,199,938 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_473437   ⟸   NM_054096
- UniProtKB: Q99JY1 (UniProtKB/Swiss-Prot),   H3BKL1 (UniProtKB/TrEMBL),   Q542S6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001171316   ⟸   NM_001177845
- UniProtKB: H3BKL1 (UniProtKB/TrEMBL),   Q542S6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001171317   ⟸   NM_001177846
- UniProtKB: H3BKL1 (UniProtKB/TrEMBL),   Q542S6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001171318   ⟸   NM_001177847
- UniProtKB: H3BKL1 (UniProtKB/TrEMBL),   Q3UB38 (UniProtKB/TrEMBL),   Q542S6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030099888   ⟸   XM_030244028
- Peptide Label: isoform X1
- UniProtKB: H3BKL1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000135429   ⟸   ENSMUST00000177052
RefSeq Acc Id: ENSMUSP00000135462   ⟸   ENSMUST00000177129
RefSeq Acc Id: ENSMUSP00000135224   ⟸   ENSMUST00000176531
RefSeq Acc Id: ENSMUSP00000135876   ⟸   ENSMUST00000176685
RefSeq Acc Id: ENSMUSP00000134984   ⟸   ENSMUST00000176611
RefSeq Acc Id: ENSMUSP00000135738   ⟸   ENSMUST00000176021
RefSeq Acc Id: ENSMUSP00000135435   ⟸   ENSMUST00000175765
Protein Domains
TIR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99JY1-F1-model_v2 AlphaFold Q99JY1 1-241 view protein structure

Promoters
RGD ID:6845272
Promoter ID:MM_KWN:56781
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000093872,   OTTMUST00000078233,   UC009OSR.1,   UC009OSS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36935,006,821 - 35,007,842 (-)MPROMDB
RGD ID:8669150
Promoter ID:EPDNEW_M12606
Type:initiation region
Name:Tirap_1
Description:Mus musculus toll-interleukin 1 receptor domain-containing adaptorprotein , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38935,199,899 - 35,199,959EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2152213 AgrOrtholog
Ensembl Genes ENSMUSG00000032041 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000134984.2 UniProtKB/TrEMBL
  ENSMUSP00000135224 ENTREZGENE
  ENSMUSP00000135224.2 UniProtKB/TrEMBL
  ENSMUSP00000135429.2 UniProtKB/TrEMBL
  ENSMUSP00000135435 ENTREZGENE
  ENSMUSP00000135435.2 UniProtKB/TrEMBL
  ENSMUSP00000135462 ENTREZGENE
  ENSMUSP00000135462.2 UniProtKB/TrEMBL
  ENSMUSP00000135738.2 UniProtKB/TrEMBL
  ENSMUSP00000135876 ENTREZGENE
  ENSMUSP00000135876.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000175765 ENTREZGENE
  ENSMUST00000175765.8 UniProtKB/TrEMBL
  ENSMUST00000176021.8 UniProtKB/TrEMBL
  ENSMUST00000176531 ENTREZGENE
  ENSMUST00000176531.8 UniProtKB/TrEMBL
  ENSMUST00000176611.2 UniProtKB/TrEMBL
  ENSMUST00000176685 ENTREZGENE
  ENSMUST00000176685.8 UniProtKB/TrEMBL
  ENSMUST00000177052.2 UniProtKB/TrEMBL
  ENSMUST00000177129 ENTREZGENE
  ENSMUST00000177129.8 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro TIR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tol-interleuk_rcpt_adapt_Tirap UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:117149 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2152213 ENTREZGENE
NCBI Gene 117149 ENTREZGENE
PANTHER PTHR22662 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TOLL/INTERLEUKIN-1 RECEPTOR DOMAIN-CONTAINING ADAPTER PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TIR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tirap PhenoGen
PIRSF TIR_Tirap UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt H3BJH1_MOUSE UniProtKB/TrEMBL
  H3BKK6_MOUSE UniProtKB/TrEMBL
  H3BKL1 ENTREZGENE, UniProtKB/TrEMBL
  H3BLC8_MOUSE UniProtKB/TrEMBL
  Q3UB38 ENTREZGENE, UniProtKB/TrEMBL
  Q542S6 ENTREZGENE, UniProtKB/TrEMBL
  Q99JY1 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q91ZW0 UniProtKB/Swiss-Prot