Mir27a (microRNA 27a) - Rat Genome Database

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Gene: Mir27a (microRNA 27a) Mus musculus
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Symbol: Mir27a
Name: microRNA 27a
RGD ID: 1607666
MGI Page MGI
Description: Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; cellular response to phenylalanine; and retina vasculature development in camera-type eye. Part of RISC complex and RISC-loading complex. Is expressed in bone; embryo; heart; limb; and long bone. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MIR27A (microRNA 27a).
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: Mir; mir-27a; Mirn27a; mmu-mir-; mmu-mir-27a
RGD Orthologs
Human
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,935,301 - 84,935,387 (+)NCBIGRCm39mm39
GRCm39 Ensembl884,935,301 - 84,935,387 (+)Ensembl
GRCm38884,208,672 - 84,208,758 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,208,672 - 84,208,758 (+)EnsemblGRCm38mm10GRCm38
MGSCv37886,732,571 - 86,732,657 (+)NCBIGRCm37mm9NCBIm37
Celera888,508,778 - 88,508,864 (+)NCBICelera
Cytogenetic Map8C2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:12007417   PMID:12554860   PMID:12919684   PMID:15538371   PMID:16369549   PMID:16381832   PMID:17369397   PMID:17604727   PMID:18762567   PMID:19878148   PMID:20060380   PMID:20215419  
PMID:20413612   PMID:20417623   PMID:20439489   PMID:20980664   PMID:21037258   PMID:21149577   PMID:21267068   PMID:21536891   PMID:21749861   PMID:22184245   PMID:22346748   PMID:22415194  
PMID:22503104   PMID:22564414   PMID:22640741   PMID:23034448   PMID:23322776   PMID:23637774   PMID:24049083   PMID:24123794   PMID:24218084   PMID:24244514   PMID:24457907   PMID:24487055  
PMID:24498167   PMID:24651435   PMID:24835395   PMID:25043848   PMID:25050919   PMID:25057207   PMID:25166914   PMID:25519956   PMID:25751060   PMID:26006230   PMID:26107383   PMID:26540574  
PMID:26709778   PMID:26822703   PMID:26834155   PMID:26850657   PMID:27142530   PMID:27554624   PMID:27612006   PMID:27636893   PMID:28365247   PMID:28400445   PMID:29089199   PMID:29101357  
PMID:29476741   PMID:29721071   PMID:30145824   PMID:30231673   PMID:30242124   PMID:30272823   PMID:30327467   PMID:30535438   PMID:30664207   PMID:30802823   PMID:31298345   PMID:31518965  
PMID:31526292   PMID:32071155   PMID:32084559   PMID:32317602   PMID:32502201   PMID:32546573   PMID:32691413   PMID:32705283   PMID:32896839   PMID:33875617   PMID:34107258  


Genomics

Comparative Map Data
Mir27a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,935,301 - 84,935,387 (+)NCBIGRCm39mm39
GRCm39 Ensembl884,935,301 - 84,935,387 (+)Ensembl
GRCm38884,208,672 - 84,208,758 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,208,672 - 84,208,758 (+)EnsemblGRCm38mm10GRCm38
MGSCv37886,732,571 - 86,732,657 (+)NCBIGRCm37mm9NCBIm37
Celera888,508,778 - 88,508,864 (+)NCBICelera
Cytogenetic Map8C2NCBI
MIR27A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1913,836,440 - 13,836,517 (-)EnsemblGRCh38hg38GRCh38
GRCh381913,836,440 - 13,836,517 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371913,947,254 - 13,947,331 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361913,808,253 - 13,808,330 (-)NCBINCBI36hg18NCBI36
Celera1913,841,002 - 13,841,079 (-)NCBI
Cytogenetic Map19p13.12NCBI
HuRef1913,518,822 - 13,518,899 (-)NCBIHuRef
CHM1_11913,947,759 - 13,947,836 (-)NCBICHM1_1
Mir27a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21923,954,831 - 23,954,917 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1923,954,831 - 23,954,917 (-)Ensembl
Rnor_6.01925,318,736 - 25,318,822 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,318,736 - 25,318,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,294,924 - 36,295,010 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1923,503,679 - 23,503,765 (-)NCBICelera
Cytogenetic Map19q11NCBI
MIR27A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12048,620,556 - 48,620,615 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2048,620,556 - 48,620,615 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2048,494,476 - 48,494,535 (+)NCBI
ROS_Cfam_1.02049,138,667 - 49,138,726 (+)NCBI
UMICH_Zoey_3.12048,349,144 - 48,349,203 (+)NCBI
UNSW_CanFamBas_1.02048,776,060 - 48,776,119 (+)NCBI
UU_Cfam_GSD_1.02049,019,128 - 49,019,187 (+)NCBI
MIR27A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl265,308,294 - 65,308,375 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1265,308,294 - 65,308,375 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,582,015 - 65,582,096 (+)NCBISscrofa10.2Sscrofa10.2susScr3


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
12904012Cfq10_mconditioned fear QTL 10 (mouse)88006677589014359Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881092664115092664Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)881619151115619151Mouse

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Runx1mmu-miR-27a-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19114653
Runx1mmu-miR-27a-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI19298589
Ppargmmu-miR-27a-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20060380
Odc1mmu-miR-27a-3pMirtarbaseexternal_infoGFP reporter assay//Immunocytochemistry//MicroarraFunctional MTI19878148
Runx1mmu-miR-27a-3pTarbaseexternal_infoReporter GenePOSITIVE
Runx1mmu-miR-27a-3pTarbaseexternal_infoWesternblitPOSITIVE
Fbxw7mmu-miR-27a-3pOncomiRDBexternal_infoNANA22628407
Dpydmmu-miR-27a-3pOncomiRDBexternal_infoNANA22306127
Cyp1a2mmu-miR-27a-3pOncomiRDBexternal_infoNANA22018270
Ccnd1mmu-miR-27a-3pOncomiRDBexternal_infoNANA21569481
Fbxw7mmu-miR-27a-3pOncomiRDBexternal_infoNANA21460851
Spry2mmu-miR-27a-3pOncomiRDBexternal_infoNANA20638779
Foxo1mmu-miR-27a-3pOncomiRDBexternal_infoNANA19574223
Phbmmu-miR-27a-3pOncomiRDBexternal_infoNANA18789835
Odc1mmu-miR-27a-5pMirecordsexternal_infoNANA19878148
Phbmmu-miR-27a-3pOncomiRDBexternal_infoNANA22505583

Predicted Targets
Summary Value
Count of predictions:29856
Count of gene targets:12806
Count of transcripts:22294
Interacting mature miRNAs:mmu-miR-27a-3p, mmu-miR-27a-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000083510
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl884,935,301 - 84,935,387 (+)Ensembl
GRCm38.p6 Ensembl884,208,672 - 84,208,758 (+)Ensembl
RefSeq Acc Id: NR_029746
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39884,935,301 - 84,935,387 (+)NCBI
GRCm38884,208,672 - 84,208,758 (+)ENTREZGENE
MGSCv37886,732,571 - 86,732,657 (+)RGD
Celera888,508,778 - 88,508,864 (+)RGD
cM Map8 ENTREZGENE
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2676902 AgrOrtholog
Ensembl Genes ENSMUSG00000065444 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000083510 ENTREZGENE
MGD MGI:2676902 ENTREZGENE
miRBase MI0000578 ENTREZGENE
NCBI Gene 387220 ENTREZGENE
PhenoGen Mir27a PhenoGen
RNAcentral URS00001B341F RNACentral
  URS00003B95DA RNACentral
  URS000075AEFF RNACentral