Otud4 (OTU domain containing 4) - Rat Genome Database
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Gene: Otud4 (OTU domain containing 4) Mus musculus
Analyze
Symbol: Otud4
Name: OTU domain containing 4
RGD ID: 1313734
MGI Page MGI
Description: Exhibits Lys63-specific deubiquitinase activity. Involved in negative regulation of interleukin-1-mediated signaling pathway; negative regulation of toll-like receptor signaling pathway; and protein K63-linked deubiquitination. Predicted to localize to cytosol. Orthologous to human OTUD4 (OTU deubiquitinase 4); INTERACTS WITH 1,2-dimethylhydrazine; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4930431L18Rik; AI449692; D8Ertd69; D8Ertd69e; mKIAA1046; OTU domain-containing protein 4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39880,366,305 - 80,404,384 (+)NCBIGRCm39mm39
GRCm38879,639,676 - 79,677,755 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl879,639,618 - 79,677,724 (+)EnsemblGRCm38mm10GRCm38
MGSCv37882,163,575 - 82,201,654 (+)NCBIGRCm37mm9NCBIm37
MGSCv36882,535,748 - 82,573,827 (+)NCBImm8
Celera883,915,553 - 83,953,642 (+)NCBICelera
Cytogenetic Map8C1NCBI
cM Map837.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (ISO)
nucleus  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11544199   PMID:12466851   PMID:12477932   PMID:12693553   PMID:14610273  
PMID:16141072   PMID:16141073   PMID:21873635   PMID:22878500   PMID:26370502   PMID:28190767   PMID:28378742   PMID:28671696   PMID:29395066   PMID:30410068   PMID:31040226   PMID:31138677  
PMID:31964525   PMID:32098917  


Genomics

Comparative Map Data
Otud4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39880,366,305 - 80,404,384 (+)NCBIGRCm39mm39
GRCm38879,639,676 - 79,677,755 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl879,639,618 - 79,677,724 (+)EnsemblGRCm38mm10GRCm38
MGSCv37882,163,575 - 82,201,654 (+)NCBIGRCm37mm9NCBIm37
MGSCv36882,535,748 - 82,573,827 (+)NCBImm8
Celera883,915,553 - 83,953,642 (+)NCBICelera
Cytogenetic Map8C1NCBI
cM Map837.74NCBI
OTUD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4145,110,838 - 145,180,589 (-)EnsemblGRCh38hg38GRCh38
GRCh384145,133,650 - 145,180,589 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374146,054,802 - 146,101,768 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364146,274,252 - 146,320,282 (-)NCBINCBI36hg18NCBI36
Celera4143,382,143 - 143,428,339 (-)NCBI
Cytogenetic Map4q31.21NCBI
HuRef4141,786,122 - 141,832,147 (-)NCBIHuRef
CHM1_14146,031,068 - 146,077,284 (-)NCBICHM1_1
Otud4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01931,895,753 - 31,942,509 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1931,899,087 - 31,942,180 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01942,799,728 - 42,846,155 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41930,124,849 - 30,167,942 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11930,129,291 - 30,172,543 (-)NCBI
Celera1927,744,764 - 27,787,846 (-)NCBICelera
Cytogenetic Map19q11NCBI
Otud4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554281,062,998 - 1,115,415 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554281,062,998 - 1,108,711 (-)NCBIChiLan1.0ChiLan1.0
OTUD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14149,141,513 - 149,187,333 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4149,135,900 - 149,182,476 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04137,480,809 - 137,527,651 (-)NCBIMhudiblu_PPA_v0panPan3
OTUD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1543,818,196 - 43,861,784 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11543,816,656 - 43,861,813 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Otud4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365353,911,904 - 3,950,675 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OTUD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl883,240,737 - 83,288,234 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1883,240,759 - 83,288,237 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2888,519,444 - 88,558,932 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OTUD4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl791,708,767 - 91,756,793 (-)Ensembl
ChlSab1.1791,709,184 - 91,756,437 (-)NCBI
Otud4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248534,091,591 - 4,145,344 (-)NCBI

Position Markers
AI449692  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38879,673,934 - 79,674,155UniSTSGRCm38
MGSCv37882,197,833 - 82,198,054UniSTSGRCm37
Celera883,949,821 - 83,950,042UniSTS
Cytogenetic Map8C3UniSTS
cM Map836.0UniSTS
Whitehead/MRC_RH21378.58UniSTS
RH126237  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38879,676,047 - 79,676,246UniSTSGRCm38
MGSCv37882,199,946 - 82,200,145UniSTSGRCm37
Celera883,951,934 - 83,952,133UniSTS
Cytogenetic Map8C3UniSTS
cM Map836.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:5473
Count of miRNA genes:863
Interacting mature miRNAs:1239
Transcripts:ENSMUST00000172614, ENSMUST00000173078, ENSMUST00000173286, ENSMUST00000173300, ENSMUST00000173868, ENSMUST00000174485
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000172614
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl879,666,823 - 79,671,378 (+)Ensembl
RefSeq Acc Id: ENSMUST00000173078   ⟹   ENSMUSP00000133939
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl879,639,618 - 79,677,724 (+)Ensembl
RefSeq Acc Id: ENSMUST00000173286   ⟹   ENSMUSP00000134097
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl879,639,704 - 79,677,672 (+)Ensembl
RefSeq Acc Id: ENSMUST00000173300
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl879,651,330 - 79,659,220 (+)Ensembl
RefSeq Acc Id: ENSMUST00000173868
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl879,651,742 - 79,661,243 (+)Ensembl
RefSeq Acc Id: ENSMUST00000174485
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl879,661,084 - 79,668,489 (+)Ensembl
RefSeq Acc Id: NM_001081164   ⟹   NP_001074633
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39880,366,305 - 80,404,384 (+)NCBI
GRCm38879,639,676 - 79,677,755 (+)ENTREZGENE
MGSCv37882,163,575 - 82,201,654 (+)RGD
Celera883,915,553 - 83,953,642 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001256033   ⟹   NP_001242962
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39880,366,305 - 80,404,384 (+)NCBI
GRCm38879,639,676 - 79,677,755 (+)ENTREZGENE
Celera883,915,553 - 83,953,642 (+)ENTREZGENE
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006531406   ⟹   XP_006531469
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39880,366,973 - 80,404,301 (+)NCBI
GRCm38879,640,104 - 79,677,755 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001074633   ⟸   NM_001081164
- Peptide Label: isoform 2
- UniProtKB: B2RRE7 (UniProtKB/Swiss-Prot),   A0A0R4J260 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001242962   ⟸   NM_001256033
- Peptide Label: isoform 1
- UniProtKB: B2RRE7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006531469   ⟸   XM_006531406
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000134097   ⟸   ENSMUST00000173286
RefSeq Acc Id: ENSMUSP00000133939   ⟸   ENSMUST00000173078
Protein Domains
OTU

Promoters
RGD ID:8667553
Promoter ID:EPDNEW_M11807
Type:initiation region
Name:Otud4_1
Description:Mus musculus OTU domain containing 4 , transcript variant 2,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38879,639,766 - 79,639,826EPDNEW
RGD ID:6843573
Promoter ID:MM_KWN:54950
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000048457,   NM_001081164
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36882,162,866 - 82,163,992 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1098801 AgrOrtholog
Ensembl Genes ENSMUSG00000036990 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000133939 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000134097 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000173078 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000173286 ENTREZGENE, UniProtKB/TrEMBL
InterPro OTU_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:73945 UniProtKB/Swiss-Prot
MGD MGI:1098801 ENTREZGENE
NCBI Gene 73945 ENTREZGENE
Pfam OTU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Otud4 PhenoGen
PROSITE OTU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.34348 ENTREZGENE
UniProt A0A0R4J260 ENTREZGENE, UniProtKB/TrEMBL
  B2RRE7 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B7ZNI5 UniProtKB/Swiss-Prot
  Q80TL3 UniProtKB/Swiss-Prot
  Q9CUN2 UniProtKB/Swiss-Prot