Otud4 (OTU domain containing 4) - Rat Genome Database
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Gene: Otud4 (OTU domain containing 4) Mus musculus
Analyze
Symbol: Otud4
Name: OTU domain containing 4
RGD ID: 1313734
MGI Page MGI
Description: Exhibits Lys63-specific deubiquitinase activity. Involved in negative regulation of interleukin-1-mediated signaling pathway; negative regulation of toll-like receptor signaling pathway; and protein K63-linked deubiquitination. Predicted to localize to cytosol. Orthologous to human OTUD4 (OTU deubiquitinase 4); INTERACTS WITH 1,2-dimethylhydrazine; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4930431L18Rik; AI449692; D8Ertd69; D8Ertd69e; mKIAA1046; OTU domain-containing protein 4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39880,366,305 - 80,404,384 (+)NCBIGRCm39mm39
GRCm38879,639,676 - 79,677,755 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl879,639,618 - 79,677,724 (+)EnsemblGRCm38mm10GRCm38
MGSCv37882,163,575 - 82,201,654 (+)NCBIGRCm37mm9NCBIm37
MGSCv36882,535,748 - 82,573,827 (+)NCBImm8
Celera883,915,553 - 83,953,642 (+)NCBICelera
Cytogenetic Map8C1NCBI
cM Map837.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11544199   PMID:12466851   PMID:12477932   PMID:12693553   PMID:14610273  
PMID:16141072   PMID:16141073   PMID:21873635   PMID:22878500   PMID:26370502   PMID:28190767   PMID:28378742   PMID:28671696   PMID:29395066   PMID:30410068   PMID:31040226   PMID:31138677  
PMID:31964525   PMID:32098917  


Genomics

Comparative Map Data
Otud4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39880,366,305 - 80,404,384 (+)NCBIGRCm39mm39
GRCm38879,639,676 - 79,677,755 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl879,639,618 - 79,677,724 (+)EnsemblGRCm38mm10GRCm38
MGSCv37882,163,575 - 82,201,654 (+)NCBIGRCm37mm9NCBIm37
MGSCv36882,535,748 - 82,573,827 (+)NCBImm8
Celera883,915,553 - 83,953,642 (+)NCBICelera
Cytogenetic Map8C1NCBI
cM Map837.74NCBI
OTUD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4145,110,838 - 145,180,589 (-)EnsemblGRCh38hg38GRCh38
GRCh384145,133,650 - 145,180,589 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374146,054,802 - 146,101,768 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364146,274,252 - 146,320,282 (-)NCBINCBI36hg18NCBI36
Celera4143,382,143 - 143,428,339 (-)NCBI
Cytogenetic Map4q31.21NCBI
HuRef4141,786,122 - 141,832,147 (-)NCBIHuRef
CHM1_14146,031,068 - 146,077,284 (-)NCBICHM1_1
Otud4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01931,895,753 - 31,942,509 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1931,899,087 - 31,942,180 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01942,799,728 - 42,846,155 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41930,124,849 - 30,167,942 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11930,129,291 - 30,172,543 (-)NCBI
Celera1927,744,764 - 27,787,846 (-)NCBICelera
Cytogenetic Map19q11NCBI
Otud4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554281,062,998 - 1,115,415 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554281,062,998 - 1,108,711 (-)NCBIChiLan1.0ChiLan1.0
OTUD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14149,141,513 - 149,187,333 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4149,135,900 - 149,182,476 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04137,480,809 - 137,527,651 (-)NCBIMhudiblu_PPA_v0panPan3
OTUD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1543,818,196 - 43,861,784 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11543,816,656 - 43,861,813 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Otud4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365353,911,904 - 3,950,675 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OTUD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl883,240,737 - 83,288,234 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1883,240,759 - 83,288,237 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2888,519,444 - 88,558,932 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OTUD4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl791,708,767 - 91,756,793 (-)Ensembl
ChlSab1.1791,709,184 - 91,756,437 (-)NCBI
Otud4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248534,091,591 - 4,145,344 (-)NCBI

Position Markers
AI449692  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38879,673,934 - 79,674,155UniSTSGRCm38
MGSCv37882,197,833 - 82,198,054UniSTSGRCm37
Celera883,949,821 - 83,950,042UniSTS
Cytogenetic Map8C3UniSTS
cM Map836.0UniSTS
Whitehead/MRC_RH21378.58UniSTS
RH126237  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38879,676,047 - 79,676,246UniSTSGRCm38
MGSCv37882,199,946 - 82,200,145UniSTSGRCm37
Celera883,951,934 - 83,952,133UniSTS
Cytogenetic Map8C3UniSTS
cM Map836.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:5473
Count of miRNA genes:863
Interacting mature miRNAs:1239
Transcripts:ENSMUST00000172614, ENSMUST00000173078, ENSMUST00000173286, ENSMUST00000173300, ENSMUST00000173868, ENSMUST00000174485
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000172614
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl879,666,823 - 79,671,378 (+)Ensembl
RefSeq Acc Id: ENSMUST00000173078   ⟹   ENSMUSP00000133939
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl879,639,618 - 79,677,724 (+)Ensembl
RefSeq Acc Id: ENSMUST00000173286   ⟹   ENSMUSP00000134097
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl879,639,704 - 79,677,672 (+)Ensembl
RefSeq Acc Id: ENSMUST00000173300
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl879,651,330 - 79,659,220 (+)Ensembl
RefSeq Acc Id: ENSMUST00000173868
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl879,651,742 - 79,661,243 (+)Ensembl
RefSeq Acc Id: ENSMUST00000174485
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl879,661,084 - 79,668,489 (+)Ensembl
RefSeq Acc Id: NM_001081164   ⟹   NP_001074633
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39880,366,305 - 80,404,384 (+)NCBI
GRCm38879,639,676 - 79,677,755 (+)ENTREZGENE
MGSCv37882,163,575 - 82,201,654 (+)RGD
Celera883,915,553 - 83,953,642 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001256033   ⟹   NP_001242962
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39880,366,305 - 80,404,384 (+)NCBI
GRCm38879,639,676 - 79,677,755 (+)ENTREZGENE
Celera883,915,553 - 83,953,642 (+)ENTREZGENE
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006531406   ⟹   XP_006531469
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39880,366,973 - 80,404,301 (+)NCBI
GRCm38879,640,104 - 79,677,755 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001074633   ⟸   NM_001081164
- Peptide Label: isoform 2
- UniProtKB: B2RRE7 (UniProtKB/Swiss-Prot),   A0A0R4J260 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001242962   ⟸   NM_001256033
- Peptide Label: isoform 1
- UniProtKB: B2RRE7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006531469   ⟸   XM_006531406
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000134097   ⟸   ENSMUST00000173286
RefSeq Acc Id: ENSMUSP00000133939   ⟸   ENSMUST00000173078
Protein Domains
OTU

Promoters
RGD ID:8667553
Promoter ID:EPDNEW_M11807
Type:initiation region
Name:Otud4_1
Description:Mus musculus OTU domain containing 4 , transcript variant 2,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38879,639,766 - 79,639,826EPDNEW
RGD ID:6843573
Promoter ID:MM_KWN:54950
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000048457,   NM_001081164
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36882,162,866 - 82,163,992 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1098801 AgrOrtholog
Ensembl Genes ENSMUSG00000036990 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000133939 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000134097 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000173078 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000173286 ENTREZGENE, UniProtKB/TrEMBL
InterPro OTU_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:73945 UniProtKB/Swiss-Prot
MGD MGI:1098801 ENTREZGENE
NCBI Gene 73945 ENTREZGENE
Pfam OTU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Otud4 PhenoGen
PROSITE OTU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.34348 ENTREZGENE
UniProt A0A0R4J260 ENTREZGENE, UniProtKB/TrEMBL
  B2RRE7 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B7ZNI5 UniProtKB/Swiss-Prot
  Q80TL3 UniProtKB/Swiss-Prot
  Q9CUN2 UniProtKB/Swiss-Prot