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ONTOLOGY REPORT - ANNOTATIONS

Term:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
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Accession:GO:0016702 term browser browse the term
Definition:Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor.
Synonyms:xref: EC:1.13.11;   reactome:R-HSA-2161775 "ALOX12 oxidises LTA4 to LXA4/B4";   reactome:R-HSA-2161907 "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4";   reactome:R-HSA-2161917 "ALOX5 oxidises 15S-HpETE to LXA4/B4";   reactome:R-HSA-5164399 "BCO2:Fe2+ cleaves betaC to APO10al and bION";   reactome:R-HSA-9018880 "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE";   reactome:R-HSA-9020274 "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA";   reactome:R-HSA-9026408 "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3";   reactome:R-HSA-9026918 "Lipoxygenase oxidises 17(S)-Hp-DHA to 7(S),17(S)-diHp-DHA"


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oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox12 arachidonate 12-lipoxygenase, 12S type enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542 		JBrowse link
G Alox12b arachidonate 12-lipoxygenase, 12R type enables ISO
IEA		 (PMID:21558561)
GO_REF:0000002		 RGD
InterPro		 PMID:21558561 GO_REF:0000002 NCBI chr10:53,863,060...53,874,938
Ensembl chr10:53,863,060...53,874,938 		JBrowse link
G Alox12e arachidonate 12-lipoxygenase, epidermal enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:55,034,392...55,041,857
Ensembl chr10:55,034,392...55,041,928 		JBrowse link
G Alox15b arachidonate 15-lipoxygenase, type B enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:53,892,496...53,901,812
Ensembl chr10:53,892,466...53,901,812 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Aloxe3 arachidonate lipoxygenase 3 enables
NOT|enables		 ISS
ISO		 GO_REF:0000024
(PMID:12881489)
(PMID:20921226), (PMID:20923767)		 UniProt
RGD		 PMID:12881489 PMID:20921226 PMID:20923767 GO_REF:0000024 NCBI chr10:53,830,219...53,854,328
Ensembl chr10:53,831,264...53,854,328 		JBrowse link
G Bco1 beta-carotene oxygenase 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr19:45,149,250...45,186,102
Ensembl chr19:45,149,265...45,186,101 		JBrowse link
G Bco2 beta-carotene oxygenase 2 enables ISO (PMID:11278918), (PMID:21302131)
(MGI:2159483|PMID:11278918), (MGI:4947204|PMID:21106934)		 RGD PMID:11278918 PMID:21106934 PMID:21302131 MGI:2159483 MGI:4947204 NCBI chr 8:50,882,174...50,907,676
Ensembl chr 8:50,882,181...50,915,467 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 enables IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 enables IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:8203528 GO_REF:0000033, RGD:1642604 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rpe65 retinoid isomerohydrolase RPE65 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:248,766,497...248,798,403
Ensembl chr 2:248,766,612...248,798,403 		JBrowse link
G Tmlhe trimethyllysine hydroxylase, epsilon enables ISO (PMID:12121276) RGD PMID:12121276 NCBI chr20:91,234...138,942
Ensembl chr20:91,272...140,386 		JBrowse link
3-hydroxyanthranilate 3,4-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Haao 3-hydroxyanthranilate 3,4-dioxygenase enables IDA
ISO
IBA
IEA		 (PMID:1611505), (PMID:7805640)
GO_REF:0000033
GO_REF:0000104
GO_REF:0000002
(PMID:12007609), (PMID:28792876), (PMID:7514594)
GO_REF:0000003
GO_REF:0000116		 RGD
GO_Central
UniProt
InterPro
RHEA		 PMID:1611505 PMID:7514594 PMID:7805640 PMID:12007609 PMID:28792876 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000116, RGD:2290301, RGD:2290370, RGD:2290302 NCBI chr 6:10,845,235...10,864,863
Ensembl chr 6:10,845,771...10,864,877 		JBrowse link
4-hydroxyphenylpyruvate dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hpd 4-hydroxyphenylpyruvate dioxygenase enables TAS
IBA
IEA
ISO
IDA		 GO_REF:0000033
GO_REF:0000002
(PMID:1339442), (PMID:31537781)
PMID:15301540
PMID:12867153
PMID:8814303		 GO_Central
InterPro
RGD		 PMID:1339442 PMID:31537781 PMID:12867153 PMID:15301540 PMID:12867153 More... GO_REF:0000002 GO_REF:0000033, RGD:632936, RGD:151356621, RGD:632936, RGD:8554707 NCBI chr12:33,381,397...33,392,750
Ensembl chr12:33,381,231...33,392,766 		JBrowse link
G Hpdl 4-hydroxyphenylpyruvate dioxygenase-like enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:130,286,627...130,288,233
Ensembl chr 5:130,286,631...130,288,233 		JBrowse link
acireductone dioxygenase (Ni2+-requiring) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adi1 acireductone dioxygenase 1 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 6:45,306,885...45,313,847
Ensembl chr 6:45,306,841...45,313,842 		JBrowse link
acireductone dioxygenase [iron(II)-requiring] activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adi1 acireductone dioxygenase 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:45,306,885...45,313,847
Ensembl chr 6:45,306,841...45,313,842 		JBrowse link
arachidonate 12(R)-lipoxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox12b arachidonate 12-lipoxygenase, 12R type enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr10:53,863,060...53,874,938
Ensembl chr10:53,863,060...53,874,938 		JBrowse link
arachidonate 12(S)-lipoxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox12 arachidonate 12-lipoxygenase, 12S type enables ISO
IBA
ISS		 (PMID:17493578), (PMID:18311922), (PMID:1851637), (PMID:2217179), (PMID:22984144), (PMID:2377602), (PMID:24282679), (PMID:8319693)
GO_REF:0000033
(MGI:6316908|PMID:11256953), (MGI:66203|PMID:8188678)
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:1851637 PMID:2217179 PMID:2377602 PMID:8188678 PMID:8319693 More... GO_REF:0000024 GO_REF:0000033 MGI:6316908 MGI:66203 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542 		JBrowse link
G Alox12b arachidonate 12-lipoxygenase, 12R type enables IEA
IBA
ISO
ISS		 GO_REF:0000107
GO_REF:0000033
(MGI:3608217|PMID:16129665), (MGI:6316908|PMID:11256953), (PMID:10100631)
(PMID:15629692)
GO_REF:0000024		 Ensembl
GO_Central
RGD
UniProt		 PMID:10100631 PMID:11256953 PMID:15629692 PMID:16129665 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:3608217 MGI:6316908 NCBI chr10:53,863,060...53,874,938
Ensembl chr10:53,863,060...53,874,938 		JBrowse link
G Alox12e arachidonate 12-lipoxygenase, epidermal enables ISS
IBA
IEA		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000107		 UniProt
GO_Central
Ensembl		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr10:55,034,392...55,041,857
Ensembl chr10:55,034,392...55,041,928 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase enables IDA
IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000117
(PMID:17493578), (PMID:18311922), (PMID:8305485)
(MGI:66203|PMID:8188678)
(PMID:1944593)		 GO_Central
UniProt
RGD		 PMID:1944593 PMID:8188678 PMID:8305485 PMID:17493578 PMID:18311922 More... GO_REF:0000033 GO_REF:0000117 MGI:66203, RGD:70288 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
arachidonate 15-lipoxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox12 arachidonate 12-lipoxygenase, 12S type enables ISO
IBA
ISS		 (PMID:17493578), (PMID:18311922)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:17493578 PMID:18311922 GO_REF:0000024 GO_REF:0000033 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542 		JBrowse link
G Alox12e arachidonate 12-lipoxygenase, epidermal enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:55,034,392...55,041,857
Ensembl chr10:55,034,392...55,041,928 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase enables IDA
IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
(MGI:66203|PMID:8188678)
(PMID:17052953), (PMID:1944593), (PMID:24282679), (PMID:8334154)		 GO_Central
Ensembl
RGD		 PMID:1944593 PMID:8188678 PMID:8334154 PMID:17052953 PMID:24282679 More... GO_REF:0000033 GO_REF:0000107 MGI:66203, RGD:70287 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Alox15b arachidonate 15-lipoxygenase, type B enables IEA
IBA
ISO
IDA		 GO_REF:0000107
GO_REF:0000033
(MGI:5810233|PMID:27435673)
(PMID:10542053), (PMID:10625675), (PMID:11956198), (PMID:17493578), (PMID:18311922), (PMID:24282679), (PMID:24497644), (PMID:27145229), (PMID:27435673), (PMID:9177185)
PMID:23382512		 Ensembl
GO_Central
RGD		 PMID:9177185 PMID:10542053 PMID:10625675 PMID:11956198 PMID:17493578 More... GO_REF:0000033 GO_REF:0000107 MGI:5810233, RGD:8554649 NCBI chr10:53,892,496...53,901,812
Ensembl chr10:53,892,466...53,901,812 		JBrowse link
arachidonate 5-lipoxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase enables ISS
IBA
ISO
IEA		 GO_REF:0000024
GO_REF:0000033
(MGI:5551713|PMID:23246375), (MGI:6392995|PMID:31642348)
GO_REF:0000107
(PMID:19022417), (PMID:21233389), (PMID:22516296), (PMID:23246375), (PMID:24282679), (PMID:24893149), (PMID:8615788), (PMID:8631361)		 UniProt
GO_Central
RGD
Ensembl		 PMID:8615788 PMID:8631361 PMID:19022417 PMID:21233389 PMID:22516296 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:5551713 MGI:6392995 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein contributes_to IDA RGD PMID:2300173 RGD:69749 NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986 		JBrowse link
arachidonate 8(R)-lipoxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox12b arachidonate 12-lipoxygenase, 12R type enables ISO
IEA		 (MGI:6316908|PMID:11256953)
GO_REF:0000107		 RGD
Ensembl		 PMID:11256953 GO_REF:0000107 MGI:6316908 NCBI chr10:53,863,060...53,874,938
Ensembl chr10:53,863,060...53,874,938 		JBrowse link
arachidonate 8(S)-lipoxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox15b arachidonate 15-lipoxygenase, type B enables IEA
ISO		 GO_REF:0000107
(MGI:1097306|PMID:9305900), (MGI:3784332|PMID:10965849), (MGI:5508744|PMID:10625675), (MGI:6414723|PMID:16112079)		 Ensembl
RGD		 PMID:9305900 PMID:10625675 PMID:10965849 PMID:16112079 GO_REF:0000107 MGI:1097306 MGI:3784332 MGI:5508744 MGI:6414723 NCBI chr10:53,892,496...53,901,812
Ensembl chr10:53,892,466...53,901,812 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
beta,beta-carotene-9',10'-cleaving oxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bco2 beta-carotene oxygenase 2 enables ISO (MGI:2159483|PMID:11278918), (MGI:4947204|PMID:21106934) RGD PMID:11278918 PMID:21106934 MGI:2159483 MGI:4947204 NCBI chr 8:50,882,174...50,907,676
Ensembl chr 8:50,882,181...50,915,467 		JBrowse link
beta-carotene 15,15'-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bco1 beta-carotene oxygenase 1 enables IDA
IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
(MGI:1931377|PMID:11092891), (MGI:3587559|PMID:15951442)
(PMID:11401432), (PMID:17951468), (PMID:24668807)		 GO_Central
Ensembl
RGD		 PMID:11092891 PMID:11401432 PMID:15951442 PMID:17951468 PMID:24668807 More... GO_REF:0000033 GO_REF:0000107 MGI:1931377 MGI:3587559, RGD:634627 NCBI chr19:45,149,250...45,186,102
Ensembl chr19:45,149,265...45,186,101 		JBrowse link
G Bco2 beta-carotene oxygenase 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:50,882,174...50,907,676
Ensembl chr 8:50,882,181...50,915,467 		JBrowse link
G Rpe65 retinoid isomerohydrolase RPE65 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:248,766,497...248,798,403
Ensembl chr 2:248,766,612...248,798,403 		JBrowse link
G Rps13 ribosomal protein S13 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:170,572,925...170,575,355
Ensembl chr 1:170,572,921...170,575,355
Ensembl chr 3:170,572,921...170,575,355 		JBrowse link
G Rps13l1 ribosomal protein S13 like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:56,457,121...56,457,669
Ensembl chr 5:56,457,124...56,457,669 		JBrowse link
carotenoid dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bco1 beta-carotene oxygenase 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:45,149,250...45,186,102
Ensembl chr19:45,149,265...45,186,101 		JBrowse link
G Bco2 beta-carotene oxygenase 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:50,882,174...50,907,676
Ensembl chr 8:50,882,181...50,915,467 		JBrowse link
G Rps13 ribosomal protein S13 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:170,572,925...170,575,355
Ensembl chr 1:170,572,921...170,575,355
Ensembl chr 3:170,572,921...170,575,355 		JBrowse link
G Rps13l1 ribosomal protein S13 like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:56,457,121...56,457,669
Ensembl chr 5:56,457,124...56,457,669 		JBrowse link
cysteamine dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ado 2-aminoethanethiol dioxygenase enables ISO (PMID:17581819), (PMID:29752763), (PMID:31273118), (PMID:32601061)
(MGI:3722450|PMID:17581819), (MGI:6874249|PMID:32601061)		 RGD PMID:17581819 PMID:29752763 PMID:31273118 PMID:32601061 MGI:3722450 MGI:6874249 NCBI chr20:21,044,815...21,045,983
Ensembl chr20:21,044,555...21,049,235 		JBrowse link
cysteine dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdo1 cysteine dioxygenase type 1 enables TAS
IBA
IEA
ISO
IDA		 GO_REF:0000033
GO_REF:0000104
(MGI:3620384|PMID:16492780)
(PMID:17135237)
PMID:9824269		 GO_Central
UniProt
RGD		 PMID:16492780 PMID:17135237 PMID:2334417 PMID:9824269 PMID:16611641 GO_REF:0000033 GO_REF:0000104 MGI:3620384, RGD:68765, RGD:8554270, RGD:2301357 NCBI chr18:39,432,473...39,447,253
Ensembl chr18:39,432,474...39,447,296 		JBrowse link
homogentisate 1,2-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hgd homogentisate 1, 2-dioxygenase enables ISO
IBA		 (PMID:8782815)
GO_REF:0000033
(MGI:6867296|PMID:7705358)		 RGD
GO_Central		 PMID:7705358 PMID:8782815 GO_REF:0000033 MGI:6867296 NCBI chr11:63,086,750...63,138,325
Ensembl chr11:63,086,752...63,138,323 		JBrowse link
indoleamine 2,3-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ido1 indoleamine 2,3-dioxygenase 1 enables IDA
IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
(PMID:25310899)		 GO_Central
Ensembl
RGD		 PMID:25310899 PMID:10719243 PMID:11513477 PMID:3400092 GO_REF:0000033 GO_REF:0000107, RGD:2290190, RGD:2290543, RGD:2290313 NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730 		JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 enables IEA
ISO
IBA		 GO_REF:0000107
(PMID:17499941), (PMID:17671174)
GO_REF:0000033
(PMID:17671174)		 Ensembl
RGD
GO_Central		 PMID:17499941 PMID:17671174 GO_REF:0000033 GO_REF:0000107 NCBI chr16:67,459,158...67,498,052
Ensembl chr16:67,459,190...67,496,324 		JBrowse link
linoleate 13S-lipoxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox12 arachidonate 12-lipoxygenase, 12S type enables ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(MGI:6316908|PMID:11256953)
(PMID:8319693)		 UniProt
GO_Central
RGD		 PMID:8319693 PMID:11256953 GO_REF:0000024 GO_REF:0000033 MGI:6316908 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542 		JBrowse link
G Alox12e arachidonate 12-lipoxygenase, epidermal enables ISS
IBA
IEA		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000107		 UniProt
GO_Central
Ensembl		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr10:55,034,392...55,041,857
Ensembl chr10:55,034,392...55,041,928 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase enables ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:8334154)		 UniProt
GO_Central
RGD		 PMID:8334154 GO_REF:0000024 GO_REF:0000033 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Alox15b arachidonate 15-lipoxygenase, type B enables ISO
IEA		 (PMID:10542053)
GO_REF:0000107		 RGD
Ensembl		 PMID:10542053 GO_REF:0000107 NCBI chr10:53,892,496...53,901,812
Ensembl chr10:53,892,466...53,901,812 		JBrowse link
linoleate 9S-lipoxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox12b arachidonate 12-lipoxygenase, 12R type enables ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:3608217|PMID:16129665)		 UniProt
Ensembl
RGD		 PMID:16129665 GO_REF:0000024 GO_REF:0000107 MGI:3608217 NCBI chr10:53,863,060...53,874,938
Ensembl chr10:53,863,060...53,874,938 		JBrowse link
G Alox15b arachidonate 15-lipoxygenase, type B enables IEA
ISO		 GO_REF:0000107
(MGI:1097306|PMID:9305900)		 Ensembl
RGD		 PMID:9305900 GO_REF:0000107 MGI:1097306 NCBI chr10:53,892,496...53,901,812
Ensembl chr10:53,892,466...53,901,812 		JBrowse link
quercetin 2,3-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pir pirin enables ISO
IBA
ISS		 (PMID:15951572)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:15951572 GO_REF:0000024 GO_REF:0000033 NCBI chr  X:30,108,536...30,219,269
Ensembl chr  X:30,108,538...30,219,218 		JBrowse link
sulfur dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ethe1 ETHE1, persulfide dioxygenase enables ISO
IBA		 (PMID:23144459)
GO_REF:0000033		 RGD
GO_Central		 PMID:23144459 GO_REF:0000033 NCBI chr 1:80,184,037...80,199,092
Ensembl chr 1:80,183,894...80,199,052 		JBrowse link
tryptophan 2,3-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ido1 indoleamine 2,3-dioxygenase 1 enables IEA
ISO
IBA		 GO_REF:0000107
(PMID:11751753)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:11751753 GO_REF:0000033 GO_REF:0000107 NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730 		JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:67,459,158...67,498,052
Ensembl chr16:67,459,190...67,496,324 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase enables IDA
IBA
ISO		 GO_REF:0000033
(PMID:27762317), (PMID:28285122)		 GO_Central
RGD		 PMID:27762317 PMID:28285122 PMID:10719243 PMID:7236232 PMID:3899109 More... GO_REF:0000033, RGD:2290190, RGD:2303721, RGD:2291804, RGD:2290313 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20483
    catalytic activity 6036
      oxidoreductase activity 850
        dioxygenase activity 98
          oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 28
            1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity 0
            1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity 0
            1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity 0
            1-hydroxy-2-naphthoate 1,2-dioxygenase activity 0
            2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity 0
            2,2',3-trihydroxybiphenyl dioxygenase activity 0
            2,3-dihydroxy DDT 1,2-dioxygenase activity 0
            2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity 0
            2,3-dihydroxy-p-cumate dioxygenase activity 0
            2,3-dihydroxybenzoate 2,3-dioxygenase activity 0
            2,3-dihydroxybenzoate 3,4-dioxygenase activity 0
            2,3-dihydroxybiphenyl 1,2-dioxygenase activity 0
            2,3-dihydroxydiphenyl ether dioxygenase activity 0
            2,3-dihydroxyindole 2,3-dioxygenase activity 0
            2,4'-dihydroxyacetophenone dioxygenase activity 0
            2,5-dihydroxypyridine 5,6-dioxygenase activity 0
            2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity 0
            2-aminophenol 1,6-dioxygenase activity 0
            2-mercaptobenzothiazole dioxygenase activity 0
            3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity 0
            3,4-dihydroxyphenanthrene dioxygenase activity 0
            3,4-dihydroxyphenylacetate 2,3-dioxygenase activity 0
            3,5-dichlorocatechol 1,2-dioxygenase activity 0
            3-carboxyethylcatechol 2,3-dioxygenase activity 0
            3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity 0
            3-hydroxy-2-naphthoate 2,3-dioxygenase activity 0
            3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity 0
            3-hydroxyanthranilate 3,4-dioxygenase activity 1
            4,5-dihydroxybenzo(a)pyrene dioxygenase activity 0
            4,5-dihydroxypyrene dioxygenase activity 0
            4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity 0
            4-hydroxycatechol 1,2-dioxygenase activity 0
            4-hydroxymandelate synthase activity 0
            4-hydroxyphenylpyruvate dioxygenase activity 2
            5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity 0
            5,6-dimethylbenzimidazole synthase activity 0
            5-aminosalicylate dioxygenase activity 0
            7,8-dihydroxy benzo(a)pyrene dioxygenase activity 0
            7,8-dihydroxykynurenate 8,8a-dioxygenase activity 0
            9,10-dihydroxybenzo(a)pyrene dioxygenase activity 0
            9-cis-10'-apo-beta-carotenal cleavage oxygenase activity 0
            9-cis-beta-carotene 9',10'-cleavage oxygenase activity 0
            acetylacetone-cleaving enzyme activity 0
            acireductone dioxygenase (Ni2+-requiring) activity 1
            acireductone dioxygenase [iron(II)-requiring] activity 1
            all-trans-8'-apo-beta-carotenal 15,15'-oxygenase activity 0
            all-trans-beta-apo-10'-carotenal cleavage oxygenase activity 0
            arachidonate 12(R)-lipoxygenase activity 1
            arachidonate 12(S)-lipoxygenase activity 5
            arachidonate 15-lipoxygenase activity 4
            arachidonate 5-lipoxygenase activity 2
            arachidonate 8(R)-lipoxygenase activity 1
            arachidonate 8(S)-lipoxygenase activity 2
            benzo(a)pyrene 11,12-dioxygenase activity 0
            benzo(a)pyrene 4,5-dioxygenase activity 0
            benzo(a)pyrene 7,8-dioxygenase activity 0
            benzo(a)pyrene 9,10-dioxygenase activity 0
            beta,beta-carotene-9',10'-cleaving oxygenase activity 1
            beta-carotene 15,15'-dioxygenase activity 5
            biphenyl-2,3-diol 1,2-dioxygenase activity 0
            caffeate 3,4-dioxygenase activity 0
            carbazole 1,9a-dioxygenase activity 0
            carotenoid dioxygenase activity + 4
            catechol dioxygenase activity + 0
            chloridazon-catechol dioxygenase activity 0
            chlorite O2-lyase activity 0
            chlorocatechol 1,2-dioxygenase activity 0
            cysteamine dioxygenase activity 1
            cysteine dioxygenase activity 1
            dihydroxydibenzothiophene dioxygenase activity 0
            dihydroxyfluorene dioxygenase activity + 0
            diphenyl ether 1,2-dioxygenase activity 0
            fatty acid alpha-oxygenase activity 0
            gallate dioxygenase activity 0
            gentisate 1,2-dioxygenase activity 0
            homogentisate 1,2-dioxygenase activity 1
            hydroquinone 1,2-dioxygenase activity 0
            hydroxyquinol 1,2-dioxygenase activity 0
            indole 2,3-dioxygenase activity 0
            indoleamine 2,3-dioxygenase activity 2
            lignostilbene alpha beta-dioxygenase activity 0
            linoleate 11-lipoxygenase activity 0
            linoleate 13S-lipoxygenase activity 4
            linoleate 8R-lipoxygenase activity 0
            linoleate 9R-lipoxygenase activity 0
            linoleate 9S-lipoxygenase activity 2
            linolenate 9R-lipoxygenase activity 0
            lutein oxygenase activity 0
            p-cumate 2,3-dioxygenase activity 0
            phenanthrene dioxygenase activity 0
            phenanthrene-4-carboxylate dioxygenase activity 0
            protocatechuate 3,4-dioxygenase activity 0
            protocatechuate 3,4-dioxygenase type II activity 0
            protocatechuate 4,5-dioxygenase activity 0
            pyrene dioxygenase activity 0
            pyridine-3,4-diol dioxygenase activity 0
            pyrogallol 1,2-oxygenase activity 0
            quercetin 2,3-dioxygenase activity 1
            stizolobate synthase activity 0
            stizolobinate synthase activity 0
            styrene dioxygenase activity 0
            sulfur dioxygenase activity 1
            sulfur oxygenase/reductase activity 0
            tetrachlorobenzene dioxygenase activity 0
            tryptophan 2,3-dioxygenase activity 3
            violaxanthin oxygenase activity 0
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