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ONTOLOGY REPORT - ANNOTATIONS


Term:indoleamine 2,3-dioxygenase activity
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Accession:GO:0033754 term browser browse the term
Definition:Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl-D-kynurenine, and L-tryptophan produces N-formyl-L-kynurenine.
Synonyms:narrow_synonym: D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) activity
 broad_synonym: tryptophan pyrrolase activity
 related_synonym: IDO
 xref: EC:1.13.11.52;   MetaCyc:RXN-8664;   MetaCyc:RXN-8665;   RHEA:14189



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indoleamine 2,3-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ido1 indoleamine 2,3-dioxygenase 1 enables IDA
IBA
ISO
IEA
PMID:21873635
(PMID:25310899)
GO_REF:0000107
RGD
Ensembl
PMID:25310899 PMID:10719243 PMID:21873635 PMID:3400092 PMID:11513477 GO_REF:0000107, RGD:2290190, RGD:13792537, RGD:2290313, RGD:2290543 NCBI chr16:67,430,684...67,442,459
Ensembl chr16:67,430,578...67,442,730
JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 enables IEA
ISO
IBA
GO_REF:0000107
(PMID:17671174)
PMID:21873635
(MGI:3712725|PMID:17499941), (MGI:3719924|PMID:17671174)
Ensembl
RGD
PMID:17499941 PMID:17671174 PMID:21873635 GO_REF:0000107 MGI:3712725 MGI:3719924, RGD:13792537 NCBI chr16:67,459,158...67,498,052
Ensembl chr16:67,459,190...67,496,324
JBrowse link

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  molecular_function 19910
    catalytic activity 5746
      oxidoreductase activity 814
        dioxygenase activity 93
          oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 25
            indoleamine 2,3-dioxygenase activity 2
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